Mutagenetix > Incidental Mutation

Incidental Mutation 'R5041:Or51h7'

452799

Institutional Source

Beutler Lab

Gene Symbol

Or51h7

Ensembl Gene

ENSMUSG00000052785

Gene Name

olfactory receptor family 51 subfamily H member 7

Synonyms

Olfr573, MOR10-3P, MOR10-4, GA_x6K02T2PBJ9-5653743-5652872

MMRRC Submission

042631-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

R5041 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

102590889-102591782 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 102591785 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000147664 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064830] [ENSMUST00000210571]

AlphaFold

A0A1B0GRU2

Predicted Effect

probably null
Transcript: ENSMUST00000064830

SMART Domains

Protein: ENSMUSP00000065147
Gene: ENSMUSG00000052785

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	296	9.3e-109	PFAM
Pfam:7tm_1	43	288	4.6e-17	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000064830

Predicted Effect

probably null
Transcript: ENSMUST00000210571

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.6%
20x: 93.5%

Validation Efficiency

98% (42/43)

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrg7	A	G	16: 56,550,711 (GRCm39)	F667S	probably benign	Het
Akna	A	G	4: 63,305,381 (GRCm39)	Y462H	possibly damaging	Het
Anxa11	G	T	14: 25,875,188 (GRCm39)	E278*	probably null	Het
Ap3s2	T	C	7: 79,570,267 (GRCm39)	Y20C	probably benign	Het
Atxn7	T	C	14: 14,096,317 (GRCm38)		probably null	Het
AW551984	T	C	9: 39,511,894 (GRCm39)	Y39C	probably damaging	Het
Becn1	A	T	11: 101,179,662 (GRCm39)	S442T	probably benign	Het
Bhlhe40	C	T	6: 108,639,546 (GRCm39)	T108I	probably damaging	Het
Cnst	A	G	1: 179,432,593 (GRCm39)	D252G	probably damaging	Het
Cpxm1	A	G	2: 130,235,990 (GRCm39)	S391P	probably damaging	Het
Ctnna2	T	A	6: 76,892,746 (GRCm39)	N814Y	probably damaging	Het
Ddx3y	T	A	Y: 1,266,611 (GRCm39)	Y282F	probably benign	Het
Ddx56	A	G	11: 6,214,178 (GRCm39)	V357A	probably damaging	Het
Frmpd1	T	G	4: 45,278,878 (GRCm39)	C534W	probably damaging	Het
Gimap8	A	G	6: 48,636,097 (GRCm39)	N621D	probably damaging	Het
Herc1	T	A	9: 66,336,327 (GRCm39)	I1624N	possibly damaging	Het
Htr7	A	C	19: 36,034,467 (GRCm39)	W63G	probably benign	Het
Ly6g6c	T	A	17: 35,284,428 (GRCm39)		probably null	Het
Macf1	T	C	4: 123,290,839 (GRCm39)		probably null	Het
Mfrp	A	G	9: 44,013,575 (GRCm39)	D62G	probably damaging	Het
Ncam1	T	C	9: 49,478,085 (GRCm39)	Y173C	probably damaging	Het
Nwd1	T	C	8: 73,431,683 (GRCm39)	V1185A	possibly damaging	Het
Or4c113	A	T	2: 88,885,265 (GRCm39)	C168*	probably null	Het
Pcf11	G	A	7: 92,307,613 (GRCm39)	P852S	probably benign	Het
Pramel25	T	C	4: 143,520,260 (GRCm39)	V4A	probably benign	Het
Ralgapa2	T	C	2: 146,327,071 (GRCm39)	I63V	probably benign	Het
Rsf1	GCGGCGGCG	GCGGCGGCGTCGGCGGCG	7: 97,229,132 (GRCm39)		probably benign	Het
Rubcnl	T	C	14: 75,287,572 (GRCm39)	F619L	probably damaging	Het
Sec24d	A	T	3: 123,087,880 (GRCm39)	Q247L	probably damaging	Het
Spmap2l	A	G	5: 77,203,928 (GRCm39)	T319A	probably benign	Het
Spns3	G	T	11: 72,427,373 (GRCm39)	Q306K	possibly damaging	Het
Sstr1	T	C	12: 58,259,941 (GRCm39)	V188A	possibly damaging	Het
Supt5	A	T	7: 28,014,805 (GRCm39)	L1024Q	probably damaging	Het
Tent4b	CCCAACAACGCCAACAA	CCCAACAA	8: 88,981,878 (GRCm39)		probably benign	Het
Unc13b	T	A	4: 43,237,836 (GRCm39)	H3452Q	probably benign	Het
Usp28	A	G	9: 48,949,073 (GRCm39)	Q864R	probably benign	Het
Vmn2r43	T	C	7: 8,247,806 (GRCm39)	T786A	probably damaging	Het
Yy1	TCACCACCACCACCACCACCACCACCACC	TCACCACCACCACCACCACCACCACCACCACC	12: 108,759,557 (GRCm39)		probably benign	Het

Other mutations in Or51h7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0472:Or51h7	UTSW	7	102,591,258 (GRCm39)	nonsense	probably null
R1537:Or51h7	UTSW	7	102,591,547 (GRCm39)	missense	probably damaging	1.00
R2168:Or51h7	UTSW	7	102,591,678 (GRCm39)	missense	probably benign	0.00
R3781:Or51h7	UTSW	7	102,591,278 (GRCm39)	missense	probably benign
R4198:Or51h7	UTSW	7	102,591,004 (GRCm39)	missense	probably damaging	1.00
R4200:Or51h7	UTSW	7	102,591,004 (GRCm39)	missense	probably damaging	1.00
R4333:Or51h7	UTSW	7	102,591,176 (GRCm39)	missense	possibly damaging	0.50
R4838:Or51h7	UTSW	7	102,591,453 (GRCm39)	missense	probably damaging	1.00
R5371:Or51h7	UTSW	7	102,591,719 (GRCm39)	missense	probably benign
R5668:Or51h7	UTSW	7	102,591,128 (GRCm39)	missense	probably benign	0.44
R7836:Or51h7	UTSW	7	102,591,125 (GRCm39)	missense	possibly damaging	0.94
R7887:Or51h7	UTSW	7	102,591,358 (GRCm39)	missense	possibly damaging	0.94
R7991:Or51h7	UTSW	7	102,591,760 (GRCm39)	missense	probably benign	0.12
R9660:Or51h7	UTSW	7	102,591,259 (GRCm39)	missense	probably damaging	1.00
R9717:Or51h7	UTSW	7	102,591,165 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCAAAGCCAACATGCAGAGG -3'
(R):5'- CCACCACGTATGAACTGCTAG -3'

Sequencing Primer
(F):5'- GTAGTACATAGGCTCATGGAGG -3'
(R):5'- CCACGTATGAACTGCTAGAAAAAG -3'

Posted On

2017-01-06