Incidental Mutation 'R0553:Or5k8'
ID 45301
Institutional Source Beutler Lab
Gene Symbol Or5k8
Ensembl Gene ENSMUSG00000060663
Gene Name olfactory receptor family 5 subfamily K member 8
Synonyms GA_x54KRFPKG5P-55026345-55025418, MOR184-10P, MOR184-1, GA_x54KRFPKG5P-54993816-54992890, Olfr175-ps1, Olfr175, Olfr174
MMRRC Submission 038745-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.122) question?
Stock # R0553 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 58644144-58647124 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 58644518 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 185 (Y185N)
Ref Sequence ENSEMBL: ENSMUSP00000150202 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079955] [ENSMUST00000215069]
AlphaFold A0A140T8K4
Predicted Effect probably damaging
Transcript: ENSMUST00000079955
AA Change: Y185N

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000078873
Gene: ENSMUSG00000060663
AA Change: Y185N

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.3e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 305 6.8e-6 PFAM
Pfam:7tm_1 41 290 2.5e-18 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215069
AA Change: Y185N

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
Meta Mutation Damage Score 0.4618 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.6%
  • 20x: 93.1%
Validation Efficiency 100% (42/42)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530002B09Rik A T 4: 122,596,128 (GRCm39) M120L unknown Het
Aadacl4fm5 T A 4: 144,503,985 (GRCm39) I389L possibly damaging Het
Adamts13 T A 2: 26,881,346 (GRCm39) C774* probably null Het
Amh A G 10: 80,642,010 (GRCm39) probably benign Het
Armh4 T C 14: 49,920,143 (GRCm39) I729V probably damaging Het
Cd40 G A 2: 164,912,661 (GRCm39) R204Q probably benign Het
Cfap210 C A 2: 69,619,785 (GRCm39) R8L probably damaging Het
Clhc1 A C 11: 29,511,366 (GRCm39) probably benign Het
Fbxl17 G A 17: 63,663,846 (GRCm39) R67C probably damaging Het
Flg2 A T 3: 93,110,891 (GRCm39) H973L unknown Het
Fut2 T A 7: 45,300,698 (GRCm39) I25F probably damaging Het
Galnt7 T C 8: 58,005,464 (GRCm39) probably benign Het
Gmppb A T 9: 107,926,996 (GRCm39) M56L probably benign Het
Grm3 C A 5: 9,620,048 (GRCm39) A399S probably benign Het
H2-T5 G T 17: 36,478,949 (GRCm39) P100Q probably damaging Het
Hey2 G A 10: 30,716,485 (GRCm39) probably benign Het
Ift172 A G 5: 31,433,186 (GRCm39) probably benign Het
Kcnh5 C A 12: 75,184,447 (GRCm39) C92F probably benign Het
Kdm1a T C 4: 136,282,609 (GRCm39) D229G probably damaging Het
Klf11 C G 12: 24,705,089 (GRCm39) P164R probably benign Het
Klhl41 G A 2: 69,500,554 (GRCm39) R5Q probably benign Het
Krtcap3 T C 5: 31,409,147 (GRCm39) V6A probably benign Het
Ltbr A C 6: 125,290,351 (GRCm39) probably null Het
Mmp17 T G 5: 129,675,734 (GRCm39) S298A probably benign Het
Nacc2 T A 2: 25,979,602 (GRCm39) E278V possibly damaging Het
Or8b12b T A 9: 37,684,627 (GRCm39) I224N probably benign Het
Otop2 C T 11: 115,220,288 (GRCm39) A376V probably damaging Het
Pdia2 T C 17: 26,415,217 (GRCm39) E504G probably damaging Het
Pdzph1 C T 17: 59,229,722 (GRCm39) V979M probably damaging Het
Pou5f1 A G 17: 35,820,374 (GRCm39) K86R possibly damaging Het
Ptprq A G 10: 107,546,488 (GRCm39) F269L probably benign Het
Rb1 A T 14: 73,449,152 (GRCm39) C659* probably null Het
Rnf8 T C 17: 29,840,613 (GRCm39) probably null Het
Rras T G 7: 44,669,980 (GRCm39) I137M probably benign Het
Slc38a9 A T 13: 112,850,732 (GRCm39) H372L probably damaging Het
Spata9 T C 13: 76,125,898 (GRCm39) probably null Het
Tas2r115 T C 6: 132,714,922 (GRCm39) T10A probably benign Het
Ttn T C 2: 76,629,237 (GRCm39) E12621G probably damaging Het
Unc80 A T 1: 66,545,828 (GRCm39) I460F probably damaging Het
Wdr17 C T 8: 55,146,131 (GRCm39) A90T possibly damaging Het
Zbtb24 C T 10: 41,327,993 (GRCm39) A293V possibly damaging Het
Zpld2 T C 4: 133,929,829 (GRCm39) T159A possibly damaging Het
Other mutations in Or5k8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01402:Or5k8 APN 16 58,644,958 (GRCm39) missense probably damaging 1.00
IGL01404:Or5k8 APN 16 58,644,958 (GRCm39) missense probably damaging 1.00
IGL01867:Or5k8 APN 16 58,644,337 (GRCm39) missense probably damaging 1.00
IGL02073:Or5k8 APN 16 58,644,169 (GRCm39) missense probably benign
IGL02393:Or5k8 APN 16 58,644,409 (GRCm39) missense probably damaging 0.99
IGL02474:Or5k8 APN 16 58,645,019 (GRCm39) missense probably benign
IGL02548:Or5k8 APN 16 58,644,691 (GRCm39) missense probably benign 0.42
IGL02948:Or5k8 APN 16 58,644,451 (GRCm39) missense probably benign 0.00
PIT4504001:Or5k8 UTSW 16 58,644,671 (GRCm39) missense probably benign 0.00
R1191:Or5k8 UTSW 16 58,644,922 (GRCm39) missense probably benign
R1201:Or5k8 UTSW 16 58,644,226 (GRCm39) missense probably damaging 0.98
R1458:Or5k8 UTSW 16 58,645,039 (GRCm39) missense probably null 0.68
R1469:Or5k8 UTSW 16 58,644,973 (GRCm39) missense probably benign
R1469:Or5k8 UTSW 16 58,644,973 (GRCm39) missense probably benign
R1843:Or5k8 UTSW 16 58,644,440 (GRCm39) missense probably damaging 0.99
R2147:Or5k8 UTSW 16 58,644,842 (GRCm39) missense probably damaging 0.99
R2421:Or5k8 UTSW 16 58,644,709 (GRCm39) missense probably damaging 1.00
R4370:Or5k8 UTSW 16 58,644,956 (GRCm39) missense probably benign 0.00
R4621:Or5k8 UTSW 16 58,644,469 (GRCm39) missense possibly damaging 0.94
R4622:Or5k8 UTSW 16 58,644,469 (GRCm39) missense possibly damaging 0.94
R4623:Or5k8 UTSW 16 58,644,469 (GRCm39) missense possibly damaging 0.94
R4711:Or5k8 UTSW 16 58,645,069 (GRCm39) start codon destroyed probably null 0.98
R5323:Or5k8 UTSW 16 58,645,066 (GRCm39) missense probably benign
R5447:Or5k8 UTSW 16 58,644,846 (GRCm39) nonsense probably null
R5457:Or5k8 UTSW 16 58,644,796 (GRCm39) missense probably damaging 0.97
R5546:Or5k8 UTSW 16 58,644,516 (GRCm39) nonsense probably null
R5623:Or5k8 UTSW 16 58,644,706 (GRCm39) missense probably benign 0.02
R5767:Or5k8 UTSW 16 58,644,316 (GRCm39) missense probably benign 0.42
R6270:Or5k8 UTSW 16 58,644,782 (GRCm39) missense probably damaging 1.00
R6449:Or5k8 UTSW 16 58,644,889 (GRCm39) missense probably damaging 1.00
R7356:Or5k8 UTSW 16 58,644,718 (GRCm39) missense probably damaging 0.99
R7521:Or5k8 UTSW 16 58,644,257 (GRCm39) missense probably benign 0.00
R7638:Or5k8 UTSW 16 58,644,958 (GRCm39) missense probably damaging 1.00
R7814:Or5k8 UTSW 16 58,644,365 (GRCm39) missense probably damaging 0.98
R9109:Or5k8 UTSW 16 58,644,677 (GRCm39) missense probably damaging 1.00
R9276:Or5k8 UTSW 16 58,644,734 (GRCm39) missense probably benign 0.09
R9681:Or5k8 UTSW 16 58,644,176 (GRCm39) missense possibly damaging 0.90
X0011:Or5k8 UTSW 16 58,645,026 (GRCm39) missense probably benign
Z1176:Or5k8 UTSW 16 58,644,670 (GRCm39) frame shift probably null
Z1177:Or5k8 UTSW 16 58,645,061 (GRCm39) missense possibly damaging 0.47
Predicted Primers PCR Primer
(F):5'- ATCAGTTCAAATTGGTTCCAGTTCCCA -3'
(R):5'- GATGTCCAAGAAGCTCTGCCTTCAAA -3'

Sequencing Primer
(F):5'- CAACTTTCTTCGTACAGGTGG -3'
(R):5'- GAAGCTCTGCCTTCAAATGACC -3'
Posted On 2013-06-11