|Institutional Source||Beutler Lab|
|Gene Name||adenylate kinase 5|
|Is this an essential gene?||Probably non essential (E-score: 0.090)|
|Stock #||IGL03097 (G1)|
|Chromosomal Location||152462815-152668360 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||A to G at 152660514 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000042785 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000045262]|
|Predicted Effect||probably null
|Meta Mutation Damage Score||0.526|
|Coding Region Coverage||
|Validation Efficiency||90% (46/51)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ak5||
(F):5'- GTGTATTTGGGAAAAGCCTATTTGC -3'
(R):5'- TGTTCCAAGCCAGAAGACCC -3'
(F):5'- AAAATCGCCTGATAATGGTGTG -3'
(R):5'- GACCCCATAGAGTACTTGGAAACTTG -3'