Incidental Mutation 'IGL00331:Zfp207'
ID4535
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp207
Ensembl Gene ENSMUSG00000017421
Gene Namezinc finger protein 207
Synonyms8430401D15Rik, Zep
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL00331
Quality Score
Status
Chromosome11
Chromosomal Location80383279-80405733 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 80389002 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 111 (D111G)
Ref Sequence ENSEMBL: ENSMUSP00000103851 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017567] [ENSMUST00000053740] [ENSMUST00000108216] [ENSMUST00000153824] [ENSMUST00000165565] [ENSMUST00000178665] [ENSMUST00000188489]
Predicted Effect probably benign
Transcript: ENSMUST00000017567
AA Change: D111G

PolyPhen 2 Score 0.332 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000017567
Gene: ENSMUSG00000017421
AA Change: D111G

DomainStartEndE-ValueType
ZnF_C2H2 11 34 3.29e1 SMART
ZnF_C2H2 35 58 2.29e0 SMART
low complexity region 98 126 N/A INTRINSIC
low complexity region 145 184 N/A INTRINSIC
low complexity region 200 237 N/A INTRINSIC
low complexity region 252 269 N/A INTRINSIC
low complexity region 274 286 N/A INTRINSIC
low complexity region 295 310 N/A INTRINSIC
low complexity region 312 350 N/A INTRINSIC
low complexity region 379 424 N/A INTRINSIC
low complexity region 429 458 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000053740
AA Change: D111G

PolyPhen 2 Score 0.332 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000054168
Gene: ENSMUSG00000017421
AA Change: D111G

DomainStartEndE-ValueType
ZnF_C2H2 11 34 3.29e1 SMART
ZnF_C2H2 35 58 2.29e0 SMART
low complexity region 98 126 N/A INTRINSIC
low complexity region 145 184 N/A INTRINSIC
low complexity region 200 237 N/A INTRINSIC
low complexity region 252 269 N/A INTRINSIC
low complexity region 283 300 N/A INTRINSIC
low complexity region 306 313 N/A INTRINSIC
low complexity region 326 341 N/A INTRINSIC
low complexity region 343 381 N/A INTRINSIC
low complexity region 410 455 N/A INTRINSIC
low complexity region 460 489 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108216
AA Change: D111G

PolyPhen 2 Score 0.423 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000103851
Gene: ENSMUSG00000017421
AA Change: D111G

DomainStartEndE-ValueType
ZnF_C2H2 11 34 3.29e1 SMART
ZnF_C2H2 35 58 2.29e0 SMART
low complexity region 98 126 N/A INTRINSIC
low complexity region 145 184 N/A INTRINSIC
low complexity region 200 237 N/A INTRINSIC
low complexity region 252 269 N/A INTRINSIC
low complexity region 283 300 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000123726
Predicted Effect probably benign
Transcript: ENSMUST00000153824
AA Change: D100G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000115924
Gene: ENSMUSG00000017421
AA Change: D100G

DomainStartEndE-ValueType
ZnF_C2H2 3 23 1.34e2 SMART
ZnF_C2H2 24 47 2.29e0 SMART
low complexity region 87 115 N/A INTRINSIC
low complexity region 134 173 N/A INTRINSIC
low complexity region 189 226 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000165565
AA Change: D111G

PolyPhen 2 Score 0.332 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000132968
Gene: ENSMUSG00000017421
AA Change: D111G

DomainStartEndE-ValueType
ZnF_C2H2 11 34 3.29e1 SMART
ZnF_C2H2 35 58 2.29e0 SMART
low complexity region 98 126 N/A INTRINSIC
low complexity region 145 221 N/A INTRINSIC
low complexity region 236 253 N/A INTRINSIC
low complexity region 267 284 N/A INTRINSIC
low complexity region 290 297 N/A INTRINSIC
low complexity region 310 325 N/A INTRINSIC
low complexity region 327 365 N/A INTRINSIC
low complexity region 394 439 N/A INTRINSIC
low complexity region 444 473 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000178665
AA Change: D111G

PolyPhen 2 Score 0.332 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000136727
Gene: ENSMUSG00000017421
AA Change: D111G

DomainStartEndE-ValueType
ZnF_C2H2 11 34 3.29e1 SMART
ZnF_C2H2 35 58 2.29e0 SMART
low complexity region 98 126 N/A INTRINSIC
low complexity region 145 184 N/A INTRINSIC
low complexity region 200 237 N/A INTRINSIC
low complexity region 252 269 N/A INTRINSIC
low complexity region 274 286 N/A INTRINSIC
low complexity region 295 310 N/A INTRINSIC
low complexity region 312 350 N/A INTRINSIC
low complexity region 379 424 N/A INTRINSIC
low complexity region 429 458 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000188489
AA Change: D111G

PolyPhen 2 Score 0.332 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000139653
Gene: ENSMUSG00000017421
AA Change: D111G

DomainStartEndE-ValueType
ZnF_C2H2 11 34 3.29e1 SMART
ZnF_C2H2 35 58 2.29e0 SMART
low complexity region 98 126 N/A INTRINSIC
low complexity region 145 184 N/A INTRINSIC
low complexity region 200 237 N/A INTRINSIC
low complexity region 252 269 N/A INTRINSIC
low complexity region 274 286 N/A INTRINSIC
low complexity region 295 310 N/A INTRINSIC
low complexity region 312 350 N/A INTRINSIC
low complexity region 379 424 N/A INTRINSIC
low complexity region 429 458 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aamp C A 1: 74,281,436 probably benign Het
Adamts19 T A 18: 59,007,325 probably benign Het
Afg3l1 T A 8: 123,487,389 F190I probably benign Het
Alms1 T A 6: 85,641,371 S2800T possibly damaging Het
Alox5 A T 6: 116,415,517 W348R probably damaging Het
Atp13a5 G A 16: 29,267,014 Q823* probably null Het
Atp6v1b2 T C 8: 69,088,934 probably null Het
Chuk T C 19: 44,088,023 I416M possibly damaging Het
Dmbt1 A T 7: 131,099,290 Q1066L possibly damaging Het
Dnah5 A G 15: 28,421,620 T3873A probably damaging Het
Endog C T 2: 30,172,900 T184M probably damaging Het
Fam166b G A 4: 43,428,158 R100W possibly damaging Het
Fcgbp T C 7: 28,101,541 probably benign Het
Flii A G 11: 60,715,833 I1061T probably benign Het
Hdac2 T A 10: 36,997,071 N308K probably damaging Het
Hoxa2 T G 6: 52,163,517 Y163S probably damaging Het
Hsd3b7 T C 7: 127,802,972 L263P probably damaging Het
Klf17 T C 4: 117,761,038 T41A probably benign Het
Lrrfip1 T C 1: 91,068,621 M42T probably damaging Het
Mapk8ip1 C T 2: 92,385,188 V614I probably benign Het
Mocs1 T G 17: 49,435,264 probably null Het
Moxd1 T C 10: 24,282,555 probably benign Het
Mterf1a T C 5: 3,891,610 E86G probably damaging Het
Muc4 A G 16: 32,753,185 D1021G probably benign Het
Nomo1 T C 7: 46,045,336 S212P possibly damaging Het
Olfr1471 A G 19: 13,445,624 D204G probably benign Het
Olfr893 T A 9: 38,209,238 Y60N probably damaging Het
Phf21a A C 2: 92,348,029 T385P probably damaging Het
Piwil4 A T 9: 14,715,031 probably benign Het
Pknox1 T C 17: 31,599,645 probably null Het
Prr14l T C 5: 32,831,066 I362V probably benign Het
Sergef C T 7: 46,635,420 probably null Het
Sez6l T C 5: 112,424,645 D948G probably damaging Het
Skor1 A T 9: 63,146,441 L54Q probably damaging Het
Sntn C T 14: 13,679,086 Q87* probably null Het
Syde2 A G 3: 146,014,341 K772E possibly damaging Het
Taf2 T A 15: 55,071,449 probably null Het
Tbc1d13 T A 2: 30,140,511 Y113N probably damaging Het
Tmem154 T C 3: 84,684,415 F91L probably benign Het
Tmem63a A G 1: 180,966,497 D533G possibly damaging Het
Tmprss15 A T 16: 78,985,994 N712K possibly damaging Het
Trip12 A T 1: 84,730,541 D603E probably damaging Het
Trmt11 T C 10: 30,566,449 D246G probably damaging Het
Vmn1r174 T A 7: 23,754,533 M208K possibly damaging Het
Wdr54 T C 6: 83,155,773 H33R probably benign Het
Other mutations in Zfp207
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00402:Zfp207 APN 11 80393085 missense probably benign 0.07
IGL01610:Zfp207 APN 11 80385970 missense probably damaging 1.00
R0440:Zfp207 UTSW 11 80395507 unclassified probably benign
R1926:Zfp207 UTSW 11 80395427 nonsense probably null
R4614:Zfp207 UTSW 11 80395190 unclassified probably benign
R5103:Zfp207 UTSW 11 80391910 missense probably damaging 1.00
R5647:Zfp207 UTSW 11 80393133 missense possibly damaging 0.72
R6845:Zfp207 UTSW 11 80395491 unclassified probably benign
R6919:Zfp207 UTSW 11 80395503 unclassified probably benign
R7131:Zfp207 UTSW 11 80395528 missense unknown
R7216:Zfp207 UTSW 11 80395178 missense unknown
Posted On2012-04-20