Incidental Mutation 'R5849:Stk11ip'
ID 453743
Institutional Source Beutler Lab
Gene Symbol Stk11ip
Ensembl Gene ENSMUSG00000026213
Gene Name serine/threonine kinase 11 interacting protein
Synonyms 1200014D22Rik, LIP1, LKB1IP
MMRRC Submission 044066-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5849 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 75498173-75513979 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 75503999 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000109182 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027414] [ENSMUST00000027414] [ENSMUST00000027414] [ENSMUST00000113553] [ENSMUST00000113553] [ENSMUST00000113553]
AlphaFold Q3TAA7
Predicted Effect probably null
Transcript: ENSMUST00000027414
SMART Domains Protein: ENSMUSP00000027414
Gene: ENSMUSG00000026213

DomainStartEndE-ValueType
low complexity region 25 41 N/A INTRINSIC
SCOP:d1h6ua2 74 291 2e-19 SMART
Blast:LRR 208 231 2e-6 BLAST
Blast:LRR 253 276 5e-6 BLAST
Blast:LRR 278 304 2e-8 BLAST
low complexity region 376 386 N/A INTRINSIC
coiled coil region 495 528 N/A INTRINSIC
low complexity region 752 767 N/A INTRINSIC
low complexity region 948 959 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000027414
SMART Domains Protein: ENSMUSP00000027414
Gene: ENSMUSG00000026213

DomainStartEndE-ValueType
low complexity region 25 41 N/A INTRINSIC
SCOP:d1h6ua2 74 291 2e-19 SMART
Blast:LRR 208 231 2e-6 BLAST
Blast:LRR 253 276 5e-6 BLAST
Blast:LRR 278 304 2e-8 BLAST
low complexity region 376 386 N/A INTRINSIC
coiled coil region 495 528 N/A INTRINSIC
low complexity region 752 767 N/A INTRINSIC
low complexity region 948 959 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000027414
SMART Domains Protein: ENSMUSP00000027414
Gene: ENSMUSG00000026213

DomainStartEndE-ValueType
low complexity region 25 41 N/A INTRINSIC
SCOP:d1h6ua2 74 291 2e-19 SMART
Blast:LRR 208 231 2e-6 BLAST
Blast:LRR 253 276 5e-6 BLAST
Blast:LRR 278 304 2e-8 BLAST
low complexity region 376 386 N/A INTRINSIC
coiled coil region 495 528 N/A INTRINSIC
low complexity region 752 767 N/A INTRINSIC
low complexity region 948 959 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000113553
SMART Domains Protein: ENSMUSP00000109182
Gene: ENSMUSG00000026213

DomainStartEndE-ValueType
Pfam:LIP1 4 94 2.9e-45 PFAM
low complexity region 175 194 N/A INTRINSIC
Blast:LRR 208 231 2e-6 BLAST
Blast:LRR 253 276 5e-6 BLAST
Blast:LRR 278 304 2e-8 BLAST
low complexity region 376 386 N/A INTRINSIC
coiled coil region 495 528 N/A INTRINSIC
low complexity region 752 767 N/A INTRINSIC
low complexity region 948 959 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000113553
SMART Domains Protein: ENSMUSP00000109182
Gene: ENSMUSG00000026213

DomainStartEndE-ValueType
Pfam:LIP1 4 94 2.9e-45 PFAM
low complexity region 175 194 N/A INTRINSIC
Blast:LRR 208 231 2e-6 BLAST
Blast:LRR 253 276 5e-6 BLAST
Blast:LRR 278 304 2e-8 BLAST
low complexity region 376 386 N/A INTRINSIC
coiled coil region 495 528 N/A INTRINSIC
low complexity region 752 767 N/A INTRINSIC
low complexity region 948 959 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000113553
SMART Domains Protein: ENSMUSP00000109182
Gene: ENSMUSG00000026213

DomainStartEndE-ValueType
Pfam:LIP1 4 94 2.9e-45 PFAM
low complexity region 175 194 N/A INTRINSIC
Blast:LRR 208 231 2e-6 BLAST
Blast:LRR 253 276 5e-6 BLAST
Blast:LRR 278 304 2e-8 BLAST
low complexity region 376 386 N/A INTRINSIC
coiled coil region 495 528 N/A INTRINSIC
low complexity region 752 767 N/A INTRINSIC
low complexity region 948 959 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129652
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129794
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140963
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154303
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156838
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.3%
Validation Efficiency 96% (72/75)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930553M12Rik T C 4: 88,786,596 (GRCm39) I7M unknown Het
Abca8b C A 11: 109,868,639 (GRCm39) G175V probably damaging Het
Agbl1 T C 7: 75,974,846 (GRCm39) S113P probably benign Het
Ak9 A G 10: 41,224,045 (GRCm39) D486G probably benign Het
Aopep A G 13: 63,163,312 (GRCm39) D111G probably benign Het
Arhgap11a T C 2: 113,665,192 (GRCm39) S469G probably null Het
Comtd1 C T 14: 21,898,188 (GRCm39) G48D probably damaging Het
Cyp27a1 T C 1: 74,775,843 (GRCm39) S343P probably damaging Het
Dcun1d1 T A 3: 35,970,333 (GRCm39) probably benign Het
Dennd4c T C 4: 86,744,223 (GRCm39) I1404T possibly damaging Het
Dlgap5 A G 14: 47,626,892 (GRCm39) S766P possibly damaging Het
Ebf1 T A 11: 44,881,331 (GRCm39) probably null Het
Flcn T A 11: 59,695,586 (GRCm39) I4L probably damaging Het
Gm57858 A T 3: 36,087,026 (GRCm39) D189E possibly damaging Het
Grin2c T C 11: 115,151,817 (GRCm39) T48A probably benign Het
Hyal5 T A 6: 24,891,555 (GRCm39) S456R probably benign Het
Igf1r A G 7: 67,839,781 (GRCm39) D696G probably benign Het
Iqgap1 A T 7: 80,452,906 (GRCm39) V13D probably benign Het
Itgal A G 7: 126,916,492 (GRCm39) N728S probably benign Het
Kcnb1 T A 2: 166,947,946 (GRCm39) I301F probably damaging Het
Kcnd3 A G 3: 105,366,111 (GRCm39) probably benign Het
Kdm4a C T 4: 118,019,037 (GRCm39) R393Q probably benign Het
Lcn9 G A 2: 25,713,268 (GRCm39) probably null Het
Madcam1 T A 10: 79,500,824 (GRCm39) M47K probably benign Het
Matn3 A G 12: 9,008,829 (GRCm39) Q314R probably benign Het
Msh3 A T 13: 92,386,386 (GRCm39) D826E possibly damaging Het
Muc4 A T 16: 32,595,213 (GRCm39) T3088S possibly damaging Het
Mup3 T G 4: 62,005,172 (GRCm39) probably null Het
Myo15b A G 11: 115,772,759 (GRCm39) K1807E probably damaging Het
Myrip A G 9: 120,282,759 (GRCm39) D688G probably damaging Het
Nup153 A G 13: 46,840,452 (GRCm39) F1052S probably damaging Het
Oplah T A 15: 76,181,547 (GRCm39) probably benign Het
Or4f14d A T 2: 111,960,223 (GRCm39) I311K probably benign Het
Or52r1c T A 7: 102,734,728 (GRCm39) M1K probably null Het
Or6z3 A T 7: 6,463,993 (GRCm39) I162F possibly damaging Het
Or9g19 A T 2: 85,600,768 (GRCm39) I208F probably benign Het
Pacsin2 A G 15: 83,274,719 (GRCm39) F120L possibly damaging Het
Ppp1r36 C A 12: 76,485,931 (GRCm39) P363Q probably damaging Het
Rai1 C A 11: 60,081,347 (GRCm39) H1804N possibly damaging Het
Rictor G A 15: 6,823,487 (GRCm39) E1555K probably benign Het
Rnf214 G A 9: 45,779,386 (GRCm39) P455S probably damaging Het
Rnf220 T C 4: 117,134,809 (GRCm39) T188A possibly damaging Het
S1pr4 C T 10: 81,335,157 (GRCm39) V106M possibly damaging Het
Sall2 C A 14: 52,551,704 (GRCm39) S495I probably benign Het
Sars2 A G 7: 28,443,683 (GRCm39) E95G possibly damaging Het
Sema3f G A 9: 107,559,815 (GRCm39) T693M probably damaging Het
Slfn2 C A 11: 82,960,402 (GRCm39) T127K probably benign Het
Snrpe T A 1: 133,536,652 (GRCm39) I43L probably benign Het
Srsf1 T C 11: 87,938,684 (GRCm39) I7T possibly damaging Het
Ssbp1 T A 6: 40,453,837 (GRCm39) probably benign Het
Stbd1 T G 5: 92,752,854 (GRCm39) F115V probably benign Het
Taf1b T A 12: 24,550,524 (GRCm39) N36K probably damaging Het
Tanc1 A T 2: 59,630,248 (GRCm39) M743L probably benign Het
Tnfsf12 C A 11: 69,577,793 (GRCm39) R208L probably damaging Het
Trafd1 T C 5: 121,511,534 (GRCm39) D428G probably damaging Het
Trim24 A G 6: 37,934,664 (GRCm39) E793G probably damaging Het
Tspan32 T C 7: 142,569,324 (GRCm39) C100R probably damaging Het
Ttn T C 2: 76,576,586 (GRCm39) D16442G probably damaging Het
Ube3c T A 5: 29,863,407 (GRCm39) L894Q probably damaging Het
Wfs1 C G 5: 37,130,608 (GRCm39) G213R probably damaging Het
Zfp384 G A 6: 125,001,062 (GRCm39) A45T possibly damaging Het
Zfp865 G T 7: 5,034,086 (GRCm39) K690N probably damaging Het
Other mutations in Stk11ip
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00961:Stk11ip APN 1 75,506,910 (GRCm39) missense probably damaging 1.00
IGL01776:Stk11ip APN 1 75,504,465 (GRCm39) missense probably benign 0.02
IGL02752:Stk11ip APN 1 75,501,325 (GRCm39) critical splice acceptor site probably null
IGL03132:Stk11ip APN 1 75,512,733 (GRCm39) missense probably benign 0.00
IGL03188:Stk11ip APN 1 75,511,079 (GRCm39) missense probably benign 0.00
R6768_Stk11ip_021 UTSW 1 75,509,279 (GRCm39) missense probably benign
sienna UTSW 1 75,503,999 (GRCm39) splice site probably null
R0234:Stk11ip UTSW 1 75,505,711 (GRCm39) missense possibly damaging 0.47
R0234:Stk11ip UTSW 1 75,505,711 (GRCm39) missense possibly damaging 0.47
R0617:Stk11ip UTSW 1 75,508,932 (GRCm39) splice site probably null
R0712:Stk11ip UTSW 1 75,504,091 (GRCm39) missense probably damaging 0.99
R1672:Stk11ip UTSW 1 75,505,629 (GRCm39) nonsense probably null
R1694:Stk11ip UTSW 1 75,504,030 (GRCm39) missense probably damaging 1.00
R1891:Stk11ip UTSW 1 75,509,060 (GRCm39) missense probably benign 0.08
R2061:Stk11ip UTSW 1 75,506,228 (GRCm39) missense possibly damaging 0.94
R2094:Stk11ip UTSW 1 75,502,165 (GRCm39) splice site probably benign
R2851:Stk11ip UTSW 1 75,505,911 (GRCm39) splice site probably benign
R2852:Stk11ip UTSW 1 75,505,911 (GRCm39) splice site probably benign
R4765:Stk11ip UTSW 1 75,503,799 (GRCm39) missense probably damaging 1.00
R4775:Stk11ip UTSW 1 75,510,497 (GRCm39) missense possibly damaging 0.95
R4785:Stk11ip UTSW 1 75,506,925 (GRCm39) missense possibly damaging 0.95
R5002:Stk11ip UTSW 1 75,509,187 (GRCm39) intron probably benign
R5524:Stk11ip UTSW 1 75,508,971 (GRCm39) missense probably damaging 1.00
R5538:Stk11ip UTSW 1 75,504,979 (GRCm39) missense probably damaging 1.00
R5927:Stk11ip UTSW 1 75,501,335 (GRCm39) missense possibly damaging 0.93
R6053:Stk11ip UTSW 1 75,510,899 (GRCm39) critical splice donor site probably null
R6485:Stk11ip UTSW 1 75,506,612 (GRCm39) missense possibly damaging 0.47
R6734:Stk11ip UTSW 1 75,509,013 (GRCm39) missense probably benign 0.04
R6768:Stk11ip UTSW 1 75,509,279 (GRCm39) missense probably benign
R7070:Stk11ip UTSW 1 75,504,259 (GRCm39) missense probably benign 0.39
R7882:Stk11ip UTSW 1 75,506,108 (GRCm39) missense probably benign 0.03
R8804:Stk11ip UTSW 1 75,511,900 (GRCm39) missense probably benign 0.15
R9086:Stk11ip UTSW 1 75,506,818 (GRCm39) missense possibly damaging 0.76
R9642:Stk11ip UTSW 1 75,510,899 (GRCm39) critical splice donor site probably null
R9648:Stk11ip UTSW 1 75,505,585 (GRCm39) missense probably damaging 0.99
X0066:Stk11ip UTSW 1 75,511,070 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TACTGAGGGCCAATGAGCTC -3'
(R):5'- TTCCAGATAGAGCTGAGGGCAG -3'

Sequencing Primer
(F):5'- GCCAATGAGCTCCGCAG -3'
(R):5'- ATCGGATGCCCCCTATGTGAAG -3'
Posted On 2017-02-10