Incidental Mutation 'R5862:Zscan29'
ID 453955
Institutional Source Beutler Lab
Gene Symbol Zscan29
Ensembl Gene ENSMUSG00000050619
Gene Name zinc finger SCAN domains 29
Synonyms Zfp690
MMRRC Submission 043231-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.159) question?
Stock # R5862 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 120988754-121001606 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 120994518 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Asparagine at position 489 (T489N)
Ref Sequence ENSEMBL: ENSMUSP00000125987 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079024] [ENSMUST00000110661] [ENSMUST00000146243] [ENSMUST00000163766]
AlphaFold E9Q5B4
Predicted Effect possibly damaging
Transcript: ENSMUST00000079024
AA Change: T454N

PolyPhen 2 Score 0.770 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000078033
Gene: ENSMUSG00000050619
AA Change: T454N

DomainStartEndE-ValueType
SCAN 13 125 5.83e-70 SMART
Pfam:Myb_DNA-bind_4 238 323 3e-21 PFAM
Pfam:Myb_DNA-bind_4 399 484 4.1e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000110661
AA Change: T454N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000106289
Gene: ENSMUSG00000050619
AA Change: T454N

DomainStartEndE-ValueType
SCAN 13 125 5.83e-70 SMART
Pfam:Myb_DNA-bind_4 238 323 5.4e-21 PFAM
Pfam:Myb_DNA-bind_4 399 484 7.4e-22 PFAM
low complexity region 518 532 N/A INTRINSIC
ZnF_C2H2 665 687 2.99e-4 SMART
ZnF_C2H2 693 715 2.75e-3 SMART
ZnF_C2H2 721 743 8.02e-5 SMART
ZnF_C2H2 749 771 1.13e-4 SMART
ZnF_C2H2 777 799 1.18e-2 SMART
ZnF_C2H2 805 827 1.33e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000146243
SMART Domains Protein: ENSMUSP00000120997
Gene: ENSMUSG00000050619

DomainStartEndE-ValueType
SCAN 13 118 4.23e-58 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156370
Predicted Effect probably damaging
Transcript: ENSMUST00000163766
AA Change: T489N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000125987
Gene: ENSMUSG00000050619
AA Change: T489N

DomainStartEndE-ValueType
SCAN 13 125 5.83e-70 SMART
Pfam:Myb_DNA-bind_4 238 323 5.9e-21 PFAM
Pfam:Myb_DNA-bind_4 434 519 1.3e-21 PFAM
low complexity region 553 567 N/A INTRINSIC
ZnF_C2H2 700 722 2.99e-4 SMART
ZnF_C2H2 728 750 2.75e-3 SMART
ZnF_C2H2 756 778 8.02e-5 SMART
ZnF_C2H2 784 806 1.13e-4 SMART
ZnF_C2H2 812 834 1.18e-2 SMART
ZnF_C2H2 840 862 1.33e-1 SMART
Meta Mutation Damage Score 0.1673 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahctf1 A G 1: 179,615,895 (GRCm39) Y326H probably damaging Het
Alpk2 T A 18: 65,440,360 (GRCm39) K811N probably damaging Het
Ap3b1 T A 13: 94,684,278 (GRCm39) M1014K unknown Het
Bphl G A 13: 34,247,967 (GRCm39) V247I possibly damaging Het
C6 A T 15: 4,764,745 (GRCm39) D147V possibly damaging Het
Clec18a G A 8: 111,808,190 (GRCm39) H71Y possibly damaging Het
Cse1l A G 2: 166,757,127 (GRCm39) T10A probably benign Het
Cyp2b9 G T 7: 25,887,232 (GRCm39) G214C probably benign Het
Dctn6 A T 8: 34,575,571 (GRCm39) probably null Het
Dnaja4 G T 9: 54,606,625 (GRCm39) probably benign Het
Dpp8 A T 9: 64,953,004 (GRCm39) S227C probably benign Het
Ecel1 T C 1: 87,077,318 (GRCm39) N630S probably benign Het
Etnppl T C 3: 130,425,473 (GRCm39) V426A possibly damaging Het
Golgb1 A T 16: 36,746,453 (GRCm39) silent Het
Hapln3 A T 7: 78,771,639 (GRCm39) H83Q possibly damaging Het
Hmgxb4 A G 8: 75,727,683 (GRCm39) K222R probably damaging Het
Hsf5 C A 11: 87,513,817 (GRCm39) T294K probably damaging Het
Ighv12-2 A G 12: 114,091,557 (GRCm39) noncoding transcript Het
Lrch3 A T 16: 32,816,179 (GRCm39) H587L probably damaging Het
Macroh2a1 T A 13: 56,222,084 (GRCm39) I359L probably damaging Het
Mboat1 C T 13: 30,419,680 (GRCm39) T339M probably damaging Het
Mief1 G A 15: 80,132,586 (GRCm39) R156Q probably benign Het
Ms4a6b T A 19: 11,499,167 (GRCm39) F94I probably benign Het
Neb T A 2: 52,069,554 (GRCm39) R307* probably null Het
Neu4 A G 1: 93,950,652 (GRCm39) I147V probably benign Het
Or5m9b T C 2: 85,905,990 (GRCm39) I302T probably benign Het
Pcyox1 A G 6: 86,368,656 (GRCm39) probably null Het
Pik3ap1 T A 19: 41,320,784 (GRCm39) D145V probably damaging Het
Pja2 T C 17: 64,604,821 (GRCm39) D454G probably benign Het
Plekhg1 C T 10: 3,887,914 (GRCm39) T281M probably damaging Het
Ptprq T C 10: 107,401,739 (GRCm39) I1918V probably benign Het
Rasgef1a A C 6: 118,057,405 (GRCm39) R35S probably benign Het
Rnf167 A G 11: 70,541,918 (GRCm39) T308A probably damaging Het
Sfmbt2 C T 2: 10,406,863 (GRCm39) T54I possibly damaging Het
Sh3bp5 C A 14: 31,099,452 (GRCm39) R265L probably benign Het
Shkbp1 G T 7: 27,042,829 (GRCm39) S536* probably null Het
Taf2 C A 15: 54,911,719 (GRCm39) V566L possibly damaging Het
Tmed6 G T 8: 107,790,786 (GRCm39) T87K probably damaging Het
Tyms A T 5: 30,268,408 (GRCm39) D97E probably damaging Het
Usp20 T A 2: 30,896,461 (GRCm39) L188* probably null Het
Zbtb10 T A 3: 9,330,276 (GRCm39) S545T probably damaging Het
Other mutations in Zscan29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01935:Zscan29 APN 2 121,000,538 (GRCm39) missense probably damaging 1.00
IGL01938:Zscan29 APN 2 120,996,690 (GRCm39) missense probably benign 0.16
IGL02220:Zscan29 APN 2 120,997,170 (GRCm39) missense probably damaging 0.99
IGL02370:Zscan29 APN 2 120,994,314 (GRCm39) missense probably benign 0.00
IGL02585:Zscan29 APN 2 120,994,357 (GRCm39) nonsense probably null
R0284:Zscan29 UTSW 2 120,997,214 (GRCm39) unclassified probably benign
R0842:Zscan29 UTSW 2 120,991,960 (GRCm39) missense possibly damaging 0.84
R1245:Zscan29 UTSW 2 120,996,984 (GRCm39) missense probably damaging 1.00
R1586:Zscan29 UTSW 2 120,991,641 (GRCm39) missense probably damaging 1.00
R1654:Zscan29 UTSW 2 120,995,260 (GRCm39) missense probably benign 0.06
R1958:Zscan29 UTSW 2 121,000,289 (GRCm39) critical splice donor site probably null
R2073:Zscan29 UTSW 2 120,991,336 (GRCm39) nonsense probably null
R2085:Zscan29 UTSW 2 121,000,427 (GRCm39) nonsense probably null
R2145:Zscan29 UTSW 2 121,000,587 (GRCm39) missense probably damaging 1.00
R2201:Zscan29 UTSW 2 120,999,883 (GRCm39) missense probably damaging 1.00
R2875:Zscan29 UTSW 2 120,994,581 (GRCm39) missense probably damaging 1.00
R2876:Zscan29 UTSW 2 120,994,581 (GRCm39) missense probably damaging 1.00
R3861:Zscan29 UTSW 2 120,991,212 (GRCm39) missense probably benign 0.01
R4244:Zscan29 UTSW 2 120,995,275 (GRCm39) splice site probably null
R4245:Zscan29 UTSW 2 120,995,275 (GRCm39) splice site probably null
R4447:Zscan29 UTSW 2 121,000,367 (GRCm39) splice site probably null
R4662:Zscan29 UTSW 2 120,997,096 (GRCm39) missense probably benign 0.26
R4757:Zscan29 UTSW 2 120,991,392 (GRCm39) missense possibly damaging 0.92
R4777:Zscan29 UTSW 2 120,999,805 (GRCm39) missense probably damaging 0.96
R4905:Zscan29 UTSW 2 120,991,864 (GRCm39) missense possibly damaging 0.53
R4970:Zscan29 UTSW 2 120,999,676 (GRCm39) splice site probably null
R5860:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5861:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5916:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5917:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5918:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R6335:Zscan29 UTSW 2 120,991,917 (GRCm39) missense possibly damaging 0.49
R7214:Zscan29 UTSW 2 120,999,761 (GRCm39) nonsense probably null
R7326:Zscan29 UTSW 2 120,991,469 (GRCm39) missense probably damaging 1.00
R7997:Zscan29 UTSW 2 120,991,221 (GRCm39) missense probably benign 0.01
R8787:Zscan29 UTSW 2 120,996,876 (GRCm39) missense probably damaging 1.00
RF001:Zscan29 UTSW 2 120,994,477 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- CTGGTTCTCTGGAGGCAACAAG -3'
(R):5'- ACTGGTTTTCCTAGAAGCCG -3'

Sequencing Primer
(F):5'- CTCTGGAGGCAACAAGAAACTGTTTC -3'
(R):5'- GTTTTCCTAGAAGCCGGCAGTAAAAC -3'
Posted On 2017-02-10