Mutagenetix > Incidental Mutation

Incidental Mutation 'R5884:Ptprd'

454559

Institutional Source

Beutler Lab

Gene Symbol

Ptprd

Ensembl Gene

ENSMUSG00000028399

Gene Name

protein tyrosine phosphatase receptor type D

Synonyms

1110002J03Rik, B230219D21Rik, 3000002J10Rik

MMRRC Submission

044087-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5884 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

75859475-78130198 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 75900927 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 1061 (Y1061H)

Ref Sequence

ENSEMBL: ENSMUSP00000133328 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050757] [ENSMUST00000098005] [ENSMUST00000102834] [ENSMUST00000107289] [ENSMUST00000173376] [ENSMUST00000174023] [ENSMUST00000174180] [ENSMUST00000174531] [ENSMUST00000174831]

AlphaFold

Q64487

Predicted Effect

probably damaging
Transcript: ENSMUST00000050757
AA Change: Y1061H

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000058466
Gene: ENSMUSG00000028399
AA Change: Y1061H

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	208	1.38e-15	SMART
IGc2	238	299	8.13e-4	SMART
FN3	313	392	7.92e-14	SMART
FN3	408	491	5.73e-11	SMART
IG_like	499	593	8.34e1	SMART
FN3	506	584	9.1e-14	SMART
FN3	597	674	1.21e0	SMART
transmembrane domain	847	869	N/A	INTRINSIC
low complexity region	870	882	N/A	INTRINSIC
PTPc	949	1207	6.38e-134	SMART
PTPc	1236	1498	9.17e-135	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000098005
AA Change: Y1062H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000095614
Gene: ENSMUSG00000028399
AA Change: Y1062H

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	214	8.5e-16	SMART
low complexity region	225	237	N/A	INTRINSIC
IGc2	248	309	8.13e-4	SMART
FN3	323	402	7.92e-14	SMART
FN3	418	501	5.73e-11	SMART
IG_like	509	603	8.34e1	SMART
FN3	516	594	9.1e-14	SMART
FN3	607	684	1.21e0	SMART
transmembrane domain	857	879	N/A	INTRINSIC
low complexity region	886	897	N/A	INTRINSIC
PTPc	950	1208	6.38e-134	SMART
PTPc	1237	1499	9.17e-135	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000102834
AA Change: Y810H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000099898
Gene: ENSMUSG00000028399
AA Change: Y810H

Domain	Start	End	E-Value	Type
IGc2	1	62	8.13e-4	SMART
FN3	76	155	7.92e-14	SMART
FN3	171	254	5.73e-11	SMART
IG_like	262	356	8.34e1	SMART
FN3	269	347	9.1e-14	SMART
FN3	360	437	1.21e0	SMART
transmembrane domain	610	632	N/A	INTRINSIC
low complexity region	633	645	N/A	INTRINSIC
PTPc	698	956	6.38e-134	SMART
PTPc	985	1247	9.17e-135	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000107289
AA Change: Y1468H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000102910
Gene: ENSMUSG00000028399
AA Change: Y1468H

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	214	8.5e-16	SMART
low complexity region	225	237	N/A	INTRINSIC
IGc2	248	309	8.13e-4	SMART
FN3	323	402	7.92e-14	SMART
FN3	418	501	5.73e-11	SMART
IG_like	509	603	8.34e1	SMART
FN3	516	594	9.1e-14	SMART
FN3	609	696	2.72e-12	SMART
FN3	712	809	2.87e-11	SMART
FN3	824	904	4.96e-6	SMART
FN3	919	1003	4.12e-12	SMART
FN3	1018	1095	1.95e0	SMART
transmembrane domain	1268	1290	N/A	INTRINSIC
low complexity region	1291	1303	N/A	INTRINSIC
PTPc	1356	1614	6.38e-134	SMART
PTPc	1643	1905	9.17e-135	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000173376
AA Change: Y1064H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000133468
Gene: ENSMUSG00000028399
AA Change: Y1064H

Domain	Start	End	E-Value	Type
IGc2	43	112	8.57e-12	SMART
IGc2	145	221	8.5e-16	SMART
low complexity region	232	244	N/A	INTRINSIC
IGc2	255	316	8.13e-4	SMART
FN3	330	409	7.92e-14	SMART
FN3	425	508	5.73e-11	SMART
IG_like	516	610	8.34e1	SMART
FN3	523	601	9.1e-14	SMART
FN3	614	691	1.21e0	SMART
transmembrane domain	864	886	N/A	INTRINSIC
low complexity region	887	899	N/A	INTRINSIC
PTPc	952	1210	6.38e-134	SMART
PTPc	1239	1501	9.17e-135	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000174023
AA Change: Y1058H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000133562
Gene: ENSMUSG00000028399
AA Change: Y1058H

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	211	4.88e-16	SMART
low complexity region	222	234	N/A	INTRINSIC
IGc2	245	306	8.13e-4	SMART
FN3	320	399	7.92e-14	SMART
FN3	415	498	5.73e-11	SMART
IG_like	506	600	8.34e1	SMART
FN3	513	591	9.1e-14	SMART
FN3	604	681	1.21e0	SMART
transmembrane domain	853	875	N/A	INTRINSIC
low complexity region	882	893	N/A	INTRINSIC
PTPc	946	1204	6.38e-134	SMART
PTPc	1233	1495	9.17e-135	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000174180
AA Change: Y1446H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000133973
Gene: ENSMUSG00000028399
AA Change: Y1446H

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	205	2.09e-15	SMART
IGc2	235	296	8.13e-4	SMART
FN3	310	389	7.92e-14	SMART
FN3	405	488	5.73e-11	SMART
IG_like	496	590	8.34e1	SMART
FN3	503	581	9.1e-14	SMART
FN3	596	683	2.72e-12	SMART
FN3	699	787	6.15e-11	SMART
FN3	802	882	4.96e-6	SMART
FN3	897	981	4.12e-12	SMART
FN3	996	1073	1.95e0	SMART
transmembrane domain	1246	1268	N/A	INTRINSIC
low complexity region	1269	1281	N/A	INTRINSIC
PTPc	1334	1592	6.38e-134	SMART
PTPc	1621	1883	9.17e-135	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000174531
AA Change: Y1051H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000134229
Gene: ENSMUSG00000028399
AA Change: Y1051H

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	208	1.38e-15	SMART
low complexity region	219	231	N/A	INTRINSIC
IGc2	242	303	8.13e-4	SMART
FN3	317	396	7.92e-14	SMART
FN3	412	495	5.73e-11	SMART
IG_like	503	597	8.34e1	SMART
FN3	510	588	9.1e-14	SMART
FN3	601	678	1.21e0	SMART
transmembrane domain	851	873	N/A	INTRINSIC
low complexity region	874	886	N/A	INTRINSIC
PTPc	939	1197	6.38e-134	SMART
PTPc	1226	1488	9.17e-135	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000174831
AA Change: Y1061H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000133328
Gene: ENSMUSG00000028399
AA Change: Y1061H

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	214	8.5e-16	SMART
low complexity region	225	237	N/A	INTRINSIC
IGc2	248	309	8.13e-4	SMART
FN3	323	402	7.92e-14	SMART
FN3	418	501	5.73e-11	SMART
IG_like	509	603	8.34e1	SMART
FN3	516	594	9.1e-14	SMART
FN3	607	684	1.21e0	SMART
transmembrane domain	856	878	N/A	INTRINSIC
low complexity region	885	896	N/A	INTRINSIC
PTPc	949	1207	6.38e-134	SMART
PTPc	1236	1498	9.17e-135	SMART

Meta Mutation Damage Score

0.9475

Coding Region Coverage

1x: 99.9%
3x: 99.4%
10x: 95.6%
20x: 82.8%

Validation Efficiency

96% (66/69)

MGI Phenotype

PHENOTYPE: Homozygotes for a targeted null mutation exhibit impaired learning of spatial tasks, enhanced long-term potentiation at hippocampal synapses, and high mortality associated with reduced food intake. [provided by MGI curators]

Allele List at MGI

All alleles(9) : Targeted(4) Gene trapped(5)

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Bmp5	T	C	9: 75,805,836 (GRCm39)	M446T	probably damaging	Het
Cacna1g	C	T	11: 94,328,693 (GRCm39)	A1052T	probably damaging	Het
Cand1	C	T	10: 119,049,670 (GRCm39)	A359T	possibly damaging	Het
Ccne2	A	T	4: 11,199,411 (GRCm39)	T271S	probably benign	Het
Cep112	A	G	11: 108,461,142 (GRCm39)	T546A	probably damaging	Het
Ces1g	A	G	8: 94,033,558 (GRCm39)	S455P	probably benign	Het
Dnah11	A	T	12: 118,141,269 (GRCm39)	C496S	probably benign	Het
Dtx3l	C	G	16: 35,752,603 (GRCm39)	E668Q	probably benign	Het
Dysf	T	A	6: 84,163,063 (GRCm39)	F1579I	probably damaging	Het
Emx2	T	G	19: 59,452,461 (GRCm39)	D248E	probably damaging	Het
Eri2	A	C	7: 119,371,552 (GRCm39)	*275E	probably null	Het
F5	G	A	1: 164,023,215 (GRCm39)	R1591H	probably benign	Het
Fabp3	A	G	4: 130,206,131 (GRCm39)	T41A	probably benign	Het
Fam89a	C	T	8: 125,478,508 (GRCm39)	R14H	probably damaging	Het
Gbe1	T	A	16: 70,325,763 (GRCm39)		probably null	Het
Golga3	A	G	5: 110,364,761 (GRCm39)	E1211G	probably damaging	Het
Gpa33	T	C	1: 165,980,329 (GRCm39)	S131P	probably damaging	Het
Hyal6	T	C	6: 24,743,368 (GRCm39)	Y355H	probably damaging	Het
Ide	A	T	19: 37,249,552 (GRCm39)		probably null	Het
Ighv5-21	A	T	12: 114,283,806 (GRCm39)		probably benign	Het
Iglc1	A	T	16: 18,880,741 (GRCm39)		probably benign	Het
Impa1	A	T	3: 10,381,284 (GRCm39)	N199K	probably damaging	Het
Irx5	A	C	8: 93,087,258 (GRCm39)	T397P	possibly damaging	Het
Lonp2	A	G	8: 87,368,254 (GRCm39)	Y356C	probably damaging	Het
Matn4	A	T	2: 164,246,528 (GRCm39)		probably benign	Het
Mplkipl1	C	T	19: 61,164,364 (GRCm39)	G24R	unknown	Het
Nav2	T	A	7: 49,246,917 (GRCm39)	Y2147*	probably null	Het
Nek5	C	T	8: 22,578,817 (GRCm39)		probably null	Het
Omt2b	A	G	9: 78,235,839 (GRCm39)	M55V	probably benign	Het
Or5d37	A	G	2: 87,924,140 (GRCm39)	Y47H	probably damaging	Het
Or6z1	C	A	7: 6,504,842 (GRCm39)	V128L	probably benign	Het
Or9g8	T	A	2: 85,607,399 (GRCm39)	I157K	probably damaging	Het
Parp4	T	A	14: 56,852,207 (GRCm39)	H796Q	probably damaging	Het
Pex2	T	C	3: 5,626,359 (GRCm39)	E150G	probably benign	Het
Poglut2	T	C	1: 44,156,260 (GRCm39)	N109S	probably benign	Het
Psmb2	T	A	4: 126,578,014 (GRCm39)	V64E	possibly damaging	Het
Psmd6	C	T	14: 14,116,526 (GRCm38)	R63H	probably damaging	Het
Rab23	A	G	1: 33,763,967 (GRCm39)		probably benign	Het
Rad51ap2	GAAAAGGAAACTATTTAAAA	GAAAA	12: 11,507,534 (GRCm39)		probably benign	Het
Reg1	C	T	6: 78,405,200 (GRCm39)	S141L	possibly damaging	Het
Rock1	A	T	18: 10,099,361 (GRCm39)	I680K	probably benign	Het
Sez6l2	A	G	7: 126,569,328 (GRCm39)		probably benign	Het
Slc34a2	A	T	5: 53,226,722 (GRCm39)	Q615L	possibly damaging	Het
Slu7	A	G	11: 43,334,245 (GRCm39)	K424E	probably benign	Het
Tctn2	A	T	5: 124,741,895 (GRCm39)		noncoding transcript	Het
Tmem87a	T	A	2: 120,234,605 (GRCm39)		probably benign	Het
Trappc4	A	G	9: 44,315,385 (GRCm39)	F198L	probably damaging	Het
Usp33	C	T	3: 152,073,967 (GRCm39)	T271I	probably benign	Het
Vmn1r15	T	A	6: 57,235,993 (GRCm39)	I287K	probably damaging	Het
Vmn2r75	A	C	7: 85,814,578 (GRCm39)	I305R	probably benign	Het
Wdr26	T	C	1: 181,015,106 (GRCm39)		probably benign	Het
Zzz3	T	C	3: 152,156,295 (GRCm39)	S684P	probably damaging	Het

Other mutations in Ptprd

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00964:Ptprd	APN	4	75,916,793 (GRCm39)	nonsense	probably null
IGL01067:Ptprd	APN	4	75,977,922 (GRCm39)	missense	probably damaging	1.00
IGL01121:Ptprd	APN	4	75,872,438 (GRCm39)	splice site	probably benign
IGL01531:Ptprd	APN	4	76,003,757 (GRCm39)	missense	probably damaging	0.98
IGL01661:Ptprd	APN	4	75,872,320 (GRCm39)	missense	probably damaging	1.00
IGL01723:Ptprd	APN	4	76,161,910 (GRCm39)	missense	probably damaging	1.00
IGL01735:Ptprd	APN	4	76,055,057 (GRCm39)	splice site	probably null
IGL01810:Ptprd	APN	4	76,058,744 (GRCm39)	splice site	probably benign
IGL01834:Ptprd	APN	4	76,046,832 (GRCm39)	missense	probably damaging	1.00
IGL01835:Ptprd	APN	4	76,165,058 (GRCm39)	missense	probably benign	0.02
IGL01867:Ptprd	APN	4	76,161,884 (GRCm39)	missense	probably damaging	1.00
IGL02582:Ptprd	APN	4	75,865,361 (GRCm39)	missense	probably damaging	1.00
IGL02591:Ptprd	APN	4	75,900,287 (GRCm39)	missense	probably damaging	1.00
IGL02741:Ptprd	APN	4	76,051,521 (GRCm39)	missense	probably damaging	1.00
IGL02866:Ptprd	APN	4	75,968,674 (GRCm39)	missense	probably damaging	1.00
IGL02960:Ptprd	APN	4	76,047,105 (GRCm39)	missense	probably damaging	1.00
IGL03155:Ptprd	APN	4	75,984,456 (GRCm39)	missense	possibly damaging	0.95
IGL03230:Ptprd	APN	4	75,968,654 (GRCm39)	nonsense	probably null
IGL03343:Ptprd	APN	4	75,977,966 (GRCm39)	missense	probably damaging	1.00
unhurried	UTSW	4	76,018,870 (GRCm39)	nonsense	probably null
ANU22:Ptprd	UTSW	4	76,018,693 (GRCm39)	missense	probably damaging	0.99
F5493:Ptprd	UTSW	4	76,002,645 (GRCm39)	missense	probably damaging	1.00
P0033:Ptprd	UTSW	4	76,047,091 (GRCm39)	nonsense	probably null
R0044:Ptprd	UTSW	4	76,004,566 (GRCm39)	missense	probably benign	0.08
R0044:Ptprd	UTSW	4	76,004,566 (GRCm39)	missense	probably benign	0.08
R0076:Ptprd	UTSW	4	75,865,276 (GRCm39)	splice site	probably benign
R0137:Ptprd	UTSW	4	76,055,140 (GRCm39)	missense	probably benign	0.24
R0358:Ptprd	UTSW	4	75,863,226 (GRCm39)	missense	probably damaging	1.00
R0365:Ptprd	UTSW	4	76,055,083 (GRCm39)	missense	probably damaging	1.00
R0385:Ptprd	UTSW	4	76,046,902 (GRCm39)	missense	probably damaging	1.00
R0601:Ptprd	UTSW	4	76,018,711 (GRCm39)	missense	probably benign
R0646:Ptprd	UTSW	4	76,002,640 (GRCm39)	missense	probably damaging	0.99
R0667:Ptprd	UTSW	4	75,875,583 (GRCm39)	missense	probably damaging	1.00
R0707:Ptprd	UTSW	4	75,875,476 (GRCm39)	missense	probably damaging	1.00
R0734:Ptprd	UTSW	4	76,058,834 (GRCm39)	missense	probably damaging	1.00
R0827:Ptprd	UTSW	4	76,047,152 (GRCm39)	missense	probably damaging	0.98
R0932:Ptprd	UTSW	4	76,055,122 (GRCm39)	missense	probably damaging	1.00
R1069:Ptprd	UTSW	4	76,018,870 (GRCm39)	nonsense	probably null
R1069:Ptprd	UTSW	4	75,916,724 (GRCm39)	splice site	probably benign
R1086:Ptprd	UTSW	4	76,051,495 (GRCm39)	missense	probably damaging	1.00
R1439:Ptprd	UTSW	4	75,984,437 (GRCm39)	missense	probably damaging	1.00
R1440:Ptprd	UTSW	4	76,002,789 (GRCm39)	missense	probably damaging	0.98
R1688:Ptprd	UTSW	4	75,900,921 (GRCm39)	missense	probably damaging	1.00
R1858:Ptprd	UTSW	4	75,865,384 (GRCm39)	missense	probably damaging	1.00
R2001:Ptprd	UTSW	4	75,872,359 (GRCm39)	missense	probably damaging	1.00
R2020:Ptprd	UTSW	4	76,051,398 (GRCm39)	missense	probably damaging	1.00
R2023:Ptprd	UTSW	4	75,875,341 (GRCm39)	missense	probably damaging	1.00
R2413:Ptprd	UTSW	4	76,051,437 (GRCm39)	missense	probably damaging	1.00
R2510:Ptprd	UTSW	4	76,004,248 (GRCm39)	critical splice donor site	probably null
R2914:Ptprd	UTSW	4	75,865,338 (GRCm39)	missense	probably damaging	1.00
R2971:Ptprd	UTSW	4	76,025,561 (GRCm39)	missense	probably benign	0.10
R3051:Ptprd	UTSW	4	76,018,867 (GRCm39)	missense	probably damaging	1.00
R3433:Ptprd	UTSW	4	76,004,248 (GRCm39)	critical splice donor site	probably null
R3964:Ptprd	UTSW	4	75,978,073 (GRCm39)	splice site	probably benign
R4009:Ptprd	UTSW	4	75,874,634 (GRCm39)	missense	possibly damaging	0.94
R4394:Ptprd	UTSW	4	76,046,922 (GRCm39)	missense	probably damaging	1.00
R4420:Ptprd	UTSW	4	75,957,614 (GRCm39)	missense	possibly damaging	0.92
R4424:Ptprd	UTSW	4	76,021,200 (GRCm39)	missense	probably benign	0.22
R4575:Ptprd	UTSW	4	76,162,023 (GRCm39)	missense	possibly damaging	0.55
R4578:Ptprd	UTSW	4	76,162,023 (GRCm39)	missense	possibly damaging	0.55
R4715:Ptprd	UTSW	4	76,025,570 (GRCm39)	missense	probably benign	0.03
R4782:Ptprd	UTSW	4	76,009,769 (GRCm39)	missense	probably benign	0.01
R4785:Ptprd	UTSW	4	76,058,790 (GRCm39)	missense	probably benign	0.05
R4799:Ptprd	UTSW	4	76,009,769 (GRCm39)	missense	probably benign	0.01
R4944:Ptprd	UTSW	4	76,047,136 (GRCm39)	missense	probably damaging	1.00
R4950:Ptprd	UTSW	4	76,058,752 (GRCm39)	splice site	probably null
R4969:Ptprd	UTSW	4	76,051,542 (GRCm39)	missense	probably damaging	1.00
R5153:Ptprd	UTSW	4	75,930,339 (GRCm39)	missense	probably damaging	1.00
R5164:Ptprd	UTSW	4	76,018,995 (GRCm39)	splice site	probably null
R5287:Ptprd	UTSW	4	75,872,405 (GRCm39)	nonsense	probably null
R5305:Ptprd	UTSW	4	75,900,863 (GRCm39)	missense	probably damaging	1.00
R5362:Ptprd	UTSW	4	76,047,050 (GRCm39)	missense	probably damaging	1.00
R5403:Ptprd	UTSW	4	75,872,405 (GRCm39)	nonsense	probably null
R5531:Ptprd	UTSW	4	75,977,904 (GRCm39)	critical splice donor site	probably null
R5543:Ptprd	UTSW	4	75,977,990 (GRCm39)	missense	probably damaging	1.00
R5634:Ptprd	UTSW	4	75,990,255 (GRCm39)	missense	probably benign	0.01
R5719:Ptprd	UTSW	4	75,972,839 (GRCm39)	critical splice acceptor site	probably null
R6247:Ptprd	UTSW	4	75,984,528 (GRCm39)	missense	probably benign	0.06
R6250:Ptprd	UTSW	4	76,047,232 (GRCm39)	missense	probably damaging	1.00
R6335:Ptprd	UTSW	4	75,872,420 (GRCm39)	missense	probably damaging	1.00
R6352:Ptprd	UTSW	4	76,009,789 (GRCm39)	splice site	probably null
R6533:Ptprd	UTSW	4	76,046,765 (GRCm39)	missense	probably damaging	1.00
R6756:Ptprd	UTSW	4	75,873,536 (GRCm39)	missense	probably damaging	1.00
R6782:Ptprd	UTSW	4	76,243,377 (GRCm39)	splice site	probably null
R7131:Ptprd	UTSW	4	75,984,577 (GRCm39)	missense	probably damaging	1.00
R7170:Ptprd	UTSW	4	75,990,199 (GRCm39)	missense	probably benign	0.06
R7233:Ptprd	UTSW	4	75,978,020 (GRCm39)	missense	probably benign	0.00
R7246:Ptprd	UTSW	4	76,046,913 (GRCm39)	missense	probably damaging	1.00
R7413:Ptprd	UTSW	4	76,165,076 (GRCm39)	missense	probably benign	0.00
R7428:Ptprd	UTSW	4	76,004,705 (GRCm39)	missense	probably benign	0.03
R7442:Ptprd	UTSW	4	75,978,058 (GRCm39)	nonsense	probably null
R7491:Ptprd	UTSW	4	76,051,392 (GRCm39)	missense	probably benign	0.23
R7526:Ptprd	UTSW	4	75,984,564 (GRCm39)	missense	probably benign	0.00
R7609:Ptprd	UTSW	4	75,990,240 (GRCm39)	missense	probably benign	0.03
R7612:Ptprd	UTSW	4	76,004,696 (GRCm39)	missense	probably benign	0.45
R7659:Ptprd	UTSW	4	76,047,153 (GRCm39)	missense	probably benign	0.03
R7743:Ptprd	UTSW	4	76,004,326 (GRCm39)	missense	probably damaging	1.00
R7748:Ptprd	UTSW	4	76,017,741 (GRCm39)	missense	probably null	0.39
R7788:Ptprd	UTSW	4	75,916,841 (GRCm39)	missense	probably damaging	1.00
R7836:Ptprd	UTSW	4	75,900,881 (GRCm39)	missense	probably damaging	0.99
R7937:Ptprd	UTSW	4	76,013,772 (GRCm39)	missense	probably benign	0.00
R8000:Ptprd	UTSW	4	75,984,479 (GRCm39)	missense	possibly damaging	0.95
R8018:Ptprd	UTSW	4	76,003,757 (GRCm39)	missense	probably damaging	0.98
R8072:Ptprd	UTSW	4	76,004,273 (GRCm39)	missense	probably benign	0.01
R8119:Ptprd	UTSW	4	76,047,263 (GRCm39)	missense	probably benign	0.00
R8350:Ptprd	UTSW	4	75,868,898 (GRCm39)	missense	probably damaging	1.00
R8387:Ptprd	UTSW	4	75,873,526 (GRCm39)	missense	probably damaging	1.00
R8458:Ptprd	UTSW	4	75,984,496 (GRCm39)	missense	probably benign	0.00
R8529:Ptprd	UTSW	4	76,047,262 (GRCm39)	missense	probably damaging	1.00
R8699:Ptprd	UTSW	4	75,959,629 (GRCm39)	missense	probably benign
R8924:Ptprd	UTSW	4	75,916,736 (GRCm39)	critical splice donor site	probably null
R8984:Ptprd	UTSW	4	75,863,251 (GRCm39)	missense	probably damaging	1.00
R9024:Ptprd	UTSW	4	75,874,567 (GRCm39)	missense	probably damaging	1.00
R9204:Ptprd	UTSW	4	75,872,315 (GRCm39)	missense	possibly damaging	0.46
R9206:Ptprd	UTSW	4	75,872,315 (GRCm39)	missense	possibly damaging	0.46
R9259:Ptprd	UTSW	4	75,990,200 (GRCm39)	missense	probably damaging	0.99
R9311:Ptprd	UTSW	4	76,051,320 (GRCm39)	missense	probably benign	0.25
R9417:Ptprd	UTSW	4	75,865,335 (GRCm39)	missense	probably damaging	0.99
R9427:Ptprd	UTSW	4	76,051,440 (GRCm39)	missense	probably benign	0.01
R9579:Ptprd	UTSW	4	75,872,315 (GRCm39)	missense	possibly damaging	0.46
R9580:Ptprd	UTSW	4	75,872,315 (GRCm39)	missense	possibly damaging	0.46
R9701:Ptprd	UTSW	4	75,916,896 (GRCm39)	missense	probably damaging	1.00
RF016:Ptprd	UTSW	4	76,046,892 (GRCm39)	missense	probably benign	0.01
RF023:Ptprd	UTSW	4	76,046,802 (GRCm39)	missense	probably damaging	0.98
Z1176:Ptprd	UTSW	4	76,051,451 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TGCCAGTGGGACCAAGATTTAAG -3'
(R):5'- CCCAGAAAATTGAATCTGTTACTGC -3'

Sequencing Primer
(F):5'- GACCAAGATTTAAGTAAAAAGGCTTG -3'
(R):5'- ATTGGCATTGGAGGAGTAATTTAC -3'

Posted On

2017-02-10