Incidental Mutation 'R5851:Or4p22'
ID 454651
Institutional Source Beutler Lab
Gene Symbol Or4p22
Ensembl Gene ENSMUSG00000051424
Gene Name olfactory receptor family 4 subfamily P member 22
Synonyms MOR225-3, GA_x6K02T2Q125-49974190-49975125, Olfr1184
MMRRC Submission 044067-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R5851 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 88317078-88318013 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 88317204 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 43 (I43V)
Ref Sequence ENSEMBL: ENSMUSP00000149649 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050038] [ENSMUST00000216675]
AlphaFold Q8VG86
Predicted Effect possibly damaging
Transcript: ENSMUST00000050038
AA Change: I43V

PolyPhen 2 Score 0.541 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000058679
Gene: ENSMUSG00000051424
AA Change: I43V

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 2.2e-47 PFAM
Pfam:7tm_1 39 285 2.3e-14 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216675
AA Change: I43V

PolyPhen 2 Score 0.541 (Sensitivity: 0.88; Specificity: 0.91)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.0%
Validation Efficiency 100% (75/75)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca2 A G 2: 25,332,322 (GRCm39) N1452D possibly damaging Het
Abhd15 T C 11: 77,409,273 (GRCm39) L329P probably benign Het
Add3 T C 19: 53,225,205 (GRCm39) S442P probably damaging Het
Arhgef18 T C 8: 3,484,980 (GRCm39) F228L probably damaging Het
Bptf A T 11: 107,001,688 (GRCm39) Y475N probably damaging Het
C3 T C 17: 57,518,612 (GRCm39) N1257S probably null Het
Cdkl1 A T 12: 69,803,338 (GRCm39) Y179* probably null Het
Ceacam1 T C 7: 25,174,025 (GRCm39) N210S possibly damaging Het
Celf3 T A 3: 94,386,433 (GRCm39) I7N probably damaging Het
Clxn T A 16: 14,738,300 (GRCm39) L155H probably damaging Het
Cmpk1 A G 4: 114,844,167 (GRCm39) V55A possibly damaging Het
Csrnp1 C T 9: 119,802,144 (GRCm39) G305D possibly damaging Het
Dnah3 A G 7: 119,638,585 (GRCm39) S1266P possibly damaging Het
Edc4 T C 8: 106,617,499 (GRCm39) L1077P probably damaging Het
Fam174a G A 1: 95,252,868 (GRCm39) G157S probably damaging Het
Fubp3 T A 2: 31,488,622 (GRCm39) D159E probably benign Het
Garem2 C T 5: 30,319,288 (GRCm39) T250M probably damaging Het
H2-Eb1 C T 17: 34,528,745 (GRCm39) P92L probably benign Het
Ifnl3 G T 7: 28,222,936 (GRCm39) C69F probably damaging Het
Itga2b C A 11: 102,348,427 (GRCm39) probably benign Het
Klhl33 A T 14: 51,130,335 (GRCm39) D386E probably damaging Het
Lin9 T A 1: 180,496,763 (GRCm39) L351I probably benign Het
Loricrin G A 3: 91,987,846 (GRCm39) A480V unknown Het
Msh3 G T 13: 92,352,030 (GRCm39) Q1041K probably benign Het
Mtrex G A 13: 113,045,486 (GRCm39) R349W probably damaging Het
Myo1e G A 9: 70,291,086 (GRCm39) G959E probably benign Het
Nfat5 G T 8: 108,074,359 (GRCm39) V338L probably damaging Het
Nrf1 A G 6: 30,089,975 (GRCm39) H18R possibly damaging Het
Nup160 A G 2: 90,537,382 (GRCm39) D752G probably benign Het
Obscn A T 11: 58,885,526 (GRCm39) L2489* probably null Het
Or51q1c A G 7: 103,652,659 (GRCm39) E59G probably benign Het
Paip1 T C 13: 119,577,301 (GRCm39) S215P possibly damaging Het
Pate2 T A 9: 35,581,797 (GRCm39) Y26* probably null Het
Pcdhb10 A G 18: 37,545,811 (GRCm39) I296V probably benign Het
Pdzph1 T G 17: 59,280,741 (GRCm39) T514P probably benign Het
Pnlip G A 19: 58,662,224 (GRCm39) W123* probably null Het
Prmt2 C A 10: 76,072,574 (GRCm39) C9F possibly damaging Het
Rbl1 T A 2: 157,009,245 (GRCm39) K763N probably benign Het
Rfk C T 19: 17,372,562 (GRCm39) A28V probably damaging Het
Scart1 C T 7: 139,807,940 (GRCm39) P704S possibly damaging Het
Sdk1 G A 5: 141,948,424 (GRCm39) V590I probably benign Het
Sele A G 1: 163,877,143 (GRCm39) K140E probably benign Het
Sla G A 15: 66,655,572 (GRCm39) T189I probably damaging Het
Slc46a2 A G 4: 59,913,906 (GRCm39) V339A probably damaging Het
Slc5a9 A G 4: 111,742,797 (GRCm39) F432L probably benign Het
Slc6a19 A G 13: 73,839,859 (GRCm39) F141S possibly damaging Het
Tas2r123 T C 6: 132,824,271 (GRCm39) L56S probably damaging Het
Tektip1 A T 10: 81,200,711 (GRCm39) probably null Het
Tmem245 T C 4: 56,916,770 (GRCm39) I53V probably benign Het
Tor2a A T 2: 32,651,619 (GRCm39) Q278L probably benign Het
Trav6-3 A G 14: 53,667,572 (GRCm39) M15V probably benign Het
Ttc28 G A 5: 111,383,335 (GRCm39) probably benign Het
Ubap2 G A 4: 41,206,268 (GRCm39) Q534* probably null Het
Yju2 C T 17: 56,274,582 (GRCm39) S298F probably damaging Het
Zfp954 C A 7: 7,118,624 (GRCm39) E307* probably null Het
Zscan21 A G 5: 138,124,740 (GRCm39) K219E probably benign Het
Other mutations in Or4p22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01286:Or4p22 APN 2 88,317,592 (GRCm39) missense probably damaging 1.00
IGL01288:Or4p22 APN 2 88,317,592 (GRCm39) missense probably damaging 1.00
IGL01790:Or4p22 APN 2 88,317,270 (GRCm39) missense possibly damaging 0.65
IGL02070:Or4p22 APN 2 88,317,346 (GRCm39) missense probably damaging 1.00
IGL02247:Or4p22 APN 2 88,317,771 (GRCm39) missense probably benign 0.00
IGL02932:Or4p22 APN 2 88,317,519 (GRCm39) missense probably benign 0.01
IGL02997:Or4p22 APN 2 88,317,732 (GRCm39) missense probably damaging 0.99
IGL03161:Or4p22 APN 2 88,317,792 (GRCm39) missense probably benign 0.01
PIT4531001:Or4p22 UTSW 2 88,317,601 (GRCm39) missense possibly damaging 0.95
R3713:Or4p22 UTSW 2 88,317,787 (GRCm39) missense probably damaging 1.00
R3715:Or4p22 UTSW 2 88,317,787 (GRCm39) missense probably damaging 1.00
R4421:Or4p22 UTSW 2 88,317,585 (GRCm39) missense probably damaging 1.00
R4514:Or4p22 UTSW 2 88,317,709 (GRCm39) missense probably benign 0.05
R5096:Or4p22 UTSW 2 88,317,646 (GRCm39) missense possibly damaging 0.89
R5661:Or4p22 UTSW 2 88,317,441 (GRCm39) missense probably damaging 0.98
R6458:Or4p22 UTSW 2 88,317,562 (GRCm39) missense possibly damaging 0.90
R7073:Or4p22 UTSW 2 88,317,651 (GRCm39) missense probably benign 0.00
R7102:Or4p22 UTSW 2 88,317,492 (GRCm39) missense probably damaging 1.00
R7145:Or4p22 UTSW 2 88,317,721 (GRCm39) missense probably damaging 1.00
R7221:Or4p22 UTSW 2 88,317,973 (GRCm39) missense probably damaging 0.97
R8827:Or4p22 UTSW 2 88,317,165 (GRCm39) missense probably damaging 0.96
R9324:Or4p22 UTSW 2 88,317,787 (GRCm39) missense probably damaging 1.00
R9645:Or4p22 UTSW 2 88,317,373 (GRCm39) missense possibly damaging 0.89
X0063:Or4p22 UTSW 2 88,317,834 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- TGATTCAACTGAATTGTTGCTTCTG -3'
(R):5'- GATTTCAATCATTCCAAAGAAGTGC -3'

Sequencing Primer
(F):5'- CTGAATTGTTGCTTCTGAAATTCTC -3'
(R):5'- TCATTCCAAAGAAGTGCATGGC -3'
Posted On 2017-02-10