Incidental Mutation 'R5852:Scrn3'
ID 454711
Institutional Source Beutler Lab
Gene Symbol Scrn3
Ensembl Gene ENSMUSG00000008226
Gene Name secernin 3
Synonyms 4833415E20Rik
MMRRC Submission 043227-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5852 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 73142980-73168158 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 73161349 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 312 (F312L)
Ref Sequence ENSEMBL: ENSMUSP00000088320 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090811]
AlphaFold Q3TMH2
Predicted Effect probably damaging
Transcript: ENSMUST00000090811
AA Change: F312L

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000088320
Gene: ENSMUSG00000008226
AA Change: F312L

DomainStartEndE-ValueType
Pfam:Peptidase_C69 50 268 4.7e-13 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123621
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154158
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 T A 12: 118,891,139 (GRCm39) I453F probably damaging Het
Anpep C T 7: 79,488,720 (GRCm39) W402* probably null Het
Apcdd1 T C 18: 63,070,134 (GRCm39) S134P probably damaging Het
Ccdc154 T C 17: 25,382,183 (GRCm39) V34A probably benign Het
Cntn3 A T 6: 102,397,377 (GRCm39) N65K probably damaging Het
Cntn6 G T 6: 104,812,706 (GRCm39) V663F probably damaging Het
Crisp3 A T 17: 40,536,711 (GRCm39) C201* probably null Het
Dnhd1 T A 7: 105,344,955 (GRCm39) W2100R probably damaging Het
Dync2h1 A T 9: 7,011,290 (GRCm39) S3634R probably benign Het
Entrep2 T A 7: 64,425,579 (GRCm39) H171L probably damaging Het
Gucy1a2 T C 9: 3,865,460 (GRCm39) F645L probably damaging Het
Hs6st3 G T 14: 120,106,738 (GRCm39) R382L probably damaging Het
Il27 T A 7: 126,191,786 (GRCm39) T89S possibly damaging Het
Iqgap2 C T 13: 95,811,880 (GRCm39) R707H probably damaging Het
Klhl23 T A 2: 69,654,613 (GRCm39) I161N probably benign Het
Lrrk2 G A 15: 91,640,152 (GRCm39) E1566K probably damaging Het
Mia3 A G 1: 183,113,713 (GRCm39) V437A probably benign Het
Ncoa6 G T 2: 155,247,419 (GRCm39) H1962N possibly damaging Het
Nox4 C T 7: 86,988,172 (GRCm39) T361I probably damaging Het
Pappa2 T C 1: 158,544,584 (GRCm39) Y1748C probably damaging Het
Phyhip T C 14: 70,699,369 (GRCm39) probably null Het
Pkhd1 A G 1: 20,447,632 (GRCm39) F2254L probably benign Het
Plxnb1 A G 9: 108,935,518 (GRCm39) Y1018C probably damaging Het
Pnoc C T 14: 65,648,671 (GRCm39) V8I probably benign Het
Prss29 A G 17: 25,541,408 (GRCm39) D256G probably benign Het
Sephs1 A G 2: 4,904,339 (GRCm39) E239G possibly damaging Het
Tti1 A G 2: 157,842,593 (GRCm39) L812P probably damaging Het
Wdr1 A G 5: 38,694,518 (GRCm39) S62P probably benign Het
Zfp106 A G 2: 120,346,487 (GRCm39) S1659P probably damaging Het
Zng1 A G 19: 24,932,769 (GRCm39) V88A possibly damaging Het
Other mutations in Scrn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02012:Scrn3 APN 2 73,148,773 (GRCm39) critical splice donor site probably null
IGL02676:Scrn3 APN 2 73,160,215 (GRCm39) missense probably benign
PIT4445001:Scrn3 UTSW 2 73,148,673 (GRCm39) missense possibly damaging 0.90
PIT4519001:Scrn3 UTSW 2 73,161,347 (GRCm39) missense possibly damaging 0.95
PIT4519001:Scrn3 UTSW 2 73,148,768 (GRCm39) missense possibly damaging 0.78
R2105:Scrn3 UTSW 2 73,160,196 (GRCm39) missense probably damaging 0.96
R3973:Scrn3 UTSW 2 73,166,121 (GRCm39) missense possibly damaging 0.66
R3974:Scrn3 UTSW 2 73,166,121 (GRCm39) missense possibly damaging 0.66
R3975:Scrn3 UTSW 2 73,166,121 (GRCm39) missense possibly damaging 0.66
R4206:Scrn3 UTSW 2 73,149,845 (GRCm39) critical splice donor site probably null
R5340:Scrn3 UTSW 2 73,166,154 (GRCm39) nonsense probably null
R5545:Scrn3 UTSW 2 73,166,125 (GRCm39) missense possibly damaging 0.64
R6819:Scrn3 UTSW 2 73,149,826 (GRCm39) missense probably damaging 0.98
R7664:Scrn3 UTSW 2 73,149,714 (GRCm39) missense possibly damaging 0.90
R8260:Scrn3 UTSW 2 73,166,202 (GRCm39) missense probably damaging 1.00
R8350:Scrn3 UTSW 2 73,160,113 (GRCm39) missense possibly damaging 0.95
R8450:Scrn3 UTSW 2 73,160,113 (GRCm39) missense possibly damaging 0.95
R8906:Scrn3 UTSW 2 73,161,355 (GRCm39) missense possibly damaging 0.75
R8906:Scrn3 UTSW 2 73,161,352 (GRCm39) missense probably benign 0.34
R8915:Scrn3 UTSW 2 73,148,636 (GRCm39) missense probably damaging 0.99
R9355:Scrn3 UTSW 2 73,166,077 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGCCTAAATGACACGGCAC -3'
(R):5'- CGGTGGGTCTGAGAATAACTATTTC -3'

Sequencing Primer
(F):5'- CCGGGCACAATACAAGAT -3'
(R):5'- TCTTCATGAAAGACAAAAAGAAAGC -3'
Posted On 2017-02-10