Incidental Mutation 'R5853:Cd209b'
ID 454765
Institutional Source Beutler Lab
Gene Symbol Cd209b
Ensembl Gene ENSMUSG00000065987
Gene Name CD209b antigen
Synonyms 1810030I22Rik, mSIGNR1, SIGNR1
MMRRC Submission 044068-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R5853 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 3967655-3976841 bp(-) (GRCm39)
Type of Mutation splice site (3 bp from exon)
DNA Base Change (assembly) T to C at 3976549 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140695 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084086] [ENSMUST00000084086] [ENSMUST00000111014] [ENSMUST00000111014] [ENSMUST00000171635] [ENSMUST00000171635] [ENSMUST00000171635] [ENSMUST00000171635] [ENSMUST00000188386] [ENSMUST00000188386] [ENSMUST00000188386] [ENSMUST00000188386]
AlphaFold Q8CJ91
Predicted Effect probably null
Transcript: ENSMUST00000084086
SMART Domains Protein: ENSMUSP00000081104
Gene: ENSMUSG00000065987

DomainStartEndE-ValueType
transmembrane domain 53 75 N/A INTRINSIC
low complexity region 91 102 N/A INTRINSIC
CLECT 195 316 3.63e-31 SMART
Predicted Effect probably null
Transcript: ENSMUST00000084086
SMART Domains Protein: ENSMUSP00000081104
Gene: ENSMUSG00000065987

DomainStartEndE-ValueType
transmembrane domain 53 75 N/A INTRINSIC
low complexity region 91 102 N/A INTRINSIC
CLECT 195 316 3.63e-31 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000111014
SMART Domains Protein: ENSMUSP00000106643
Gene: ENSMUSG00000065987

DomainStartEndE-ValueType
low complexity region 61 72 N/A INTRINSIC
CLECT 165 307 2.43e-23 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000111014
SMART Domains Protein: ENSMUSP00000106643
Gene: ENSMUSG00000065987

DomainStartEndE-ValueType
low complexity region 61 72 N/A INTRINSIC
CLECT 165 307 2.43e-23 SMART
Predicted Effect probably null
Transcript: ENSMUST00000171635
SMART Domains Protein: ENSMUSP00000126070
Gene: ENSMUSG00000065987

DomainStartEndE-ValueType
low complexity region 61 72 N/A INTRINSIC
CLECT 165 286 3.63e-31 SMART
Predicted Effect probably null
Transcript: ENSMUST00000171635
SMART Domains Protein: ENSMUSP00000126070
Gene: ENSMUSG00000065987

DomainStartEndE-ValueType
low complexity region 61 72 N/A INTRINSIC
CLECT 165 286 3.63e-31 SMART
Predicted Effect probably null
Transcript: ENSMUST00000171635
SMART Domains Protein: ENSMUSP00000126070
Gene: ENSMUSG00000065987

DomainStartEndE-ValueType
low complexity region 61 72 N/A INTRINSIC
CLECT 165 286 3.63e-31 SMART
Predicted Effect probably null
Transcript: ENSMUST00000171635
SMART Domains Protein: ENSMUSP00000126070
Gene: ENSMUSG00000065987

DomainStartEndE-ValueType
low complexity region 61 72 N/A INTRINSIC
CLECT 165 286 3.63e-31 SMART
Predicted Effect probably null
Transcript: ENSMUST00000188386
SMART Domains Protein: ENSMUSP00000140695
Gene: ENSMUSG00000065987

DomainStartEndE-ValueType
low complexity region 61 72 N/A INTRINSIC
CLECT 165 307 2.43e-23 SMART
Predicted Effect probably null
Transcript: ENSMUST00000188386
SMART Domains Protein: ENSMUSP00000140695
Gene: ENSMUSG00000065987

DomainStartEndE-ValueType
low complexity region 61 72 N/A INTRINSIC
CLECT 165 307 2.43e-23 SMART
Predicted Effect probably null
Transcript: ENSMUST00000188386
SMART Domains Protein: ENSMUSP00000140695
Gene: ENSMUSG00000065987

DomainStartEndE-ValueType
low complexity region 61 72 N/A INTRINSIC
CLECT 165 307 2.43e-23 SMART
Predicted Effect probably null
Transcript: ENSMUST00000188386
SMART Domains Protein: ENSMUSP00000140695
Gene: ENSMUSG00000065987

DomainStartEndE-ValueType
low complexity region 61 72 N/A INTRINSIC
CLECT 165 307 2.43e-23 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mutants are more susceptible to S. pneumoniae infection and fail to clear the bacteria from the circulation. Marginal zone and peritoneal macrophages are impaired in recognizing the bacteria. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca15 G A 7: 119,939,806 (GRCm39) V303I probably benign Het
Abca4 G T 3: 121,897,180 (GRCm39) V620L probably benign Het
Ankk1 A T 9: 49,329,995 (GRCm39) V320E possibly damaging Het
Aoah G T 13: 21,184,072 (GRCm39) A379S probably benign Het
Apol7e A G 15: 77,598,667 (GRCm39) D44G probably benign Het
Atf2 T C 2: 73,658,813 (GRCm39) probably null Het
Chek1 G A 9: 36,624,983 (GRCm39) S366L probably damaging Het
Chpf2 T C 5: 24,797,190 (GRCm39) L712P probably damaging Het
Clmn C A 12: 104,750,161 (GRCm39) probably null Het
Cnksr3 T C 10: 7,092,977 (GRCm39) D178G probably benign Het
Cpox T C 16: 58,495,780 (GRCm39) Y366H probably damaging Het
Dnah3 A G 7: 119,538,056 (GRCm39) F3632S probably damaging Het
Eif5b T A 1: 38,076,388 (GRCm39) D645E probably damaging Het
Emilin1 G A 5: 31,075,966 (GRCm39) E736K probably damaging Het
Gcnt4 G A 13: 97,083,160 (GRCm39) R152Q probably benign Het
Il6st T C 13: 112,618,071 (GRCm39) S162P probably damaging Het
Iqub T C 6: 24,491,601 (GRCm39) K362E probably benign Het
Kif22 G T 7: 126,632,539 (GRCm39) P257Q possibly damaging Het
Lhx2 T C 2: 38,259,053 (GRCm39) V378A probably damaging Het
Lipo3 A G 19: 33,759,630 (GRCm39) V202A probably benign Het
Lrp1b T A 2: 40,553,738 (GRCm39) N366I unknown Het
Mbip T C 12: 56,382,662 (GRCm39) D268G probably damaging Het
Mc5r A G 18: 68,472,564 (GRCm39) M308V probably benign Het
Mndal C A 1: 173,690,070 (GRCm39) G420V probably damaging Het
Nbea A T 3: 55,899,822 (GRCm39) N1442K probably damaging Het
Ndufv1 A T 19: 4,058,811 (GRCm39) probably null Het
Ofcc1 A G 13: 40,360,193 (GRCm39) S279P probably benign Het
Or4k2 A T 14: 50,424,326 (GRCm39) M116K possibly damaging Het
Or6b2b T C 1: 92,419,439 (GRCm39) I13V probably benign Het
Pabpc1l A T 2: 163,891,438 (GRCm39) H552L probably benign Het
Pigr T A 1: 130,774,341 (GRCm39) C440* probably null Het
Pramel11 A G 4: 143,623,490 (GRCm39) V228A probably benign Het
Prss30 C T 17: 24,191,820 (GRCm39) V271I probably damaging Het
Psme4 T A 11: 30,741,234 (GRCm39) probably null Het
Qrich1 T A 9: 108,410,807 (GRCm39) probably benign Het
Rem1 C G 2: 152,470,200 (GRCm39) A62G possibly damaging Het
Rftn1 T C 17: 50,354,354 (GRCm39) N58S probably damaging Het
Rp9 G A 9: 22,360,065 (GRCm39) probably benign Het
Rrp1b G A 17: 32,275,658 (GRCm39) V402I possibly damaging Het
Slc25a33 A T 4: 149,838,349 (GRCm39) Y108N probably benign Het
Slc3a1 A G 17: 85,340,008 (GRCm39) M189V probably damaging Het
Slc44a1 A C 4: 53,528,682 (GRCm39) K144T probably benign Het
Tbc1d13 T A 2: 30,027,393 (GRCm39) H100Q probably damaging Het
Timm29 T C 9: 21,504,749 (GRCm39) V139A probably damaging Het
Tmem70 T C 1: 16,735,556 (GRCm39) W9R possibly damaging Het
Tspan1 A G 4: 116,020,502 (GRCm39) probably null Het
Unc13a T C 8: 72,107,773 (GRCm39) probably null Het
Uroc1 T C 6: 90,323,738 (GRCm39) F395S probably damaging Het
Uvrag A C 7: 98,537,284 (GRCm39) L637R possibly damaging Het
Vmn1r213 T G 13: 23,195,684 (GRCm39) L3W probably benign Het
Zfp280d C T 9: 72,238,224 (GRCm39) T528I probably benign Het
Zfp526 C T 7: 24,924,601 (GRCm39) Q287* probably null Het
Other mutations in Cd209b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Cd209b APN 8 3,969,945 (GRCm39) splice site probably benign
IGL01596:Cd209b APN 8 3,968,744 (GRCm39) missense probably damaging 1.00
IGL03211:Cd209b APN 8 3,968,830 (GRCm39) splice site probably benign
R1434:Cd209b UTSW 8 3,973,367 (GRCm39) missense possibly damaging 0.49
R4127:Cd209b UTSW 8 3,968,714 (GRCm39) missense probably damaging 1.00
R4387:Cd209b UTSW 8 3,975,960 (GRCm39) missense probably damaging 0.99
R4388:Cd209b UTSW 8 3,975,960 (GRCm39) missense probably damaging 0.99
R4389:Cd209b UTSW 8 3,975,960 (GRCm39) missense probably damaging 0.99
R4708:Cd209b UTSW 8 3,974,215 (GRCm39) missense probably damaging 0.99
R4710:Cd209b UTSW 8 3,974,215 (GRCm39) missense probably damaging 0.99
R4911:Cd209b UTSW 8 3,976,640 (GRCm39) critical splice acceptor site probably null
R5454:Cd209b UTSW 8 3,975,396 (GRCm39) missense probably damaging 0.98
R5814:Cd209b UTSW 8 3,973,348 (GRCm39) missense probably damaging 0.99
R5867:Cd209b UTSW 8 3,974,246 (GRCm39) missense possibly damaging 0.62
R5996:Cd209b UTSW 8 3,968,688 (GRCm39) missense probably benign 0.39
R7020:Cd209b UTSW 8 3,968,783 (GRCm39) missense probably damaging 0.99
R7187:Cd209b UTSW 8 3,976,638 (GRCm39) missense probably benign
R7695:Cd209b UTSW 8 3,976,005 (GRCm39) missense probably benign
R7712:Cd209b UTSW 8 3,973,299 (GRCm39) missense possibly damaging 0.83
R7975:Cd209b UTSW 8 3,975,948 (GRCm39) missense probably benign 0.41
R8309:Cd209b UTSW 8 3,976,559 (GRCm39) nonsense probably null
R8317:Cd209b UTSW 8 3,972,018 (GRCm39) missense probably damaging 0.99
R9159:Cd209b UTSW 8 3,974,245 (GRCm39) missense possibly damaging 0.70
R9214:Cd209b UTSW 8 3,968,771 (GRCm39) missense probably benign 0.22
Predicted Primers PCR Primer
(F):5'- ACAACCTGTGATGTCTCCCCTAG -3'
(R):5'- AGAAGCCAAGATGCAGCCTC -3'

Sequencing Primer
(F):5'- GTGATGTCTCCCCTAGCCATC -3'
(R):5'- AAGATGCAGCCTCTTAGCTC -3'
Posted On 2017-02-10