Incidental Mutation 'R5853:Clmn'
ID 454777
Institutional Source Beutler Lab
Gene Symbol Clmn
Ensembl Gene ENSMUSG00000021097
Gene Name calmin
Synonyms 9330188N17Rik
MMRRC Submission 044068-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5853 (G1)
Quality Score 225
Status Not validated
Chromosome 12
Chromosomal Location 104729376-104831335 bp(-) (GRCm39)
Type of Mutation splice site (5 bp from exon)
DNA Base Change (assembly) C to A at 104750161 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000105563 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109936] [ENSMUST00000109937] [ENSMUST00000222323] [ENSMUST00000223103] [ENSMUST00000223177] [ENSMUST00000223342]
AlphaFold Q8C5W0
Predicted Effect probably null
Transcript: ENSMUST00000109936
SMART Domains Protein: ENSMUSP00000105562
Gene: ENSMUSG00000021097

DomainStartEndE-ValueType
CH 34 137 2.29e-19 SMART
low complexity region 144 168 N/A INTRINSIC
CH 189 286 9.9e-15 SMART
low complexity region 471 482 N/A INTRINSIC
low complexity region 633 650 N/A INTRINSIC
low complexity region 679 691 N/A INTRINSIC
low complexity region 777 801 N/A INTRINSIC
low complexity region 869 887 N/A INTRINSIC
low complexity region 949 965 N/A INTRINSIC
transmembrane domain 996 1013 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000109937
SMART Domains Protein: ENSMUSP00000105563
Gene: ENSMUSG00000021097

DomainStartEndE-ValueType
CH 34 137 2.29e-19 SMART
low complexity region 144 168 N/A INTRINSIC
CH 189 286 9.9e-15 SMART
low complexity region 471 482 N/A INTRINSIC
low complexity region 633 650 N/A INTRINSIC
low complexity region 679 691 N/A INTRINSIC
low complexity region 777 801 N/A INTRINSIC
low complexity region 869 887 N/A INTRINSIC
low complexity region 949 965 N/A INTRINSIC
transmembrane domain 1027 1044 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000222323
Predicted Effect noncoding transcript
Transcript: ENSMUST00000222412
Predicted Effect probably benign
Transcript: ENSMUST00000223103
Predicted Effect probably benign
Transcript: ENSMUST00000223177
Predicted Effect probably benign
Transcript: ENSMUST00000223342
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca15 G A 7: 119,939,806 (GRCm39) V303I probably benign Het
Abca4 G T 3: 121,897,180 (GRCm39) V620L probably benign Het
Ankk1 A T 9: 49,329,995 (GRCm39) V320E possibly damaging Het
Aoah G T 13: 21,184,072 (GRCm39) A379S probably benign Het
Apol7e A G 15: 77,598,667 (GRCm39) D44G probably benign Het
Atf2 T C 2: 73,658,813 (GRCm39) probably null Het
Cd209b T C 8: 3,976,549 (GRCm39) probably null Het
Chek1 G A 9: 36,624,983 (GRCm39) S366L probably damaging Het
Chpf2 T C 5: 24,797,190 (GRCm39) L712P probably damaging Het
Cnksr3 T C 10: 7,092,977 (GRCm39) D178G probably benign Het
Cpox T C 16: 58,495,780 (GRCm39) Y366H probably damaging Het
Dnah3 A G 7: 119,538,056 (GRCm39) F3632S probably damaging Het
Eif5b T A 1: 38,076,388 (GRCm39) D645E probably damaging Het
Emilin1 G A 5: 31,075,966 (GRCm39) E736K probably damaging Het
Gcnt4 G A 13: 97,083,160 (GRCm39) R152Q probably benign Het
Il6st T C 13: 112,618,071 (GRCm39) S162P probably damaging Het
Iqub T C 6: 24,491,601 (GRCm39) K362E probably benign Het
Kif22 G T 7: 126,632,539 (GRCm39) P257Q possibly damaging Het
Lhx2 T C 2: 38,259,053 (GRCm39) V378A probably damaging Het
Lipo3 A G 19: 33,759,630 (GRCm39) V202A probably benign Het
Lrp1b T A 2: 40,553,738 (GRCm39) N366I unknown Het
Mbip T C 12: 56,382,662 (GRCm39) D268G probably damaging Het
Mc5r A G 18: 68,472,564 (GRCm39) M308V probably benign Het
Mndal C A 1: 173,690,070 (GRCm39) G420V probably damaging Het
Nbea A T 3: 55,899,822 (GRCm39) N1442K probably damaging Het
Ndufv1 A T 19: 4,058,811 (GRCm39) probably null Het
Ofcc1 A G 13: 40,360,193 (GRCm39) S279P probably benign Het
Or4k2 A T 14: 50,424,326 (GRCm39) M116K possibly damaging Het
Or6b2b T C 1: 92,419,439 (GRCm39) I13V probably benign Het
Pabpc1l A T 2: 163,891,438 (GRCm39) H552L probably benign Het
Pigr T A 1: 130,774,341 (GRCm39) C440* probably null Het
Pramel11 A G 4: 143,623,490 (GRCm39) V228A probably benign Het
Prss30 C T 17: 24,191,820 (GRCm39) V271I probably damaging Het
Psme4 T A 11: 30,741,234 (GRCm39) probably null Het
Qrich1 T A 9: 108,410,807 (GRCm39) probably benign Het
Rem1 C G 2: 152,470,200 (GRCm39) A62G possibly damaging Het
Rftn1 T C 17: 50,354,354 (GRCm39) N58S probably damaging Het
Rp9 G A 9: 22,360,065 (GRCm39) probably benign Het
Rrp1b G A 17: 32,275,658 (GRCm39) V402I possibly damaging Het
Slc25a33 A T 4: 149,838,349 (GRCm39) Y108N probably benign Het
Slc3a1 A G 17: 85,340,008 (GRCm39) M189V probably damaging Het
Slc44a1 A C 4: 53,528,682 (GRCm39) K144T probably benign Het
Tbc1d13 T A 2: 30,027,393 (GRCm39) H100Q probably damaging Het
Timm29 T C 9: 21,504,749 (GRCm39) V139A probably damaging Het
Tmem70 T C 1: 16,735,556 (GRCm39) W9R possibly damaging Het
Tspan1 A G 4: 116,020,502 (GRCm39) probably null Het
Unc13a T C 8: 72,107,773 (GRCm39) probably null Het
Uroc1 T C 6: 90,323,738 (GRCm39) F395S probably damaging Het
Uvrag A C 7: 98,537,284 (GRCm39) L637R possibly damaging Het
Vmn1r213 T G 13: 23,195,684 (GRCm39) L3W probably benign Het
Zfp280d C T 9: 72,238,224 (GRCm39) T528I probably benign Het
Zfp526 C T 7: 24,924,601 (GRCm39) Q287* probably null Het
Other mutations in Clmn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01132:Clmn APN 12 104,740,810 (GRCm39) critical splice acceptor site probably null
IGL01509:Clmn APN 12 104,747,162 (GRCm39) missense probably benign 0.00
IGL01530:Clmn APN 12 104,758,115 (GRCm39) missense probably damaging 1.00
IGL01768:Clmn APN 12 104,747,978 (GRCm39) missense probably damaging 0.99
IGL01779:Clmn APN 12 104,748,399 (GRCm39) missense probably benign 0.04
IGL02139:Clmn APN 12 104,747,358 (GRCm39) missense probably benign 0.01
IGL02157:Clmn APN 12 104,748,177 (GRCm39) missense probably benign 0.00
IGL02519:Clmn APN 12 104,758,112 (GRCm39) missense probably damaging 1.00
IGL02820:Clmn APN 12 104,739,493 (GRCm39) missense probably damaging 0.99
IGL03036:Clmn APN 12 104,740,782 (GRCm39) missense probably damaging 0.97
R0255:Clmn UTSW 12 104,748,023 (GRCm39) missense probably benign
R0478:Clmn UTSW 12 104,751,750 (GRCm39) missense probably damaging 0.99
R0739:Clmn UTSW 12 104,747,276 (GRCm39) missense possibly damaging 0.55
R0761:Clmn UTSW 12 104,747,817 (GRCm39) missense probably damaging 0.99
R0834:Clmn UTSW 12 104,738,086 (GRCm39) missense probably damaging 1.00
R0834:Clmn UTSW 12 104,738,085 (GRCm39) missense probably damaging 1.00
R0864:Clmn UTSW 12 104,756,274 (GRCm39) missense possibly damaging 0.94
R1569:Clmn UTSW 12 104,747,340 (GRCm39) missense probably damaging 1.00
R1638:Clmn UTSW 12 104,748,281 (GRCm39) missense probably benign 0.13
R1940:Clmn UTSW 12 104,756,361 (GRCm39) missense probably damaging 1.00
R1974:Clmn UTSW 12 104,758,121 (GRCm39) missense probably damaging 1.00
R2113:Clmn UTSW 12 104,747,067 (GRCm39) missense probably benign
R4815:Clmn UTSW 12 104,751,825 (GRCm39) missense probably damaging 1.00
R4863:Clmn UTSW 12 104,763,353 (GRCm39) missense probably damaging 1.00
R4883:Clmn UTSW 12 104,748,307 (GRCm39) missense probably benign 0.04
R5577:Clmn UTSW 12 104,743,329 (GRCm39) missense probably damaging 1.00
R5867:Clmn UTSW 12 104,748,014 (GRCm39) missense probably damaging 0.98
R6041:Clmn UTSW 12 104,748,131 (GRCm39) missense probably benign 0.00
R6093:Clmn UTSW 12 104,738,215 (GRCm39) missense probably benign 0.00
R6233:Clmn UTSW 12 104,751,714 (GRCm39) missense probably damaging 1.00
R6239:Clmn UTSW 12 104,747,104 (GRCm39) missense probably benign 0.00
R6628:Clmn UTSW 12 104,740,045 (GRCm39) missense probably damaging 1.00
R6771:Clmn UTSW 12 104,740,041 (GRCm39) missense probably benign 0.04
R7448:Clmn UTSW 12 104,751,687 (GRCm39) missense possibly damaging 0.90
R7633:Clmn UTSW 12 104,748,371 (GRCm39) missense probably benign
R8901:Clmn UTSW 12 104,747,211 (GRCm39) missense probably benign 0.20
R8937:Clmn UTSW 12 104,763,341 (GRCm39) missense probably damaging 1.00
R9654:Clmn UTSW 12 104,748,193 (GRCm39) missense probably damaging 0.99
X0028:Clmn UTSW 12 104,751,661 (GRCm39) missense probably benign 0.11
Z1177:Clmn UTSW 12 104,747,635 (GRCm39) missense probably benign 0.27
Predicted Primers PCR Primer
(F):5'- GTCACAGGTGGTTTAGAAATGG -3'
(R):5'- GGCAGCCACCTTTAACCAAG -3'

Sequencing Primer
(F):5'- CACAGGTGGTTTAGAAATGGAAATAG -3'
(R):5'- CTCAGAGTCTAAATTTCTTCCAGGGG -3'
Posted On 2017-02-10