Incidental Mutation 'R5857:Or10x4'
ID 454934
Institutional Source Beutler Lab
Gene Symbol Or10x4
Ensembl Gene ENSMUSG00000059503
Gene Name olfactory receptor family 10 subfamily X member 4
Synonyms MOR267-7, GA_x6K02T2MFC0-1145-1312, GA_x6K02T2P20D-20771141-20770212, Olfr415, Olfr248
MMRRC Submission 044069-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R5857 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 174218612-174219621 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 174218674 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Arginine at position 13 (I13R)
Ref Sequence ENSEMBL: ENSMUSP00000074799 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075329]
AlphaFold E9Q1L6
Predicted Effect possibly damaging
Transcript: ENSMUST00000075329
AA Change: I13R

PolyPhen 2 Score 0.592 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000074799
Gene: ENSMUSG00000059503
AA Change: I13R

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 1.2e-40 PFAM
Pfam:7tm_1 39 303 7.5e-22 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.6%
Validation Efficiency 95% (55/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik A G 8: 73,203,369 (GRCm39) I266V probably benign Het
Anks6 C T 4: 47,039,736 (GRCm39) A492T possibly damaging Het
Ano1 A T 7: 144,190,840 (GRCm39) C415S probably benign Het
Anxa3 T A 5: 96,976,651 (GRCm39) probably null Het
Apob T C 12: 8,065,397 (GRCm39) V4089A probably benign Het
Arhgap23 C T 11: 97,342,405 (GRCm39) A229V possibly damaging Het
Atad5 T C 11: 80,022,155 (GRCm39) F1447L probably benign Het
Btbd8 T A 5: 107,609,398 (GRCm39) D212E probably damaging Het
Ccdc38 G T 10: 93,398,695 (GRCm39) A58S possibly damaging Het
Cep112 T C 11: 108,422,297 (GRCm39) probably benign Het
Col4a2 G A 8: 11,475,442 (GRCm39) G622D probably damaging Het
Crhbp T A 13: 95,578,740 (GRCm39) Q134L probably benign Het
Ctnnbl1 T C 2: 157,631,018 (GRCm39) S145P probably damaging Het
Cyp4f16 T A 17: 32,755,998 (GRCm39) L9Q probably damaging Het
Dchs2 T G 3: 83,177,620 (GRCm39) I891S possibly damaging Het
Disp3 A T 4: 148,333,640 (GRCm39) V1066D probably benign Het
Dlgap1 A G 17: 71,122,388 (GRCm39) probably benign Het
Dnah3 TTCCTC TTC 7: 119,550,244 (GRCm39) probably benign Het
Efl1 T A 7: 82,412,397 (GRCm39) C929S probably benign Het
Gatb T C 3: 85,483,239 (GRCm39) F82S probably damaging Het
Gk5 C A 9: 96,001,508 (GRCm39) S2* probably null Het
Gpr135 G A 12: 72,117,614 (GRCm39) A51V probably benign Het
Hoxa9 T A 6: 52,201,277 (GRCm39) N255Y probably damaging Het
Igkv8-18 T C 6: 70,332,904 (GRCm39) V15A probably benign Het
Ism2 T C 12: 87,326,835 (GRCm39) D368G probably damaging Het
Krtap6-2 A T 16: 89,216,530 (GRCm39) S146T unknown Het
Lama1 T A 17: 68,114,838 (GRCm39) L2329H probably damaging Het
Llgl2 T A 11: 115,741,107 (GRCm39) I507N probably damaging Het
Lmna GCTGCCCACAC GC 3: 88,389,838 (GRCm39) probably benign Het
Lrfn3 A T 7: 30,058,863 (GRCm39) I454N possibly damaging Het
Mdn1 C A 4: 32,670,646 (GRCm39) T437K probably benign Het
Nat8f3 T C 6: 85,738,735 (GRCm39) Y9C probably damaging Het
Niban2 T A 2: 32,799,920 (GRCm39) N82K probably benign Het
Nlrp4d C A 7: 10,116,304 (GRCm39) G156V noncoding transcript Het
Npnt A T 3: 132,614,110 (GRCm39) C167S probably damaging Het
Nr3c2 A G 8: 77,635,496 (GRCm39) N199S possibly damaging Het
Or8b12i C T 9: 20,082,535 (GRCm39) D111N probably damaging Het
Or8b37 T G 9: 37,959,049 (GRCm39) V177G probably benign Het
Pabpc1l T A 2: 163,886,175 (GRCm39) probably null Het
Pi4ka A G 16: 17,176,848 (GRCm39) I366T probably benign Het
Prl7a1 A T 13: 27,824,684 (GRCm39) D50E probably damaging Het
Rad52 T G 6: 119,887,968 (GRCm39) probably null Het
Rbm19 T A 5: 120,271,007 (GRCm39) L610Q probably damaging Het
Rnd2 C T 11: 101,359,825 (GRCm39) L57F probably damaging Het
Scube1 G T 15: 83,491,461 (GRCm39) probably benign Het
Sptbn4 G T 7: 27,118,138 (GRCm39) R314S possibly damaging Het
Togaram1 T A 12: 65,042,331 (GRCm39) I1130K possibly damaging Het
Tsc2 T C 17: 24,818,981 (GRCm39) E1352G probably damaging Het
Ube2d2a A G 18: 35,938,596 (GRCm39) T142A probably benign Het
Vps18 T C 2: 119,128,014 (GRCm39) Y946H probably damaging Het
Other mutations in Or10x4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01649:Or10x4 APN 1 174,218,974 (GRCm39) missense probably damaging 1.00
R0375:Or10x4 UTSW 1 174,218,775 (GRCm39) missense probably damaging 1.00
R1720:Or10x4 UTSW 1 174,219,486 (GRCm39) missense probably benign 0.00
R1906:Or10x4 UTSW 1 174,218,730 (GRCm39) missense probably damaging 1.00
R1996:Or10x4 UTSW 1 174,218,983 (GRCm39) missense probably damaging 1.00
R2009:Or10x4 UTSW 1 174,218,995 (GRCm39) missense possibly damaging 0.94
R4745:Or10x4 UTSW 1 174,219,442 (GRCm39) missense probably damaging 1.00
R5294:Or10x4 UTSW 1 174,218,791 (GRCm39) missense probably benign
R5297:Or10x4 UTSW 1 174,218,766 (GRCm39) missense probably benign 0.21
R5665:Or10x4 UTSW 1 174,218,941 (GRCm39) missense probably damaging 1.00
R5784:Or10x4 UTSW 1 174,218,965 (GRCm39) missense probably damaging 1.00
R6943:Or10x4 UTSW 1 174,219,407 (GRCm39) nonsense probably null
R6975:Or10x4 UTSW 1 174,219,243 (GRCm39) missense probably benign 0.10
R7114:Or10x4 UTSW 1 174,218,805 (GRCm39) missense probably damaging 0.96
R7614:Or10x4 UTSW 1 174,219,220 (GRCm39) missense probably damaging 0.99
R8036:Or10x4 UTSW 1 174,219,382 (GRCm39) missense probably damaging 1.00
R8674:Or10x4 UTSW 1 174,219,258 (GRCm39) missense probably damaging 1.00
R8777:Or10x4 UTSW 1 174,218,848 (GRCm39) missense probably damaging 1.00
R8777-TAIL:Or10x4 UTSW 1 174,218,848 (GRCm39) missense probably damaging 1.00
R9139:Or10x4 UTSW 1 174,218,649 (GRCm39) missense probably damaging 1.00
R9178:Or10x4 UTSW 1 174,219,229 (GRCm39) missense probably benign 0.36
R9256:Or10x4 UTSW 1 174,219,109 (GRCm39) missense probably benign 0.11
R9449:Or10x4 UTSW 1 174,218,742 (GRCm39) missense probably benign
R9668:Or10x4 UTSW 1 174,218,898 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- AGGAAATCGTATCGTCTACATACAGG -3'
(R):5'- TAGTCAGGGTGTAGCAGGTC -3'

Sequencing Primer
(F):5'- ACAGGGTTGAGTTTTGCCAAAC -3'
(R):5'- CAGGGTGTAGCAGGTCTCAGAG -3'
Posted On 2017-02-10