Incidental Mutation 'R5859:Zswim9'
ID 455058
Institutional Source Beutler Lab
Gene Symbol Zswim9
Ensembl Gene ENSMUSG00000070814
Gene Name zinc finger SWIM-type containing 9
Synonyms 6330408A02Rik
MMRRC Submission 044071-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R5859 (G1)
Quality Score 108
Status Validated
Chromosome 7
Chromosomal Location 12992894-13012647 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 12995371 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 262 (V262M)
Ref Sequence ENSEMBL: ENSMUSP00000104172 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108532] [ENSMUST00000119139] [ENSMUST00000119558]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000108532
AA Change: V262M

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000104172
Gene: ENSMUSG00000070814
AA Change: V262M

DomainStartEndE-ValueType
low complexity region 213 224 N/A INTRINSIC
low complexity region 405 423 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000119139
AA Change: V262M

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000112652
Gene: ENSMUSG00000070814
AA Change: V262M

DomainStartEndE-ValueType
low complexity region 213 224 N/A INTRINSIC
low complexity region 405 423 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000119558
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135898
Meta Mutation Damage Score 0.0956 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.4%
  • 20x: 91.9%
Validation Efficiency 93% (70/75)
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam5 A T 8: 25,303,477 (GRCm39) V150E probably benign Het
Alg11 A G 8: 22,555,857 (GRCm39) K373E probably benign Het
Arl14ep C T 2: 106,799,398 (GRCm39) probably benign Het
Ascc2 G A 11: 4,608,284 (GRCm39) G227R probably benign Het
Ash1l C T 3: 88,976,300 (GRCm39) P2627S probably damaging Het
Btla T G 16: 45,059,402 (GRCm39) probably null Het
Btnl10 C T 11: 58,813,138 (GRCm39) P256S probably benign Het
Cep162 C T 9: 87,086,145 (GRCm39) A1060T probably damaging Het
Cfap54 T A 10: 92,852,386 (GRCm39) K907* probably null Het
Chpf A T 1: 75,452,072 (GRCm39) F461I probably damaging Het
Chrdl2 A G 7: 99,670,114 (GRCm39) Y79C probably damaging Het
Copb2 G A 9: 98,450,161 (GRCm39) C40Y probably benign Het
Cyfip1 T C 7: 55,574,929 (GRCm39) L1060P probably damaging Het
Drg1 G A 11: 3,209,273 (GRCm39) probably benign Het
Erich3 A G 3: 154,468,134 (GRCm39) D862G possibly damaging Het
Flii G T 11: 60,607,137 (GRCm39) Y946* probably null Het
Glt8d2 T C 10: 82,507,915 (GRCm39) M1V probably null Het
Gm21136 T A 7: 38,567,165 (GRCm39) noncoding transcript Het
Gramd1c T C 16: 43,812,454 (GRCm39) T393A possibly damaging Het
Gucy2d T A 7: 98,101,090 (GRCm39) I471N probably benign Het
Hps3 G A 3: 20,063,034 (GRCm39) T711M probably benign Het
Hs3st4 A T 7: 123,582,831 (GRCm39) D143V probably benign Het
Kif17 T A 4: 138,018,744 (GRCm39) M461K possibly damaging Het
Klhdc7a T A 4: 139,694,885 (GRCm39) S21C probably damaging Het
Klk15 G A 7: 43,587,800 (GRCm39) R76H probably benign Het
Lnpk G A 2: 74,399,372 (GRCm39) T57I possibly damaging Het
Ltbp2 A G 12: 84,840,837 (GRCm39) V999A possibly damaging Het
Ltbr T C 6: 125,289,771 (GRCm39) H141R probably damaging Het
Lvrn T C 18: 47,026,816 (GRCm39) F805L probably damaging Het
Ms4a13 A T 19: 11,161,280 (GRCm39) C86* probably null Het
Ncbp1 A G 4: 46,163,026 (GRCm39) N480S probably benign Het
Nelfcd T G 2: 174,268,856 (GRCm39) *592G probably null Het
Neurog2 T C 3: 127,427,664 (GRCm39) V96A probably benign Het
Nod1 A T 6: 54,907,162 (GRCm39) W902R probably benign Het
Or12d13 T C 17: 37,647,260 (GRCm39) I288V possibly damaging Het
Or4k15c T A 14: 50,321,484 (GRCm39) Y218F probably damaging Het
Or55b3 T C 7: 102,126,957 (GRCm39) Y40C possibly damaging Het
Or6d13 T C 6: 116,517,861 (GRCm39) L149P probably damaging Het
Pcdha11 A T 18: 37,140,336 (GRCm39) H655L probably damaging Het
Plpp7 A G 2: 31,985,996 (GRCm39) E58G probably benign Het
Psph A T 5: 129,867,685 (GRCm39) probably benign Het
Rab11fip1 A C 8: 27,644,748 (GRCm39) S346A probably damaging Het
Rreb1 C A 13: 38,131,384 (GRCm39) P1513T probably benign Het
Rreb1 C T 13: 38,131,385 (GRCm39) P1513L probably benign Het
Rsf1 C T 7: 97,334,766 (GRCm39) R1300C probably damaging Het
Scap A G 9: 110,203,115 (GRCm39) N263S probably benign Het
Sec24d A T 3: 123,072,961 (GRCm39) probably benign Het
Slain2 T C 5: 73,105,888 (GRCm39) probably benign Het
Slc6a18 G T 13: 73,816,278 (GRCm39) T367N probably benign Het
Slk T A 19: 47,597,481 (GRCm39) D96E probably benign Het
Spag5 G A 11: 78,204,360 (GRCm39) V514I probably benign Het
St8sia2 T C 7: 73,616,654 (GRCm39) D107G probably damaging Het
Tgfbr3 T A 5: 107,288,381 (GRCm39) I427F probably benign Het
Tlr2 T G 3: 83,743,810 (GRCm39) T758P possibly damaging Het
Tmem270 A G 5: 134,931,738 (GRCm39) V68A probably benign Het
Vmn2r106 T A 17: 20,505,583 (GRCm39) H37L possibly damaging Het
Vmn2r27 T G 6: 124,177,647 (GRCm39) R452S probably damaging Het
Wdr5 A G 2: 27,423,362 (GRCm39) Y252C probably damaging Het
Other mutations in Zswim9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01926:Zswim9 APN 7 12,994,248 (GRCm39) missense possibly damaging 0.53
IGL02063:Zswim9 APN 7 12,994,608 (GRCm39) missense probably damaging 0.98
R0568:Zswim9 UTSW 7 12,994,952 (GRCm39) missense probably damaging 0.99
R0680:Zswim9 UTSW 7 12,994,248 (GRCm39) missense probably benign 0.10
R1438:Zswim9 UTSW 7 13,011,144 (GRCm39) missense possibly damaging 0.86
R1600:Zswim9 UTSW 7 13,003,497 (GRCm39) missense probably damaging 1.00
R1678:Zswim9 UTSW 7 13,011,337 (GRCm39) missense probably benign 0.04
R1745:Zswim9 UTSW 7 13,003,482 (GRCm39) missense probably damaging 1.00
R1938:Zswim9 UTSW 7 12,994,141 (GRCm39) nonsense probably null
R2025:Zswim9 UTSW 7 13,003,292 (GRCm39) missense probably damaging 0.98
R3149:Zswim9 UTSW 7 13,011,196 (GRCm39) missense possibly damaging 0.94
R3150:Zswim9 UTSW 7 13,011,196 (GRCm39) missense possibly damaging 0.94
R3176:Zswim9 UTSW 7 13,011,196 (GRCm39) missense possibly damaging 0.94
R3177:Zswim9 UTSW 7 13,011,196 (GRCm39) missense possibly damaging 0.94
R3276:Zswim9 UTSW 7 13,011,196 (GRCm39) missense possibly damaging 0.94
R3277:Zswim9 UTSW 7 13,011,196 (GRCm39) missense possibly damaging 0.94
R3950:Zswim9 UTSW 7 12,995,503 (GRCm39) missense possibly damaging 0.95
R4554:Zswim9 UTSW 7 13,011,088 (GRCm39) missense probably benign 0.33
R4866:Zswim9 UTSW 7 12,995,095 (GRCm39) missense probably damaging 0.99
R4953:Zswim9 UTSW 7 13,003,484 (GRCm39) missense probably damaging 1.00
R5330:Zswim9 UTSW 7 12,993,912 (GRCm39) missense probably damaging 1.00
R5394:Zswim9 UTSW 7 12,994,909 (GRCm39) missense probably damaging 1.00
R5408:Zswim9 UTSW 7 12,994,753 (GRCm39) missense possibly damaging 0.66
R5654:Zswim9 UTSW 7 12,995,094 (GRCm39) missense probably damaging 0.99
R5810:Zswim9 UTSW 7 12,994,662 (GRCm39) missense probably damaging 0.98
R6235:Zswim9 UTSW 7 12,995,529 (GRCm39) missense probably damaging 1.00
R6239:Zswim9 UTSW 7 12,995,257 (GRCm39) nonsense probably null
R6249:Zswim9 UTSW 7 12,994,903 (GRCm39) missense probably damaging 0.98
R6394:Zswim9 UTSW 7 12,994,889 (GRCm39) missense probably damaging 0.99
R7077:Zswim9 UTSW 7 12,993,679 (GRCm39) missense probably damaging 1.00
R7133:Zswim9 UTSW 7 12,993,664 (GRCm39) missense probably damaging 0.98
R7178:Zswim9 UTSW 7 12,993,924 (GRCm39) missense possibly damaging 0.53
R7595:Zswim9 UTSW 7 12,994,998 (GRCm39) missense probably benign 0.21
R8005:Zswim9 UTSW 7 12,995,064 (GRCm39) missense probably damaging 0.98
R8138:Zswim9 UTSW 7 12,995,337 (GRCm39) missense probably damaging 1.00
R8282:Zswim9 UTSW 7 12,995,536 (GRCm39) missense probably benign
R8818:Zswim9 UTSW 7 12,994,456 (GRCm39) missense probably benign 0.19
R9241:Zswim9 UTSW 7 13,003,360 (GRCm39) missense probably damaging 1.00
R9277:Zswim9 UTSW 7 12,994,983 (GRCm39) missense probably damaging 0.96
R9787:Zswim9 UTSW 7 12,994,205 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ACTGAAGAGCGTCTCTAGACCC -3'
(R):5'- TCTACAGGTGAAGCTGGTGTTC -3'

Sequencing Primer
(F):5'- AGAGCGTCTCTAGACCCTGAGC -3'
(R):5'- TGTTCGTGGAGGATCAAGCAATG -3'
Posted On 2017-02-10