Incidental Mutation 'R5859:Vmn2r106'
ID |
455088 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r106
|
Ensembl Gene |
ENSMUSG00000091656 |
Gene Name |
vomeronasal 2, receptor 106 |
Synonyms |
EG224576 |
MMRRC Submission |
044071-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.163)
|
Stock # |
R5859 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
20487809-20505692 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 20505583 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Histidine to Leucine
at position 37
(H37L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000126534
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167464]
|
AlphaFold |
E9PY92 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000167464
AA Change: H37L
PolyPhen 2
Score 0.716 (Sensitivity: 0.86; Specificity: 0.92)
|
SMART Domains |
Protein: ENSMUSP00000126534 Gene: ENSMUSG00000091656 AA Change: H37L
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
83 |
471 |
3.8e-37 |
PFAM |
Pfam:NCD3G
|
514 |
567 |
5.7e-22 |
PFAM |
Pfam:7tm_3
|
596 |
835 |
1.3e-49 |
PFAM |
|
Meta Mutation Damage Score |
0.1795 |
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.4%
- 20x: 91.9%
|
Validation Efficiency |
93% (70/75) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 58 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adam5 |
A |
T |
8: 25,303,477 (GRCm39) |
V150E |
probably benign |
Het |
Alg11 |
A |
G |
8: 22,555,857 (GRCm39) |
K373E |
probably benign |
Het |
Arl14ep |
C |
T |
2: 106,799,398 (GRCm39) |
|
probably benign |
Het |
Ascc2 |
G |
A |
11: 4,608,284 (GRCm39) |
G227R |
probably benign |
Het |
Ash1l |
C |
T |
3: 88,976,300 (GRCm39) |
P2627S |
probably damaging |
Het |
Btla |
T |
G |
16: 45,059,402 (GRCm39) |
|
probably null |
Het |
Btnl10 |
C |
T |
11: 58,813,138 (GRCm39) |
P256S |
probably benign |
Het |
Cep162 |
C |
T |
9: 87,086,145 (GRCm39) |
A1060T |
probably damaging |
Het |
Cfap54 |
T |
A |
10: 92,852,386 (GRCm39) |
K907* |
probably null |
Het |
Chpf |
A |
T |
1: 75,452,072 (GRCm39) |
F461I |
probably damaging |
Het |
Chrdl2 |
A |
G |
7: 99,670,114 (GRCm39) |
Y79C |
probably damaging |
Het |
Copb2 |
G |
A |
9: 98,450,161 (GRCm39) |
C40Y |
probably benign |
Het |
Cyfip1 |
T |
C |
7: 55,574,929 (GRCm39) |
L1060P |
probably damaging |
Het |
Drg1 |
G |
A |
11: 3,209,273 (GRCm39) |
|
probably benign |
Het |
Erich3 |
A |
G |
3: 154,468,134 (GRCm39) |
D862G |
possibly damaging |
Het |
Flii |
G |
T |
11: 60,607,137 (GRCm39) |
Y946* |
probably null |
Het |
Glt8d2 |
T |
C |
10: 82,507,915 (GRCm39) |
M1V |
probably null |
Het |
Gm21136 |
T |
A |
7: 38,567,165 (GRCm39) |
|
noncoding transcript |
Het |
Gramd1c |
T |
C |
16: 43,812,454 (GRCm39) |
T393A |
possibly damaging |
Het |
Gucy2d |
T |
A |
7: 98,101,090 (GRCm39) |
I471N |
probably benign |
Het |
Hps3 |
G |
A |
3: 20,063,034 (GRCm39) |
T711M |
probably benign |
Het |
Hs3st4 |
A |
T |
7: 123,582,831 (GRCm39) |
D143V |
probably benign |
Het |
Kif17 |
T |
A |
4: 138,018,744 (GRCm39) |
M461K |
possibly damaging |
Het |
Klhdc7a |
T |
A |
4: 139,694,885 (GRCm39) |
S21C |
probably damaging |
Het |
Klk15 |
G |
A |
7: 43,587,800 (GRCm39) |
R76H |
probably benign |
Het |
Lnpk |
G |
A |
2: 74,399,372 (GRCm39) |
T57I |
possibly damaging |
Het |
Ltbp2 |
A |
G |
12: 84,840,837 (GRCm39) |
V999A |
possibly damaging |
Het |
Ltbr |
T |
C |
6: 125,289,771 (GRCm39) |
H141R |
probably damaging |
Het |
Lvrn |
T |
C |
18: 47,026,816 (GRCm39) |
F805L |
probably damaging |
Het |
Ms4a13 |
A |
T |
19: 11,161,280 (GRCm39) |
C86* |
probably null |
Het |
Ncbp1 |
A |
G |
4: 46,163,026 (GRCm39) |
N480S |
probably benign |
Het |
Nelfcd |
T |
G |
2: 174,268,856 (GRCm39) |
*592G |
probably null |
Het |
Neurog2 |
T |
C |
3: 127,427,664 (GRCm39) |
V96A |
probably benign |
Het |
Nod1 |
A |
T |
6: 54,907,162 (GRCm39) |
W902R |
probably benign |
Het |
Or12d13 |
T |
C |
17: 37,647,260 (GRCm39) |
I288V |
possibly damaging |
Het |
Or4k15c |
T |
A |
14: 50,321,484 (GRCm39) |
Y218F |
probably damaging |
Het |
Or55b3 |
T |
C |
7: 102,126,957 (GRCm39) |
Y40C |
possibly damaging |
Het |
Or6d13 |
T |
C |
6: 116,517,861 (GRCm39) |
L149P |
probably damaging |
Het |
Pcdha11 |
A |
T |
18: 37,140,336 (GRCm39) |
H655L |
probably damaging |
Het |
Plpp7 |
A |
G |
2: 31,985,996 (GRCm39) |
E58G |
probably benign |
Het |
Psph |
A |
T |
5: 129,867,685 (GRCm39) |
|
probably benign |
Het |
Rab11fip1 |
A |
C |
8: 27,644,748 (GRCm39) |
S346A |
probably damaging |
Het |
Rreb1 |
C |
A |
13: 38,131,384 (GRCm39) |
P1513T |
probably benign |
Het |
Rreb1 |
C |
T |
13: 38,131,385 (GRCm39) |
P1513L |
probably benign |
Het |
Rsf1 |
C |
T |
7: 97,334,766 (GRCm39) |
R1300C |
probably damaging |
Het |
Scap |
A |
G |
9: 110,203,115 (GRCm39) |
N263S |
probably benign |
Het |
Sec24d |
A |
T |
3: 123,072,961 (GRCm39) |
|
probably benign |
Het |
Slain2 |
T |
C |
5: 73,105,888 (GRCm39) |
|
probably benign |
Het |
Slc6a18 |
G |
T |
13: 73,816,278 (GRCm39) |
T367N |
probably benign |
Het |
Slk |
T |
A |
19: 47,597,481 (GRCm39) |
D96E |
probably benign |
Het |
Spag5 |
G |
A |
11: 78,204,360 (GRCm39) |
V514I |
probably benign |
Het |
St8sia2 |
T |
C |
7: 73,616,654 (GRCm39) |
D107G |
probably damaging |
Het |
Tgfbr3 |
T |
A |
5: 107,288,381 (GRCm39) |
I427F |
probably benign |
Het |
Tlr2 |
T |
G |
3: 83,743,810 (GRCm39) |
T758P |
possibly damaging |
Het |
Tmem270 |
A |
G |
5: 134,931,738 (GRCm39) |
V68A |
probably benign |
Het |
Vmn2r27 |
T |
G |
6: 124,177,647 (GRCm39) |
R452S |
probably damaging |
Het |
Wdr5 |
A |
G |
2: 27,423,362 (GRCm39) |
Y252C |
probably damaging |
Het |
Zswim9 |
C |
T |
7: 12,995,371 (GRCm39) |
V262M |
probably damaging |
Het |
|
Other mutations in Vmn2r106 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00979:Vmn2r106
|
APN |
17 |
20,497,837 (GRCm39) |
missense |
possibly damaging |
0.90 |
IGL01313:Vmn2r106
|
APN |
17 |
20,498,651 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01419:Vmn2r106
|
APN |
17 |
20,499,807 (GRCm39) |
missense |
probably benign |
0.06 |
IGL01574:Vmn2r106
|
APN |
17 |
20,488,572 (GRCm39) |
missense |
possibly damaging |
0.94 |
IGL01796:Vmn2r106
|
APN |
17 |
20,488,314 (GRCm39) |
missense |
possibly damaging |
0.79 |
IGL01893:Vmn2r106
|
APN |
17 |
20,497,730 (GRCm39) |
missense |
probably benign |
0.06 |
IGL01895:Vmn2r106
|
APN |
17 |
20,499,227 (GRCm39) |
missense |
probably benign |
0.02 |
IGL02378:Vmn2r106
|
APN |
17 |
20,497,791 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02430:Vmn2r106
|
APN |
17 |
20,499,158 (GRCm39) |
missense |
probably benign |
0.38 |
IGL02664:Vmn2r106
|
APN |
17 |
20,488,344 (GRCm39) |
missense |
possibly damaging |
0.88 |
IGL03308:Vmn2r106
|
APN |
17 |
20,498,785 (GRCm39) |
nonsense |
probably null |
|
IGL03384:Vmn2r106
|
APN |
17 |
20,488,405 (GRCm39) |
missense |
probably damaging |
0.99 |
R0401:Vmn2r106
|
UTSW |
17 |
20,499,281 (GRCm39) |
missense |
possibly damaging |
0.86 |
R0842:Vmn2r106
|
UTSW |
17 |
20,488,465 (GRCm39) |
missense |
probably damaging |
1.00 |
R0964:Vmn2r106
|
UTSW |
17 |
20,487,859 (GRCm39) |
missense |
probably benign |
0.00 |
R1235:Vmn2r106
|
UTSW |
17 |
20,499,741 (GRCm39) |
missense |
probably benign |
0.00 |
R1709:Vmn2r106
|
UTSW |
17 |
20,499,373 (GRCm39) |
missense |
probably benign |
0.12 |
R1712:Vmn2r106
|
UTSW |
17 |
20,498,997 (GRCm39) |
missense |
probably benign |
0.01 |
R1770:Vmn2r106
|
UTSW |
17 |
20,488,560 (GRCm39) |
missense |
probably damaging |
0.99 |
R2049:Vmn2r106
|
UTSW |
17 |
20,488,566 (GRCm39) |
missense |
possibly damaging |
0.90 |
R2245:Vmn2r106
|
UTSW |
17 |
20,488,423 (GRCm39) |
missense |
probably benign |
0.13 |
R2336:Vmn2r106
|
UTSW |
17 |
20,488,470 (GRCm39) |
missense |
probably benign |
0.18 |
R2910:Vmn2r106
|
UTSW |
17 |
20,498,946 (GRCm39) |
missense |
probably damaging |
1.00 |
R3025:Vmn2r106
|
UTSW |
17 |
20,499,147 (GRCm39) |
missense |
probably benign |
0.00 |
R3944:Vmn2r106
|
UTSW |
17 |
20,487,913 (GRCm39) |
missense |
probably damaging |
1.00 |
R4081:Vmn2r106
|
UTSW |
17 |
20,487,818 (GRCm39) |
nonsense |
probably null |
|
R4153:Vmn2r106
|
UTSW |
17 |
20,488,080 (GRCm39) |
missense |
probably damaging |
1.00 |
R4356:Vmn2r106
|
UTSW |
17 |
20,499,910 (GRCm39) |
missense |
probably benign |
0.06 |
R4426:Vmn2r106
|
UTSW |
17 |
20,505,641 (GRCm39) |
missense |
probably benign |
0.00 |
R4590:Vmn2r106
|
UTSW |
17 |
20,497,728 (GRCm39) |
missense |
probably damaging |
0.99 |
R4661:Vmn2r106
|
UTSW |
17 |
20,487,885 (GRCm39) |
missense |
probably benign |
0.10 |
R5106:Vmn2r106
|
UTSW |
17 |
20,499,395 (GRCm39) |
critical splice acceptor site |
probably null |
|
R5341:Vmn2r106
|
UTSW |
17 |
20,497,788 (GRCm39) |
missense |
probably benign |
0.00 |
R5509:Vmn2r106
|
UTSW |
17 |
20,498,684 (GRCm39) |
missense |
probably damaging |
0.99 |
R5826:Vmn2r106
|
UTSW |
17 |
20,499,133 (GRCm39) |
missense |
probably benign |
|
R5937:Vmn2r106
|
UTSW |
17 |
20,505,667 (GRCm39) |
nonsense |
probably null |
|
R5972:Vmn2r106
|
UTSW |
17 |
20,498,738 (GRCm39) |
missense |
probably benign |
|
R6056:Vmn2r106
|
UTSW |
17 |
20,487,806 (GRCm39) |
splice site |
probably null |
|
R6108:Vmn2r106
|
UTSW |
17 |
20,488,638 (GRCm39) |
missense |
probably benign |
0.11 |
R6114:Vmn2r106
|
UTSW |
17 |
20,488,638 (GRCm39) |
missense |
probably benign |
0.11 |
R6115:Vmn2r106
|
UTSW |
17 |
20,488,638 (GRCm39) |
missense |
probably benign |
0.11 |
R6132:Vmn2r106
|
UTSW |
17 |
20,488,666 (GRCm39) |
missense |
probably benign |
|
R6208:Vmn2r106
|
UTSW |
17 |
20,488,591 (GRCm39) |
missense |
probably damaging |
0.99 |
R6217:Vmn2r106
|
UTSW |
17 |
20,488,501 (GRCm39) |
missense |
probably benign |
0.10 |
R6289:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R6378:Vmn2r106
|
UTSW |
17 |
20,498,667 (GRCm39) |
missense |
probably benign |
0.19 |
R6390:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R6391:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R6392:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R6405:Vmn2r106
|
UTSW |
17 |
20,499,361 (GRCm39) |
missense |
probably benign |
0.22 |
R6427:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R6428:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R6435:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R6436:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R6437:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R6511:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R6512:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R6587:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R6703:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R6730:Vmn2r106
|
UTSW |
17 |
20,499,096 (GRCm39) |
missense |
possibly damaging |
0.64 |
R6961:Vmn2r106
|
UTSW |
17 |
20,488,646 (GRCm39) |
nonsense |
probably null |
|
R7054:Vmn2r106
|
UTSW |
17 |
20,499,182 (GRCm39) |
missense |
probably damaging |
0.96 |
R7379:Vmn2r106
|
UTSW |
17 |
20,488,037 (GRCm39) |
missense |
possibly damaging |
0.75 |
R7402:Vmn2r106
|
UTSW |
17 |
20,487,883 (GRCm39) |
missense |
probably damaging |
0.99 |
R7497:Vmn2r106
|
UTSW |
17 |
20,488,201 (GRCm39) |
missense |
probably damaging |
1.00 |
R7692:Vmn2r106
|
UTSW |
17 |
20,505,490 (GRCm39) |
missense |
possibly damaging |
0.96 |
R8539:Vmn2r106
|
UTSW |
17 |
20,499,271 (GRCm39) |
missense |
probably benign |
0.00 |
R8827:Vmn2r106
|
UTSW |
17 |
20,487,868 (GRCm39) |
missense |
probably benign |
0.05 |
R8872:Vmn2r106
|
UTSW |
17 |
20,488,401 (GRCm39) |
missense |
probably benign |
0.19 |
R9118:Vmn2r106
|
UTSW |
17 |
20,505,667 (GRCm39) |
missense |
probably benign |
0.00 |
R9254:Vmn2r106
|
UTSW |
17 |
20,496,066 (GRCm39) |
missense |
probably damaging |
1.00 |
R9379:Vmn2r106
|
UTSW |
17 |
20,496,066 (GRCm39) |
missense |
probably damaging |
1.00 |
R9571:Vmn2r106
|
UTSW |
17 |
20,505,641 (GRCm39) |
missense |
probably benign |
0.17 |
|
Predicted Primers |
PCR Primer
(F):5'- TTTATTCCACCTGAGAGAGGAAAAG -3'
(R):5'- AGTTCAAAGTACCCATGGTCAC -3'
Sequencing Primer
(F):5'- CCACCTGAGAGAGGAAAAGAAGCC -3'
(R):5'- GTACCCATGGTCACAAAAATGTG -3'
|
Posted On |
2017-02-10 |