Incidental Mutation 'R5870:Dlgap3'
ID 455110
Institutional Source Beutler Lab
Gene Symbol Dlgap3
Ensembl Gene ENSMUSG00000042388
Gene Name DLG associated protein 3
Synonyms Prpl8, SAP90/PSD 95 associated protein 3, DAP3, Sapap3, PSD-95/SAP90-binding protein 3
MMRRC Submission 044078-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R5870 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 127062997-127130815 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 127089502 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 366 (L366*)
Ref Sequence ENSEMBL: ENSMUSP00000101700 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046659] [ENSMUST00000106092] [ENSMUST00000106094]
AlphaFold Q6PFD5
Predicted Effect probably null
Transcript: ENSMUST00000046659
AA Change: L366*
SMART Domains Protein: ENSMUSP00000039724
Gene: ENSMUSG00000042388
AA Change: L366*

DomainStartEndE-ValueType
low complexity region 53 88 N/A INTRINSIC
low complexity region 145 159 N/A INTRINSIC
low complexity region 200 243 N/A INTRINSIC
low complexity region 258 284 N/A INTRINSIC
low complexity region 338 354 N/A INTRINSIC
internal_repeat_1 387 411 6.49e-5 PROSPERO
low complexity region 419 429 N/A INTRINSIC
internal_repeat_1 493 517 6.49e-5 PROSPERO
low complexity region 539 550 N/A INTRINSIC
low complexity region 597 615 N/A INTRINSIC
Pfam:GKAP 619 977 1.3e-137 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000106092
AA Change: L366*
SMART Domains Protein: ENSMUSP00000101698
Gene: ENSMUSG00000042388
AA Change: L366*

DomainStartEndE-ValueType
low complexity region 53 88 N/A INTRINSIC
low complexity region 145 159 N/A INTRINSIC
low complexity region 200 243 N/A INTRINSIC
low complexity region 258 284 N/A INTRINSIC
low complexity region 338 354 N/A INTRINSIC
internal_repeat_1 387 411 5.59e-5 PROSPERO
low complexity region 419 429 N/A INTRINSIC
internal_repeat_1 493 517 5.59e-5 PROSPERO
low complexity region 539 550 N/A INTRINSIC
low complexity region 597 615 N/A INTRINSIC
Pfam:GKAP 619 966 1.8e-127 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000106094
AA Change: L366*
SMART Domains Protein: ENSMUSP00000101700
Gene: ENSMUSG00000042388
AA Change: L366*

DomainStartEndE-ValueType
low complexity region 53 88 N/A INTRINSIC
low complexity region 145 159 N/A INTRINSIC
low complexity region 200 243 N/A INTRINSIC
low complexity region 258 284 N/A INTRINSIC
low complexity region 338 354 N/A INTRINSIC
internal_repeat_1 387 411 6.49e-5 PROSPERO
low complexity region 419 429 N/A INTRINSIC
internal_repeat_1 493 517 6.49e-5 PROSPERO
low complexity region 539 550 N/A INTRINSIC
low complexity region 597 615 N/A INTRINSIC
Pfam:GKAP 626 977 1.3e-149 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.4%
  • 10x: 97.2%
  • 20x: 91.1%
Validation Efficiency 93% (84/90)
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit skin lesions associated with excessive grooming, increased anxiety-related behaviors, altered synaptic transmission and abnormal sleep patterns. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy9 A G 16: 4,236,232 (GRCm39) V156A probably damaging Het
Ak6 C A 13: 100,791,932 (GRCm39) P125Q probably damaging Het
Aqp4 A C 18: 15,532,946 (GRCm39) V49G probably damaging Het
Arfgef1 A G 1: 10,251,163 (GRCm39) I874T probably damaging Het
Arid1a T C 4: 133,408,387 (GRCm39) D2040G unknown Het
Atp1a3 T G 7: 24,697,003 (GRCm39) D220A probably benign Het
C2cd4c A T 10: 79,448,043 (GRCm39) I368N possibly damaging Het
Ccnt1 G A 15: 98,441,394 (GRCm39) Q625* probably null Het
Cd177 T A 7: 24,455,757 (GRCm39) H255L probably benign Het
Cdipt G A 7: 126,578,094 (GRCm39) V114M probably benign Het
Coro1b T A 19: 4,199,384 (GRCm39) H14Q probably damaging Het
Ctdp1 T A 18: 80,451,901 (GRCm39) D158V unknown Het
Cts7 A T 13: 61,503,545 (GRCm39) S140T probably damaging Het
Dnah9 C T 11: 65,976,036 (GRCm39) A1338T probably benign Het
Dock7 T C 4: 98,952,199 (GRCm39) I424V probably benign Het
Dock8 G T 19: 25,109,490 (GRCm39) A891S probably benign Het
Dync2i1 A G 12: 116,219,865 (GRCm39) S26P possibly damaging Het
Elmod3 A G 6: 72,571,721 (GRCm39) probably null Het
Eps15 G A 4: 109,218,507 (GRCm39) E107K probably damaging Het
Esco1 A T 18: 10,593,744 (GRCm39) probably null Het
Fuz A G 7: 44,549,742 (GRCm39) T407A probably damaging Het
Galr1 A T 18: 82,424,197 (GRCm39) F27I probably benign Het
Glt1d1 A G 5: 127,754,344 (GRCm39) Y182C probably damaging Het
Gm37240 A T 3: 84,597,828 (GRCm39) probably benign Het
Gm37610 A G 6: 41,061,848 (GRCm39) noncoding transcript Het
Gm6658 G T 8: 91,635,020 (GRCm39) probably benign Het
Gm9376 A G 14: 118,504,789 (GRCm39) T74A possibly damaging Het
Hadha G A 5: 30,349,284 (GRCm39) S109F possibly damaging Het
Herc3 A T 6: 58,893,435 (GRCm39) Q899L probably benign Het
Ift172 C T 5: 31,434,284 (GRCm39) E485K probably benign Het
Lrrc8e A G 8: 4,285,725 (GRCm39) K650R possibly damaging Het
Ly6d A T 15: 74,635,381 (GRCm39) V10D possibly damaging Het
Med27 A G 2: 29,279,823 (GRCm39) probably null Het
Med29 A T 7: 28,091,922 (GRCm39) V56E probably damaging Het
Mobp A G 9: 119,996,919 (GRCm39) K17E probably damaging Het
Mrpl37 G A 4: 106,923,919 (GRCm39) T25I probably benign Het
Myh1 A G 11: 67,092,805 (GRCm39) D33G possibly damaging Het
Nrg3 T A 14: 39,194,586 (GRCm39) I58F possibly damaging Het
Or52e2 A G 7: 102,804,948 (GRCm39) I2T probably benign Het
Or7e176 A G 9: 20,171,874 (GRCm39) D246G probably benign Het
Padi1 T A 4: 140,553,892 (GRCm39) D359V probably benign Het
Pcdh7 T C 5: 57,877,753 (GRCm39) V436A possibly damaging Het
Pgm3 C A 9: 86,452,414 (GRCm39) K15N probably damaging Het
Phip A T 9: 82,790,730 (GRCm39) probably benign Het
Pot1a G A 6: 25,778,950 (GRCm39) T48I possibly damaging Het
Ppic T C 18: 53,542,333 (GRCm39) K125R probably benign Het
Ppm1j T C 3: 104,692,811 (GRCm39) V440A possibly damaging Het
Prg4 T A 1: 150,331,300 (GRCm39) K458* probably null Het
Rd3 A T 1: 191,717,261 (GRCm39) M244L probably benign Het
Rflnb A G 11: 75,912,864 (GRCm39) Y175H probably benign Het
Rnf157 T A 11: 116,237,900 (GRCm39) S574C probably benign Het
Sardh A G 2: 27,110,653 (GRCm39) probably null Het
Senp3 C T 11: 69,569,048 (GRCm39) probably null Het
Siglec1 G A 2: 130,914,767 (GRCm39) R1450C probably damaging Het
Sim2 A G 16: 93,924,193 (GRCm39) H446R probably damaging Het
Spon1 T C 7: 113,631,021 (GRCm39) I444T probably damaging Het
Srebf1 T A 11: 60,094,410 (GRCm39) Q568H possibly damaging Het
Stxbp4 A T 11: 90,428,782 (GRCm39) I441N possibly damaging Het
Sugt1 G A 14: 79,846,451 (GRCm39) V163I probably benign Het
Surf1 G T 2: 26,806,271 (GRCm39) probably benign Het
Synj2 A G 17: 6,088,128 (GRCm39) E1348G probably benign Het
Tc2n A T 12: 101,619,111 (GRCm39) V349D probably damaging Het
Ten1 A G 11: 116,105,751 (GRCm39) R112G possibly damaging Het
Tm9sf4 A G 2: 153,036,201 (GRCm39) D321G probably damaging Het
Ttll12 A T 15: 83,461,237 (GRCm39) M594K probably damaging Het
Ttn T A 2: 76,703,058 (GRCm39) probably benign Het
Usp28 C T 9: 48,937,285 (GRCm39) Q185* probably null Het
Vmn2r112 A G 17: 22,838,004 (GRCm39) I822V probably benign Het
Zc3hc1 A T 6: 30,382,682 (GRCm39) L88* probably null Het
Zfr T A 15: 12,160,701 (GRCm39) V758D probably damaging Het
Zfyve27 T G 19: 42,160,110 (GRCm39) L42R probably benign Het
Other mutations in Dlgap3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01667:Dlgap3 APN 4 127,127,690 (GRCm39) missense probably benign 0.01
IGL03122:Dlgap3 APN 4 127,089,018 (GRCm39) missense possibly damaging 0.86
IGL03259:Dlgap3 APN 4 127,094,077 (GRCm39) missense probably benign 0.05
Compulsive UTSW 4 127,089,502 (GRCm39) nonsense probably null
R0363:Dlgap3 UTSW 4 127,129,314 (GRCm39) missense probably damaging 1.00
R1222:Dlgap3 UTSW 4 127,088,406 (GRCm39) start codon destroyed probably null 0.01
R1386:Dlgap3 UTSW 4 127,088,719 (GRCm39) missense possibly damaging 0.81
R1603:Dlgap3 UTSW 4 127,089,021 (GRCm39) missense probably damaging 1.00
R2073:Dlgap3 UTSW 4 127,089,159 (GRCm39) missense probably damaging 0.99
R2119:Dlgap3 UTSW 4 127,129,982 (GRCm39) missense probably benign
R2696:Dlgap3 UTSW 4 127,088,416 (GRCm39) missense probably damaging 1.00
R3076:Dlgap3 UTSW 4 127,089,499 (GRCm39) missense probably damaging 1.00
R3738:Dlgap3 UTSW 4 127,089,399 (GRCm39) missense probably damaging 0.99
R4344:Dlgap3 UTSW 4 127,108,141 (GRCm39) missense possibly damaging 0.84
R4676:Dlgap3 UTSW 4 127,127,554 (GRCm39) missense probably damaging 0.99
R4720:Dlgap3 UTSW 4 127,089,508 (GRCm39) critical splice donor site probably null
R4893:Dlgap3 UTSW 4 127,088,776 (GRCm39) missense probably damaging 1.00
R5384:Dlgap3 UTSW 4 127,130,123 (GRCm39) missense probably damaging 1.00
R5841:Dlgap3 UTSW 4 127,089,193 (GRCm39) missense probably damaging 1.00
R6379:Dlgap3 UTSW 4 127,128,767 (GRCm39) missense probably damaging 1.00
R7028:Dlgap3 UTSW 4 127,089,310 (GRCm39) missense possibly damaging 0.74
R7454:Dlgap3 UTSW 4 127,128,852 (GRCm39) missense probably null 0.01
R7479:Dlgap3 UTSW 4 127,088,418 (GRCm39) missense possibly damaging 0.72
R8104:Dlgap3 UTSW 4 127,129,947 (GRCm39) missense probably damaging 0.99
R8853:Dlgap3 UTSW 4 127,088,810 (GRCm39) missense probably damaging 0.99
R8921:Dlgap3 UTSW 4 127,127,463 (GRCm39) missense probably damaging 0.99
R9483:Dlgap3 UTSW 4 127,127,665 (GRCm39) missense probably damaging 0.96
R9717:Dlgap3 UTSW 4 127,129,287 (GRCm39) missense probably damaging 1.00
R9777:Dlgap3 UTSW 4 127,130,127 (GRCm39) missense possibly damaging 0.87
X0024:Dlgap3 UTSW 4 127,129,965 (GRCm39) missense probably damaging 1.00
Z1177:Dlgap3 UTSW 4 127,129,291 (GRCm39) missense probably damaging 1.00
Z1177:Dlgap3 UTSW 4 127,088,777 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCCTACAGGGACTTGAGCTTC -3'
(R):5'- CCTTCATTGTACAAATGGGGAAAG -3'

Sequencing Primer
(F):5'- AGCTTCAAGGGGCGTTC -3'
(R):5'- CATTGTACAAATGGGGAAAGGGAGG -3'
Posted On 2017-02-10