Incidental Mutation 'R5874:Zswim3'
ID 455366
Institutional Source Beutler Lab
Gene Symbol Zswim3
Ensembl Gene ENSMUSG00000045822
Gene Name zinc finger SWIM-type containing 3
Synonyms 4921517A06Rik
MMRRC Submission 044081-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R5874 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 164647034-164664047 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 164662032 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 171 (I171V)
Ref Sequence ENSEMBL: ENSMUSP00000050970 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017908] [ENSMUST00000052107] [ENSMUST00000132282]
AlphaFold Q8CFL8
Predicted Effect probably benign
Transcript: ENSMUST00000017908
SMART Domains Protein: ENSMUSP00000017908
Gene: ENSMUSG00000017764

DomainStartEndE-ValueType
Pfam:SWIM 342 375 2e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000052107
AA Change: I171V

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000050970
Gene: ENSMUSG00000045822
AA Change: I171V

DomainStartEndE-ValueType
low complexity region 436 453 N/A INTRINSIC
low complexity region 474 489 N/A INTRINSIC
ZnF_PMZ 546 573 2.09e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000132282
Meta Mutation Damage Score 0.0589 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.8%
  • 20x: 93.6%
Validation Efficiency 98% (86/88)
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432E11Rik G A 7: 29,280,610 (GRCm39) noncoding transcript Het
Adam17 T C 12: 21,379,087 (GRCm39) D654G possibly damaging Het
Ankhd1 A T 18: 36,773,322 (GRCm39) H1373L possibly damaging Het
Ankrd17 T C 5: 90,416,656 (GRCm39) probably benign Het
Calu A G 6: 29,372,617 (GRCm39) D112G probably damaging Het
Camk2a G C 18: 61,076,272 (GRCm39) probably benign Het
Cpn1 C A 19: 43,944,951 (GRCm39) R452L probably benign Het
Csmd3 T A 15: 47,507,666 (GRCm39) E2780V probably damaging Het
Ctnna2 T C 6: 76,879,413 (GRCm39) T824A probably benign Het
Cuedc2 C T 19: 46,319,824 (GRCm39) V164M possibly damaging Het
Cyp2d34 T A 15: 82,503,243 (GRCm39) D74V probably benign Het
Ddi2 A G 4: 141,422,780 (GRCm39) S311P probably damaging Het
Ddx10 A C 9: 53,140,498 (GRCm39) I301R possibly damaging Het
Dmpk T C 7: 18,826,007 (GRCm39) probably benign Het
Dnah7b C T 1: 46,230,885 (GRCm39) T1381I probably damaging Het
Dst T A 1: 34,218,670 (GRCm39) N1703K probably damaging Het
Dtwd1 T A 2: 126,000,359 (GRCm39) H98Q probably damaging Het
Ecel1 A C 1: 87,075,731 (GRCm39) V769G probably benign Het
Eno4 T C 19: 58,935,238 (GRCm39) V150A probably benign Het
Evc2 C T 5: 37,574,883 (GRCm39) probably benign Het
Ext1 T A 15: 52,965,148 (GRCm39) Q406L possibly damaging Het
Foxf2 A G 13: 31,810,775 (GRCm39) H238R probably benign Het
Frem2 C G 3: 53,444,910 (GRCm39) G2407A probably benign Het
Fzd10 A G 5: 128,678,364 (GRCm39) E28G probably benign Het
Galnt15 T C 14: 31,774,324 (GRCm39) F363L probably damaging Het
Gm1758 C T 16: 14,325,037 (GRCm39) noncoding transcript Het
Gm5866 C T 5: 52,739,956 (GRCm39) noncoding transcript Het
Heatr9 T A 11: 83,405,426 (GRCm39) M345L probably benign Het
Il23r A T 6: 67,408,629 (GRCm39) F404Y possibly damaging Het
Lrrc8a T C 2: 30,147,148 (GRCm39) I654T probably damaging Het
Napg A T 18: 63,111,091 (GRCm39) K18* probably null Het
Ndst3 A T 3: 123,355,556 (GRCm39) W573R probably damaging Het
Nin T C 12: 70,077,692 (GRCm39) S1038G possibly damaging Het
Nudt12 T A 17: 59,317,279 (GRCm39) R123* probably null Het
Oas1g T A 5: 121,015,081 (GRCm39) N361Y probably benign Het
Or5p51 T A 7: 107,444,377 (GRCm39) I188L probably benign Het
Or7a35 T A 10: 78,853,191 (GRCm39) F12I possibly damaging Het
Or8h10 A T 2: 86,808,786 (GRCm39) M118K probably damaging Het
Osbpl10 T C 9: 115,055,828 (GRCm39) F667L probably damaging Het
Phldb2 T C 16: 45,621,988 (GRCm39) D664G probably damaging Het
Piezo2 C T 18: 63,160,972 (GRCm39) V2263M probably damaging Het
Pkd1l1 A G 11: 8,858,688 (GRCm39) L615P probably damaging Het
Pnpla7 G A 2: 24,901,661 (GRCm39) M562I probably benign Het
Pou2af2 A T 9: 51,201,672 (GRCm39) L128* probably null Het
Ppp1r13b C A 12: 111,811,423 (GRCm39) R155L probably damaging Het
Pygb C T 2: 150,628,798 (GRCm39) P4L probably benign Het
Rbm44 T C 1: 91,084,562 (GRCm39) probably null Het
Rilpl2 T C 5: 124,607,876 (GRCm39) T115A probably benign Het
Rin3 A G 12: 102,356,102 (GRCm39) Y801C probably damaging Het
Rnf112 A G 11: 61,340,273 (GRCm39) V619A probably damaging Het
Rnf182 A G 13: 43,821,563 (GRCm39) E38G probably benign Het
Scgb2b24 T A 7: 33,436,830 (GRCm39) Y94F probably damaging Het
Serac1 C A 17: 6,094,188 (GRCm39) probably benign Het
Shld2 T C 14: 33,967,215 (GRCm39) T114A probably benign Het
Slc6a19 A T 13: 73,832,487 (GRCm39) V402D probably damaging Het
Slco1a8 A T 6: 141,917,961 (GRCm39) H638Q probably benign Het
Slco2b1 T A 7: 99,316,301 (GRCm39) M410L probably benign Het
Smarca2 T C 19: 26,753,469 (GRCm39) probably benign Het
Sned1 A G 1: 93,193,067 (GRCm39) Y409C probably damaging Het
Sorcs2 A G 5: 36,386,555 (GRCm39) V161A probably damaging Het
Spring1 T C 5: 118,397,504 (GRCm39) V162A probably damaging Het
Sptb T C 12: 76,645,501 (GRCm39) E2029G possibly damaging Het
Stx7 T A 10: 24,058,659 (GRCm39) probably null Het
Taf4b T C 18: 14,937,611 (GRCm39) V228A probably benign Het
Tbc1d1 A G 5: 64,507,273 (GRCm39) *1163W probably null Het
Tor4a G A 2: 25,084,847 (GRCm39) A352V probably damaging Het
Trpm4 A G 7: 44,977,173 (GRCm39) F81S probably damaging Het
Ttn T A 2: 76,780,436 (GRCm39) D1105V probably damaging Het
Vcf1 T A 11: 113,568,220 (GRCm39) R78S probably damaging Het
Yju2b T A 8: 84,985,177 (GRCm39) D364V possibly damaging Het
Zfp551 A G 7: 12,150,101 (GRCm39) L436P probably damaging Het
Zfp975 G T 7: 42,312,312 (GRCm39) D100E probably benign Het
Zwint C T 10: 72,492,294 (GRCm39) probably benign Het
Other mutations in Zswim3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00517:Zswim3 APN 2 164,663,011 (GRCm39) missense probably damaging 1.00
IGL01345:Zswim3 APN 2 164,662,057 (GRCm39) missense probably damaging 1.00
IGL01608:Zswim3 APN 2 164,663,440 (GRCm39) missense probably damaging 1.00
IGL01621:Zswim3 APN 2 164,663,440 (GRCm39) missense probably damaging 1.00
IGL01634:Zswim3 APN 2 164,661,922 (GRCm39) missense probably damaging 0.99
IGL02165:Zswim3 APN 2 164,663,035 (GRCm39) missense possibly damaging 0.94
IGL02173:Zswim3 APN 2 164,662,759 (GRCm39) missense probably damaging 1.00
IGL02336:Zswim3 APN 2 164,662,297 (GRCm39) missense probably damaging 0.98
IGL02379:Zswim3 APN 2 164,662,602 (GRCm39) splice site probably null
R0321:Zswim3 UTSW 2 164,662,279 (GRCm39) missense possibly damaging 0.83
R1489:Zswim3 UTSW 2 164,661,901 (GRCm39) missense probably benign 0.00
R2126:Zswim3 UTSW 2 164,661,913 (GRCm39) missense probably benign 0.31
R2176:Zswim3 UTSW 2 164,662,614 (GRCm39) missense probably benign 0.08
R2859:Zswim3 UTSW 2 164,662,309 (GRCm39) missense probably damaging 1.00
R3853:Zswim3 UTSW 2 164,662,777 (GRCm39) missense possibly damaging 0.61
R4434:Zswim3 UTSW 2 164,662,563 (GRCm39) missense probably benign 0.00
R4435:Zswim3 UTSW 2 164,662,563 (GRCm39) missense probably benign 0.00
R4436:Zswim3 UTSW 2 164,662,563 (GRCm39) missense probably benign 0.00
R4438:Zswim3 UTSW 2 164,662,563 (GRCm39) missense probably benign 0.00
R4805:Zswim3 UTSW 2 164,662,099 (GRCm39) missense possibly damaging 0.52
R6417:Zswim3 UTSW 2 164,662,653 (GRCm39) missense probably damaging 0.97
R6420:Zswim3 UTSW 2 164,662,653 (GRCm39) missense probably damaging 0.97
R6722:Zswim3 UTSW 2 164,662,544 (GRCm39) splice site probably null
R6786:Zswim3 UTSW 2 164,662,771 (GRCm39) missense probably damaging 1.00
R7266:Zswim3 UTSW 2 164,662,402 (GRCm39) missense probably benign 0.41
R7467:Zswim3 UTSW 2 164,661,795 (GRCm39) missense possibly damaging 0.59
R7487:Zswim3 UTSW 2 164,662,135 (GRCm39) missense probably damaging 0.99
R7788:Zswim3 UTSW 2 164,661,699 (GRCm39) missense probably damaging 1.00
R8191:Zswim3 UTSW 2 164,662,128 (GRCm39) missense probably damaging 1.00
R8308:Zswim3 UTSW 2 164,663,566 (GRCm39) missense probably damaging 1.00
R8794:Zswim3 UTSW 2 164,662,687 (GRCm39) missense probably damaging 0.98
R9353:Zswim3 UTSW 2 164,662,261 (GRCm39) missense probably damaging 1.00
R9527:Zswim3 UTSW 2 164,662,285 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCTTCTGGAGGAATCCCTG -3'
(R):5'- TCCTTGTTCTCCACCAAGAAAG -3'

Sequencing Primer
(F):5'- GAGGAATCCCTGCTAGCAAG -3'
(R):5'- CATACAGAATATGGCCCTGGCTG -3'
Posted On 2017-02-10