Incidental Mutation 'R5874:Nin'
| ID |
455404 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nin
|
| Ensembl Gene |
ENSMUSG00000021068 |
| Gene Name |
ninein |
| Synonyms |
3110068G20Rik |
| MMRRC Submission |
044081-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5874 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
70058209-70160491 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 70077692 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 1038
(S1038G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000152530
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021468]
[ENSMUST00000085314]
[ENSMUST00000095666]
[ENSMUST00000169074]
[ENSMUST00000220689]
[ENSMUST00000222237]
[ENSMUST00000223257]
[ENSMUST00000222835]
|
| AlphaFold |
Q61043 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000021468
AA Change: S1745G
PolyPhen 2
Score 0.276 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000021468
Gene: ENSMUSG00000021068
AA Change: S1745G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000085314
AA Change: S1745G
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000082422
Gene: ENSMUSG00000021068
AA Change: S1745G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
4.15e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
4.15e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1971 |
2045 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000095666
AA Change: S1745G
PolyPhen 2
Score 0.276 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000093327
Gene: ENSMUSG00000021068
AA Change: S1745G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169074
AA Change: S1745G
PolyPhen 2
Score 0.276 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000129648
Gene: ENSMUSG00000021068
AA Change: S1745G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000220689
AA Change: S1038G
PolyPhen 2
Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221486
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000221579
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000222237
AA Change: S1745G
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000223257
AA Change: S1745G
PolyPhen 2
Score 0.210 (Sensitivity: 0.92; Specificity: 0.88)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000222835
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000222137
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000223048
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000223469
|
| Meta Mutation Damage Score |
0.0599 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.8%
- 20x: 93.6%
|
| Validation Efficiency |
98% (86/88) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 73 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930432E11Rik |
G |
A |
7: 29,280,610 (GRCm39) |
|
noncoding transcript |
Het |
| Adam17 |
T |
C |
12: 21,379,087 (GRCm39) |
D654G |
possibly damaging |
Het |
| Ankhd1 |
A |
T |
18: 36,773,322 (GRCm39) |
H1373L |
possibly damaging |
Het |
| Ankrd17 |
T |
C |
5: 90,416,656 (GRCm39) |
|
probably benign |
Het |
| Calu |
A |
G |
6: 29,372,617 (GRCm39) |
D112G |
probably damaging |
Het |
| Camk2a |
G |
C |
18: 61,076,272 (GRCm39) |
|
probably benign |
Het |
| Cpn1 |
C |
A |
19: 43,944,951 (GRCm39) |
R452L |
probably benign |
Het |
| Csmd3 |
T |
A |
15: 47,507,666 (GRCm39) |
E2780V |
probably damaging |
Het |
| Ctnna2 |
T |
C |
6: 76,879,413 (GRCm39) |
T824A |
probably benign |
Het |
| Cuedc2 |
C |
T |
19: 46,319,824 (GRCm39) |
V164M |
possibly damaging |
Het |
| Cyp2d34 |
T |
A |
15: 82,503,243 (GRCm39) |
D74V |
probably benign |
Het |
| Ddi2 |
A |
G |
4: 141,422,780 (GRCm39) |
S311P |
probably damaging |
Het |
| Ddx10 |
A |
C |
9: 53,140,498 (GRCm39) |
I301R |
possibly damaging |
Het |
| Dmpk |
T |
C |
7: 18,826,007 (GRCm39) |
|
probably benign |
Het |
| Dnah7b |
C |
T |
1: 46,230,885 (GRCm39) |
T1381I |
probably damaging |
Het |
| Dst |
T |
A |
1: 34,218,670 (GRCm39) |
N1703K |
probably damaging |
Het |
| Dtwd1 |
T |
A |
2: 126,000,359 (GRCm39) |
H98Q |
probably damaging |
Het |
| Ecel1 |
A |
C |
1: 87,075,731 (GRCm39) |
V769G |
probably benign |
Het |
| Eno4 |
T |
C |
19: 58,935,238 (GRCm39) |
V150A |
probably benign |
Het |
| Evc2 |
C |
T |
5: 37,574,883 (GRCm39) |
|
probably benign |
Het |
| Ext1 |
T |
A |
15: 52,965,148 (GRCm39) |
Q406L |
possibly damaging |
Het |
| Foxf2 |
A |
G |
13: 31,810,775 (GRCm39) |
H238R |
probably benign |
Het |
| Frem2 |
C |
G |
3: 53,444,910 (GRCm39) |
G2407A |
probably benign |
Het |
| Fzd10 |
A |
G |
5: 128,678,364 (GRCm39) |
E28G |
probably benign |
Het |
| Galnt15 |
T |
C |
14: 31,774,324 (GRCm39) |
F363L |
probably damaging |
Het |
| Gm1758 |
C |
T |
16: 14,325,037 (GRCm39) |
|
noncoding transcript |
Het |
| Gm5866 |
C |
T |
5: 52,739,956 (GRCm39) |
|
noncoding transcript |
Het |
| Heatr9 |
T |
A |
11: 83,405,426 (GRCm39) |
M345L |
probably benign |
Het |
| Il23r |
A |
T |
6: 67,408,629 (GRCm39) |
F404Y |
possibly damaging |
Het |
| Lrrc8a |
T |
C |
2: 30,147,148 (GRCm39) |
I654T |
probably damaging |
Het |
| Napg |
A |
T |
18: 63,111,091 (GRCm39) |
K18* |
probably null |
Het |
| Ndst3 |
A |
T |
3: 123,355,556 (GRCm39) |
W573R |
probably damaging |
Het |
| Nudt12 |
T |
A |
17: 59,317,279 (GRCm39) |
R123* |
probably null |
Het |
| Oas1g |
T |
A |
5: 121,015,081 (GRCm39) |
N361Y |
probably benign |
Het |
| Or5p51 |
T |
A |
7: 107,444,377 (GRCm39) |
I188L |
probably benign |
Het |
| Or7a35 |
T |
A |
10: 78,853,191 (GRCm39) |
F12I |
possibly damaging |
Het |
| Or8h10 |
A |
T |
2: 86,808,786 (GRCm39) |
M118K |
probably damaging |
Het |
| Osbpl10 |
T |
C |
9: 115,055,828 (GRCm39) |
F667L |
probably damaging |
Het |
| Phldb2 |
T |
C |
16: 45,621,988 (GRCm39) |
D664G |
probably damaging |
Het |
| Piezo2 |
C |
T |
18: 63,160,972 (GRCm39) |
V2263M |
probably damaging |
Het |
| Pkd1l1 |
A |
G |
11: 8,858,688 (GRCm39) |
L615P |
probably damaging |
Het |
| Pnpla7 |
G |
A |
2: 24,901,661 (GRCm39) |
M562I |
probably benign |
Het |
| Pou2af2 |
A |
T |
9: 51,201,672 (GRCm39) |
L128* |
probably null |
Het |
| Ppp1r13b |
C |
A |
12: 111,811,423 (GRCm39) |
R155L |
probably damaging |
Het |
| Pygb |
C |
T |
2: 150,628,798 (GRCm39) |
P4L |
probably benign |
Het |
| Rbm44 |
T |
C |
1: 91,084,562 (GRCm39) |
|
probably null |
Het |
| Rilpl2 |
T |
C |
5: 124,607,876 (GRCm39) |
T115A |
probably benign |
Het |
| Rin3 |
A |
G |
12: 102,356,102 (GRCm39) |
Y801C |
probably damaging |
Het |
| Rnf112 |
A |
G |
11: 61,340,273 (GRCm39) |
V619A |
probably damaging |
Het |
| Rnf182 |
A |
G |
13: 43,821,563 (GRCm39) |
E38G |
probably benign |
Het |
| Scgb2b24 |
T |
A |
7: 33,436,830 (GRCm39) |
Y94F |
probably damaging |
Het |
| Serac1 |
C |
A |
17: 6,094,188 (GRCm39) |
|
probably benign |
Het |
| Shld2 |
T |
C |
14: 33,967,215 (GRCm39) |
T114A |
probably benign |
Het |
| Slc6a19 |
A |
T |
13: 73,832,487 (GRCm39) |
V402D |
probably damaging |
Het |
| Slco1a8 |
A |
T |
6: 141,917,961 (GRCm39) |
H638Q |
probably benign |
Het |
| Slco2b1 |
T |
A |
7: 99,316,301 (GRCm39) |
M410L |
probably benign |
Het |
| Smarca2 |
T |
C |
19: 26,753,469 (GRCm39) |
|
probably benign |
Het |
| Sned1 |
A |
G |
1: 93,193,067 (GRCm39) |
Y409C |
probably damaging |
Het |
| Sorcs2 |
A |
G |
5: 36,386,555 (GRCm39) |
V161A |
probably damaging |
Het |
| Spring1 |
T |
C |
5: 118,397,504 (GRCm39) |
V162A |
probably damaging |
Het |
| Sptb |
T |
C |
12: 76,645,501 (GRCm39) |
E2029G |
possibly damaging |
Het |
| Stx7 |
T |
A |
10: 24,058,659 (GRCm39) |
|
probably null |
Het |
| Taf4b |
T |
C |
18: 14,937,611 (GRCm39) |
V228A |
probably benign |
Het |
| Tbc1d1 |
A |
G |
5: 64,507,273 (GRCm39) |
*1163W |
probably null |
Het |
| Tor4a |
G |
A |
2: 25,084,847 (GRCm39) |
A352V |
probably damaging |
Het |
| Trpm4 |
A |
G |
7: 44,977,173 (GRCm39) |
F81S |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,780,436 (GRCm39) |
D1105V |
probably damaging |
Het |
| Vcf1 |
T |
A |
11: 113,568,220 (GRCm39) |
R78S |
probably damaging |
Het |
| Yju2b |
T |
A |
8: 84,985,177 (GRCm39) |
D364V |
possibly damaging |
Het |
| Zfp551 |
A |
G |
7: 12,150,101 (GRCm39) |
L436P |
probably damaging |
Het |
| Zfp975 |
G |
T |
7: 42,312,312 (GRCm39) |
D100E |
probably benign |
Het |
| Zswim3 |
A |
G |
2: 164,662,032 (GRCm39) |
I171V |
probably benign |
Het |
| Zwint |
C |
T |
10: 72,492,294 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Nin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00472:Nin
|
APN |
12 |
70,076,862 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL00677:Nin
|
APN |
12 |
70,073,634 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00823:Nin
|
APN |
12 |
70,061,567 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01103:Nin
|
APN |
12 |
70,103,532 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01113:Nin
|
APN |
12 |
70,078,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01420:Nin
|
APN |
12 |
70,092,188 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01556:Nin
|
APN |
12 |
70,089,962 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01663:Nin
|
APN |
12 |
70,090,439 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL02002:Nin
|
APN |
12 |
70,109,473 (GRCm39) |
nonsense |
probably null |
|
|
IGL02030:Nin
|
APN |
12 |
70,092,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02202:Nin
|
APN |
12 |
70,102,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02207:Nin
|
APN |
12 |
70,103,431 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02257:Nin
|
APN |
12 |
70,149,465 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02394:Nin
|
APN |
12 |
70,090,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02531:Nin
|
APN |
12 |
70,067,706 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL03028:Nin
|
APN |
12 |
70,082,044 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL03155:Nin
|
APN |
12 |
70,078,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03197:Nin
|
APN |
12 |
70,073,584 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02835:Nin
|
UTSW |
12 |
70,103,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0131:Nin
|
UTSW |
12 |
70,097,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0131:Nin
|
UTSW |
12 |
70,097,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0132:Nin
|
UTSW |
12 |
70,097,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0211:Nin
|
UTSW |
12 |
70,061,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0211:Nin
|
UTSW |
12 |
70,061,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0734:Nin
|
UTSW |
12 |
70,076,887 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0947:Nin
|
UTSW |
12 |
70,107,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1085:Nin
|
UTSW |
12 |
70,067,736 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1367:Nin
|
UTSW |
12 |
70,090,703 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1452:Nin
|
UTSW |
12 |
70,064,424 (GRCm39) |
nonsense |
probably null |
|
|
R1477:Nin
|
UTSW |
12 |
70,090,958 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1518:Nin
|
UTSW |
12 |
70,061,547 (GRCm39) |
missense |
probably benign |
0.27 |
|
R1566:Nin
|
UTSW |
12 |
70,101,253 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1572:Nin
|
UTSW |
12 |
70,085,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1583:Nin
|
UTSW |
12 |
70,078,512 (GRCm39) |
missense |
probably benign |
|
|
R1584:Nin
|
UTSW |
12 |
70,089,443 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1699:Nin
|
UTSW |
12 |
70,092,337 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1699:Nin
|
UTSW |
12 |
70,077,712 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1765:Nin
|
UTSW |
12 |
70,089,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1794:Nin
|
UTSW |
12 |
70,090,569 (GRCm39) |
nonsense |
probably null |
|
|
R1952:Nin
|
UTSW |
12 |
70,077,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2004:Nin
|
UTSW |
12 |
70,072,251 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2025:Nin
|
UTSW |
12 |
70,076,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2060:Nin
|
UTSW |
12 |
70,089,192 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R2213:Nin
|
UTSW |
12 |
70,092,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2224:Nin
|
UTSW |
12 |
70,108,004 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2247:Nin
|
UTSW |
12 |
70,101,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2972:Nin
|
UTSW |
12 |
70,109,487 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3776:Nin
|
UTSW |
12 |
70,085,456 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R3881:Nin
|
UTSW |
12 |
70,089,315 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3930:Nin
|
UTSW |
12 |
70,125,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3959:Nin
|
UTSW |
12 |
70,097,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4229:Nin
|
UTSW |
12 |
70,097,984 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4359:Nin
|
UTSW |
12 |
70,061,712 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4423:Nin
|
UTSW |
12 |
70,089,752 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4461:Nin
|
UTSW |
12 |
70,089,359 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4639:Nin
|
UTSW |
12 |
70,085,375 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4791:Nin
|
UTSW |
12 |
70,090,581 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4839:Nin
|
UTSW |
12 |
70,137,325 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4912:Nin
|
UTSW |
12 |
70,090,837 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5712:Nin
|
UTSW |
12 |
70,089,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5726:Nin
|
UTSW |
12 |
70,124,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5804:Nin
|
UTSW |
12 |
70,092,375 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5992:Nin
|
UTSW |
12 |
70,092,298 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6077:Nin
|
UTSW |
12 |
70,066,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6184:Nin
|
UTSW |
12 |
70,090,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6307:Nin
|
UTSW |
12 |
70,061,631 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6315:Nin
|
UTSW |
12 |
70,092,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6326:Nin
|
UTSW |
12 |
70,091,955 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6492:Nin
|
UTSW |
12 |
70,101,308 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6562:Nin
|
UTSW |
12 |
70,102,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6578:Nin
|
UTSW |
12 |
70,107,968 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6613:Nin
|
UTSW |
12 |
70,077,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7112:Nin
|
UTSW |
12 |
70,149,573 (GRCm39) |
missense |
|
|
|
R7170:Nin
|
UTSW |
12 |
70,091,013 (GRCm39) |
missense |
|
|
|
R7324:Nin
|
UTSW |
12 |
70,090,508 (GRCm39) |
missense |
|
|
|
R7338:Nin
|
UTSW |
12 |
70,090,838 (GRCm39) |
missense |
|
|
|
R7372:Nin
|
UTSW |
12 |
70,102,803 (GRCm39) |
missense |
|
|
|
R7431:Nin
|
UTSW |
12 |
70,124,997 (GRCm39) |
missense |
|
|
|
R7577:Nin
|
UTSW |
12 |
70,109,480 (GRCm39) |
missense |
|
|
|
R7655:Nin
|
UTSW |
12 |
70,089,542 (GRCm39) |
missense |
|
|
|
R7656:Nin
|
UTSW |
12 |
70,089,542 (GRCm39) |
missense |
|
|
|
R7683:Nin
|
UTSW |
12 |
70,124,956 (GRCm39) |
missense |
|
|
|
R7769:Nin
|
UTSW |
12 |
70,090,004 (GRCm39) |
missense |
|
|
|
R7981:Nin
|
UTSW |
12 |
70,089,591 (GRCm39) |
missense |
|
|
|
R8138:Nin
|
UTSW |
12 |
70,089,672 (GRCm39) |
missense |
|
|
|
R8141:Nin
|
UTSW |
12 |
70,076,795 (GRCm39) |
missense |
|
|
|
R8754:Nin
|
UTSW |
12 |
70,077,787 (GRCm39) |
intron |
probably benign |
|
|
R8790:Nin
|
UTSW |
12 |
70,067,793 (GRCm39) |
missense |
|
|
|
R8899:Nin
|
UTSW |
12 |
70,077,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8974:Nin
|
UTSW |
12 |
70,124,932 (GRCm39) |
missense |
|
|
|
R9085:Nin
|
UTSW |
12 |
70,076,786 (GRCm39) |
nonsense |
probably null |
|
|
R9143:Nin
|
UTSW |
12 |
70,137,349 (GRCm39) |
missense |
|
|
|
R9380:Nin
|
UTSW |
12 |
70,074,805 (GRCm39) |
missense |
|
|
|
R9496:Nin
|
UTSW |
12 |
70,102,762 (GRCm39) |
missense |
|
|
|
R9638:Nin
|
UTSW |
12 |
70,067,618 (GRCm39) |
missense |
|
|
|
R9709:Nin
|
UTSW |
12 |
70,149,468 (GRCm39) |
missense |
|
|
|
R9745:Nin
|
UTSW |
12 |
70,089,899 (GRCm39) |
missense |
|
|
|
R9792:Nin
|
UTSW |
12 |
70,094,009 (GRCm39) |
missense |
|
|
|
Z1176:Nin
|
UTSW |
12 |
70,095,938 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1177:Nin
|
UTSW |
12 |
70,101,200 (GRCm39) |
missense |
|
|
|
Z1177:Nin
|
UTSW |
12 |
70,090,869 (GRCm39) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- GTCTCAAATGATGTCCCATGGG -3'
(R):5'- GTCAGGAAAGCATCACTCCTCC -3'
Sequencing Primer
(F):5'- CATGGGATCATTCTGAGGCTCC -3'
(R):5'- TTCTCCTCAAGGCAGATGGG -3'
|
| Posted On |
2017-02-10 |
Incidental Mutation