Incidental Mutation 'R0556:Or4a66'
ID 45541
Institutional Source Beutler Lab
Gene Symbol Or4a66
Ensembl Gene ENSMUSG00000075120
Gene Name olfactory receptor family 4 subfamily A member 66
Synonyms Olfr1196, GA_x6K02T2Q125-50181139-50180195, MOR225-5
MMRRC Submission 038748-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R0556 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 88530727-88531671 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 88531115 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glycine at position 186 (V186G)
Ref Sequence ENSEMBL: ENSMUSP00000149902 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000104892] [ENSMUST00000216928] [ENSMUST00000216977]
AlphaFold Q7TR14
Predicted Effect possibly damaging
Transcript: ENSMUST00000104892
AA Change: V186G

PolyPhen 2 Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000100488
Gene: ENSMUSG00000075120
AA Change: V186G

DomainStartEndE-ValueType
Pfam:7tm_4 29 302 7.2e-47 PFAM
Pfam:7tm_1 39 285 1.3e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216928
AA Change: V186G

PolyPhen 2 Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216977
AA Change: V186G

PolyPhen 2 Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 96.9%
  • 20x: 94.7%
Validation Efficiency 98% (64/65)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1600012H06Rik T A 17: 15,164,213 (GRCm39) Y113* probably null Het
4930402F06Rik T C 2: 35,280,482 (GRCm39) probably benign Het
Acad11 A G 9: 103,992,501 (GRCm39) E481G probably damaging Het
Aldh1a1 A T 19: 20,611,842 (GRCm39) N389Y probably damaging Het
Bmpr2 C T 1: 59,854,487 (GRCm39) T112M probably damaging Het
Bms1 A G 6: 118,390,140 (GRCm39) Y227H probably damaging Het
Cab39 A G 1: 85,763,212 (GRCm39) probably benign Het
Ccn3 A T 15: 54,612,563 (GRCm39) T191S probably damaging Het
Ccno T C 13: 113,124,820 (GRCm39) probably null Het
Cct6b A G 11: 82,610,270 (GRCm39) probably benign Het
Cd101 A C 3: 100,927,970 (GRCm39) I37S probably damaging Het
Ces1a T C 8: 93,771,740 (GRCm39) H19R probably benign Het
Clec16a A G 16: 10,456,649 (GRCm39) probably null Het
Cntnap1 T C 11: 101,074,822 (GRCm39) F831S probably benign Het
Col24a1 A G 3: 145,020,489 (GRCm39) T287A possibly damaging Het
Colgalt2 C T 1: 152,347,564 (GRCm39) probably benign Het
Cpd A G 11: 76,693,171 (GRCm39) probably benign Het
Cyp3a16 C A 5: 145,392,790 (GRCm39) M145I probably benign Het
Ddx54 T A 5: 120,757,719 (GRCm39) probably benign Het
Dock7 A T 4: 98,833,426 (GRCm39) L1925Q probably damaging Het
Eif4g1 A T 16: 20,494,544 (GRCm39) Y127F probably damaging Het
Erap1 T A 13: 74,808,444 (GRCm39) V52E probably damaging Het
Fbxo6 G T 4: 148,230,632 (GRCm39) T210N probably damaging Het
Fcgbpl1 C T 7: 27,858,803 (GRCm39) H2308Y probably benign Het
Garre1 T C 7: 33,939,222 (GRCm39) T222A probably damaging Het
Gnat3 T G 5: 18,224,596 (GRCm39) V332G probably damaging Het
Ift22 T A 5: 136,940,145 (GRCm39) probably null Het
Igkv4-71 A G 6: 69,220,171 (GRCm39) C109R probably damaging Het
Igsf10 A G 3: 59,236,296 (GRCm39) L1295P probably benign Het
Itga4 T C 2: 79,155,983 (GRCm39) I983T probably benign Het
Lhcgr A T 17: 89,079,491 (GRCm39) V65D probably damaging Het
Mau2 G C 8: 70,495,082 (GRCm39) T85R probably damaging Het
Morc2a T C 11: 3,631,809 (GRCm39) probably null Het
Morc2b A T 17: 33,356,812 (GRCm39) M320K probably benign Het
Ms4a18 C A 19: 10,991,065 (GRCm39) V10F probably damaging Het
Mstn A T 1: 53,103,284 (GRCm39) I207F probably benign Het
Mtor A G 4: 148,553,837 (GRCm39) E812G possibly damaging Het
Myo1h A G 5: 114,457,852 (GRCm39) Y121C probably damaging Het
Or11g27 T C 14: 50,771,381 (GRCm39) S171P probably benign Het
Or8b53 A T 9: 38,667,041 (GRCm39) D19V possibly damaging Het
Plcd3 G A 11: 102,968,632 (GRCm39) T353M probably damaging Het
Pnpla7 T A 2: 24,942,313 (GRCm39) probably null Het
Ppp1r12b T A 1: 134,705,060 (GRCm39) Y876F probably damaging Het
Prelid2 T A 18: 42,084,245 (GRCm39) probably benign Het
Prickle1 A G 15: 93,398,662 (GRCm39) L722P probably benign Het
Prr12 A G 7: 44,680,093 (GRCm39) L1887P unknown Het
Ptk2b A G 14: 66,409,593 (GRCm39) L481P probably damaging Het
Rgl3 T A 9: 21,887,140 (GRCm39) K531* probably null Het
Sacs A G 14: 61,421,407 (GRCm39) I115V probably damaging Het
Septin3 G T 15: 82,167,966 (GRCm39) probably benign Het
Simc1 T C 13: 54,673,160 (GRCm39) S503P probably benign Het
Stard9 T C 2: 120,529,404 (GRCm39) V1887A probably benign Het
Synj2 T A 17: 6,088,230 (GRCm39) L1427* probably null Het
Taar2 A G 10: 23,816,793 (GRCm39) D111G probably damaging Het
Tlr5 A G 1: 182,801,716 (GRCm39) N340S probably damaging Het
Tmco2 A G 4: 120,966,314 (GRCm39) L14P probably damaging Het
Tnik A T 3: 28,679,367 (GRCm39) D746V possibly damaging Het
Trip11 C A 12: 101,850,777 (GRCm39) E811* probably null Het
Ttll9 T C 2: 152,815,526 (GRCm39) probably null Het
Uchl1 A G 5: 66,839,824 (GRCm39) E122G probably benign Het
Vwa3b C A 1: 37,203,566 (GRCm39) probably benign Het
Zan T C 5: 137,452,482 (GRCm39) N1533S unknown Het
Zfp687 G T 3: 94,917,719 (GRCm39) D684E probably damaging Het
Other mutations in Or4a66
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01309:Or4a66 APN 2 88,531,310 (GRCm39) missense probably damaging 1.00
R0269:Or4a66 UTSW 2 88,531,040 (GRCm39) missense probably damaging 0.99
R0561:Or4a66 UTSW 2 88,530,914 (GRCm39) missense possibly damaging 0.91
R0617:Or4a66 UTSW 2 88,531,040 (GRCm39) missense probably damaging 0.99
R1497:Or4a66 UTSW 2 88,531,106 (GRCm39) missense probably damaging 1.00
R1676:Or4a66 UTSW 2 88,531,661 (GRCm39) missense probably benign 0.00
R3979:Or4a66 UTSW 2 88,530,792 (GRCm39) missense probably benign 0.08
R4791:Or4a66 UTSW 2 88,531,242 (GRCm39) missense probably benign 0.00
R4836:Or4a66 UTSW 2 88,531,544 (GRCm39) missense probably damaging 1.00
R5917:Or4a66 UTSW 2 88,531,049 (GRCm39) missense possibly damaging 0.94
R6232:Or4a66 UTSW 2 88,531,161 (GRCm39) missense probably benign 0.21
R6392:Or4a66 UTSW 2 88,531,011 (GRCm39) missense probably damaging 1.00
R7033:Or4a66 UTSW 2 88,531,164 (GRCm39) missense probably damaging 1.00
R7360:Or4a66 UTSW 2 88,531,331 (GRCm39) missense probably damaging 1.00
R7640:Or4a66 UTSW 2 88,531,230 (GRCm39) missense probably benign
R8968:Or4a66 UTSW 2 88,531,137 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GGGGATTCAACATTGGGGCAATCAC -3'
(R):5'- GGACCGCTATGTTGCCATTGTCAAG -3'

Sequencing Primer
(F):5'- TTGGGGCAATCACAGTGTAAAAC -3'
(R):5'- GCCATTGTCAAGCCCCTG -3'
Posted On 2013-06-11