Incidental Mutation 'R5877:Odf2l'
ID 455582
Institutional Source Beutler Lab
Gene Symbol Odf2l
Ensembl Gene ENSMUSG00000028256
Gene Name outer dense fiber of sperm tails 2-like
Synonyms 4733401D09Rik, 9630045K08Rik
MMRRC Submission 044083-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.171) question?
Stock # R5877 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 144824349-144859676 bp(+) (GRCm39)
Type of Mutation splice site (2869 bp from exon)
DNA Base Change (assembly) A to G at 144834771 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000142780 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029920] [ENSMUST00000098538] [ENSMUST00000098539] [ENSMUST00000106192] [ENSMUST00000106192] [ENSMUST00000196552] [ENSMUST00000196857] [ENSMUST00000199124]
AlphaFold Q9D478
Predicted Effect probably null
Transcript: ENSMUST00000029920
SMART Domains Protein: ENSMUSP00000029920
Gene: ENSMUSG00000028256

DomainStartEndE-ValueType
coiled coil region 31 58 N/A INTRINSIC
coiled coil region 85 183 N/A INTRINSIC
coiled coil region 206 367 N/A INTRINSIC
coiled coil region 388 508 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000098538
SMART Domains Protein: ENSMUSP00000096140
Gene: ENSMUSG00000028256

DomainStartEndE-ValueType
coiled coil region 31 58 N/A INTRINSIC
low complexity region 77 88 N/A INTRINSIC
coiled coil region 128 226 N/A INTRINSIC
coiled coil region 249 604 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000098539
SMART Domains Protein: ENSMUSP00000096141
Gene: ENSMUSG00000028256

DomainStartEndE-ValueType
coiled coil region 31 58 N/A INTRINSIC
low complexity region 77 88 N/A INTRINSIC
coiled coil region 128 226 N/A INTRINSIC
coiled coil region 249 410 N/A INTRINSIC
coiled coil region 431 551 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000106192
SMART Domains Protein: ENSMUSP00000101798
Gene: ENSMUSG00000028256

DomainStartEndE-ValueType
coiled coil region 31 58 N/A INTRINSIC
low complexity region 77 88 N/A INTRINSIC
coiled coil region 128 226 N/A INTRINSIC
coiled coil region 249 410 N/A INTRINSIC
coiled coil region 431 551 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000106192
SMART Domains Protein: ENSMUSP00000101798
Gene: ENSMUSG00000028256

DomainStartEndE-ValueType
coiled coil region 31 58 N/A INTRINSIC
low complexity region 77 88 N/A INTRINSIC
coiled coil region 128 226 N/A INTRINSIC
coiled coil region 249 410 N/A INTRINSIC
coiled coil region 431 551 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000196552
Predicted Effect probably null
Transcript: ENSMUST00000196857
SMART Domains Protein: ENSMUSP00000143513
Gene: ENSMUSG00000028256

DomainStartEndE-ValueType
coiled coil region 31 58 N/A INTRINSIC
low complexity region 77 88 N/A INTRINSIC
coiled coil region 128 203 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000198764
Predicted Effect probably null
Transcript: ENSMUST00000198764
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196898
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199307
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199045
Predicted Effect probably null
Transcript: ENSMUST00000199124
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.7%
Validation Efficiency 97% (68/70)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam6b A T 12: 113,453,822 (GRCm39) H213L probably damaging Het
Alk A G 17: 72,274,521 (GRCm39) W597R probably damaging Het
Ark2n G T 18: 77,730,902 (GRCm39) probably null Het
Ash1l G A 3: 88,888,891 (GRCm39) V257I probably benign Het
Atp9b C T 18: 80,796,004 (GRCm39) V957I probably benign Het
Birc2 A C 9: 7,849,347 (GRCm39) C576G probably damaging Het
Brca2 T C 5: 150,466,686 (GRCm39) M2150T possibly damaging Het
C3ar1 T G 6: 122,827,581 (GRCm39) D212A probably benign Het
Cacna1s T C 1: 136,028,405 (GRCm39) F914S probably damaging Het
Camk1d T C 2: 5,570,476 (GRCm39) I62V probably benign Het
Caskin1 T C 17: 24,724,239 (GRCm39) M1009T possibly damaging Het
Casp2 A G 6: 42,253,571 (GRCm39) probably benign Het
Cd2bp2 T A 7: 126,793,971 (GRCm39) Y106F probably damaging Het
Celsr3 G A 9: 108,722,926 (GRCm39) C2763Y probably damaging Het
Cyp2g1 T G 7: 26,516,065 (GRCm39) L310V possibly damaging Het
Dusp22 G A 13: 30,891,944 (GRCm39) V99M probably damaging Het
Elp1 A T 4: 56,787,807 (GRCm39) W375R probably damaging Het
Fam131b G A 6: 42,297,913 (GRCm39) S92L probably benign Het
Fbxw10 A T 11: 62,748,542 (GRCm39) N390Y probably damaging Het
Flg2 A T 3: 93,110,756 (GRCm39) H928L unknown Het
Gapdhs T C 7: 30,431,772 (GRCm39) T280A probably damaging Het
Hdac11 A G 6: 91,134,524 (GRCm39) K50E probably damaging Het
Hif3a G T 7: 16,785,071 (GRCm39) A181E probably damaging Het
Itgb8 A G 12: 119,166,271 (GRCm39) S87P probably benign Het
Klhl12 T A 1: 134,411,558 (GRCm39) Y302* probably null Het
Lhx1 C A 11: 84,413,065 (GRCm39) D30Y probably damaging Het
Mrpl40 A G 16: 18,691,135 (GRCm39) Y148H probably damaging Het
Myh13 A T 11: 67,244,484 (GRCm39) H1007L possibly damaging Het
Nhlrc2 T C 19: 56,559,016 (GRCm39) I167T probably damaging Het
Nxpe3 A T 16: 55,686,564 (GRCm39) I148K probably damaging Het
Otud7b C T 3: 96,059,277 (GRCm39) R347* probably null Het
P3h4 G T 11: 100,304,843 (GRCm39) H181Q probably benign Het
P4htm T A 9: 108,460,932 (GRCm39) Y180F possibly damaging Het
Pcna-ps2 A G 19: 9,261,463 (GRCm39) I241V probably benign Het
Pcnx2 T C 8: 126,480,467 (GRCm39) S1947G probably damaging Het
Piezo2 T C 18: 63,247,005 (GRCm39) I336V probably benign Het
Plcd1 T C 9: 118,905,240 (GRCm39) D157G probably damaging Het
Plekhm2 A C 4: 141,367,004 (GRCm39) I212S probably damaging Het
Pmvk G T 3: 89,371,676 (GRCm39) C57F probably benign Het
Pole T C 5: 110,480,329 (GRCm39) S91P probably benign Het
Ppargc1b C G 18: 61,442,164 (GRCm39) D591H probably damaging Het
Ppp4r3b A T 11: 29,159,356 (GRCm39) D570V probably damaging Het
Pxdn T A 12: 30,053,045 (GRCm39) I1074N probably damaging Het
Ralgapa2 A T 2: 146,230,489 (GRCm39) D1025E probably damaging Het
Ralgps1 A G 2: 33,133,640 (GRCm39) probably benign Het
Rasal1 C T 5: 120,817,135 (GRCm39) probably benign Het
Rps2 A T 17: 24,939,890 (GRCm39) probably benign Het
Scn7a G C 2: 66,530,217 (GRCm39) Y709* probably null Het
Skint1 T A 4: 111,878,720 (GRCm39) C217* probably null Het
Slc50a1 T C 3: 89,176,460 (GRCm39) Y82C probably damaging Het
Slc9a4 T C 1: 40,651,423 (GRCm39) V567A probably benign Het
Snx27 A T 3: 94,410,270 (GRCm39) W469R probably damaging Het
Sos2 A G 12: 69,643,569 (GRCm39) L937P probably damaging Het
Ssh1 T C 5: 114,081,181 (GRCm39) T728A probably benign Het
Tnfrsf8 G A 4: 145,019,257 (GRCm39) R193C probably benign Het
Tut4 T C 4: 108,370,120 (GRCm39) V673A probably damaging Het
Usp33 T A 3: 152,085,113 (GRCm39) M583K possibly damaging Het
Usp33 G A 3: 152,085,233 (GRCm39) C623Y probably damaging Het
Wdfy3 T C 5: 102,017,855 (GRCm39) I2562V probably damaging Het
Wnk2 T C 13: 49,220,782 (GRCm39) D1175G probably damaging Het
Zfp341 G A 2: 154,474,209 (GRCm39) E338K probably damaging Het
Zfp398 A G 6: 47,817,638 (GRCm39) probably benign Het
Zp2 T A 7: 119,732,562 (GRCm39) K661N probably null Het
Other mutations in Odf2l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00685:Odf2l APN 3 144,833,634 (GRCm39) missense possibly damaging 0.93
IGL00821:Odf2l APN 3 144,856,748 (GRCm39) missense probably damaging 1.00
IGL01984:Odf2l APN 3 144,845,590 (GRCm39) nonsense probably null
R0080:Odf2l UTSW 3 144,830,084 (GRCm39) missense possibly damaging 0.63
R0133:Odf2l UTSW 3 144,854,302 (GRCm39) missense probably damaging 0.96
R0436:Odf2l UTSW 3 144,831,877 (GRCm39) missense possibly damaging 0.91
R1218:Odf2l UTSW 3 144,854,693 (GRCm39) missense probably damaging 1.00
R1521:Odf2l UTSW 3 144,854,797 (GRCm39) missense possibly damaging 0.93
R1677:Odf2l UTSW 3 144,845,543 (GRCm39) critical splice acceptor site probably null
R1884:Odf2l UTSW 3 144,856,809 (GRCm39) missense probably damaging 1.00
R2151:Odf2l UTSW 3 144,854,785 (GRCm39) missense possibly damaging 0.86
R2910:Odf2l UTSW 3 144,830,084 (GRCm39) missense probably benign 0.00
R2911:Odf2l UTSW 3 144,830,084 (GRCm39) missense probably benign 0.00
R4552:Odf2l UTSW 3 144,856,844 (GRCm39) missense probably benign 0.02
R4640:Odf2l UTSW 3 144,834,706 (GRCm39) missense probably damaging 1.00
R4667:Odf2l UTSW 3 144,833,801 (GRCm39) missense probably benign 0.04
R5472:Odf2l UTSW 3 144,852,627 (GRCm39) missense probably benign 0.00
R5769:Odf2l UTSW 3 144,841,492 (GRCm39) missense possibly damaging 0.91
R6026:Odf2l UTSW 3 144,854,797 (GRCm39) missense possibly damaging 0.93
R6031:Odf2l UTSW 3 144,845,624 (GRCm39) missense probably damaging 1.00
R6031:Odf2l UTSW 3 144,845,624 (GRCm39) missense probably damaging 1.00
R6351:Odf2l UTSW 3 144,841,479 (GRCm39) missense probably benign 0.11
R6454:Odf2l UTSW 3 144,859,181 (GRCm39) missense possibly damaging 0.93
R6462:Odf2l UTSW 3 144,852,672 (GRCm39) missense probably damaging 1.00
R6888:Odf2l UTSW 3 144,854,379 (GRCm39) critical splice donor site probably null
R7008:Odf2l UTSW 3 144,838,495 (GRCm39) missense probably damaging 1.00
R7121:Odf2l UTSW 3 144,845,581 (GRCm39) missense possibly damaging 0.93
R7151:Odf2l UTSW 3 144,832,827 (GRCm39) missense probably benign 0.26
R7542:Odf2l UTSW 3 144,859,197 (GRCm39) missense probably damaging 0.99
R7664:Odf2l UTSW 3 144,854,345 (GRCm39) missense probably benign 0.41
R7811:Odf2l UTSW 3 144,859,148 (GRCm39) missense probably benign 0.00
R7816:Odf2l UTSW 3 144,856,776 (GRCm39) missense probably damaging 1.00
R7913:Odf2l UTSW 3 144,859,244 (GRCm39) nonsense probably null
R8090:Odf2l UTSW 3 144,832,796 (GRCm39) missense probably damaging 0.96
R8205:Odf2l UTSW 3 144,856,495 (GRCm39) critical splice acceptor site probably benign
R8222:Odf2l UTSW 3 144,833,799 (GRCm39) missense probably damaging 1.00
R8829:Odf2l UTSW 3 144,833,820 (GRCm39) missense probably benign 0.02
R8832:Odf2l UTSW 3 144,833,820 (GRCm39) missense probably benign 0.02
R8862:Odf2l UTSW 3 144,833,758 (GRCm39) unclassified probably benign
R9136:Odf2l UTSW 3 144,851,698 (GRCm39) missense
R9778:Odf2l UTSW 3 144,854,789 (GRCm39) missense possibly damaging 0.60
Predicted Primers PCR Primer
(F):5'- TGAAGTACATCTATGAGGCCACAG -3'
(R):5'- ATGGAGATTTCAGGCGAGAC -3'

Sequencing Primer
(F):5'- CATCTATGAGGCCACAGTATATGG -3'
(R):5'- TTCAGGCGAGACATCTCATG -3'
Posted On 2017-02-10