Incidental Mutation 'R5903:Lrig3'
ID 456454
Institutional Source Beutler Lab
Gene Symbol Lrig3
Ensembl Gene ENSMUSG00000020105
Gene Name leucine-rich repeats and immunoglobulin-like domains 3
Synonyms 9430095K15Rik, 9030421L11Rik, 9130004I02Rik
MMRRC Submission 044101-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.249) question?
Stock # R5903 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 125802088-125851228 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 125844347 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 604 (S604P)
Ref Sequence ENSEMBL: ENSMUSP00000074360 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074807]
AlphaFold Q6P1C6
PDB Structure Crystal structure of an Immunoglobulin I-set domain of Lrig3 protein (Lrig3) from MUS MUSCULUS at 1.70 A resolution [X-RAY DIFFRACTION]
Predicted Effect probably damaging
Transcript: ENSMUST00000074807
AA Change: S604P

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000074360
Gene: ENSMUSG00000020105
AA Change: S604P

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
LRRNT 46 78 6.74e-2 SMART
LRR 72 96 4.45e1 SMART
LRR 97 120 1.06e1 SMART
LRR 144 166 1.14e0 SMART
LRR 168 189 1.62e2 SMART
LRR 190 214 1.09e1 SMART
LRR 215 237 1.71e1 SMART
LRR 238 261 2.29e0 SMART
LRR 262 285 3.07e-1 SMART
LRR 286 309 2.49e-1 SMART
LRR 310 333 1.29e1 SMART
LRR 334 357 6.22e0 SMART
LRR 358 384 6.05e0 SMART
LRR_TYP 385 408 1.56e-2 SMART
LRR_TYP 409 432 1.79e-2 SMART
LRRCT 444 494 2.35e-7 SMART
IGc2 511 588 1.65e-4 SMART
IGc2 615 683 1.33e-8 SMART
IGc2 709 774 2.78e-11 SMART
transmembrane domain 805 827 N/A INTRINSIC
low complexity region 1069 1081 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218580
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219974
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220332
Meta Mutation Damage Score 0.1902 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.8%
Validation Efficiency 98% (58/59)
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele or severely hypomorphic gene trap allele exhibit fusion of the lateral semicircular canal and circling behavior. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130230L23Rik A G 5: 66,145,661 (GRCm39) V150A unknown Het
Abraxas1 T C 5: 100,965,824 (GRCm39) probably null Het
Actl7a G T 4: 56,743,827 (GRCm39) R118L probably damaging Het
Atg2b T C 12: 105,605,618 (GRCm39) D1449G possibly damaging Het
Atg7 G A 6: 114,683,254 (GRCm39) W439* probably null Het
Atp6v0a2 T A 5: 124,789,343 (GRCm39) I370N probably damaging Het
B4galt1 T C 4: 40,807,760 (GRCm39) D347G probably damaging Het
Baz2b C T 2: 59,790,233 (GRCm39) C660Y probably damaging Het
Ccdc88c T C 12: 100,896,801 (GRCm39) Y1390C probably damaging Het
Cdcp1 G A 9: 123,002,837 (GRCm39) Q745* probably null Het
Cep97 G A 16: 55,739,889 (GRCm39) S185L probably damaging Het
Clec4d A G 6: 123,244,020 (GRCm39) H43R probably damaging Het
Cntn3 T A 6: 102,219,094 (GRCm39) M509L probably benign Het
Cntrob A C 11: 69,200,201 (GRCm39) S564R possibly damaging Het
Cyp2j8 T A 4: 96,395,514 (GRCm39) N37I possibly damaging Het
Edc4 A G 8: 106,617,219 (GRCm39) T1029A probably benign Het
Fhip2b A T 14: 70,829,121 (GRCm39) V64E probably damaging Het
Fmnl1 G T 11: 103,062,270 (GRCm39) probably null Het
Fzd6 T A 15: 38,870,783 (GRCm39) M1K probably null Het
Gle1 C A 2: 29,830,293 (GRCm39) T283N probably benign Het
Hsd17b14 T C 7: 45,215,386 (GRCm39) V161A probably damaging Het
Hsf2 T C 10: 57,380,819 (GRCm39) S218P probably benign Het
Ipo7 T A 7: 109,650,020 (GRCm39) C736S probably damaging Het
Itpkb G T 1: 180,241,540 (GRCm39) V737L probably damaging Het
Itpr1 T C 6: 108,466,758 (GRCm39) probably benign Het
Kcnh8 G T 17: 53,110,364 (GRCm39) V192L possibly damaging Het
Kctd10 G A 5: 114,518,523 (GRCm39) probably benign Het
Kdm3a C A 6: 71,609,234 (GRCm39) probably benign Het
Kif5a T A 10: 127,066,447 (GRCm39) M990L probably benign Het
Klf12 A G 14: 100,260,124 (GRCm39) S202P probably damaging Het
Krt81 T G 15: 101,358,083 (GRCm39) Q390P probably damaging Het
Ms4a1 A T 19: 11,235,612 (GRCm39) V48D probably damaging Het
Mta1 C T 12: 113,100,239 (GRCm39) P688L probably damaging Het
Oas1h T C 5: 121,009,040 (GRCm39) V250A probably damaging Het
Or10c1 A T 17: 37,521,912 (GRCm39) Y277* probably null Het
Or52z13 G T 7: 103,247,128 (GRCm39) G202* probably null Het
P2rx3 T C 2: 84,831,071 (GRCm39) E265G possibly damaging Het
Pdzd8 A G 19: 59,333,718 (GRCm39) I101T possibly damaging Het
Psme4 A T 11: 30,791,589 (GRCm39) N1148I probably benign Het
Rnf213 T C 11: 119,312,195 (GRCm39) L874P probably damaging Het
Sart3 T C 5: 113,889,300 (GRCm39) Y508C probably damaging Het
Sez6l2 T C 7: 126,569,305 (GRCm39) probably benign Het
Slc9b1 C T 3: 135,098,655 (GRCm39) probably benign Het
Stmn3 T C 2: 180,950,573 (GRCm39) K78E possibly damaging Het
Thsd4 T A 9: 60,301,389 (GRCm39) N302I possibly damaging Het
Trdv5 A T 14: 54,386,242 (GRCm39) H74Q probably benign Het
Tubb4b C T 2: 25,113,993 (GRCm39) R77H probably benign Het
Ugt1a6a C T 1: 88,142,845 (GRCm39) P113L probably damaging Het
Unc5a T A 13: 55,147,503 (GRCm39) C438S possibly damaging Het
Zan C A 5: 137,440,396 (GRCm39) C1946F unknown Het
Other mutations in Lrig3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00333:Lrig3 APN 10 125,849,017 (GRCm39) missense probably benign 0.00
IGL00426:Lrig3 APN 10 125,808,006 (GRCm39) nonsense probably null
IGL00969:Lrig3 APN 10 125,832,984 (GRCm39) missense probably damaging 1.00
IGL01376:Lrig3 APN 10 125,830,335 (GRCm39) missense probably benign 0.01
IGL01510:Lrig3 APN 10 125,844,567 (GRCm39) missense probably damaging 1.00
IGL01825:Lrig3 APN 10 125,845,886 (GRCm39) missense probably damaging 0.98
IGL02231:Lrig3 APN 10 125,833,041 (GRCm39) missense probably damaging 1.00
IGL02377:Lrig3 APN 10 125,850,743 (GRCm39) missense probably benign 0.00
IGL02648:Lrig3 APN 10 125,802,463 (GRCm39) missense probably benign
IGL02832:Lrig3 APN 10 125,842,871 (GRCm39) missense probably benign 0.37
IGL03266:Lrig3 APN 10 125,849,151 (GRCm39) missense probably benign 0.28
R0023:Lrig3 UTSW 10 125,846,088 (GRCm39) missense probably damaging 1.00
R0129:Lrig3 UTSW 10 125,842,812 (GRCm39) missense probably damaging 1.00
R0183:Lrig3 UTSW 10 125,846,061 (GRCm39) missense probably damaging 1.00
R0226:Lrig3 UTSW 10 125,807,986 (GRCm39) splice site probably benign
R0233:Lrig3 UTSW 10 125,849,395 (GRCm39) splice site probably null
R0233:Lrig3 UTSW 10 125,849,395 (GRCm39) splice site probably null
R0336:Lrig3 UTSW 10 125,802,574 (GRCm39) missense probably benign 0.04
R0348:Lrig3 UTSW 10 125,849,317 (GRCm39) nonsense probably null
R0502:Lrig3 UTSW 10 125,844,605 (GRCm39) missense probably damaging 1.00
R0639:Lrig3 UTSW 10 125,846,090 (GRCm39) missense probably damaging 1.00
R1099:Lrig3 UTSW 10 125,842,883 (GRCm39) splice site probably null
R1220:Lrig3 UTSW 10 125,832,945 (GRCm39) missense probably damaging 1.00
R1230:Lrig3 UTSW 10 125,838,840 (GRCm39) missense probably damaging 1.00
R1398:Lrig3 UTSW 10 125,838,957 (GRCm39) missense probably benign 0.00
R1451:Lrig3 UTSW 10 125,845,926 (GRCm39) missense possibly damaging 0.92
R1523:Lrig3 UTSW 10 125,844,567 (GRCm39) missense probably damaging 1.00
R1545:Lrig3 UTSW 10 125,844,416 (GRCm39) missense possibly damaging 0.80
R1661:Lrig3 UTSW 10 125,833,570 (GRCm39) missense probably benign 0.12
R1665:Lrig3 UTSW 10 125,833,570 (GRCm39) missense probably benign 0.12
R1673:Lrig3 UTSW 10 125,846,036 (GRCm39) missense probably damaging 1.00
R1778:Lrig3 UTSW 10 125,845,944 (GRCm39) missense probably damaging 1.00
R1800:Lrig3 UTSW 10 125,832,920 (GRCm39) splice site probably null
R1840:Lrig3 UTSW 10 125,849,258 (GRCm39) nonsense probably null
R1882:Lrig3 UTSW 10 125,845,694 (GRCm39) missense possibly damaging 0.89
R1900:Lrig3 UTSW 10 125,838,262 (GRCm39) splice site probably benign
R2160:Lrig3 UTSW 10 125,833,565 (GRCm39) missense possibly damaging 0.95
R2200:Lrig3 UTSW 10 125,832,478 (GRCm39) splice site probably null
R2294:Lrig3 UTSW 10 125,802,363 (GRCm39) nonsense probably null
R2518:Lrig3 UTSW 10 125,830,310 (GRCm39) missense probably benign 0.07
R3037:Lrig3 UTSW 10 125,845,901 (GRCm39) missense probably damaging 1.00
R3236:Lrig3 UTSW 10 125,833,056 (GRCm39) missense probably damaging 1.00
R4073:Lrig3 UTSW 10 125,849,277 (GRCm39) missense probably benign
R4074:Lrig3 UTSW 10 125,849,277 (GRCm39) missense probably benign
R4075:Lrig3 UTSW 10 125,849,277 (GRCm39) missense probably benign
R4077:Lrig3 UTSW 10 125,845,656 (GRCm39) missense probably damaging 1.00
R4079:Lrig3 UTSW 10 125,845,656 (GRCm39) missense probably damaging 1.00
R4405:Lrig3 UTSW 10 125,846,877 (GRCm39) missense probably benign 0.00
R4425:Lrig3 UTSW 10 125,849,273 (GRCm39) missense probably benign 0.00
R4505:Lrig3 UTSW 10 125,849,216 (GRCm39) missense probably benign 0.00
R4860:Lrig3 UTSW 10 125,846,921 (GRCm39) missense probably benign 0.36
R4860:Lrig3 UTSW 10 125,846,921 (GRCm39) missense probably benign 0.36
R4903:Lrig3 UTSW 10 125,832,482 (GRCm39) critical splice acceptor site probably null
R5201:Lrig3 UTSW 10 125,849,020 (GRCm39) missense possibly damaging 0.48
R5307:Lrig3 UTSW 10 125,842,559 (GRCm39) missense probably damaging 1.00
R5402:Lrig3 UTSW 10 125,844,609 (GRCm39) missense probably damaging 1.00
R5557:Lrig3 UTSW 10 125,808,003 (GRCm39) missense probably damaging 1.00
R5792:Lrig3 UTSW 10 125,845,788 (GRCm39) missense probably damaging 1.00
R6280:Lrig3 UTSW 10 125,846,848 (GRCm39) missense probably benign 0.18
R6484:Lrig3 UTSW 10 125,832,478 (GRCm39) splice site probably null
R6985:Lrig3 UTSW 10 125,850,738 (GRCm39) missense possibly damaging 0.64
R7089:Lrig3 UTSW 10 125,832,993 (GRCm39) missense probably damaging 1.00
R7177:Lrig3 UTSW 10 125,842,712 (GRCm39) missense probably benign 0.02
R7347:Lrig3 UTSW 10 125,845,835 (GRCm39) missense probably damaging 1.00
R9093:Lrig3 UTSW 10 125,845,950 (GRCm39) missense possibly damaging 0.51
R9188:Lrig3 UTSW 10 125,838,935 (GRCm39) missense possibly damaging 0.80
R9295:Lrig3 UTSW 10 125,850,722 (GRCm39) missense probably benign 0.00
R9378:Lrig3 UTSW 10 125,832,953 (GRCm39) missense probably damaging 0.98
R9526:Lrig3 UTSW 10 125,850,736 (GRCm39) missense probably benign
R9567:Lrig3 UTSW 10 125,845,964 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGTCAACTTCATATCTACGGCTCTG -3'
(R):5'- AGCTGTAAACCCCGATGTCC -3'

Sequencing Primer
(F):5'- TACGGCTCTGACTCTGAGTTAGAAAG -3'
(R):5'- TCGATCTTCACGTCCACGATGAAG -3'
Posted On 2017-02-15