Mutagenetix > Incidental Mutation

Incidental Mutation 'R5903:Or10c1'

456471

Institutional Source

Beutler Lab

Gene Symbol

Or10c1

Ensembl Gene

ENSMUSG00000049561

Gene Name

olfactory receptor family 10 subfamily C member 1

Synonyms

Olfr95, GA_x6K02T2PSCP-1651760-1650822, MOR263-6

MMRRC Submission

044101-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

R5903 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

37521804-37522742 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 37521912 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 277 (Y277*)

Ref Sequence

ENSEMBL: ENSMUSP00000150480 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060728] [ENSMUST00000216318]

AlphaFold

Q8VFE2

Predicted Effect

probably null
Transcript: ENSMUST00000060728
AA Change: Y277*

SMART Domains

Protein: ENSMUSP00000058929
Gene: ENSMUSG00000049561
AA Change: Y277*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	30	307	1.9e-57	PFAM
Pfam:7TM_GPCR_Srsx	34	259	1.7e-6	PFAM
Pfam:7tm_1	40	289	2.2e-24	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000216318
AA Change: Y277*

Meta Mutation Damage Score

0.9716

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.6%
20x: 92.8%

Validation Efficiency

98% (58/59)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9130230L23Rik	A	G	5: 66,145,661 (GRCm39)	V150A	unknown	Het
Abraxas1	T	C	5: 100,965,824 (GRCm39)		probably null	Het
Actl7a	G	T	4: 56,743,827 (GRCm39)	R118L	probably damaging	Het
Atg2b	T	C	12: 105,605,618 (GRCm39)	D1449G	possibly damaging	Het
Atg7	G	A	6: 114,683,254 (GRCm39)	W439*	probably null	Het
Atp6v0a2	T	A	5: 124,789,343 (GRCm39)	I370N	probably damaging	Het
B4galt1	T	C	4: 40,807,760 (GRCm39)	D347G	probably damaging	Het
Baz2b	C	T	2: 59,790,233 (GRCm39)	C660Y	probably damaging	Het
Ccdc88c	T	C	12: 100,896,801 (GRCm39)	Y1390C	probably damaging	Het
Cdcp1	G	A	9: 123,002,837 (GRCm39)	Q745*	probably null	Het
Cep97	G	A	16: 55,739,889 (GRCm39)	S185L	probably damaging	Het
Clec4d	A	G	6: 123,244,020 (GRCm39)	H43R	probably damaging	Het
Cntn3	T	A	6: 102,219,094 (GRCm39)	M509L	probably benign	Het
Cntrob	A	C	11: 69,200,201 (GRCm39)	S564R	possibly damaging	Het
Cyp2j8	T	A	4: 96,395,514 (GRCm39)	N37I	possibly damaging	Het
Edc4	A	G	8: 106,617,219 (GRCm39)	T1029A	probably benign	Het
Fhip2b	A	T	14: 70,829,121 (GRCm39)	V64E	probably damaging	Het
Fmnl1	G	T	11: 103,062,270 (GRCm39)		probably null	Het
Fzd6	T	A	15: 38,870,783 (GRCm39)	M1K	probably null	Het
Gle1	C	A	2: 29,830,293 (GRCm39)	T283N	probably benign	Het
Hsd17b14	T	C	7: 45,215,386 (GRCm39)	V161A	probably damaging	Het
Hsf2	T	C	10: 57,380,819 (GRCm39)	S218P	probably benign	Het
Ipo7	T	A	7: 109,650,020 (GRCm39)	C736S	probably damaging	Het
Itpkb	G	T	1: 180,241,540 (GRCm39)	V737L	probably damaging	Het
Itpr1	T	C	6: 108,466,758 (GRCm39)		probably benign	Het
Kcnh8	G	T	17: 53,110,364 (GRCm39)	V192L	possibly damaging	Het
Kctd10	G	A	5: 114,518,523 (GRCm39)		probably benign	Het
Kdm3a	C	A	6: 71,609,234 (GRCm39)		probably benign	Het
Kif5a	T	A	10: 127,066,447 (GRCm39)	M990L	probably benign	Het
Klf12	A	G	14: 100,260,124 (GRCm39)	S202P	probably damaging	Het
Krt81	T	G	15: 101,358,083 (GRCm39)	Q390P	probably damaging	Het
Lrig3	T	C	10: 125,844,347 (GRCm39)	S604P	probably damaging	Het
Ms4a1	A	T	19: 11,235,612 (GRCm39)	V48D	probably damaging	Het
Mta1	C	T	12: 113,100,239 (GRCm39)	P688L	probably damaging	Het
Oas1h	T	C	5: 121,009,040 (GRCm39)	V250A	probably damaging	Het
Or52z13	G	T	7: 103,247,128 (GRCm39)	G202*	probably null	Het
P2rx3	T	C	2: 84,831,071 (GRCm39)	E265G	possibly damaging	Het
Pdzd8	A	G	19: 59,333,718 (GRCm39)	I101T	possibly damaging	Het
Psme4	A	T	11: 30,791,589 (GRCm39)	N1148I	probably benign	Het
Rnf213	T	C	11: 119,312,195 (GRCm39)	L874P	probably damaging	Het
Sart3	T	C	5: 113,889,300 (GRCm39)	Y508C	probably damaging	Het
Sez6l2	T	C	7: 126,569,305 (GRCm39)		probably benign	Het
Slc9b1	C	T	3: 135,098,655 (GRCm39)		probably benign	Het
Stmn3	T	C	2: 180,950,573 (GRCm39)	K78E	possibly damaging	Het
Thsd4	T	A	9: 60,301,389 (GRCm39)	N302I	possibly damaging	Het
Trdv5	A	T	14: 54,386,242 (GRCm39)	H74Q	probably benign	Het
Tubb4b	C	T	2: 25,113,993 (GRCm39)	R77H	probably benign	Het
Ugt1a6a	C	T	1: 88,142,845 (GRCm39)	P113L	probably damaging	Het
Unc5a	T	A	13: 55,147,503 (GRCm39)	C438S	possibly damaging	Het
Zan	C	A	5: 137,440,396 (GRCm39)	C1946F	unknown	Het

Other mutations in Or10c1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02147:Or10c1	APN	17	37,521,877 (GRCm39)	missense	probably damaging	1.00
IGL03306:Or10c1	APN	17	37,522,568 (GRCm39)	missense	probably damaging	1.00
PIT4377001:Or10c1	UTSW	17	37,521,980 (GRCm39)	missense	probably benign	0.00
R0668:Or10c1	UTSW	17	37,522,535 (GRCm39)	missense	probably damaging	1.00
R0909:Or10c1	UTSW	17	37,521,809 (GRCm39)	missense	probably benign	0.33
R1442:Or10c1	UTSW	17	37,522,595 (GRCm39)	missense	probably benign	0.00
R1557:Or10c1	UTSW	17	37,522,244 (GRCm39)	missense	probably damaging	1.00
R1758:Or10c1	UTSW	17	37,522,204 (GRCm39)	missense	possibly damaging	0.88
R3195:Or10c1	UTSW	17	37,522,427 (GRCm39)	missense	possibly damaging	0.87
R3749:Or10c1	UTSW	17	37,522,691 (GRCm39)	missense	possibly damaging	0.55
R3778:Or10c1	UTSW	17	37,522,649 (GRCm39)	missense	probably benign
R4458:Or10c1	UTSW	17	37,522,204 (GRCm39)	missense	possibly damaging	0.88
R4591:Or10c1	UTSW	17	37,522,010 (GRCm39)	missense	probably benign
R5058:Or10c1	UTSW	17	37,522,558 (GRCm39)	missense	probably damaging	1.00
R5060:Or10c1	UTSW	17	37,522,307 (GRCm39)	missense	probably benign	0.00
R6294:Or10c1	UTSW	17	37,522,517 (GRCm39)	missense	probably benign	0.19
R6689:Or10c1	UTSW	17	37,522,048 (GRCm39)	missense	probably damaging	1.00
R7196:Or10c1	UTSW	17	37,522,084 (GRCm39)	missense	probably damaging	1.00
R7677:Or10c1	UTSW	17	37,522,386 (GRCm39)	nonsense	probably null
R8132:Or10c1	UTSW	17	37,522,207 (GRCm39)	missense	probably damaging	1.00
R8340:Or10c1	UTSW	17	37,522,075 (GRCm39)	missense	possibly damaging	0.78
R8380:Or10c1	UTSW	17	37,522,232 (GRCm39)	missense	possibly damaging	0.90
R9716:Or10c1	UTSW	17	37,522,355 (GRCm39)	missense	possibly damaging	0.50

Predicted Primers

PCR Primer
(F):5'- ATGTTGAGGGAGTCAATAGCTC -3'
(R):5'- TTCTTAGCTCCTACGGACGG -3'

Sequencing Primer
(F):5'- TGAGGGAGTCAATAGCTCTTTAAG -3'
(R):5'- TAGCTCCTACGGACGGATCCTG -3'

Posted On

2017-02-15