Incidental Mutation 'R0558:Insrr'
| ID |
45701 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Insrr
|
| Ensembl Gene |
ENSMUSG00000005640 |
| Gene Name |
insulin receptor-related receptor |
| Synonyms |
|
| MMRRC Submission |
038750-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.274)
|
| Stock # |
R0558 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
87704258-87723408 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 87718288 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 927
(T927I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000103208
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000029711]
[ENSMUST00000029714]
[ENSMUST00000090981]
[ENSMUST00000107582]
|
| AlphaFold |
Q9WTL4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000029711
AA Change: T927I
PolyPhen 2
Score 0.775 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000029711
Gene: ENSMUSG00000005640
AA Change: T927I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
47 |
159 |
1.8e-25 |
PFAM |
|
FU
|
225 |
268 |
9.54e-11 |
SMART |
|
Pfam:Recep_L_domain
|
346 |
460 |
3.8e-28 |
PFAM |
|
FN3
|
483 |
586 |
9.19e-1 |
SMART |
|
FN3
|
605 |
798 |
6.45e-5 |
SMART |
|
FN3
|
816 |
899 |
6.35e-4 |
SMART |
|
TyrKc
|
979 |
1246 |
4.61e-128 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000029714
|
| SMART Domains |
Protein: ENSMUSP00000029714
Gene: ENSMUSG00000028073
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
78 |
N/A |
INTRINSIC |
|
EGF
|
102 |
130 |
3.82e-2 |
SMART |
|
EGF_like
|
132 |
173 |
2.92e1 |
SMART |
|
EGF_like
|
146 |
185 |
1.92e0 |
SMART |
|
EGF_like
|
189 |
246 |
1.99e0 |
SMART |
|
EGF
|
217 |
258 |
1.04e1 |
SMART |
|
EGF_Lam
|
274 |
313 |
1.21e-4 |
SMART |
|
EGF
|
312 |
344 |
4.03e-1 |
SMART |
|
EGF_Lam
|
361 |
402 |
1.33e-1 |
SMART |
|
EGF
|
401 |
433 |
1.18e-2 |
SMART |
|
EGF_like
|
449 |
488 |
1.72e0 |
SMART |
|
EGF
|
487 |
519 |
6.92e0 |
SMART |
|
EGF_Lam
|
535 |
574 |
2.08e-3 |
SMART |
|
EGF
|
573 |
605 |
5.49e-3 |
SMART |
|
EGF_Lam
|
620 |
660 |
1.58e-3 |
SMART |
|
EGF
|
659 |
691 |
3.1e-2 |
SMART |
|
EGF
|
702 |
734 |
2.53e1 |
SMART |
|
transmembrane domain
|
754 |
776 |
N/A |
INTRINSIC |
|
low complexity region
|
809 |
822 |
N/A |
INTRINSIC |
|
low complexity region
|
829 |
835 |
N/A |
INTRINSIC |
|
low complexity region
|
954 |
971 |
N/A |
INTRINSIC |
|
low complexity region
|
993 |
1002 |
N/A |
INTRINSIC |
|
low complexity region
|
1019 |
1031 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000090981
|
| SMART Domains |
Protein: ENSMUSP00000088503
Gene: ENSMUSG00000028073
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
78 |
N/A |
INTRINSIC |
|
EGF
|
102 |
130 |
3.82e-2 |
SMART |
|
EGF_like
|
132 |
173 |
2.92e1 |
SMART |
|
EGF_like
|
146 |
185 |
1.92e0 |
SMART |
|
EGF_like
|
189 |
246 |
1.99e0 |
SMART |
|
EGF
|
217 |
258 |
1.04e1 |
SMART |
|
EGF_Lam
|
274 |
313 |
1.21e-4 |
SMART |
|
EGF
|
312 |
344 |
4.03e-1 |
SMART |
|
EGF_Lam
|
361 |
402 |
1.33e-1 |
SMART |
|
EGF
|
401 |
433 |
1.18e-2 |
SMART |
|
EGF_like
|
449 |
488 |
1.72e0 |
SMART |
|
EGF
|
487 |
519 |
6.92e0 |
SMART |
|
EGF_Lam
|
535 |
574 |
2.08e-3 |
SMART |
|
EGF
|
573 |
605 |
5.49e-3 |
SMART |
|
EGF_Lam
|
620 |
660 |
1.58e-3 |
SMART |
|
EGF
|
659 |
691 |
3.1e-2 |
SMART |
|
EGF
|
702 |
734 |
2.53e1 |
SMART |
|
transmembrane domain
|
754 |
776 |
N/A |
INTRINSIC |
|
low complexity region
|
809 |
822 |
N/A |
INTRINSIC |
|
low complexity region
|
829 |
835 |
N/A |
INTRINSIC |
|
low complexity region
|
954 |
971 |
N/A |
INTRINSIC |
|
low complexity region
|
993 |
1002 |
N/A |
INTRINSIC |
|
low complexity region
|
1019 |
1031 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000107582
AA Change: T927I
PolyPhen 2
Score 0.775 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000103208
Gene: ENSMUSG00000005640
AA Change: T927I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
47 |
159 |
7.7e-25 |
PFAM |
|
FU
|
225 |
268 |
9.54e-11 |
SMART |
|
Pfam:Recep_L_domain
|
346 |
460 |
1.6e-28 |
PFAM |
|
FN3
|
483 |
586 |
9.19e-1 |
SMART |
|
FN3
|
605 |
798 |
6.45e-5 |
SMART |
|
FN3
|
816 |
899 |
6.35e-4 |
SMART |
|
TyrKc
|
979 |
1246 |
4.61e-128 |
SMART |
|
| Meta Mutation Damage Score |
0.1102 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.8%
|
| Validation Efficiency |
100% (80/80) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a targeted null mutation exhibit no anomalies in pancreatic islet morphology, beta-cell mass or pancreatic secretory function. This mutation in combination with Insr mutant mice does not affect the diabetes predisposition of Insr mutant mice. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc2 |
G |
A |
19: 43,789,163 (GRCm39) |
G273R |
probably benign |
Het |
| Adamts10 |
T |
C |
17: 33,769,583 (GRCm39) |
V935A |
probably benign |
Het |
| Anapc15-ps |
T |
C |
10: 95,508,983 (GRCm39) |
D90G |
probably damaging |
Het |
| Atic |
T |
A |
1: 71,602,947 (GRCm39) |
V107E |
probably benign |
Het |
| Atp4b |
T |
C |
8: 13,443,523 (GRCm39) |
T52A |
possibly damaging |
Het |
| Cacna1h |
C |
T |
17: 25,600,524 (GRCm39) |
A1606T |
probably damaging |
Het |
| Cacng6 |
T |
A |
7: 3,483,324 (GRCm39) |
Y217* |
probably null |
Het |
| Cc2d2a |
T |
G |
5: 43,881,729 (GRCm39) |
|
probably benign |
Het |
| Cd226 |
T |
A |
18: 89,225,338 (GRCm39) |
H78Q |
probably benign |
Het |
| Cers3 |
A |
G |
7: 66,433,166 (GRCm39) |
D161G |
probably damaging |
Het |
| Ces1f |
T |
C |
8: 94,002,017 (GRCm39) |
H37R |
probably benign |
Het |
| Cfhr4 |
A |
G |
1: 139,667,230 (GRCm39) |
V376A |
probably damaging |
Het |
| Chek1 |
T |
A |
9: 36,623,411 (GRCm39) |
N421I |
possibly damaging |
Het |
| Cibar1 |
T |
C |
4: 12,164,095 (GRCm39) |
D248G |
probably damaging |
Het |
| Cma2 |
T |
C |
14: 56,210,249 (GRCm39) |
Y45H |
probably damaging |
Het |
| Cmas |
C |
A |
6: 142,720,970 (GRCm39) |
Y401* |
probably null |
Het |
| Cyp2j8 |
A |
T |
4: 96,332,871 (GRCm39) |
S492T |
probably benign |
Het |
| Dnah12 |
T |
C |
14: 26,430,465 (GRCm39) |
S358P |
probably benign |
Het |
| Dnajc13 |
T |
C |
9: 104,079,151 (GRCm39) |
|
probably null |
Het |
| Ep400 |
A |
C |
5: 110,832,933 (GRCm39) |
|
probably benign |
Het |
| Fam209 |
T |
A |
2: 172,314,758 (GRCm39) |
N82K |
probably benign |
Het |
| G3bp2 |
A |
T |
5: 92,221,056 (GRCm39) |
Y20N |
probably damaging |
Het |
| Gli2 |
T |
C |
1: 118,765,379 (GRCm39) |
D924G |
probably benign |
Het |
| Gm10787 |
T |
C |
10: 76,857,850 (GRCm39) |
|
noncoding transcript |
Het |
| Gm11568 |
A |
G |
11: 99,748,872 (GRCm39) |
R26G |
unknown |
Het |
| Hivep3 |
T |
G |
4: 119,953,763 (GRCm39) |
L693R |
probably damaging |
Het |
| Hook1 |
A |
G |
4: 95,881,449 (GRCm39) |
|
probably benign |
Het |
| Ibtk |
A |
C |
9: 85,619,591 (GRCm39) |
D116E |
probably damaging |
Het |
| Irx1 |
T |
G |
13: 72,107,747 (GRCm39) |
S312R |
probably benign |
Het |
| Itga11 |
T |
C |
9: 62,659,570 (GRCm39) |
Y441H |
probably benign |
Het |
| Itsn1 |
A |
G |
16: 91,696,511 (GRCm39) |
D38G |
possibly damaging |
Het |
| Kat6b |
G |
T |
14: 21,719,489 (GRCm39) |
E1280D |
probably benign |
Het |
| Kcnk10 |
T |
A |
12: 98,402,560 (GRCm39) |
Y293F |
possibly damaging |
Het |
| Krt74 |
T |
A |
15: 101,669,398 (GRCm39) |
|
noncoding transcript |
Het |
| Lars1 |
T |
G |
18: 42,347,902 (GRCm39) |
I974L |
probably benign |
Het |
| Limch1 |
A |
G |
5: 67,126,498 (GRCm39) |
D42G |
probably damaging |
Het |
| Mau2 |
G |
C |
8: 70,495,082 (GRCm39) |
T85R |
probably damaging |
Het |
| Mkrn3 |
A |
G |
7: 62,068,612 (GRCm39) |
I393T |
probably benign |
Het |
| Mpl |
A |
C |
4: 118,301,217 (GRCm39) |
S541R |
probably damaging |
Het |
| Nfrkb |
T |
C |
9: 31,321,564 (GRCm39) |
S754P |
possibly damaging |
Het |
| Or4c125 |
A |
G |
2: 89,170,580 (GRCm39) |
L22P |
probably benign |
Het |
| Or5bw2 |
T |
C |
7: 6,573,652 (GRCm39) |
Y221H |
possibly damaging |
Het |
| Or5d41 |
A |
G |
2: 88,054,818 (GRCm39) |
V186A |
possibly damaging |
Het |
| Or8g18 |
T |
A |
9: 39,149,496 (GRCm39) |
T75S |
probably damaging |
Het |
| P2rx7 |
A |
T |
5: 122,811,861 (GRCm39) |
I391F |
possibly damaging |
Het |
| Pbrm1 |
T |
A |
14: 30,807,016 (GRCm39) |
|
probably null |
Het |
| Pcdh8 |
T |
C |
14: 80,007,516 (GRCm39) |
D349G |
probably damaging |
Het |
| Pias1 |
A |
G |
9: 62,789,291 (GRCm39) |
S639P |
possibly damaging |
Het |
| Pkhd1l1 |
A |
T |
15: 44,347,820 (GRCm39) |
I232F |
probably damaging |
Het |
| Plxnc1 |
C |
T |
10: 94,673,797 (GRCm39) |
R995Q |
probably damaging |
Het |
| Pnliprp2 |
T |
A |
19: 58,762,519 (GRCm39) |
S375T |
probably benign |
Het |
| Prkar1b |
C |
T |
5: 139,005,847 (GRCm39) |
V313M |
probably benign |
Het |
| Prr35 |
T |
C |
17: 26,166,523 (GRCm39) |
N338S |
probably benign |
Het |
| Ptpn13 |
T |
C |
5: 103,677,583 (GRCm39) |
S734P |
probably damaging |
Het |
| Rdh1 |
T |
C |
10: 127,595,810 (GRCm39) |
W2R |
possibly damaging |
Het |
| Rsph10b |
A |
T |
5: 143,886,156 (GRCm39) |
I285L |
probably benign |
Het |
| Rubcnl |
T |
C |
14: 75,284,987 (GRCm39) |
F502S |
probably damaging |
Het |
| Ryr2 |
T |
A |
13: 11,653,329 (GRCm39) |
I3693F |
probably damaging |
Het |
| Ryr2 |
T |
C |
13: 11,814,747 (GRCm39) |
Y675C |
probably damaging |
Het |
| Scaper |
T |
C |
9: 55,593,207 (GRCm39) |
T477A |
probably benign |
Het |
| Scn2a |
G |
T |
2: 65,542,269 (GRCm39) |
V791L |
probably benign |
Het |
| Sdk1 |
A |
T |
5: 142,117,820 (GRCm39) |
T1573S |
probably damaging |
Het |
| Sema3c |
A |
T |
5: 17,919,413 (GRCm39) |
H483L |
probably benign |
Het |
| Sema6c |
T |
C |
3: 95,076,002 (GRCm39) |
S219P |
probably damaging |
Het |
| Slc10a5 |
T |
G |
3: 10,400,177 (GRCm39) |
E161A |
probably damaging |
Het |
| Slc22a23 |
C |
T |
13: 34,528,366 (GRCm39) |
G139S |
possibly damaging |
Het |
| Slc34a3 |
C |
T |
2: 25,123,077 (GRCm39) |
|
probably benign |
Het |
| Slc38a9 |
A |
T |
13: 112,865,730 (GRCm39) |
|
probably null |
Het |
| Taok1 |
A |
C |
11: 77,450,670 (GRCm39) |
S367R |
possibly damaging |
Het |
| Tlr6 |
G |
A |
5: 65,112,203 (GRCm39) |
Q235* |
probably null |
Het |
| Top2a |
A |
G |
11: 98,887,665 (GRCm39) |
V1281A |
probably benign |
Het |
| Tpgs1 |
T |
C |
10: 79,511,616 (GRCm39) |
Y253H |
probably damaging |
Het |
| Tubgcp3 |
T |
C |
8: 12,703,462 (GRCm39) |
T288A |
probably benign |
Het |
| Ubr4 |
A |
G |
4: 139,154,213 (GRCm39) |
E2140G |
probably benign |
Het |
| Uso1 |
A |
G |
5: 92,321,878 (GRCm39) |
Q257R |
probably benign |
Het |
| Zfp106 |
A |
G |
2: 120,362,677 (GRCm39) |
V48A |
probably damaging |
Het |
| Zfp174 |
T |
A |
16: 3,666,118 (GRCm39) |
S128T |
possibly damaging |
Het |
| Zscan26 |
T |
A |
13: 21,629,225 (GRCm39) |
D426V |
probably benign |
Het |
|
| Other mutations in Insrr |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00718:Insrr
|
APN |
3 |
87,720,981 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL00801:Insrr
|
APN |
3 |
87,721,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01628:Insrr
|
APN |
3 |
87,708,099 (GRCm39) |
nonsense |
probably null |
|
|
IGL01755:Insrr
|
APN |
3 |
87,721,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02100:Insrr
|
APN |
3 |
87,718,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02261:Insrr
|
APN |
3 |
87,708,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02366:Insrr
|
APN |
3 |
87,717,216 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02387:Insrr
|
APN |
3 |
87,720,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02478:Insrr
|
APN |
3 |
87,716,719 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL02550:Insrr
|
APN |
3 |
87,711,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02555:Insrr
|
APN |
3 |
87,721,124 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02673:Insrr
|
APN |
3 |
87,720,368 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02724:Insrr
|
APN |
3 |
87,716,879 (GRCm39) |
missense |
probably benign |
0.31 |
|
IGL02798:Insrr
|
APN |
3 |
87,717,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02969:Insrr
|
APN |
3 |
87,721,498 (GRCm39) |
nonsense |
probably null |
|
|
IGL03073:Insrr
|
APN |
3 |
87,717,245 (GRCm39) |
splice site |
probably benign |
|
|
IGL03178:Insrr
|
APN |
3 |
87,709,848 (GRCm39) |
splice site |
probably null |
|
|
IGL03389:Insrr
|
APN |
3 |
87,716,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03399:Insrr
|
APN |
3 |
87,716,638 (GRCm39) |
missense |
probably null |
0.99 |
|
IGL02799:Insrr
|
UTSW |
3 |
87,720,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0011:Insrr
|
UTSW |
3 |
87,716,923 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0053:Insrr
|
UTSW |
3 |
87,707,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0053:Insrr
|
UTSW |
3 |
87,707,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0357:Insrr
|
UTSW |
3 |
87,715,953 (GRCm39) |
splice site |
probably null |
|
|
R0501:Insrr
|
UTSW |
3 |
87,717,991 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0504:Insrr
|
UTSW |
3 |
87,720,463 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0522:Insrr
|
UTSW |
3 |
87,708,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0555:Insrr
|
UTSW |
3 |
87,721,744 (GRCm39) |
splice site |
probably benign |
|
|
R0599:Insrr
|
UTSW |
3 |
87,720,440 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1312:Insrr
|
UTSW |
3 |
87,707,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1694:Insrr
|
UTSW |
3 |
87,711,369 (GRCm39) |
missense |
probably benign |
|
|
R1785:Insrr
|
UTSW |
3 |
87,717,879 (GRCm39) |
splice site |
probably null |
|
|
R1786:Insrr
|
UTSW |
3 |
87,717,879 (GRCm39) |
splice site |
probably null |
|
|
R1892:Insrr
|
UTSW |
3 |
87,721,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1950:Insrr
|
UTSW |
3 |
87,721,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2080:Insrr
|
UTSW |
3 |
87,721,598 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R2094:Insrr
|
UTSW |
3 |
87,710,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2130:Insrr
|
UTSW |
3 |
87,717,879 (GRCm39) |
splice site |
probably null |
|
|
R2131:Insrr
|
UTSW |
3 |
87,717,879 (GRCm39) |
splice site |
probably null |
|
|
R2133:Insrr
|
UTSW |
3 |
87,717,879 (GRCm39) |
splice site |
probably null |
|
|
R2220:Insrr
|
UTSW |
3 |
87,716,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2259:Insrr
|
UTSW |
3 |
87,707,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2404:Insrr
|
UTSW |
3 |
87,709,974 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4027:Insrr
|
UTSW |
3 |
87,716,906 (GRCm39) |
missense |
probably benign |
|
|
R4042:Insrr
|
UTSW |
3 |
87,721,134 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4510:Insrr
|
UTSW |
3 |
87,715,978 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4511:Insrr
|
UTSW |
3 |
87,715,978 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4571:Insrr
|
UTSW |
3 |
87,708,194 (GRCm39) |
missense |
probably benign |
|
|
R4870:Insrr
|
UTSW |
3 |
87,718,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5057:Insrr
|
UTSW |
3 |
87,722,572 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5393:Insrr
|
UTSW |
3 |
87,718,007 (GRCm39) |
splice site |
probably null |
|
|
R5685:Insrr
|
UTSW |
3 |
87,707,803 (GRCm39) |
splice site |
probably null |
|
|
R6039:Insrr
|
UTSW |
3 |
87,716,608 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6039:Insrr
|
UTSW |
3 |
87,716,608 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6047:Insrr
|
UTSW |
3 |
87,711,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6276:Insrr
|
UTSW |
3 |
87,707,826 (GRCm39) |
nonsense |
probably null |
|
|
R6298:Insrr
|
UTSW |
3 |
87,720,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6726:Insrr
|
UTSW |
3 |
87,720,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6727:Insrr
|
UTSW |
3 |
87,720,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6728:Insrr
|
UTSW |
3 |
87,720,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6796:Insrr
|
UTSW |
3 |
87,720,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7041:Insrr
|
UTSW |
3 |
87,722,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7169:Insrr
|
UTSW |
3 |
87,715,901 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7270:Insrr
|
UTSW |
3 |
87,710,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7340:Insrr
|
UTSW |
3 |
87,721,623 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7398:Insrr
|
UTSW |
3 |
87,716,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7473:Insrr
|
UTSW |
3 |
87,711,838 (GRCm39) |
splice site |
probably null |
|
|
R7815:Insrr
|
UTSW |
3 |
87,716,002 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8159:Insrr
|
UTSW |
3 |
87,707,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8289:Insrr
|
UTSW |
3 |
87,721,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8309:Insrr
|
UTSW |
3 |
87,717,749 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8312:Insrr
|
UTSW |
3 |
87,707,791 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8445:Insrr
|
UTSW |
3 |
87,720,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8917:Insrr
|
UTSW |
3 |
87,718,276 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8960:Insrr
|
UTSW |
3 |
87,720,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8989:Insrr
|
UTSW |
3 |
87,722,664 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9015:Insrr
|
UTSW |
3 |
87,720,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9202:Insrr
|
UTSW |
3 |
87,720,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9251:Insrr
|
UTSW |
3 |
87,717,391 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9327:Insrr
|
UTSW |
3 |
87,721,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9646:Insrr
|
UTSW |
3 |
87,721,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF022:Insrr
|
UTSW |
3 |
87,711,792 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
Z1177:Insrr
|
UTSW |
3 |
87,708,134 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Z1192:Insrr
|
UTSW |
3 |
87,709,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGATTTCCACTCAGCACCAGCC -3'
(R):5'- TCACAGCAGAACCTGCTTGCTC -3'
Sequencing Primer
(F):5'- CCTGCCCATGACCATGC -3'
(R):5'- TGTTGTCACCCCAGCTAAGAG -3'
|
| Posted On |
2013-06-11 |
Incidental Mutation