Incidental Mutation 'R5898:Ifi213'
ID 457626
Institutional Source Beutler Lab
Gene Symbol Ifi213
Ensembl Gene ENSMUSG00000073491
Gene Name interferon activated gene 213
Synonyms Pyr-A, Pydc4, E030037K03Rik
MMRRC Submission 044097-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R5898 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 173393849-173426840 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 173396545 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 510 (M510V)
Ref Sequence ENSEMBL: ENSMUSP00000117222 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000150649]
AlphaFold D3Z5G0
Predicted Effect probably benign
Transcript: ENSMUST00000150649
AA Change: M510V

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000117222
Gene: ENSMUSG00000073491
AA Change: M510V

DomainStartEndE-ValueType
PYRIN 10 88 3.71e-20 SMART
low complexity region 101 112 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000178186
Predicted Effect noncoding transcript
Transcript: ENSMUST00000179648
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.9%
  • 20x: 93.8%
Validation Efficiency 96% (86/90)
Allele List at MGI
Other mutations in this stock
Total: 83 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik G T 10: 100,448,762 (GRCm39) R158L possibly damaging Het
1700017N19Rik G A 10: 100,451,070 (GRCm39) M179I probably benign Het
Abhd12 T C 2: 150,681,698 (GRCm39) I231V possibly damaging Het
Adsl A G 15: 80,845,554 (GRCm39) probably null Het
Ahnak C A 19: 8,991,131 (GRCm39) N4138K possibly damaging Het
Ahnak T C 19: 8,995,575 (GRCm39) S5620P probably damaging Het
Akap13 C T 7: 75,378,894 (GRCm39) T2145I probably damaging Het
Alpk2 T A 18: 65,440,694 (GRCm39) Q700L probably damaging Het
Apobec1 T C 6: 122,557,732 (GRCm39) Y159C probably damaging Het
Atg9a T C 1: 75,162,916 (GRCm39) T395A probably damaging Het
Atp6v1f A G 6: 29,467,957 (GRCm39) I48V probably benign Het
BC051665 A C 13: 60,930,518 (GRCm39) V278G probably damaging Het
Bicd1 A T 6: 149,415,201 (GRCm39) H638L probably damaging Het
Cacna2d4 A G 6: 119,251,192 (GRCm39) Y460C probably damaging Het
Ccdc157 C A 11: 4,094,538 (GRCm39) R496L probably benign Het
Cdcp3 T G 7: 130,843,696 (GRCm39) probably null Het
Cep44 C G 8: 56,994,056 (GRCm39) V174L probably damaging Het
Clca3a1 G T 3: 144,722,522 (GRCm39) F283L possibly damaging Het
Csk T C 9: 57,537,585 (GRCm39) T110A probably benign Het
Cspg4 T A 9: 56,792,506 (GRCm39) probably null Het
Cutc A G 19: 43,748,468 (GRCm39) I124V probably benign Het
Cyp2d9 A G 15: 82,339,725 (GRCm39) T104A probably benign Het
Cyp2j9 G T 4: 96,465,951 (GRCm39) T294K probably benign Het
D630003M21Rik T A 2: 158,046,577 (GRCm39) probably null Het
Dcaf15 G T 8: 84,825,081 (GRCm39) F450L probably damaging Het
Ddhd1 A T 14: 45,840,125 (GRCm39) I723K probably damaging Het
Dnah17 C T 11: 118,005,039 (GRCm39) A782T probably benign Het
Dnah3 T C 7: 119,677,724 (GRCm39) D399G probably benign Het
Dync2h1 T C 9: 7,148,717 (GRCm39) N909S probably benign Het
Erbin A G 13: 103,975,813 (GRCm39) probably null Het
Fanci G A 7: 79,083,069 (GRCm39) V682I probably benign Het
Fap A T 2: 62,403,847 (GRCm39) F9L probably benign Het
Fat3 T C 9: 15,849,757 (GRCm39) I3882V probably benign Het
Fkbp15 A T 4: 62,244,294 (GRCm39) probably null Het
Fsd2 T C 7: 81,186,975 (GRCm39) Y601C probably damaging Het
Gm5900 T C 7: 104,599,468 (GRCm39) noncoding transcript Het
Gramd4 G T 15: 85,984,985 (GRCm39) G82V probably damaging Het
Hc C T 2: 34,887,449 (GRCm39) V1352I probably benign Het
Hsph1 A T 5: 149,548,623 (GRCm39) N466K probably damaging Het
Ice2 T A 9: 69,315,544 (GRCm39) D133E probably benign Het
Itpkb T G 1: 180,248,880 (GRCm39) L861R probably damaging Het
Kbtbd3 T A 9: 4,330,476 (GRCm39) D283E probably damaging Het
Man2a1 A G 17: 64,932,375 (GRCm39) K154R probably benign Het
Masp1 T A 16: 23,310,677 (GRCm39) I252F probably damaging Het
Megf11 G T 9: 64,593,246 (GRCm39) C586F probably damaging Het
Myh2 C A 11: 67,083,545 (GRCm39) A1476E possibly damaging Het
Myo18b A T 5: 112,950,196 (GRCm39) probably null Het
Naip6 A T 13: 100,435,829 (GRCm39) V898E possibly damaging Het
Nav1 T C 1: 135,512,884 (GRCm39) M59V probably benign Het
Nlrp3 A T 11: 59,437,678 (GRCm39) Y119F probably benign Het
Oxa1l T A 14: 54,600,758 (GRCm39) I77N possibly damaging Het
Pcdhb8 T A 18: 37,490,537 (GRCm39) D738E possibly damaging Het
Pdia5 A T 16: 35,243,335 (GRCm39) W269R probably damaging Het
Peak1 T A 9: 56,114,622 (GRCm39) T1440S probably benign Het
Piezo1 A G 8: 123,214,682 (GRCm39) V1547A probably benign Het
Pkp1 T C 1: 135,810,259 (GRCm39) Y437C probably damaging Het
Pla2r1 T C 2: 60,253,104 (GRCm39) D1329G probably damaging Het
Ppip5k2 T C 1: 97,671,887 (GRCm39) probably benign Het
Prrg4 C T 2: 104,675,378 (GRCm39) S75N probably benign Het
Psmb9 T A 17: 34,401,266 (GRCm39) I198F probably damaging Het
Rcbtb2 T A 14: 73,399,405 (GRCm39) L23* probably null Het
Sbno1 A T 5: 124,524,854 (GRCm39) probably benign Het
Scn3a T C 2: 65,345,039 (GRCm39) E483G probably damaging Het
Sdccag8 T A 1: 176,652,388 (GRCm39) D46E probably benign Het
Selenov A G 7: 27,987,579 (GRCm39) F293L probably damaging Het
Septin2 A C 1: 93,407,023 (GRCm39) D20A probably benign Het
Shc1 T A 3: 89,334,274 (GRCm39) Y313* probably null Het
Siglec1 T A 2: 130,915,553 (GRCm39) Y1346F probably damaging Het
Slc22a5 T A 11: 53,764,559 (GRCm39) I296F probably damaging Het
Slc9c1 A G 16: 45,365,123 (GRCm39) N152S probably damaging Het
Smoc1 C T 12: 81,151,531 (GRCm39) R83* probably null Het
Ssx2ip A G 3: 146,133,586 (GRCm39) D227G possibly damaging Het
Tbrg4 T C 11: 6,567,372 (GRCm39) D576G probably damaging Het
Tbx20 T A 9: 24,670,155 (GRCm39) Y226F probably damaging Het
Trav10d G T 14: 53,048,929 (GRCm39) A107S probably damaging Het
Trim60 A T 8: 65,453,016 (GRCm39) L411* probably null Het
Ttbk2 A T 2: 120,575,521 (GRCm39) V1083D probably benign Het
Unc93a T A 17: 13,344,464 (GRCm39) Q26L probably damaging Het
Usp14 T A 18: 10,022,819 (GRCm39) N65I possibly damaging Het
Vip A T 10: 5,593,988 (GRCm39) S114C probably damaging Het
Vmn1r237 A T 17: 21,534,813 (GRCm39) I179F probably damaging Het
Wdr47 T A 3: 108,545,201 (GRCm39) probably null Het
Zfp975 A T 7: 42,311,963 (GRCm39) C217S probably damaging Het
Other mutations in Ifi213
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00678:Ifi213 APN 1 173,421,619 (GRCm39) splice site probably benign
IGL00908:Ifi213 APN 1 173,422,649 (GRCm39) missense probably damaging 1.00
IGL00964:Ifi213 APN 1 173,421,518 (GRCm39) missense possibly damaging 0.91
IGL02217:Ifi213 APN 1 173,422,598 (GRCm39) missense possibly damaging 0.91
R0709:Ifi213 UTSW 1 173,417,366 (GRCm39) missense possibly damaging 0.70
R1518:Ifi213 UTSW 1 173,417,229 (GRCm39) missense probably damaging 0.99
R1559:Ifi213 UTSW 1 173,394,784 (GRCm39) missense probably benign 0.18
R1822:Ifi213 UTSW 1 173,417,408 (GRCm39) missense probably damaging 0.99
R1839:Ifi213 UTSW 1 173,417,166 (GRCm39) missense probably damaging 0.98
R1989:Ifi213 UTSW 1 173,396,374 (GRCm39) critical splice donor site probably null
R2108:Ifi213 UTSW 1 173,396,668 (GRCm39) critical splice acceptor site probably null
R2696:Ifi213 UTSW 1 173,417,590 (GRCm39) missense probably benign
R3890:Ifi213 UTSW 1 173,394,822 (GRCm39) missense probably benign 0.33
R4544:Ifi213 UTSW 1 173,409,693 (GRCm39) splice site probably null
R4611:Ifi213 UTSW 1 173,417,480 (GRCm39) missense possibly damaging 0.91
R4689:Ifi213 UTSW 1 173,417,986 (GRCm39) missense possibly damaging 0.92
R4710:Ifi213 UTSW 1 173,394,738 (GRCm39) utr 3 prime probably benign
R5126:Ifi213 UTSW 1 173,417,581 (GRCm39) missense possibly damaging 0.85
R5472:Ifi213 UTSW 1 173,394,838 (GRCm39) splice site probably null
R5625:Ifi213 UTSW 1 173,396,629 (GRCm39) missense possibly damaging 0.73
R5789:Ifi213 UTSW 1 173,396,360 (GRCm39) splice site probably benign
R6025:Ifi213 UTSW 1 173,422,800 (GRCm39) missense probably damaging 0.99
R6149:Ifi213 UTSW 1 173,421,581 (GRCm39) missense probably benign 0.18
R6348:Ifi213 UTSW 1 173,417,848 (GRCm39) missense possibly damaging 0.46
R6564:Ifi213 UTSW 1 173,422,862 (GRCm39) start codon destroyed probably null 0.06
R7254:Ifi213 UTSW 1 173,421,529 (GRCm39) missense probably damaging 0.98
R7292:Ifi213 UTSW 1 173,422,691 (GRCm39) missense probably damaging 0.99
R7752:Ifi213 UTSW 1 173,394,784 (GRCm39) missense probably benign 0.18
R7901:Ifi213 UTSW 1 173,394,784 (GRCm39) missense probably benign 0.18
R8100:Ifi213 UTSW 1 173,422,748 (GRCm39) missense probably damaging 1.00
R8352:Ifi213 UTSW 1 173,422,835 (GRCm39) missense possibly damaging 0.92
R8425:Ifi213 UTSW 1 173,417,426 (GRCm39) missense probably benign
R8452:Ifi213 UTSW 1 173,422,835 (GRCm39) missense possibly damaging 0.92
R9357:Ifi213 UTSW 1 173,396,392 (GRCm39) missense probably benign 0.01
RF010:Ifi213 UTSW 1 173,409,719 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AGTTGACTGGCAAGAACCCTA -3'
(R):5'- TTGAGGGGTCTTGATACTTTAATGACT -3'

Sequencing Primer
(F):5'- CAGTACAGCTCCTTTAAGTGCTAGG -3'
(R):5'- TTAATGACTTCGAAGAGAGGATATGC -3'
Posted On 2017-02-15