Mutagenetix > Incidental Mutation

Incidental Mutation 'R5888:Or8k37'

457761

Institutional Source

Beutler Lab

Gene Symbol

Or8k37

Ensembl Gene

ENSMUSG00000110804

Gene Name

olfactory receptor family 8 subfamily K member 37

Synonyms

MOR192-3, MOR192-2, GA_x6K02T2Q125-48121788-48120847, Olfr1084

MMRRC Submission

044089-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.244) question?

Stock #

R5888 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

86469109-86470062 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 86469488 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Arginine at position 188 (L188R)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000216851]

AlphaFold

A0A1L1STZ9

Predicted Effect

probably damaging
Transcript: ENSMUST00000099880
AA Change: L188R

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000097465
Gene: ENSMUSG00000075177
AA Change: L188R

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	5.9e-48	PFAM
Pfam:7tm_1	41	290	7.6e-19	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000216851
AA Change: L188R

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.2%
20x: 94.9%

Validation Efficiency

94% (96/102)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 92 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adcy1	T	A	11: 7,089,095 (GRCm39)	V503E	possibly damaging	Het
Alk	C	A	17: 72,181,938 (GRCm39)	V1362L	probably damaging	Het
Ankrd55	T	A	13: 112,492,453 (GRCm39)	I208N	possibly damaging	Het
Asap2	T	A	12: 21,268,191 (GRCm39)	I319N	probably damaging	Het
Atp11b	T	C	3: 35,891,696 (GRCm39)	I1036T	probably benign	Het
B4gat1	T	C	19: 5,089,560 (GRCm39)	F186L	probably benign	Het
C3	T	A	17: 57,521,831 (GRCm39)	T1079S	probably damaging	Het
Cacul1	G	T	19: 60,525,902 (GRCm39)	T287K	possibly damaging	Het
Cbr3	G	C	16: 93,487,614 (GRCm39)	G266R	probably damaging	Het
Cd63	T	A	10: 128,748,160 (GRCm39)		probably null	Het
Chd7	G	A	4: 8,866,382 (GRCm39)	M851I	probably damaging	Het
Chst13	T	A	6: 90,286,554 (GRCm39)	H136L	probably benign	Het
Cyp2d22	T	C	15: 82,258,014 (GRCm39)	T179A	probably benign	Het
Dclre1b	A	T	3: 103,711,053 (GRCm39)	V286E	probably damaging	Het
Defb45	G	A	2: 152,435,154 (GRCm39)		probably benign	Het
Dlg1	T	C	16: 31,610,704 (GRCm39)		probably null	Het
Dock3	A	G	9: 106,901,002 (GRCm39)	V321A	probably benign	Het
Dytn	A	T	1: 63,716,396 (GRCm39)	V59E	possibly damaging	Het
Efcab3	T	C	11: 104,612,227 (GRCm39)		probably benign	Het
Eif2ak1	A	G	5: 143,823,733 (GRCm39)	I393M	probably damaging	Het
Fam83g	A	T	11: 61,593,420 (GRCm39)	E318V	probably benign	Het
Fbxo34	T	A	14: 47,767,176 (GRCm39)	F179I	probably damaging	Het
Fmo5	T	A	3: 97,549,041 (GRCm39)	Y230N	probably benign	Het
Fzd9	T	G	5: 135,278,317 (GRCm39)		probably null	Het
Gata2	T	C	6: 88,177,722 (GRCm39)	S251P	probably benign	Het
Gigyf1	A	G	5: 137,523,959 (GRCm39)	D1043G	probably damaging	Het
Gm10322	T	A	10: 59,452,125 (GRCm39)	S81T	probably benign	Het
Gm15517	A	T	7: 43,910,066 (GRCm39)		probably benign	Het
Haus4	T	C	14: 54,781,676 (GRCm39)	T232A	probably benign	Het
Hgfac	A	T	5: 35,202,751 (GRCm39)	H417L	probably damaging	Het
Iqgap2	T	C	13: 95,772,118 (GRCm39)	K1354E	possibly damaging	Het
Kcnk12	C	A	17: 88,054,077 (GRCm39)	R195L	probably benign	Het
Kcnn2	A	T	18: 45,725,412 (GRCm39)	I303F	probably damaging	Het
Kcnt1	T	C	2: 25,798,122 (GRCm39)	F879S	probably damaging	Het
Kndc1	T	C	7: 139,475,133 (GRCm39)	F11L	probably benign	Het
Kpna7	A	G	5: 144,926,605 (GRCm39)	F449S	probably damaging	Het
Krt77	G	T	15: 101,773,888 (GRCm39)	N255K	probably benign	Het
Lair1	A	T	7: 4,013,844 (GRCm39)	D134E	probably damaging	Het
Loxhd1	T	C	18: 77,490,211 (GRCm39)	V1318A	probably damaging	Het
Marchf10	A	T	11: 105,292,972 (GRCm39)	V145D	possibly damaging	Het
Mcpt1	T	A	14: 56,256,969 (GRCm39)	M169K	probably benign	Het
Mdc1	T	A	17: 36,158,712 (GRCm39)	V364E	probably benign	Het
Mfsd11	T	C	11: 116,762,210 (GRCm39)	F270S	probably damaging	Het
Mfsd4b2	T	G	10: 39,798,031 (GRCm39)	D108A	probably benign	Het
Mink1	A	T	11: 70,500,885 (GRCm39)		probably benign	Het
Mmp25	T	C	17: 23,850,048 (GRCm39)	Y504C	probably damaging	Het
Ms4a13	C	T	19: 11,168,870 (GRCm39)	V52I	probably benign	Het
Msh4	C	T	3: 153,573,360 (GRCm39)		probably null	Het
Muc5b	T	G	7: 141,412,158 (GRCm39)	S1701R	unknown	Het
Naalad2	A	T	9: 18,241,937 (GRCm39)	S656T	probably benign	Het
Ncapd2	T	C	6: 125,164,052 (GRCm39)	Y64C	probably damaging	Het
Ncapg2	T	A	12: 116,389,420 (GRCm39)	S347T	possibly damaging	Het
Ndufb11b	T	C	15: 81,864,872 (GRCm39)	S38P	probably benign	Het
Nipal4	T	C	11: 46,042,166 (GRCm39)	T172A	probably damaging	Het
Nrros	T	C	16: 31,961,905 (GRCm39)	K652R	probably benign	Het
Nrxn3	G	T	12: 89,478,855 (GRCm39)	A983S	possibly damaging	Het
Or4a76	T	A	2: 89,461,143 (GRCm39)	Y33F	probably damaging	Het
Or4ac1-ps1	T	C	2: 88,370,588 (GRCm39)		noncoding transcript	Het
Or4c115	T	A	2: 88,928,269 (GRCm39)	M1L	probably damaging	Het
Or4k77	T	C	2: 111,199,088 (GRCm39)	M37T	probably benign	Het
Or51m1	A	G	7: 103,578,239 (GRCm39)	T70A	possibly damaging	Het
Or8g24	A	T	9: 38,989,263 (GRCm39)	Y259*	probably null	Het
P2rx4	T	A	5: 122,857,228 (GRCm39)	S155T	probably benign	Het
P2rx4	T	G	5: 122,865,271 (GRCm39)	Y299D	probably damaging	Het
Pcsk6	A	T	7: 65,693,372 (GRCm39)	L7F	probably null	Het
Pdss2	T	C	10: 43,097,793 (GRCm39)		silent	Het
Pfkl	A	G	10: 77,827,204 (GRCm39)	V494A	possibly damaging	Het
Prep	G	T	10: 44,943,460 (GRCm39)	D12Y	possibly damaging	Het
Prg4	A	G	1: 150,328,101 (GRCm39)	F188S	probably damaging	Het
Ripor3	T	C	2: 167,839,207 (GRCm39)	Y98C	probably damaging	Het
Rnf216	T	A	5: 143,054,069 (GRCm39)		probably null	Het
Rnf24	A	G	2: 131,164,165 (GRCm39)		probably benign	Het
Rps18-ps6	G	A	13: 97,896,901 (GRCm39)	R66*	probably null	Het
Scn3a	A	G	2: 65,327,742 (GRCm39)	M916T	probably benign	Het
Scnm1	T	C	3: 95,037,596 (GRCm39)	I157V	probably benign	Het
Sh2b3	C	G	5: 121,967,084 (GRCm39)	R10P	possibly damaging	Het
Slc25a27	T	C	17: 43,960,585 (GRCm39)	D211G	probably damaging	Het
Slc36a4	A	T	9: 15,638,324 (GRCm39)	Y250F	probably damaging	Het
Slc4a1	T	A	11: 102,247,351 (GRCm39)	E448V	probably damaging	Het
Slit1	C	A	19: 41,731,735 (GRCm39)	C38F	probably damaging	Het
Spock3	T	A	8: 63,808,334 (GRCm39)	N410K	unknown	Het
Supt20	G	T	3: 54,619,628 (GRCm39)	W370L	probably benign	Het
Tas2r139	T	A	6: 42,118,430 (GRCm39)	N187K	probably damaging	Het
Tbc1d9b	G	A	11: 50,031,311 (GRCm39)	V111I	probably benign	Het
Thsd7b	T	A	1: 130,138,057 (GRCm39)	Y1578*	probably null	Het
Tln2	T	A	9: 67,136,685 (GRCm39)	I1267F	probably damaging	Het
Tnk2	G	A	16: 32,490,185 (GRCm39)	V363I	probably damaging	Het
Ttc32	A	G	12: 9,085,870 (GRCm39)	K139R	possibly damaging	Het
Vmn1r30	G	C	6: 58,412,550 (GRCm39)	T94S	possibly damaging	Het
Vmn1r90	G	A	7: 14,295,780 (GRCm39)	T106I	probably damaging	Het
Zfp677	T	A	17: 21,618,520 (GRCm39)	C526S	probably damaging	Het
Zfp831	T	G	2: 174,485,420 (GRCm39)	S32A	probably benign	Het

Other mutations in Or8k37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01132:Or8k37	APN	2	86,469,510 (GRCm39)	missense	probably benign	0.01
IGL01376:Or8k37	APN	2	86,469,953 (GRCm39)	missense	probably benign	0.00
IGL01387:Or8k37	APN	2	86,469,594 (GRCm39)	missense	probably benign	0.03
IGL01549:Or8k37	APN	2	86,469,876 (GRCm39)	missense	possibly damaging	0.95
IGL01549:Or8k37	APN	2	86,469,705 (GRCm39)	missense	probably benign	0.29
IGL01572:Or8k37	APN	2	86,469,283 (GRCm39)	missense	possibly damaging	0.92
IGL02084:Or8k37	APN	2	86,469,980 (GRCm39)	missense	possibly damaging	0.89
IGL02289:Or8k37	APN	2	86,469,863 (GRCm39)	missense	probably damaging	1.00
IGL02422:Or8k37	APN	2	86,469,560 (GRCm39)	missense	probably damaging	0.99
IGL02691:Or8k37	APN	2	86,469,182 (GRCm39)	missense	probably damaging	1.00
IGL02829:Or8k37	APN	2	86,469,599 (GRCm39)	missense	possibly damaging	0.60
IGL02859:Or8k37	APN	2	86,469,992 (GRCm39)	missense	probably benign	0.01
R0441:Or8k37	UTSW	2	86,469,674 (GRCm39)	missense	probably damaging	1.00
R0546:Or8k37	UTSW	2	86,469,573 (GRCm39)	missense	possibly damaging	0.86
R1186:Or8k37	UTSW	2	86,469,807 (GRCm39)	missense	probably damaging	1.00
R4465:Or8k37	UTSW	2	86,469,478 (GRCm39)	missense	probably benign	0.28
R4554:Or8k37	UTSW	2	86,469,123 (GRCm39)	missense	possibly damaging	0.74
R4670:Or8k37	UTSW	2	86,469,512 (GRCm39)	missense	possibly damaging	0.95
R4945:Or8k37	UTSW	2	86,469,833 (GRCm39)	missense	probably damaging	0.99
R5348:Or8k37	UTSW	2	86,469,150 (GRCm39)	missense	probably benign	0.39
R7001:Or8k37	UTSW	2	86,469,495 (GRCm39)	missense	probably benign	0.20
R7258:Or8k37	UTSW	2	86,469,345 (GRCm39)	nonsense	probably null
R7526:Or8k37	UTSW	2	86,470,013 (GRCm39)	missense	possibly damaging	0.93
R7646:Or8k37	UTSW	2	86,469,513 (GRCm39)	missense	probably damaging	1.00
R7915:Or8k37	UTSW	2	86,469,110 (GRCm39)	makesense	probably null

Predicted Primers

PCR Primer
(F):5'- GTCCCATAGAATATTGTAACCACTG -3'
(R):5'- ACCGCTATGTGGCCATATGTAAG -3'

Sequencing Primer
(F):5'- GAATATTGTAACCACTGTCAGGTG -3'
(R):5'- GTGGCCATATGTAAGCCTCTGC -3'

Posted On

2017-02-15