Incidental Mutation 'R5459:Grep1'
ID 457914
Institutional Source Beutler Lab
Gene Symbol Grep1
Ensembl Gene ENSMUSG00000043747
Gene Name glycine rich extracellular protein 1
Synonyms 1520401A03Rik
MMRRC Submission 043022-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R5459 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 23923462-23941757 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) C to T at 23930817 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000144664 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000178006] [ENSMUST00000178006] [ENSMUST00000201734] [ENSMUST00000201734]
AlphaFold A0A0J9YVH6
Predicted Effect noncoding transcript
Transcript: ENSMUST00000062827
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176095
Predicted Effect probably benign
Transcript: ENSMUST00000178006
SMART Domains Protein: ENSMUSP00000144253
Gene: ENSMUSG00000043747

DomainStartEndE-ValueType
low complexity region 3 16 N/A INTRINSIC
low complexity region 18 47 N/A INTRINSIC
internal_repeat_1 49 75 7.63e-5 PROSPERO
low complexity region 82 99 N/A INTRINSIC
internal_repeat_1 101 132 7.63e-5 PROSPERO
low complexity region 133 164 N/A INTRINSIC
low complexity region 174 196 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000178006
SMART Domains Protein: ENSMUSP00000144253
Gene: ENSMUSG00000043747

DomainStartEndE-ValueType
low complexity region 3 16 N/A INTRINSIC
low complexity region 18 47 N/A INTRINSIC
internal_repeat_1 49 75 7.63e-5 PROSPERO
low complexity region 82 99 N/A INTRINSIC
internal_repeat_1 101 132 7.63e-5 PROSPERO
low complexity region 133 164 N/A INTRINSIC
low complexity region 174 196 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000201734
SMART Domains Protein: ENSMUSP00000144664
Gene: ENSMUSG00000043747

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 61 69 N/A INTRINSIC
low complexity region 72 85 N/A INTRINSIC
low complexity region 87 116 N/A INTRINSIC
internal_repeat_1 117 149 3.72e-8 PROSPERO
low complexity region 151 168 N/A INTRINSIC
low complexity region 202 233 N/A INTRINSIC
low complexity region 238 258 N/A INTRINSIC
internal_repeat_1 268 310 3.72e-8 PROSPERO
low complexity region 518 528 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000201734
SMART Domains Protein: ENSMUSP00000144664
Gene: ENSMUSG00000043747

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 61 69 N/A INTRINSIC
low complexity region 72 85 N/A INTRINSIC
low complexity region 87 116 N/A INTRINSIC
internal_repeat_1 117 149 3.72e-8 PROSPERO
low complexity region 151 168 N/A INTRINSIC
low complexity region 202 233 N/A INTRINSIC
low complexity region 238 258 N/A INTRINSIC
internal_repeat_1 268 310 3.72e-8 PROSPERO
low complexity region 518 528 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2300002M23Rik A G 17: 35,879,079 (GRCm39) E139G possibly damaging Het
Abcc6 T C 7: 45,631,607 (GRCm39) N1223S probably benign Het
Adamts3 A T 5: 89,839,332 (GRCm39) probably null Het
Aloxe3 T A 11: 69,023,654 (GRCm39) F259Y possibly damaging Het
Armc9 G A 1: 86,135,694 (GRCm39) R550Q probably damaging Het
Ctnnd2 A G 15: 30,887,334 (GRCm39) D787G probably damaging Het
Dnah7b A G 1: 46,148,472 (GRCm39) I283V probably null Het
Ebf2 A G 14: 67,472,650 (GRCm39) M23V probably benign Het
Fbxw11 T C 11: 32,689,191 (GRCm39) V438A possibly damaging Het
Fcrla G A 1: 170,745,738 (GRCm39) T348M possibly damaging Het
Gpr179 A T 11: 97,227,483 (GRCm39) H1557Q probably benign Het
Gpr87 A G 3: 59,087,148 (GRCm39) V119A possibly damaging Het
Hfm1 A G 5: 107,052,629 (GRCm39) S285P probably damaging Het
Hs3st5 T C 10: 36,704,742 (GRCm39) V15A possibly damaging Het
Hyal5 C T 6: 24,891,250 (GRCm39) H355Y probably damaging Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Map4k3 T A 17: 80,917,216 (GRCm39) N587Y probably damaging Het
Mcm3ap T A 10: 76,332,316 (GRCm39) L1211* probably null Het
Mcmdc2 A G 1: 10,007,309 (GRCm39) I620V probably benign Het
Mical2 C T 7: 111,981,444 (GRCm39) H539Y probably benign Het
Myo9a T C 9: 59,791,803 (GRCm39) L1802P probably damaging Het
Neto2 T A 8: 86,397,112 (GRCm39) I47F probably benign Het
Oog3 G A 4: 143,885,815 (GRCm39) T261I probably benign Het
Or5b95 A G 19: 12,657,799 (GRCm39) E109G probably damaging Het
Pdilt A G 7: 119,086,158 (GRCm39) L519P probably benign Het
Pnpla6 A T 8: 3,585,829 (GRCm39) M844L probably benign Het
Polk C T 13: 96,631,984 (GRCm39) G250R probably damaging Het
Rasal2 A G 1: 156,985,231 (GRCm39) S839P probably damaging Het
Siae T C 9: 37,528,119 (GRCm39) Y31H probably damaging Het
Slc27a2 T C 2: 126,422,912 (GRCm39) V379A probably damaging Het
Snx9 C T 17: 5,970,913 (GRCm39) T418M probably damaging Het
Spata31e2 A C 1: 26,724,272 (GRCm39) S303A probably damaging Het
Srp72 A G 5: 77,132,185 (GRCm39) T258A probably benign Het
Tango6 T A 8: 107,576,921 (GRCm39) D1058E probably damaging Het
Tecpr1 T A 5: 144,144,234 (GRCm39) Y656F probably damaging Het
Tnik T A 3: 28,715,890 (GRCm39) I1168K probably damaging Het
Togaram1 A G 12: 65,014,510 (GRCm39) E587G probably damaging Het
Tyw1 A C 5: 130,303,547 (GRCm39) D305A probably damaging Het
Vmn1r19 T A 6: 57,381,475 (GRCm39) Y9* probably null Het
Zkscan3 A T 13: 21,578,982 (GRCm39) V142E probably damaging Het
Other mutations in Grep1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0332:Grep1 UTSW 17 23,933,578 (GRCm39) splice site probably benign
R1165:Grep1 UTSW 17 23,929,489 (GRCm39) splice site probably benign
R1539:Grep1 UTSW 17 23,936,118 (GRCm39) splice site probably benign
R2968:Grep1 UTSW 17 23,934,785 (GRCm39) missense possibly damaging 0.90
R5800:Grep1 UTSW 17 23,936,966 (GRCm39) missense probably damaging 0.96
R5967:Grep1 UTSW 17 23,931,332 (GRCm39) missense probably damaging 1.00
R6246:Grep1 UTSW 17 23,929,465 (GRCm39) nonsense probably null
R6306:Grep1 UTSW 17 23,925,124 (GRCm39) missense possibly damaging 0.66
R6892:Grep1 UTSW 17 23,931,328 (GRCm39) missense probably damaging 0.97
R7126:Grep1 UTSW 17 23,939,538 (GRCm39) missense probably benign 0.23
R7264:Grep1 UTSW 17 23,931,308 (GRCm39) missense not run
R7563:Grep1 UTSW 17 23,936,302 (GRCm39) missense probably benign 0.27
R9058:Grep1 UTSW 17 23,935,016 (GRCm39) missense probably benign 0.05
R9323:Grep1 UTSW 17 23,937,387 (GRCm39) missense unknown
R9451:Grep1 UTSW 17 23,936,187 (GRCm39) missense unknown
Z1176:Grep1 UTSW 17 23,934,737 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- TCTCATCAGACTGGACTCCC -3'
(R):5'- TCCAAAGCCAGGTGAGGTCTAC -3'

Sequencing Primer
(F):5'- CAGTTCCATTCCTAAACCCCGG -3'
(R):5'- CAGGTGAGGTCTACCCTGTG -3'
Posted On 2017-02-16