Incidental Mutation 'R0559:Or8b37'
| ID |
45794 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Or8b37
|
| Ensembl Gene |
ENSMUSG00000095893 |
| Gene Name |
olfactory receptor family 8 subfamily B member 37 |
| Synonyms |
GA_x6K02T2PVTD-31726544-31727473, MOR162-9P, MOR162-11P, Olfr1550-ps1, MOR162-13, Olfr884, MOR162-11P |
| MMRRC Submission |
038751-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.089)
|
| Stock # |
R0559 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
37957851-37961433 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 37959123 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Leucine
at position 202
(V202L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000138035
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077732]
[ENSMUST00000181088]
|
| AlphaFold |
Q7TRE1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000077732
AA Change: V202L
PolyPhen 2
Score 0.164 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000076912
Gene: ENSMUSG00000095893
AA Change: V202L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
31 |
306 |
8e-51 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
35 |
300 |
1.5e-6 |
PFAM |
|
Pfam:7tm_1
|
41 |
288 |
5.1e-24 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000181088
AA Change: V202L
PolyPhen 2
Score 0.164 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000138035
Gene: ENSMUSG00000095893
AA Change: V202L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
14 |
33 |
N/A |
INTRINSIC |
|
Pfam:7TM_GPCR_Srsx
|
35 |
300 |
1.5e-6 |
PFAM |
|
Pfam:7tm_1
|
41 |
288 |
4.6e-30 |
PFAM |
|
Pfam:7tm_4
|
138 |
281 |
3.9e-45 |
PFAM |
|
| Meta Mutation Damage Score |
0.2502 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.5%
|
| Validation Efficiency |
97% (34/35) |
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb1a |
A |
T |
5: 8,748,535 (GRCm39) |
I289F |
probably benign |
Het |
| Adam15 |
G |
A |
3: 89,251,085 (GRCm39) |
A540V |
probably damaging |
Het |
| Adat1 |
T |
C |
8: 112,709,062 (GRCm39) |
T254A |
probably damaging |
Het |
| Agtpbp1 |
A |
G |
13: 59,644,814 (GRCm39) |
V684A |
probably benign |
Het |
| Ahi1 |
A |
G |
10: 20,876,618 (GRCm39) |
|
probably benign |
Het |
| Arl5b |
T |
C |
2: 15,077,998 (GRCm39) |
Y108H |
probably damaging |
Het |
| Cep85l |
A |
G |
10: 53,224,597 (GRCm39) |
F331L |
probably benign |
Het |
| Ctnna2 |
T |
C |
6: 76,892,833 (GRCm39) |
K785E |
probably damaging |
Het |
| Dgkd |
T |
A |
1: 87,842,826 (GRCm39) |
I118N |
probably damaging |
Het |
| Dicer1 |
G |
A |
12: 104,672,560 (GRCm39) |
R896W |
probably damaging |
Het |
| Eif1ad19 |
T |
A |
12: 87,740,223 (GRCm39) |
H112L |
probably benign |
Het |
| Fbxl19 |
G |
T |
7: 127,349,390 (GRCm39) |
W160L |
possibly damaging |
Het |
| H1f8 |
T |
C |
6: 115,924,760 (GRCm39) |
Y89H |
probably damaging |
Het |
| Ipo5 |
T |
C |
14: 121,176,053 (GRCm39) |
V626A |
probably damaging |
Het |
| Isx |
A |
G |
8: 75,600,369 (GRCm39) |
K34R |
probably benign |
Het |
| Myh6 |
T |
C |
14: 55,196,011 (GRCm39) |
E596G |
probably benign |
Het |
| Olfml2a |
T |
C |
2: 38,849,832 (GRCm39) |
I516T |
probably damaging |
Het |
| Or14j5 |
C |
T |
17: 38,161,746 (GRCm39) |
R88* |
probably null |
Het |
| Or5w12 |
T |
G |
2: 87,502,244 (GRCm39) |
T156P |
possibly damaging |
Het |
| Parp9 |
T |
C |
16: 35,768,362 (GRCm39) |
F181L |
probably benign |
Het |
| Pkdcc |
G |
A |
17: 83,523,454 (GRCm39) |
G187D |
probably benign |
Het |
| Plekhh3 |
C |
T |
11: 101,055,592 (GRCm39) |
E483K |
possibly damaging |
Het |
| Ptx4 |
C |
T |
17: 25,342,082 (GRCm39) |
Q186* |
probably null |
Het |
| Qsox2 |
T |
A |
2: 26,104,169 (GRCm39) |
H287L |
probably benign |
Het |
| Rev3l |
G |
A |
10: 39,700,483 (GRCm39) |
G1660D |
probably damaging |
Het |
| Scamp1 |
G |
T |
13: 94,344,690 (GRCm39) |
A217E |
possibly damaging |
Het |
| Slc5a9 |
T |
C |
4: 111,742,779 (GRCm39) |
I438V |
probably benign |
Het |
| Sort1 |
T |
C |
3: 108,263,895 (GRCm39) |
F818S |
probably damaging |
Het |
| Srl |
G |
A |
16: 4,314,842 (GRCm39) |
P267S |
probably benign |
Het |
| Tbc1d1 |
T |
C |
5: 64,331,136 (GRCm39) |
I105T |
probably damaging |
Het |
| Tifab |
A |
G |
13: 56,324,060 (GRCm39) |
Y128H |
probably benign |
Het |
| Trp53bp1 |
A |
T |
2: 121,058,282 (GRCm39) |
S907T |
probably damaging |
Het |
| Ubr1 |
G |
A |
2: 120,778,364 (GRCm39) |
R225* |
probably null |
Het |
| Upk3bl |
A |
G |
5: 136,086,330 (GRCm39) |
T89A |
probably benign |
Het |
| Vars1 |
T |
A |
17: 35,233,034 (GRCm39) |
C916* |
probably null |
Het |
| Ywhaz |
T |
C |
15: 36,791,208 (GRCm39) |
E5G |
possibly damaging |
Het |
| Zfp91 |
T |
C |
19: 12,747,419 (GRCm39) |
D568G |
probably damaging |
Het |
| Zgpat |
T |
C |
2: 181,021,985 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Or8b37 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00870:Or8b37
|
APN |
9 |
37,959,036 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02612:Or8b37
|
APN |
9 |
37,958,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02802:Or8b37
|
UTSW |
9 |
37,959,345 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0015:Or8b37
|
UTSW |
9 |
37,958,963 (GRCm39) |
nonsense |
probably null |
|
|
R0142:Or8b37
|
UTSW |
9 |
37,959,406 (GRCm39) |
missense |
probably benign |
0.37 |
|
R0561:Or8b37
|
UTSW |
9 |
37,959,123 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0715:Or8b37
|
UTSW |
9 |
37,959,123 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0723:Or8b37
|
UTSW |
9 |
37,959,123 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0729:Or8b37
|
UTSW |
9 |
37,959,123 (GRCm39) |
missense |
probably benign |
0.16 |
|
R1350:Or8b37
|
UTSW |
9 |
37,959,111 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1869:Or8b37
|
UTSW |
9 |
37,959,498 (GRCm39) |
splice site |
probably null |
|
|
R3917:Or8b37
|
UTSW |
9 |
37,958,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4131:Or8b37
|
UTSW |
9 |
37,959,170 (GRCm39) |
nonsense |
probably null |
|
|
R4764:Or8b37
|
UTSW |
9 |
37,959,436 (GRCm39) |
missense |
probably benign |
|
|
R5857:Or8b37
|
UTSW |
9 |
37,959,049 (GRCm39) |
missense |
probably benign |
0.18 |
|
R5976:Or8b37
|
UTSW |
9 |
37,958,997 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6329:Or8b37
|
UTSW |
9 |
37,959,121 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7344:Or8b37
|
UTSW |
9 |
37,959,253 (GRCm39) |
missense |
probably benign |
|
|
R8289:Or8b37
|
UTSW |
9 |
37,959,000 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8485:Or8b37
|
UTSW |
9 |
37,959,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8973:Or8b37
|
UTSW |
9 |
37,958,839 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9026:Or8b37
|
UTSW |
9 |
37,958,885 (GRCm39) |
nonsense |
probably null |
|
|
R9378:Or8b37
|
UTSW |
9 |
37,958,775 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9395:Or8b37
|
UTSW |
9 |
37,959,136 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9655:Or8b37
|
UTSW |
9 |
37,959,387 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9731:Or8b37
|
UTSW |
9 |
37,958,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF009:Or8b37
|
UTSW |
9 |
37,959,043 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0052:Or8b37
|
UTSW |
9 |
37,958,995 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
Z1177:Or8b37
|
UTSW |
9 |
37,959,111 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCAGGTCACCATGTCTCATCAGG -3'
(R):5'- AGATGAAAGGATTCAGCATTGGACCC -3'
Sequencing Primer
(F):5'- AGGTCTGCCTATTGATGACTATG -3'
(R):5'- TTCAGCATTGGACCCAAAATGG -3'
|
| Posted On |
2013-06-11 |
Incidental Mutation