Incidental Mutation 'R5577:Zfp534'
ID 457963
Institutional Source Beutler Lab
Gene Symbol Zfp534
Ensembl Gene ENSMUSG00000062518
Gene Name zinc finger protein 534
Synonyms Gm13159
MMRRC Submission 043132-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.557) question?
Stock # R5577 (G1)
Quality Score 177
Status Not validated
Chromosome 4
Chromosomal Location 147757959-147787010 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 147759173 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamine at position 499 (K499Q)
Ref Sequence ENSEMBL: ENSMUSP00000113561 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000117638]
AlphaFold A2A7A1
Predicted Effect probably damaging
Transcript: ENSMUST00000117638
AA Change: K499Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000113561
Gene: ENSMUSG00000062518
AA Change: K499Q

DomainStartEndE-ValueType
KRAB 13 76 4.74e-16 SMART
ZnF_C2H2 240 262 2.61e-4 SMART
ZnF_C2H2 268 290 4.01e-5 SMART
ZnF_C2H2 296 318 1.3e-4 SMART
ZnF_C2H2 324 346 1.3e-4 SMART
ZnF_C2H2 352 374 1.47e-3 SMART
ZnF_C2H2 380 402 9.73e-4 SMART
ZnF_C2H2 408 430 1.95e-3 SMART
ZnF_C2H2 436 458 1.47e-3 SMART
ZnF_C2H2 464 486 4.3e-5 SMART
ZnF_C2H2 492 514 1.3e-4 SMART
ZnF_C2H2 520 542 2.57e-3 SMART
ZnF_C2H2 548 570 7.9e-4 SMART
ZnF_C2H2 576 598 3.95e-4 SMART
ZnF_C2H2 604 626 4.3e-5 SMART
ZnF_C2H2 632 654 5.21e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147722
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130023H24Rik A C 7: 127,835,826 (GRCm39) Y256D probably damaging Het
Acr C A 15: 89,458,441 (GRCm39) T374K probably benign Het
Akt2 G A 7: 27,335,731 (GRCm39) G335R probably damaging Het
Ccn3 T A 15: 54,615,897 (GRCm39) I354N possibly damaging Het
Cd177 A T 7: 24,444,562 (GRCm39) F673Y probably damaging Het
Clmn G T 12: 104,743,329 (GRCm39) S879R probably damaging Het
Csrp3 T C 7: 48,489,225 (GRCm39) H19R possibly damaging Het
Dmkn T C 7: 30,463,971 (GRCm39) S137P probably damaging Het
Eno1 C A 4: 150,331,067 (GRCm39) Y236* probably null Het
Enpp7 T A 11: 118,882,953 (GRCm39) N342K probably benign Het
Fancm T A 12: 65,177,185 (GRCm39) probably benign Het
Fshr A T 17: 89,293,351 (GRCm39) D442E probably benign Het
Gm3898 T A 9: 43,741,362 (GRCm39) noncoding transcript Het
Hdac7 A T 15: 97,709,336 (GRCm39) S43T probably benign Het
Herc1 T C 9: 66,389,263 (GRCm39) C3927R probably damaging Het
Klc4 G T 17: 46,946,355 (GRCm39) A490D probably damaging Het
Lcn9 T A 2: 25,713,663 (GRCm39) I63N probably damaging Het
Lgalsl G A 11: 20,779,316 (GRCm39) Q110* probably null Het
Lrp1b A T 2: 40,765,135 (GRCm39) M2783K possibly damaging Het
Lrrk2 A T 15: 91,649,948 (GRCm39) Y1695F probably damaging Het
Myo1e G A 9: 70,277,753 (GRCm39) E817K probably benign Het
Nav3 A T 10: 109,605,264 (GRCm39) D936E probably damaging Het
Necab3 T C 2: 154,387,076 (GRCm39) probably null Het
Nlrp1a T A 11: 70,990,400 (GRCm39) I951F probably damaging Het
Or5v1 T A 17: 37,810,493 (GRCm39) I317K probably benign Het
Or8b52 A G 9: 38,576,297 (GRCm39) I281T possibly damaging Het
Ppp2r5d T C 17: 46,998,901 (GRCm39) S54G probably benign Het
Prdx6 A G 1: 161,071,255 (GRCm39) S146P probably damaging Het
Sec24a A T 11: 51,625,448 (GRCm39) H258Q probably benign Het
Sec31a T C 5: 100,550,133 (GRCm39) T194A possibly damaging Het
Sqstm1 T C 11: 50,098,266 (GRCm39) I167V probably benign Het
Tas1r3 T C 4: 155,946,522 (GRCm39) E361G probably benign Het
Tlr1 T A 5: 65,083,428 (GRCm39) Q383L possibly damaging Het
Trappc8 G C 18: 20,969,836 (GRCm39) Y1051* probably null Het
Vmn2r2 T A 3: 64,024,416 (GRCm39) M722L probably benign Het
Vmn2r43 T C 7: 8,247,811 (GRCm39) H784R probably damaging Het
Other mutations in Zfp534
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT1430001:Zfp534 UTSW 4 147,759,917 (GRCm39) missense probably benign
PIT1430001:Zfp534 UTSW 4 147,759,880 (GRCm39) missense probably benign
PIT4142001:Zfp534 UTSW 4 147,762,770 (GRCm39) missense probably benign 0.13
PIT4142001:Zfp534 UTSW 4 147,760,031 (GRCm39) missense probably benign
R0765:Zfp534 UTSW 4 147,758,693 (GRCm39) missense probably damaging 0.99
R4368:Zfp534 UTSW 4 147,760,015 (GRCm39) missense probably benign 0.15
R4660:Zfp534 UTSW 4 147,759,175 (GRCm39) missense probably benign 0.00
R4816:Zfp534 UTSW 4 147,758,743 (GRCm39) missense possibly damaging 0.81
R5520:Zfp534 UTSW 4 147,759,887 (GRCm39) missense possibly damaging 0.58
R6154:Zfp534 UTSW 4 147,759,145 (GRCm39) missense probably benign 0.18
R6157:Zfp534 UTSW 4 147,758,947 (GRCm39) missense probably benign
R6374:Zfp534 UTSW 4 147,759,299 (GRCm39) missense probably benign 0.44
R6610:Zfp534 UTSW 4 147,758,947 (GRCm39) missense probably benign
R6764:Zfp534 UTSW 4 147,759,175 (GRCm39) missense probably benign 0.00
R6803:Zfp534 UTSW 4 147,758,926 (GRCm39) missense probably damaging 1.00
R6866:Zfp534 UTSW 4 147,758,938 (GRCm39) missense probably benign 0.18
R7027:Zfp534 UTSW 4 147,759,667 (GRCm39) missense possibly damaging 0.58
R7260:Zfp534 UTSW 4 147,759,461 (GRCm39) missense probably benign 0.03
R7455:Zfp534 UTSW 4 147,759,212 (GRCm39) missense probably damaging 1.00
R9128:Zfp534 UTSW 4 147,760,082 (GRCm39) nonsense probably null
R9199:Zfp534 UTSW 4 147,760,439 (GRCm39) missense probably benign 0.00
R9292:Zfp534 UTSW 4 147,759,095 (GRCm39) missense probably damaging 1.00
R9340:Zfp534 UTSW 4 147,758,698 (GRCm39) missense possibly damaging 0.48
R9475:Zfp534 UTSW 4 147,766,731 (GRCm39) missense probably benign 0.21
R9730:Zfp534 UTSW 4 147,759,378 (GRCm39) missense probably damaging 0.99
Z1177:Zfp534 UTSW 4 147,758,684 (GRCm39) makesense probably null
Predicted Primers
Posted On 2017-02-16