Incidental Mutation 'R5606:Vmn1r74'
| ID |
458056 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r74
|
| Ensembl Gene |
ENSMUSG00000047655 |
| Gene Name |
vomeronasal 1 receptor 74 |
| Synonyms |
V1rg5 |
| MMRRC Submission |
043157-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.062)
|
| Stock # |
R5606 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
11580702-11581616 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 11580822 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Valine
at position 41
(M41V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154746
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000050416]
[ENSMUST00000228471]
|
| AlphaFold |
Q8R290 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000050416
AA Change: M41V
PolyPhen 2
Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000055148
Gene: ENSMUSG00000047655
AA Change: M41V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
22 |
290 |
1.3e-7 |
PFAM |
|
Pfam:V1R
|
34 |
296 |
1.2e-31 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000210930
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228471
AA Change: M41V
PolyPhen 2
Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.5%
- 20x: 96.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aldh1a7 |
A |
G |
19: 20,699,731 (GRCm39) |
S75P |
probably damaging |
Het |
| Ankib1 |
A |
T |
5: 3,751,907 (GRCm39) |
I711N |
probably damaging |
Het |
| Ankmy2 |
A |
G |
12: 36,215,920 (GRCm39) |
N40S |
probably benign |
Het |
| Armc8 |
T |
C |
9: 99,418,315 (GRCm39) |
K80E |
probably benign |
Het |
| Blm |
C |
A |
7: 80,110,580 (GRCm39) |
|
probably null |
Het |
| Cand1 |
C |
A |
10: 119,047,359 (GRCm39) |
Q710H |
possibly damaging |
Het |
| Ckap2l |
A |
T |
2: 129,127,959 (GRCm39) |
I73N |
probably damaging |
Het |
| Ddx27 |
T |
A |
2: 166,861,886 (GRCm39) |
D129E |
probably benign |
Het |
| Dnm3 |
T |
C |
1: 162,113,587 (GRCm39) |
E491G |
probably damaging |
Het |
| Fgd6 |
C |
A |
10: 93,974,190 (GRCm39) |
Y1310* |
probably null |
Het |
| Hnrnph3 |
C |
T |
10: 62,855,222 (GRCm39) |
R21H |
possibly damaging |
Het |
| Hs3st4 |
C |
A |
7: 123,996,365 (GRCm39) |
Q344K |
probably damaging |
Het |
| Hyal3 |
T |
C |
9: 107,462,265 (GRCm39) |
S100P |
probably benign |
Het |
| Map3k19 |
G |
A |
1: 127,750,694 (GRCm39) |
R886C |
probably benign |
Het |
| Mmrn2 |
G |
A |
14: 34,119,581 (GRCm39) |
D187N |
probably damaging |
Het |
| Myo5c |
G |
A |
9: 75,182,790 (GRCm39) |
A810T |
probably damaging |
Het |
| Noxa1 |
T |
A |
2: 24,976,292 (GRCm39) |
E332V |
possibly damaging |
Het |
| Or10al7 |
T |
C |
17: 38,365,693 (GRCm39) |
T264A |
probably damaging |
Het |
| Or12j5 |
T |
A |
7: 140,083,713 (GRCm39) |
I220F |
probably damaging |
Het |
| Or51r1 |
T |
C |
7: 102,228,481 (GRCm39) |
S260P |
probably damaging |
Het |
| Or7c70 |
A |
G |
10: 78,683,395 (GRCm39) |
M118T |
probably benign |
Het |
| Parg |
T |
A |
14: 31,984,693 (GRCm39) |
V241E |
probably damaging |
Het |
| Pitrm1 |
T |
A |
13: 6,610,101 (GRCm39) |
V391D |
probably damaging |
Het |
| Plch1 |
A |
T |
3: 63,648,108 (GRCm39) |
V421E |
probably benign |
Het |
| Slc27a2 |
C |
T |
2: 126,406,610 (GRCm39) |
A98V |
probably damaging |
Het |
| Spta1 |
A |
T |
1: 174,047,468 (GRCm39) |
H1704L |
probably damaging |
Het |
| Tbpl2 |
G |
A |
2: 23,977,245 (GRCm39) |
P258S |
possibly damaging |
Het |
| Thoc2l |
T |
C |
5: 104,669,744 (GRCm39) |
I1422T |
probably benign |
Het |
| Tlr11 |
T |
C |
14: 50,599,717 (GRCm39) |
C568R |
probably benign |
Het |
| Tmem260 |
T |
A |
14: 48,722,437 (GRCm39) |
M324K |
probably damaging |
Het |
| Tmprss11g |
T |
A |
5: 86,635,269 (GRCm39) |
T402S |
probably damaging |
Het |
| Trim21 |
C |
G |
7: 102,208,813 (GRCm39) |
R302P |
probably damaging |
Het |
| Uox |
T |
A |
3: 146,316,057 (GRCm39) |
Y21* |
probably null |
Het |
| Vmn2r59 |
A |
C |
7: 41,695,318 (GRCm39) |
S365A |
probably benign |
Het |
| Zfp345 |
A |
T |
2: 150,316,788 (GRCm39) |
Y6* |
probably null |
Het |
| Zpld2 |
A |
C |
4: 133,927,523 (GRCm39) |
V410G |
probably benign |
Het |
|
| Other mutations in Vmn1r74 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01608:Vmn1r74
|
APN |
7 |
11,581,560 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01673:Vmn1r74
|
APN |
7 |
11,581,317 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03023:Vmn1r74
|
APN |
7 |
11,581,257 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL03409:Vmn1r74
|
APN |
7 |
11,581,240 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0393:Vmn1r74
|
UTSW |
7 |
11,581,242 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1488:Vmn1r74
|
UTSW |
7 |
11,581,510 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1707:Vmn1r74
|
UTSW |
7 |
11,581,504 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1998:Vmn1r74
|
UTSW |
7 |
11,581,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1999:Vmn1r74
|
UTSW |
7 |
11,581,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2139:Vmn1r74
|
UTSW |
7 |
11,581,243 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4027:Vmn1r74
|
UTSW |
7 |
11,580,898 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4576:Vmn1r74
|
UTSW |
7 |
11,580,696 (GRCm39) |
splice site |
probably null |
|
|
R4619:Vmn1r74
|
UTSW |
7 |
11,581,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4619:Vmn1r74
|
UTSW |
7 |
11,581,398 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R5371:Vmn1r74
|
UTSW |
7 |
11,580,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Vmn1r74
|
UTSW |
7 |
11,581,131 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6901:Vmn1r74
|
UTSW |
7 |
11,581,368 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6920:Vmn1r74
|
UTSW |
7 |
11,581,575 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7223:Vmn1r74
|
UTSW |
7 |
11,580,894 (GRCm39) |
nonsense |
probably null |
|
|
R7231:Vmn1r74
|
UTSW |
7 |
11,580,888 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7418:Vmn1r74
|
UTSW |
7 |
11,581,081 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8135:Vmn1r74
|
UTSW |
7 |
11,581,530 (GRCm39) |
missense |
probably benign |
0.36 |
|
R8692:Vmn1r74
|
UTSW |
7 |
11,580,972 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8748:Vmn1r74
|
UTSW |
7 |
11,580,903 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9004:Vmn1r74
|
UTSW |
7 |
11,580,840 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9258:Vmn1r74
|
UTSW |
7 |
11,580,999 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9564:Vmn1r74
|
UTSW |
7 |
11,581,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF049:Vmn1r74
|
UTSW |
7 |
11,581,067 (GRCm39) |
frame shift |
probably null |
|
|
RF063:Vmn1r74
|
UTSW |
7 |
11,581,067 (GRCm39) |
frame shift |
probably null |
|
|
Z1176:Vmn1r74
|
UTSW |
7 |
11,580,936 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
|
| Posted On |
2017-02-16 |
Incidental Mutation