Incidental Mutation 'R0561:Armc2'
ID 45882
Institutional Source Beutler Lab
Gene Symbol Armc2
Ensembl Gene ENSMUSG00000071324
Gene Name armadillo repeat containing 2
Synonyms 2610018I05Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0561 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 41790986-41894438 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 41869188 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 166 (V166A)
Ref Sequence ENSEMBL: ENSMUSP00000125412 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095729] [ENSMUST00000160262] [ENSMUST00000161167] [ENSMUST00000161927]
AlphaFold Q3URY6
Predicted Effect probably benign
Transcript: ENSMUST00000095729
AA Change: V166A

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000093397
Gene: ENSMUSG00000071324
AA Change: V166A

DomainStartEndE-ValueType
low complexity region 58 73 N/A INTRINSIC
low complexity region 222 237 N/A INTRINSIC
low complexity region 272 281 N/A INTRINSIC
low complexity region 324 336 N/A INTRINSIC
ARM 355 393 7.53e1 SMART
ARM 400 453 3.69e1 SMART
ARM 454 496 8.23e1 SMART
Blast:ARM 497 540 1e-16 BLAST
Blast:ARM 542 603 1e-6 BLAST
Blast:ARM 603 649 7e-20 BLAST
Blast:ARM 653 692 3e-8 BLAST
ARM 693 733 4.41e1 SMART
ARM 734 777 2.7e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000160262
AA Change: V166A

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000125412
Gene: ENSMUSG00000071324
AA Change: V166A

DomainStartEndE-ValueType
low complexity region 58 73 N/A INTRINSIC
low complexity region 222 237 N/A INTRINSIC
low complexity region 272 281 N/A INTRINSIC
low complexity region 324 336 N/A INTRINSIC
ARM 355 393 7.53e1 SMART
ARM 400 453 3.69e1 SMART
ARM 454 496 8.23e1 SMART
Blast:ARM 497 540 1e-16 BLAST
Blast:ARM 542 603 1e-6 BLAST
Blast:ARM 603 649 7e-20 BLAST
Blast:ARM 653 692 3e-8 BLAST
ARM 693 733 4.41e1 SMART
ARM 734 777 2.7e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000161167
Predicted Effect probably benign
Transcript: ENSMUST00000161927
SMART Domains Protein: ENSMUSP00000124049
Gene: ENSMUSG00000071324

DomainStartEndE-ValueType
low complexity region 58 75 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 96.9%
  • 20x: 94.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck1 A G 12: 88,335,204 (GRCm39) D30G possibly damaging Het
Apc A T 18: 34,446,356 (GRCm39) H1050L possibly damaging Het
Atp6v1b1 A T 6: 83,730,793 (GRCm39) I173F probably damaging Het
Bpifb4 A G 2: 153,786,742 (GRCm39) D298G probably damaging Het
C4b T A 17: 34,953,391 (GRCm39) S1031C probably damaging Het
Calcr A G 6: 3,692,630 (GRCm39) I408T probably damaging Het
Catsperg1 T C 7: 28,881,737 (GRCm39) N1009S probably damaging Het
Ces2a T C 8: 105,464,165 (GRCm39) S266P probably benign Het
Chrna1 A G 2: 73,396,596 (GRCm39) V433A possibly damaging Het
Ctnnb1 G A 9: 120,780,788 (GRCm39) V291M probably damaging Het
Dcbld1 T C 10: 52,138,032 (GRCm39) Y99H probably benign Het
Ddx60 A T 8: 62,470,828 (GRCm39) H1440L possibly damaging Het
Dsg1c A T 18: 20,407,832 (GRCm39) I393L probably benign Het
Eif5 G T 12: 111,506,950 (GRCm39) R128L probably benign Het
Ercc3 A G 18: 32,378,592 (GRCm39) D191G possibly damaging Het
Gp1ba A T 11: 70,530,416 (GRCm39) probably benign Het
Krt24 C T 11: 99,175,439 (GRCm39) E199K probably damaging Het
Lrif1 G T 3: 106,639,481 (GRCm39) A164S probably damaging Het
Map2 A G 1: 66,464,656 (GRCm39) D1682G probably damaging Het
Megf8 C T 7: 25,028,257 (GRCm39) P274S probably benign Het
Mslnl C T 17: 25,962,177 (GRCm39) Q192* probably null Het
Nfkb2 T C 19: 46,298,301 (GRCm39) V535A possibly damaging Het
Or10q1 A T 19: 13,726,662 (GRCm39) Y64F probably damaging Het
Or4a66 A G 2: 88,530,914 (GRCm39) I253T possibly damaging Het
Or4c11 T A 2: 88,695,024 (GRCm39) V25E possibly damaging Het
Or7a37 T A 10: 78,805,729 (GRCm39) L82* probably null Het
Or8b37 G T 9: 37,959,123 (GRCm39) V202L probably benign Het
Or8g22 C T 9: 38,958,669 (GRCm39) M15I probably damaging Het
Pag1 T A 3: 9,764,481 (GRCm39) Y224F probably damaging Het
Pbrm1 A C 14: 30,757,948 (GRCm39) I193L probably benign Het
Phrf1 T C 7: 140,834,876 (GRCm39) V17A probably benign Het
Plekhg2 T G 7: 28,069,908 (GRCm39) T42P probably benign Het
Pmp22 T A 11: 63,025,250 (GRCm39) W28R probably damaging Het
Ppp1r13b A T 12: 111,832,880 (GRCm39) H82Q probably damaging Het
Rgs8 T C 1: 153,541,668 (GRCm39) probably null Het
Rtl1 A G 12: 109,560,363 (GRCm39) V492A probably damaging Het
Slc22a27 A G 19: 7,857,527 (GRCm39) probably null Het
Slx4ip A G 2: 136,908,090 (GRCm39) E79G probably null Het
Syde1 C T 10: 78,425,210 (GRCm39) R267H probably damaging Het
Tas2r114 A G 6: 131,666,758 (GRCm39) I90T probably benign Het
Tjp3 C T 10: 81,109,674 (GRCm39) G843D probably benign Het
Tln1 A T 4: 43,550,304 (GRCm39) M453K possibly damaging Het
Ttc39a A T 4: 109,297,799 (GRCm39) Y408F probably damaging Het
Usp39 T G 6: 72,313,368 (GRCm39) Q274P probably damaging Het
Uvrag C T 7: 98,537,768 (GRCm39) V476I probably damaging Het
Vcan T A 13: 89,860,372 (GRCm39) T332S probably damaging Het
Vcan T A 13: 89,879,583 (GRCm39) H22L possibly damaging Het
Wls A G 3: 159,578,705 (GRCm39) D89G probably benign Het
Zfhx2 A T 14: 55,303,346 (GRCm39) V1546E probably benign Het
Zfp457 T A 13: 67,442,134 (GRCm39) H147L probably damaging Het
Other mutations in Armc2
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4131001:Armc2 UTSW 10 41,823,883 (GRCm39) splice site probably benign
R0144:Armc2 UTSW 10 41,823,883 (GRCm39) splice site probably benign
R0427:Armc2 UTSW 10 41,876,406 (GRCm39) missense possibly damaging 0.87
R0540:Armc2 UTSW 10 41,798,691 (GRCm39) missense probably benign 0.11
R0607:Armc2 UTSW 10 41,798,691 (GRCm39) missense probably benign 0.11
R1099:Armc2 UTSW 10 41,793,183 (GRCm39) missense probably benign 0.39
R1130:Armc2 UTSW 10 41,887,830 (GRCm39) missense possibly damaging 0.85
R2116:Armc2 UTSW 10 41,839,663 (GRCm39) missense probably damaging 0.98
R2870:Armc2 UTSW 10 41,842,696 (GRCm39) critical splice donor site probably null
R2870:Armc2 UTSW 10 41,842,696 (GRCm39) critical splice donor site probably null
R2871:Armc2 UTSW 10 41,842,696 (GRCm39) critical splice donor site probably null
R2871:Armc2 UTSW 10 41,842,696 (GRCm39) critical splice donor site probably null
R2872:Armc2 UTSW 10 41,842,696 (GRCm39) critical splice donor site probably null
R2872:Armc2 UTSW 10 41,842,696 (GRCm39) critical splice donor site probably null
R2873:Armc2 UTSW 10 41,842,696 (GRCm39) critical splice donor site probably null
R3083:Armc2 UTSW 10 41,842,726 (GRCm39) missense probably damaging 1.00
R3771:Armc2 UTSW 10 41,798,223 (GRCm39) missense probably damaging 1.00
R3784:Armc2 UTSW 10 41,798,190 (GRCm39) missense probably benign 0.08
R3880:Armc2 UTSW 10 41,839,721 (GRCm39) missense possibly damaging 0.71
R4024:Armc2 UTSW 10 41,869,054 (GRCm39) missense probably benign
R4155:Armc2 UTSW 10 41,887,863 (GRCm39) missense probably damaging 0.96
R4370:Armc2 UTSW 10 41,793,196 (GRCm39) missense probably benign 0.13
R4378:Armc2 UTSW 10 41,869,078 (GRCm39) missense possibly damaging 0.66
R4896:Armc2 UTSW 10 41,799,790 (GRCm39) missense probably damaging 1.00
R5119:Armc2 UTSW 10 41,798,144 (GRCm39) missense probably damaging 1.00
R5159:Armc2 UTSW 10 41,884,711 (GRCm39) missense probably damaging 0.96
R5517:Armc2 UTSW 10 41,839,846 (GRCm39) missense probably benign 0.29
R5640:Armc2 UTSW 10 41,887,894 (GRCm39) missense possibly damaging 0.87
R5767:Armc2 UTSW 10 41,887,923 (GRCm39) missense probably benign 0.02
R5965:Armc2 UTSW 10 41,798,568 (GRCm39) missense possibly damaging 0.94
R6897:Armc2 UTSW 10 41,869,225 (GRCm39) critical splice acceptor site probably null
R7233:Armc2 UTSW 10 41,799,800 (GRCm39) missense probably damaging 1.00
R7829:Armc2 UTSW 10 41,802,856 (GRCm39) missense probably benign
R7832:Armc2 UTSW 10 41,842,792 (GRCm39) missense probably damaging 1.00
R7999:Armc2 UTSW 10 41,887,954 (GRCm39) missense possibly damaging 0.62
R8029:Armc2 UTSW 10 41,802,996 (GRCm39) missense probably damaging 1.00
R8030:Armc2 UTSW 10 41,842,738 (GRCm39) missense possibly damaging 0.73
R8033:Armc2 UTSW 10 41,884,680 (GRCm39) missense possibly damaging 0.87
R8191:Armc2 UTSW 10 41,839,747 (GRCm39) missense probably benign 0.29
R8304:Armc2 UTSW 10 41,823,935 (GRCm39) missense probably damaging 1.00
R8334:Armc2 UTSW 10 41,799,761 (GRCm39) missense probably damaging 1.00
R8370:Armc2 UTSW 10 41,799,833 (GRCm39) missense possibly damaging 0.96
R9142:Armc2 UTSW 10 41,851,404 (GRCm39) missense probably benign 0.00
R9227:Armc2 UTSW 10 41,823,935 (GRCm39) missense probably damaging 1.00
R9230:Armc2 UTSW 10 41,823,935 (GRCm39) missense probably damaging 1.00
R9320:Armc2 UTSW 10 41,839,774 (GRCm39) missense possibly damaging 0.85
R9708:Armc2 UTSW 10 41,839,744 (GRCm39) missense possibly damaging 0.87
R9743:Armc2 UTSW 10 41,798,598 (GRCm39) missense probably benign 0.25
R9746:Armc2 UTSW 10 41,800,457 (GRCm39) missense probably damaging 1.00
Z1176:Armc2 UTSW 10 41,839,652 (GRCm39) missense probably damaging 1.00
Z1176:Armc2 UTSW 10 41,803,040 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATCATTACGGCCATCATGCGGG -3'
(R):5'- GTCTTCCTTCAGGTTGACTCCAAGC -3'

Sequencing Primer
(F):5'- TGAGAGGCAATGGTTACCCC -3'
(R):5'- CTTCAGGTTGACTCCAAGCTAATAG -3'
Posted On 2013-06-11