Incidental Mutation 'R0561:Or7a37'
ID 45885
Institutional Source Beutler Lab
Gene Symbol Or7a37
Ensembl Gene ENSMUSG00000042774
Gene Name olfactory receptor family 7 subfamily A member 37
Synonyms GA_x6K02T2QGN0-2842591-2841662, Olfr1353, MOR139-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R0561 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 78799143-78806446 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 78805729 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 82 (L82*)
Ref Sequence ENSEMBL: ENSMUSP00000145073 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039718] [ENSMUST00000204849] [ENSMUST00000205193] [ENSMUST00000205193]
AlphaFold Q8VGU8
Predicted Effect probably null
Transcript: ENSMUST00000039718
AA Change: L82*
SMART Domains Protein: ENSMUSP00000038992
Gene: ENSMUSG00000042774
AA Change: L82*

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.9e-6 PFAM
Pfam:7tm_1 41 290 9.3e-27 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000204849
AA Change: L82*
SMART Domains Protein: ENSMUSP00000145454
Gene: ENSMUSG00000042774
AA Change: L82*

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.9e-6 PFAM
Pfam:7tm_1 41 290 9.3e-27 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000205193
AA Change: L82*
SMART Domains Protein: ENSMUSP00000145073
Gene: ENSMUSG00000042774
AA Change: L82*

DomainStartEndE-ValueType
Pfam:7tm_4 31 95 5.8e-10 PFAM
Pfam:7tm_1 41 94 3.5e-8 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000205193
AA Change: L82*
SMART Domains Protein: ENSMUSP00000145073
Gene: ENSMUSG00000042774
AA Change: L82*

DomainStartEndE-ValueType
Pfam:7tm_4 31 95 5.8e-10 PFAM
Pfam:7tm_1 41 94 3.5e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219714
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 96.9%
  • 20x: 94.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck1 A G 12: 88,335,204 (GRCm39) D30G possibly damaging Het
Apc A T 18: 34,446,356 (GRCm39) H1050L possibly damaging Het
Armc2 A G 10: 41,869,188 (GRCm39) V166A probably benign Het
Atp6v1b1 A T 6: 83,730,793 (GRCm39) I173F probably damaging Het
Bpifb4 A G 2: 153,786,742 (GRCm39) D298G probably damaging Het
C4b T A 17: 34,953,391 (GRCm39) S1031C probably damaging Het
Calcr A G 6: 3,692,630 (GRCm39) I408T probably damaging Het
Catsperg1 T C 7: 28,881,737 (GRCm39) N1009S probably damaging Het
Ces2a T C 8: 105,464,165 (GRCm39) S266P probably benign Het
Chrna1 A G 2: 73,396,596 (GRCm39) V433A possibly damaging Het
Ctnnb1 G A 9: 120,780,788 (GRCm39) V291M probably damaging Het
Dcbld1 T C 10: 52,138,032 (GRCm39) Y99H probably benign Het
Ddx60 A T 8: 62,470,828 (GRCm39) H1440L possibly damaging Het
Dsg1c A T 18: 20,407,832 (GRCm39) I393L probably benign Het
Eif5 G T 12: 111,506,950 (GRCm39) R128L probably benign Het
Ercc3 A G 18: 32,378,592 (GRCm39) D191G possibly damaging Het
Gp1ba A T 11: 70,530,416 (GRCm39) probably benign Het
Krt24 C T 11: 99,175,439 (GRCm39) E199K probably damaging Het
Lrif1 G T 3: 106,639,481 (GRCm39) A164S probably damaging Het
Map2 A G 1: 66,464,656 (GRCm39) D1682G probably damaging Het
Megf8 C T 7: 25,028,257 (GRCm39) P274S probably benign Het
Mslnl C T 17: 25,962,177 (GRCm39) Q192* probably null Het
Nfkb2 T C 19: 46,298,301 (GRCm39) V535A possibly damaging Het
Or10q1 A T 19: 13,726,662 (GRCm39) Y64F probably damaging Het
Or4a66 A G 2: 88,530,914 (GRCm39) I253T possibly damaging Het
Or4c11 T A 2: 88,695,024 (GRCm39) V25E possibly damaging Het
Or8b37 G T 9: 37,959,123 (GRCm39) V202L probably benign Het
Or8g22 C T 9: 38,958,669 (GRCm39) M15I probably damaging Het
Pag1 T A 3: 9,764,481 (GRCm39) Y224F probably damaging Het
Pbrm1 A C 14: 30,757,948 (GRCm39) I193L probably benign Het
Phrf1 T C 7: 140,834,876 (GRCm39) V17A probably benign Het
Plekhg2 T G 7: 28,069,908 (GRCm39) T42P probably benign Het
Pmp22 T A 11: 63,025,250 (GRCm39) W28R probably damaging Het
Ppp1r13b A T 12: 111,832,880 (GRCm39) H82Q probably damaging Het
Rgs8 T C 1: 153,541,668 (GRCm39) probably null Het
Rtl1 A G 12: 109,560,363 (GRCm39) V492A probably damaging Het
Slc22a27 A G 19: 7,857,527 (GRCm39) probably null Het
Slx4ip A G 2: 136,908,090 (GRCm39) E79G probably null Het
Syde1 C T 10: 78,425,210 (GRCm39) R267H probably damaging Het
Tas2r114 A G 6: 131,666,758 (GRCm39) I90T probably benign Het
Tjp3 C T 10: 81,109,674 (GRCm39) G843D probably benign Het
Tln1 A T 4: 43,550,304 (GRCm39) M453K possibly damaging Het
Ttc39a A T 4: 109,297,799 (GRCm39) Y408F probably damaging Het
Usp39 T G 6: 72,313,368 (GRCm39) Q274P probably damaging Het
Uvrag C T 7: 98,537,768 (GRCm39) V476I probably damaging Het
Vcan T A 13: 89,860,372 (GRCm39) T332S probably damaging Het
Vcan T A 13: 89,879,583 (GRCm39) H22L possibly damaging Het
Wls A G 3: 159,578,705 (GRCm39) D89G probably benign Het
Zfhx2 A T 14: 55,303,346 (GRCm39) V1546E probably benign Het
Zfp457 T A 13: 67,442,134 (GRCm39) H147L probably damaging Het
Other mutations in Or7a37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02135:Or7a37 APN 10 78,805,940 (GRCm39) missense probably damaging 1.00
IGL02159:Or7a37 APN 10 78,805,735 (GRCm39) missense probably damaging 1.00
R0355:Or7a37 UTSW 10 78,806,267 (GRCm39) missense probably damaging 1.00
R1305:Or7a37 UTSW 10 78,805,933 (GRCm39) missense probably benign 0.03
R1921:Or7a37 UTSW 10 78,805,975 (GRCm39) nonsense probably null
R1922:Or7a37 UTSW 10 78,805,975 (GRCm39) nonsense probably null
R2382:Or7a37 UTSW 10 78,805,990 (GRCm39) missense probably damaging 0.99
R2920:Or7a37 UTSW 10 78,805,846 (GRCm39) missense probably damaging 1.00
R4491:Or7a37 UTSW 10 78,806,151 (GRCm39) missense probably damaging 1.00
R5113:Or7a37 UTSW 10 78,806,037 (GRCm39) missense probably benign
R5305:Or7a37 UTSW 10 78,806,390 (GRCm39) missense possibly damaging 0.68
R5744:Or7a37 UTSW 10 78,806,017 (GRCm39) missense probably damaging 1.00
R5861:Or7a37 UTSW 10 78,805,765 (GRCm39) missense probably damaging 1.00
R6197:Or7a37 UTSW 10 78,805,974 (GRCm39) missense probably damaging 1.00
R6314:Or7a37 UTSW 10 78,806,179 (GRCm39) missense probably benign
R7693:Or7a37 UTSW 10 78,806,137 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACATGATCTCTCAGGGATAAAGGCTCA -3'
(R):5'- TGATAACTGTGTAGCGCATAGGGTGA -3'

Sequencing Primer
(F):5'- CAGGACAAGAGTTGCAGAATTTCTTC -3'
(R):5'- TAGCGCATAGGGTGACAGATG -3'
Posted On 2013-06-11