Incidental Mutation 'R0562:Vmn2r75'
| ID |
45943 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r75
|
| Ensembl Gene |
ENSMUSG00000090436 |
| Gene Name |
vomeronasal 2, receptor 75 |
| Synonyms |
EG546981 |
| MMRRC Submission |
038753-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.090)
|
| Stock # |
R0562 (G1)
|
| Quality Score |
218 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
85797250-85820932 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to T
at 85797449 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tryptophan to Stop codon
at position 788
(W788*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126973
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167830]
|
| AlphaFold |
G5E8Z7 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000167830
AA Change: W788*
|
| SMART Domains |
Protein: ENSMUSP00000126973
Gene: ENSMUSG00000090436
AA Change: W788*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
80 |
466 |
2.8e-31 |
PFAM |
|
Pfam:NCD3G
|
510 |
562 |
4.6e-20 |
PFAM |
|
Pfam:7tm_3
|
593 |
829 |
7.7e-51 |
PFAM |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.9%
|
| Validation Efficiency |
100% (77/77) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acadsb |
C |
T |
7: 131,027,518 (GRCm39) |
Q63* |
probably null |
Het |
| Adam26b |
A |
T |
8: 43,973,408 (GRCm39) |
N531K |
probably benign |
Het |
| Agt |
A |
G |
8: 125,286,014 (GRCm39) |
I356T |
probably benign |
Het |
| Ankmy1 |
A |
T |
1: 92,827,413 (GRCm39) |
|
probably benign |
Het |
| Anxa3 |
C |
T |
5: 96,960,743 (GRCm39) |
S49L |
possibly damaging |
Het |
| Arap3 |
C |
A |
18: 38,108,593 (GRCm39) |
R1279L |
probably damaging |
Het |
| Azin1 |
A |
G |
15: 38,493,825 (GRCm39) |
I266T |
probably benign |
Het |
| Btnl7-ps |
T |
C |
17: 34,752,498 (GRCm39) |
|
noncoding transcript |
Het |
| Car5a |
T |
A |
8: 122,671,469 (GRCm39) |
T22S |
probably benign |
Het |
| Card6 |
A |
G |
15: 5,134,648 (GRCm39) |
I185T |
probably damaging |
Het |
| Ccdc81 |
T |
C |
7: 89,552,437 (GRCm39) |
D11G |
probably benign |
Het |
| Cep170b |
T |
C |
12: 112,705,623 (GRCm39) |
V1127A |
probably benign |
Het |
| Ces1h |
T |
C |
8: 94,083,771 (GRCm39) |
I390M |
unknown |
Het |
| Col9a1 |
T |
A |
1: 24,218,360 (GRCm39) |
|
probably null |
Het |
| Cwc27 |
C |
A |
13: 104,797,865 (GRCm39) |
E365* |
probably null |
Het |
| Cyb561a3 |
T |
C |
19: 10,564,074 (GRCm39) |
V138A |
probably benign |
Het |
| Dcaf1 |
T |
C |
9: 106,721,321 (GRCm39) |
|
probably benign |
Het |
| Dnah17 |
A |
G |
11: 117,963,726 (GRCm39) |
Y2516H |
probably damaging |
Het |
| Dsc2 |
T |
A |
18: 20,174,594 (GRCm39) |
N521Y |
probably damaging |
Het |
| Dst |
G |
A |
1: 34,267,062 (GRCm39) |
E4835K |
probably damaging |
Het |
| Duox2 |
T |
C |
2: 122,120,080 (GRCm39) |
E810G |
probably damaging |
Het |
| Dusp15 |
T |
C |
2: 152,793,268 (GRCm39) |
N3S |
possibly damaging |
Het |
| Eif1ad9 |
A |
G |
12: 88,296,436 (GRCm39) |
D138G |
unknown |
Het |
| Epha4 |
T |
C |
1: 77,365,124 (GRCm39) |
K625R |
probably benign |
Het |
| Fcgbpl1 |
G |
A |
7: 27,862,115 (GRCm39) |
V2394I |
probably benign |
Het |
| Gata5 |
C |
T |
2: 179,969,552 (GRCm39) |
|
probably null |
Het |
| Grm5 |
A |
G |
7: 87,252,227 (GRCm39) |
N159S |
probably damaging |
Het |
| Hivep3 |
T |
A |
4: 119,953,751 (GRCm39) |
M689K |
probably benign |
Het |
| Ift56 |
T |
A |
6: 38,378,064 (GRCm39) |
V292E |
probably damaging |
Het |
| Ilvbl |
G |
T |
10: 78,419,321 (GRCm39) |
G499C |
probably damaging |
Het |
| Inpp4b |
T |
C |
8: 82,494,780 (GRCm39) |
I65T |
possibly damaging |
Het |
| Jarid2 |
T |
C |
13: 45,055,835 (GRCm39) |
V208A |
probably damaging |
Het |
| Kcnh4 |
T |
C |
11: 100,641,070 (GRCm39) |
M460V |
possibly damaging |
Het |
| Klhl22 |
A |
G |
16: 17,610,488 (GRCm39) |
N580D |
probably benign |
Het |
| Klk15 |
T |
A |
7: 43,588,269 (GRCm39) |
C192* |
probably null |
Het |
| Klk1b9 |
A |
G |
7: 43,445,090 (GRCm39) |
E194G |
probably damaging |
Het |
| Lama1 |
G |
T |
17: 68,122,954 (GRCm39) |
G2779V |
probably damaging |
Het |
| Lmln |
C |
T |
16: 32,937,455 (GRCm39) |
R607* |
probably null |
Het |
| Maea |
T |
C |
5: 33,529,645 (GRCm39) |
V377A |
probably benign |
Het |
| Matk |
A |
T |
10: 81,095,525 (GRCm39) |
Y115F |
probably benign |
Het |
| Mettl18 |
A |
G |
1: 163,824,062 (GRCm39) |
K128E |
probably benign |
Het |
| Mrps22 |
T |
C |
9: 98,474,746 (GRCm39) |
H246R |
probably benign |
Het |
| Msln |
A |
T |
17: 25,971,980 (GRCm39) |
M79K |
probably benign |
Het |
| Myf6 |
G |
A |
10: 107,330,420 (GRCm39) |
P49L |
probably benign |
Het |
| Nat1 |
C |
T |
8: 67,943,963 (GRCm39) |
T113I |
possibly damaging |
Het |
| Ncor2 |
C |
T |
5: 125,162,093 (GRCm39) |
V394M |
unknown |
Het |
| Oas1c |
T |
C |
5: 120,943,669 (GRCm39) |
|
probably benign |
Het |
| Or8k21 |
T |
A |
2: 86,144,869 (GRCm39) |
T254S |
probably benign |
Het |
| Otp |
A |
T |
13: 95,013,917 (GRCm39) |
T112S |
probably damaging |
Het |
| Pcdh7 |
A |
G |
5: 57,877,405 (GRCm39) |
N320S |
probably damaging |
Het |
| Pdzd2 |
G |
T |
15: 12,592,364 (GRCm39) |
F93L |
probably damaging |
Het |
| Phf20l1 |
A |
G |
15: 66,481,453 (GRCm39) |
E283G |
probably damaging |
Het |
| Polr1e |
T |
C |
4: 45,029,421 (GRCm39) |
F342S |
probably damaging |
Het |
| Pp2d1 |
T |
A |
17: 53,846,196 (GRCm39) |
|
probably benign |
Het |
| Ptpn13 |
T |
A |
5: 103,664,291 (GRCm39) |
|
probably null |
Het |
| Reg3g |
A |
T |
6: 78,444,471 (GRCm39) |
H107Q |
possibly damaging |
Het |
| Rgl1 |
T |
C |
1: 152,415,696 (GRCm39) |
K408E |
probably damaging |
Het |
| Samd4 |
T |
C |
14: 47,314,966 (GRCm39) |
C309R |
probably damaging |
Het |
| Sestd1 |
C |
A |
2: 77,061,066 (GRCm39) |
W104L |
probably benign |
Het |
| Sfmbt1 |
T |
A |
14: 30,533,330 (GRCm39) |
|
probably null |
Het |
| Slc22a21 |
T |
A |
11: 53,870,446 (GRCm39) |
K80* |
probably null |
Het |
| Snx20 |
T |
A |
8: 89,356,630 (GRCm39) |
Q62L |
probably benign |
Het |
| Spef1l |
T |
C |
7: 139,557,026 (GRCm39) |
M120V |
probably benign |
Het |
| Stk40 |
C |
A |
4: 126,032,594 (GRCm39) |
|
probably benign |
Het |
| Taf2 |
A |
T |
15: 54,885,584 (GRCm39) |
|
probably benign |
Het |
| Tcf23 |
C |
T |
5: 31,127,654 (GRCm39) |
P152L |
probably damaging |
Het |
| Tex29 |
T |
C |
8: 11,894,138 (GRCm39) |
|
probably benign |
Het |
| Tjp3 |
A |
G |
10: 81,116,389 (GRCm39) |
V235A |
probably damaging |
Het |
| Tns3 |
A |
T |
11: 8,443,262 (GRCm39) |
I367N |
possibly damaging |
Het |
| Ttn |
T |
A |
2: 76,543,255 (GRCm39) |
M33244L |
probably benign |
Het |
| Ush2a |
A |
T |
1: 188,089,044 (GRCm39) |
N333I |
probably damaging |
Het |
| Usp34 |
T |
C |
11: 23,382,406 (GRCm39) |
|
probably benign |
Het |
| Vmn1r204 |
A |
C |
13: 22,740,848 (GRCm39) |
S160R |
probably benign |
Het |
| Vwa5b1 |
T |
C |
4: 138,363,022 (GRCm39) |
|
probably benign |
Het |
| Zbtb7a |
A |
G |
10: 80,984,163 (GRCm39) |
E535G |
probably benign |
Het |
| Zfp1004 |
T |
A |
2: 150,034,494 (GRCm39) |
C303S |
probably damaging |
Het |
| Zranb3 |
T |
C |
1: 127,964,295 (GRCm39) |
D144G |
probably benign |
Het |
|
| Other mutations in Vmn2r75 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01133:Vmn2r75
|
APN |
7 |
85,797,240 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01287:Vmn2r75
|
APN |
7 |
85,797,801 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01318:Vmn2r75
|
APN |
7 |
85,814,774 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01331:Vmn2r75
|
APN |
7 |
85,820,870 (GRCm39) |
nonsense |
probably null |
|
|
IGL01406:Vmn2r75
|
APN |
7 |
85,812,500 (GRCm39) |
splice site |
probably benign |
|
|
IGL01615:Vmn2r75
|
APN |
7 |
85,797,681 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01657:Vmn2r75
|
APN |
7 |
85,813,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02237:Vmn2r75
|
APN |
7 |
85,814,786 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02275:Vmn2r75
|
APN |
7 |
85,814,348 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02307:Vmn2r75
|
APN |
7 |
85,814,974 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03136:Vmn2r75
|
APN |
7 |
85,797,911 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL03160:Vmn2r75
|
APN |
7 |
85,797,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03244:Vmn2r75
|
APN |
7 |
85,820,933 (GRCm39) |
unclassified |
probably benign |
|
|
PIT4449001:Vmn2r75
|
UTSW |
7 |
85,814,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0049:Vmn2r75
|
UTSW |
7 |
85,797,309 (GRCm39) |
nonsense |
probably null |
|
|
R0049:Vmn2r75
|
UTSW |
7 |
85,797,309 (GRCm39) |
nonsense |
probably null |
|
|
R0083:Vmn2r75
|
UTSW |
7 |
85,814,866 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0108:Vmn2r75
|
UTSW |
7 |
85,814,866 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0276:Vmn2r75
|
UTSW |
7 |
85,797,515 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0320:Vmn2r75
|
UTSW |
7 |
85,814,288 (GRCm39) |
missense |
probably benign |
0.36 |
|
R0471:Vmn2r75
|
UTSW |
7 |
85,814,721 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0631:Vmn2r75
|
UTSW |
7 |
85,812,478 (GRCm39) |
missense |
probably null |
1.00 |
|
R0661:Vmn2r75
|
UTSW |
7 |
85,814,866 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0811:Vmn2r75
|
UTSW |
7 |
85,814,575 (GRCm39) |
missense |
probably benign |
0.38 |
|
R0812:Vmn2r75
|
UTSW |
7 |
85,814,575 (GRCm39) |
missense |
probably benign |
0.38 |
|
R0891:Vmn2r75
|
UTSW |
7 |
85,813,476 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1340:Vmn2r75
|
UTSW |
7 |
85,797,798 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1501:Vmn2r75
|
UTSW |
7 |
85,814,850 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1760:Vmn2r75
|
UTSW |
7 |
85,798,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1970:Vmn2r75
|
UTSW |
7 |
85,797,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2060:Vmn2r75
|
UTSW |
7 |
85,814,372 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2292:Vmn2r75
|
UTSW |
7 |
85,798,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3688:Vmn2r75
|
UTSW |
7 |
85,797,629 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3892:Vmn2r75
|
UTSW |
7 |
85,813,494 (GRCm39) |
missense |
probably null |
1.00 |
|
R4532:Vmn2r75
|
UTSW |
7 |
85,797,349 (GRCm39) |
nonsense |
probably null |
|
|
R4583:Vmn2r75
|
UTSW |
7 |
85,813,290 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4592:Vmn2r75
|
UTSW |
7 |
85,815,494 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4792:Vmn2r75
|
UTSW |
7 |
85,812,378 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4859:Vmn2r75
|
UTSW |
7 |
85,797,611 (GRCm39) |
missense |
probably benign |
0.35 |
|
R4896:Vmn2r75
|
UTSW |
7 |
85,820,787 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4943:Vmn2r75
|
UTSW |
7 |
85,814,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vmn2r75
|
UTSW |
7 |
85,815,375 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5048:Vmn2r75
|
UTSW |
7 |
85,814,735 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5063:Vmn2r75
|
UTSW |
7 |
85,813,372 (GRCm39) |
missense |
probably benign |
|
|
R5156:Vmn2r75
|
UTSW |
7 |
85,813,436 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R5243:Vmn2r75
|
UTSW |
7 |
85,813,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5277:Vmn2r75
|
UTSW |
7 |
85,815,500 (GRCm39) |
missense |
probably benign |
|
|
R5574:Vmn2r75
|
UTSW |
7 |
85,815,510 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5622:Vmn2r75
|
UTSW |
7 |
85,797,702 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5680:Vmn2r75
|
UTSW |
7 |
85,820,779 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5884:Vmn2r75
|
UTSW |
7 |
85,814,578 (GRCm39) |
missense |
probably benign |
|
|
R6021:Vmn2r75
|
UTSW |
7 |
85,820,820 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6217:Vmn2r75
|
UTSW |
7 |
85,815,375 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R6242:Vmn2r75
|
UTSW |
7 |
85,814,592 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6299:Vmn2r75
|
UTSW |
7 |
85,814,482 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6441:Vmn2r75
|
UTSW |
7 |
85,820,784 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6495:Vmn2r75
|
UTSW |
7 |
85,813,287 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6553:Vmn2r75
|
UTSW |
7 |
85,813,453 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6670:Vmn2r75
|
UTSW |
7 |
85,797,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7078:Vmn2r75
|
UTSW |
7 |
85,815,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7164:Vmn2r75
|
UTSW |
7 |
85,814,592 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8411:Vmn2r75
|
UTSW |
7 |
85,797,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8507:Vmn2r75
|
UTSW |
7 |
85,797,685 (GRCm39) |
nonsense |
probably null |
|
|
R8559:Vmn2r75
|
UTSW |
7 |
85,815,480 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8677:Vmn2r75
|
UTSW |
7 |
85,814,410 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8708:Vmn2r75
|
UTSW |
7 |
85,812,476 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8778:Vmn2r75
|
UTSW |
7 |
85,813,497 (GRCm39) |
missense |
probably benign |
0.40 |
|
R8968:Vmn2r75
|
UTSW |
7 |
85,820,765 (GRCm39) |
nonsense |
probably null |
|
|
R9145:Vmn2r75
|
UTSW |
7 |
85,813,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9316:Vmn2r75
|
UTSW |
7 |
85,797,313 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9363:Vmn2r75
|
UTSW |
7 |
85,815,423 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCAAGTGCCAATTTTCAGATACCTG -3'
(R):5'- AAGGTTCAGTGATTGCCTTCTACTGTG -3'
Sequencing Primer
(F):5'- CTGAAATCCAGGTCATGTGTTAG -3'
(R):5'- GTCCTTGGATACATGGGCTCTG -3'
|
| Posted On |
2013-06-11 |
Incidental Mutation