Mutagenetix > Incidental Mutation

Incidental Mutation 'R0562:Dnah17'

45966

Institutional Source

Beutler Lab

Gene Symbol

Dnah17

Ensembl Gene

ENSMUSG00000033987

Gene Name

dynein, axonemal, heavy chain 17

Synonyms

Dnahcl1, LOC382552, 2810003K23Rik, Dnahc17

MMRRC Submission

038753-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0562 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

117912549-118021460 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 117963726 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 2516 (Y2516H)

Ref Sequence

ENSEMBL: ENSMUSP00000101915 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084803] [ENSMUST00000106308] [ENSMUST00000132685]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000084803
AA Change: Y2516H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000081864
Gene: ENSMUSG00000033987
AA Change: Y2516H

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	183	766	8.5e-142	PFAM
low complexity region	1015	1028	N/A	INTRINSIC
Pfam:DHC_N2	1260	1673	5.8e-135	PFAM
Pfam:AAA_6	1793	2023	6e-161	PFAM
low complexity region	2092	2104	N/A	INTRINSIC
Pfam:AAA_5	2107	2243	7.8e-13	PFAM
Pfam:AAA_7	2400	2671	1.1e-171	PFAM
Pfam:AAA_8	2748	3015	4.9e-166	PFAM
Pfam:MT	3027	3370	3.4e-214	PFAM
Pfam:AAA_9	3388	3615	2.4e-144	PFAM
Pfam:Dynein_heavy	3742	4452	N/A	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000106308
AA Change: Y2516H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000101915
Gene: ENSMUSG00000033987
AA Change: Y2516H

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	184	764	1.7e-152	PFAM
low complexity region	1015	1028	N/A	INTRINSIC
Pfam:DHC_N2	1262	1671	4.1e-132	PFAM
Pfam:AAA_6	1793	2023	7e-149	PFAM
low complexity region	2092	2104	N/A	INTRINSIC
Pfam:AAA_5	2107	2243	2.5e-11	PFAM
Pfam:AAA_7	2400	2671	4.4e-169	PFAM
Pfam:AAA_8	2748	3015	7.1e-163	PFAM
Pfam:MT	3027	3370	1.1e-210	PFAM
Pfam:AAA_9	3392	3614	1e-84	PFAM
Pfam:Dynein_heavy	3748	4479	3.5e-230	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000132685
AA Change: Y2529H

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000120542
Gene: ENSMUSG00000033987
AA Change: Y2529H

Domain	Start	End	E-Value	Type
Pfam:DHC_N2	279	688	3.1e-132	PFAM
Pfam:AAA_6	811	1041	5.3e-149	PFAM
low complexity region	1110	1122	N/A	INTRINSIC
Blast:AAA	1123	1354	1e-104	BLAST
Pfam:AAA_7	1452	1671	8.9e-134	PFAM
Pfam:AAA_8	1763	2030	5.4e-163	PFAM
Pfam:MT	2042	2168	6.8e-52	PFAM
Pfam:MT	2163	2412	8.2e-149	PFAM
Pfam:AAA_9	2434	2656	7.9e-85	PFAM
Pfam:Dynein_heavy	2790	3457	2.6e-209	PFAM
Pfam:Dynein_heavy	3460	3569	4.6e-17	PFAM

Meta Mutation Damage Score

0.1303

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.7%
20x: 93.9%

Validation Efficiency

100% (77/77)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. DNAH17 is a heavy chain associated with axonemal dynein (Milisav and Affara, 1998 [PubMed 9545504]).[supplied by OMIM, Mar 2008]

Allele List at MGI

Other mutations in this stock

Total: 77 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acadsb	C	T	7: 131,027,518 (GRCm39)	Q63*	probably null	Het
Adam26b	A	T	8: 43,973,408 (GRCm39)	N531K	probably benign	Het
Agt	A	G	8: 125,286,014 (GRCm39)	I356T	probably benign	Het
Ankmy1	A	T	1: 92,827,413 (GRCm39)		probably benign	Het
Anxa3	C	T	5: 96,960,743 (GRCm39)	S49L	possibly damaging	Het
Arap3	C	A	18: 38,108,593 (GRCm39)	R1279L	probably damaging	Het
Azin1	A	G	15: 38,493,825 (GRCm39)	I266T	probably benign	Het
Btnl7-ps	T	C	17: 34,752,498 (GRCm39)		noncoding transcript	Het
Car5a	T	A	8: 122,671,469 (GRCm39)	T22S	probably benign	Het
Card6	A	G	15: 5,134,648 (GRCm39)	I185T	probably damaging	Het
Ccdc81	T	C	7: 89,552,437 (GRCm39)	D11G	probably benign	Het
Cep170b	T	C	12: 112,705,623 (GRCm39)	V1127A	probably benign	Het
Ces1h	T	C	8: 94,083,771 (GRCm39)	I390M	unknown	Het
Col9a1	T	A	1: 24,218,360 (GRCm39)		probably null	Het
Cwc27	C	A	13: 104,797,865 (GRCm39)	E365*	probably null	Het
Cyb561a3	T	C	19: 10,564,074 (GRCm39)	V138A	probably benign	Het
Dcaf1	T	C	9: 106,721,321 (GRCm39)		probably benign	Het
Dsc2	T	A	18: 20,174,594 (GRCm39)	N521Y	probably damaging	Het
Dst	G	A	1: 34,267,062 (GRCm39)	E4835K	probably damaging	Het
Duox2	T	C	2: 122,120,080 (GRCm39)	E810G	probably damaging	Het
Dusp15	T	C	2: 152,793,268 (GRCm39)	N3S	possibly damaging	Het
Eif1ad9	A	G	12: 88,296,436 (GRCm39)	D138G	unknown	Het
Epha4	T	C	1: 77,365,124 (GRCm39)	K625R	probably benign	Het
Fcgbpl1	G	A	7: 27,862,115 (GRCm39)	V2394I	probably benign	Het
Gata5	C	T	2: 179,969,552 (GRCm39)		probably null	Het
Grm5	A	G	7: 87,252,227 (GRCm39)	N159S	probably damaging	Het
Hivep3	T	A	4: 119,953,751 (GRCm39)	M689K	probably benign	Het
Ift56	T	A	6: 38,378,064 (GRCm39)	V292E	probably damaging	Het
Ilvbl	G	T	10: 78,419,321 (GRCm39)	G499C	probably damaging	Het
Inpp4b	T	C	8: 82,494,780 (GRCm39)	I65T	possibly damaging	Het
Jarid2	T	C	13: 45,055,835 (GRCm39)	V208A	probably damaging	Het
Kcnh4	T	C	11: 100,641,070 (GRCm39)	M460V	possibly damaging	Het
Klhl22	A	G	16: 17,610,488 (GRCm39)	N580D	probably benign	Het
Klk15	T	A	7: 43,588,269 (GRCm39)	C192*	probably null	Het
Klk1b9	A	G	7: 43,445,090 (GRCm39)	E194G	probably damaging	Het
Lama1	G	T	17: 68,122,954 (GRCm39)	G2779V	probably damaging	Het
Lmln	C	T	16: 32,937,455 (GRCm39)	R607*	probably null	Het
Maea	T	C	5: 33,529,645 (GRCm39)	V377A	probably benign	Het
Matk	A	T	10: 81,095,525 (GRCm39)	Y115F	probably benign	Het
Mettl18	A	G	1: 163,824,062 (GRCm39)	K128E	probably benign	Het
Mrps22	T	C	9: 98,474,746 (GRCm39)	H246R	probably benign	Het
Msln	A	T	17: 25,971,980 (GRCm39)	M79K	probably benign	Het
Myf6	G	A	10: 107,330,420 (GRCm39)	P49L	probably benign	Het
Nat1	C	T	8: 67,943,963 (GRCm39)	T113I	possibly damaging	Het
Ncor2	C	T	5: 125,162,093 (GRCm39)	V394M	unknown	Het
Oas1c	T	C	5: 120,943,669 (GRCm39)		probably benign	Het
Or8k21	T	A	2: 86,144,869 (GRCm39)	T254S	probably benign	Het
Otp	A	T	13: 95,013,917 (GRCm39)	T112S	probably damaging	Het
Pcdh7	A	G	5: 57,877,405 (GRCm39)	N320S	probably damaging	Het
Pdzd2	G	T	15: 12,592,364 (GRCm39)	F93L	probably damaging	Het
Phf20l1	A	G	15: 66,481,453 (GRCm39)	E283G	probably damaging	Het
Polr1e	T	C	4: 45,029,421 (GRCm39)	F342S	probably damaging	Het
Pp2d1	T	A	17: 53,846,196 (GRCm39)		probably benign	Het
Ptpn13	T	A	5: 103,664,291 (GRCm39)		probably null	Het
Reg3g	A	T	6: 78,444,471 (GRCm39)	H107Q	possibly damaging	Het
Rgl1	T	C	1: 152,415,696 (GRCm39)	K408E	probably damaging	Het
Samd4	T	C	14: 47,314,966 (GRCm39)	C309R	probably damaging	Het
Sestd1	C	A	2: 77,061,066 (GRCm39)	W104L	probably benign	Het
Sfmbt1	T	A	14: 30,533,330 (GRCm39)		probably null	Het
Slc22a21	T	A	11: 53,870,446 (GRCm39)	K80*	probably null	Het
Snx20	T	A	8: 89,356,630 (GRCm39)	Q62L	probably benign	Het
Spef1l	T	C	7: 139,557,026 (GRCm39)	M120V	probably benign	Het
Stk40	C	A	4: 126,032,594 (GRCm39)		probably benign	Het
Taf2	A	T	15: 54,885,584 (GRCm39)		probably benign	Het
Tcf23	C	T	5: 31,127,654 (GRCm39)	P152L	probably damaging	Het
Tex29	T	C	8: 11,894,138 (GRCm39)		probably benign	Het
Tjp3	A	G	10: 81,116,389 (GRCm39)	V235A	probably damaging	Het
Tns3	A	T	11: 8,443,262 (GRCm39)	I367N	possibly damaging	Het
Ttn	T	A	2: 76,543,255 (GRCm39)	M33244L	probably benign	Het
Ush2a	A	T	1: 188,089,044 (GRCm39)	N333I	probably damaging	Het
Usp34	T	C	11: 23,382,406 (GRCm39)		probably benign	Het
Vmn1r204	A	C	13: 22,740,848 (GRCm39)	S160R	probably benign	Het
Vmn2r75	C	T	7: 85,797,449 (GRCm39)	W788*	probably null	Het
Vwa5b1	T	C	4: 138,363,022 (GRCm39)		probably benign	Het
Zbtb7a	A	G	10: 80,984,163 (GRCm39)	E535G	probably benign	Het
Zfp1004	T	A	2: 150,034,494 (GRCm39)	C303S	probably damaging	Het
Zranb3	T	C	1: 127,964,295 (GRCm39)	D144G	probably benign	Het

Other mutations in Dnah17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00231:Dnah17	APN	11	117,979,040 (GRCm39)	missense	possibly damaging	0.81
IGL00531:Dnah17	APN	11	117,933,999 (GRCm39)	missense	probably damaging	0.97
IGL00764:Dnah17	APN	11	117,987,311 (GRCm39)	missense	probably damaging	0.99
IGL00795:Dnah17	APN	11	117,984,460 (GRCm39)	missense	probably benign	0.35
IGL00823:Dnah17	APN	11	117,937,987 (GRCm39)	missense	probably benign	0.22
IGL01145:Dnah17	APN	11	117,937,999 (GRCm39)	missense	possibly damaging	0.63
IGL01433:Dnah17	APN	11	117,940,760 (GRCm39)	missense	probably damaging	1.00
IGL01454:Dnah17	APN	11	117,949,223 (GRCm39)	missense	probably damaging	1.00
IGL01545:Dnah17	APN	11	118,010,394 (GRCm39)	missense	probably damaging	1.00
IGL01548:Dnah17	APN	11	117,989,438 (GRCm39)	missense	probably benign	0.21
IGL01557:Dnah17	APN	11	117,964,512 (GRCm39)	missense	probably damaging	0.98
IGL01632:Dnah17	APN	11	117,924,707 (GRCm39)	missense	probably damaging	1.00
IGL01636:Dnah17	APN	11	117,931,882 (GRCm39)	missense	probably benign	0.03
IGL01672:Dnah17	APN	11	117,932,986 (GRCm39)	missense	probably damaging	0.97
IGL01822:Dnah17	APN	11	117,972,819 (GRCm39)	missense	probably damaging	1.00
IGL01869:Dnah17	APN	11	117,943,502 (GRCm39)	missense	probably benign	0.09
IGL01916:Dnah17	APN	11	118,016,114 (GRCm39)	missense	probably benign	0.00
IGL02131:Dnah17	APN	11	117,963,734 (GRCm39)	missense	probably damaging	1.00
IGL02154:Dnah17	APN	11	118,015,087 (GRCm39)	missense	probably benign	0.01
IGL02220:Dnah17	APN	11	117,963,793 (GRCm39)	nonsense	probably null
IGL02454:Dnah17	APN	11	117,971,593 (GRCm39)	missense	probably damaging	0.98
IGL02458:Dnah17	APN	11	117,927,176 (GRCm39)	missense	probably damaging	1.00
IGL02588:Dnah17	APN	11	117,916,479 (GRCm39)	missense	possibly damaging	0.95
IGL02865:Dnah17	APN	11	117,964,374 (GRCm39)	missense	probably damaging	1.00
IGL02881:Dnah17	APN	11	117,932,944 (GRCm39)	missense	probably damaging	1.00
IGL02952:Dnah17	APN	11	117,979,094 (GRCm39)	missense	probably benign	0.03
IGL03382:Dnah17	APN	11	117,972,769 (GRCm39)	missense	probably damaging	1.00
IGL03389:Dnah17	APN	11	117,985,805 (GRCm39)	missense	probably damaging	1.00
ergos	UTSW	11	117,931,984 (GRCm39)	splice site	probably benign
watt	UTSW	11	117,971,592 (GRCm39)	missense	probably damaging	0.96
PIT4280001:Dnah17	UTSW	11	117,989,408 (GRCm39)	missense	possibly damaging	0.85
R0004:Dnah17	UTSW	11	117,950,918 (GRCm39)	missense	possibly damaging	0.90
R0112:Dnah17	UTSW	11	117,965,260 (GRCm39)	missense	possibly damaging	0.82
R0116:Dnah17	UTSW	11	117,949,132 (GRCm39)	missense	probably benign	0.01
R0157:Dnah17	UTSW	11	118,017,997 (GRCm39)	missense	probably benign
R0320:Dnah17	UTSW	11	117,943,500 (GRCm39)	missense	possibly damaging	0.56
R0362:Dnah17	UTSW	11	117,989,365 (GRCm39)	missense	probably benign	0.10
R0382:Dnah17	UTSW	11	118,019,822 (GRCm39)	missense	probably damaging	1.00
R0383:Dnah17	UTSW	11	117,958,373 (GRCm39)	missense	probably benign
R0400:Dnah17	UTSW	11	117,972,904 (GRCm39)	missense	probably damaging	1.00
R0420:Dnah17	UTSW	11	117,930,765 (GRCm39)	missense	probably damaging	1.00
R0483:Dnah17	UTSW	11	117,937,950 (GRCm39)	missense	probably benign
R0533:Dnah17	UTSW	11	118,001,363 (GRCm39)	missense	possibly damaging	0.50
R0564:Dnah17	UTSW	11	117,973,807 (GRCm39)	missense	probably damaging	1.00
R0604:Dnah17	UTSW	11	118,012,297 (GRCm39)	missense	probably benign	0.00
R0608:Dnah17	UTSW	11	117,981,575 (GRCm39)	nonsense	probably null
R0614:Dnah17	UTSW	11	117,961,394 (GRCm39)	splice site	probably benign
R0632:Dnah17	UTSW	11	117,958,508 (GRCm39)	splice site	probably benign
R0831:Dnah17	UTSW	11	117,951,097 (GRCm39)	missense	probably damaging	0.99
R0838:Dnah17	UTSW	11	117,950,930 (GRCm39)	missense	probably damaging	1.00
R0879:Dnah17	UTSW	11	117,947,661 (GRCm39)	splice site	probably benign
R1061:Dnah17	UTSW	11	117,943,514 (GRCm39)	missense	possibly damaging	0.51
R1190:Dnah17	UTSW	11	117,933,001 (GRCm39)	missense	probably damaging	1.00
R1293:Dnah17	UTSW	11	118,017,963 (GRCm39)	critical splice donor site	probably null
R1297:Dnah17	UTSW	11	118,012,192 (GRCm39)	splice site	probably benign
R1332:Dnah17	UTSW	11	117,934,041 (GRCm39)	missense	possibly damaging	0.70
R1336:Dnah17	UTSW	11	117,934,041 (GRCm39)	missense	possibly damaging	0.70
R1364:Dnah17	UTSW	11	118,016,432 (GRCm39)	splice site	probably benign
R1418:Dnah17	UTSW	11	117,964,849 (GRCm39)	missense	probably damaging	0.98
R1432:Dnah17	UTSW	11	117,914,153 (GRCm39)	missense	probably damaging	1.00
R1497:Dnah17	UTSW	11	118,005,059 (GRCm39)	missense	probably damaging	1.00
R1500:Dnah17	UTSW	11	117,991,879 (GRCm39)	missense	probably benign
R1506:Dnah17	UTSW	11	118,016,213 (GRCm39)	missense	possibly damaging	0.53
R1512:Dnah17	UTSW	11	117,985,841 (GRCm39)	missense	probably benign
R1567:Dnah17	UTSW	11	118,016,811 (GRCm39)	missense	probably damaging	1.00
R1597:Dnah17	UTSW	11	117,994,324 (GRCm39)	splice site	probably benign
R1665:Dnah17	UTSW	11	118,012,321 (GRCm39)	splice site	probably benign
R1703:Dnah17	UTSW	11	117,917,575 (GRCm39)	missense	probably damaging	1.00
R1716:Dnah17	UTSW	11	117,923,424 (GRCm39)	missense	probably benign	0.00
R1727:Dnah17	UTSW	11	117,987,362 (GRCm39)	nonsense	probably null
R1727:Dnah17	UTSW	11	117,961,315 (GRCm39)	missense	probably damaging	0.98
R1728:Dnah17	UTSW	11	117,960,345 (GRCm39)	missense	possibly damaging	0.76
R1784:Dnah17	UTSW	11	117,960,345 (GRCm39)	missense	possibly damaging	0.76
R1852:Dnah17	UTSW	11	118,012,742 (GRCm39)	missense	probably damaging	0.97
R1869:Dnah17	UTSW	11	117,938,015 (GRCm39)	nonsense	probably null
R1886:Dnah17	UTSW	11	117,998,987 (GRCm39)	missense	possibly damaging	0.62
R1893:Dnah17	UTSW	11	117,957,794 (GRCm39)	missense	probably benign	0.00
R1954:Dnah17	UTSW	11	117,915,557 (GRCm39)	missense	probably damaging	1.00
R1969:Dnah17	UTSW	11	117,995,361 (GRCm39)	missense	probably benign	0.00
R1971:Dnah17	UTSW	11	117,995,361 (GRCm39)	missense	probably benign	0.00
R1975:Dnah17	UTSW	11	117,987,362 (GRCm39)	nonsense	probably null
R1977:Dnah17	UTSW	11	118,003,417 (GRCm39)	missense	possibly damaging	0.52
R2055:Dnah17	UTSW	11	117,958,357 (GRCm39)	missense	probably benign	0.00
R2115:Dnah17	UTSW	11	118,010,628 (GRCm39)	missense	probably benign	0.00
R2132:Dnah17	UTSW	11	117,924,573 (GRCm39)	missense	probably damaging	0.98
R2200:Dnah17	UTSW	11	117,993,235 (GRCm39)	splice site	probably benign
R2277:Dnah17	UTSW	11	117,987,387 (GRCm39)	missense	possibly damaging	0.81
R2279:Dnah17	UTSW	11	117,987,387 (GRCm39)	missense	possibly damaging	0.81
R2400:Dnah17	UTSW	11	118,017,210 (GRCm39)	critical splice acceptor site	probably null
R2402:Dnah17	UTSW	11	118,016,800 (GRCm39)	missense	probably benign	0.10
R2497:Dnah17	UTSW	11	117,977,850 (GRCm39)	splice site	probably null
R2923:Dnah17	UTSW	11	117,984,373 (GRCm39)	missense	probably damaging	1.00
R3121:Dnah17	UTSW	11	117,931,912 (GRCm39)	missense	probably damaging	1.00
R3236:Dnah17	UTSW	11	117,985,680 (GRCm39)	missense	probably benign	0.08
R3237:Dnah17	UTSW	11	117,985,680 (GRCm39)	missense	probably benign	0.08
R3498:Dnah17	UTSW	11	117,971,675 (GRCm39)	splice site	probably benign
R3499:Dnah17	UTSW	11	117,971,675 (GRCm39)	splice site	probably benign
R3746:Dnah17	UTSW	11	117,973,742 (GRCm39)	missense	probably benign	0.00
R3749:Dnah17	UTSW	11	117,973,742 (GRCm39)	missense	probably benign	0.00
R3762:Dnah17	UTSW	11	117,995,352 (GRCm39)	missense	probably benign	0.00
R3826:Dnah17	UTSW	11	117,931,984 (GRCm39)	splice site	probably benign
R3828:Dnah17	UTSW	11	117,931,984 (GRCm39)	splice site	probably benign
R3829:Dnah17	UTSW	11	117,931,984 (GRCm39)	splice site	probably benign
R3877:Dnah17	UTSW	11	117,915,533 (GRCm39)	missense	probably damaging	1.00
R3899:Dnah17	UTSW	11	117,985,634 (GRCm39)	missense	possibly damaging	0.78
R3900:Dnah17	UTSW	11	117,985,634 (GRCm39)	missense	possibly damaging	0.78
R3911:Dnah17	UTSW	11	117,971,675 (GRCm39)	splice site	probably benign
R3913:Dnah17	UTSW	11	117,971,675 (GRCm39)	splice site	probably benign
R3930:Dnah17	UTSW	11	117,971,675 (GRCm39)	splice site	probably benign
R3931:Dnah17	UTSW	11	117,971,675 (GRCm39)	splice site	probably benign
R3969:Dnah17	UTSW	11	117,931,984 (GRCm39)	splice site	probably benign
R3970:Dnah17	UTSW	11	117,931,984 (GRCm39)	splice site	probably benign
R4056:Dnah17	UTSW	11	117,961,364 (GRCm39)	missense	probably benign	0.05
R4113:Dnah17	UTSW	11	118,003,420 (GRCm39)	missense	possibly damaging	0.50
R4295:Dnah17	UTSW	11	118,009,598 (GRCm39)	missense	probably damaging	1.00
R4324:Dnah17	UTSW	11	117,985,039 (GRCm39)	missense	probably benign	0.01
R4412:Dnah17	UTSW	11	117,964,509 (GRCm39)	missense	probably damaging	1.00
R4413:Dnah17	UTSW	11	117,915,994 (GRCm39)	missense	probably benign	0.00
R4422:Dnah17	UTSW	11	117,972,799 (GRCm39)	missense	possibly damaging	0.91
R4552:Dnah17	UTSW	11	117,943,769 (GRCm39)	missense	possibly damaging	0.79
R4669:Dnah17	UTSW	11	117,965,119 (GRCm39)	missense	probably benign	0.02
R4677:Dnah17	UTSW	11	118,010,640 (GRCm39)	missense	probably damaging	1.00
R4716:Dnah17	UTSW	11	117,964,474 (GRCm39)	missense	probably benign	0.02
R4832:Dnah17	UTSW	11	117,917,606 (GRCm39)	missense	probably damaging	1.00
R4868:Dnah17	UTSW	11	117,999,038 (GRCm39)	missense	probably benign	0.03
R4897:Dnah17	UTSW	11	117,969,419 (GRCm39)	missense	probably damaging	1.00
R4928:Dnah17	UTSW	11	117,918,259 (GRCm39)	missense	probably damaging	1.00
R4937:Dnah17	UTSW	11	117,932,980 (GRCm39)	missense	probably damaging	1.00
R4957:Dnah17	UTSW	11	117,965,124 (GRCm39)	missense	probably benign	0.44
R5008:Dnah17	UTSW	11	118,001,403 (GRCm39)	missense	probably benign	0.01
R5016:Dnah17	UTSW	11	117,971,592 (GRCm39)	missense	probably damaging	0.96
R5027:Dnah17	UTSW	11	117,993,365 (GRCm39)	missense	probably benign	0.01
R5133:Dnah17	UTSW	11	118,007,939 (GRCm39)	missense	probably benign	0.00
R5140:Dnah17	UTSW	11	117,977,771 (GRCm39)	missense	probably damaging	1.00
R5146:Dnah17	UTSW	11	118,005,005 (GRCm39)	missense	probably damaging	0.99
R5151:Dnah17	UTSW	11	117,918,293 (GRCm39)	missense	probably damaging	1.00
R5153:Dnah17	UTSW	11	117,973,800 (GRCm39)	nonsense	probably null
R5192:Dnah17	UTSW	11	117,925,185 (GRCm39)	missense	possibly damaging	0.96
R5315:Dnah17	UTSW	11	118,018,109 (GRCm39)	missense	possibly damaging	0.79
R5317:Dnah17	UTSW	11	118,018,109 (GRCm39)	missense	possibly damaging	0.79
R5335:Dnah17	UTSW	11	118,003,340 (GRCm39)	missense	probably damaging	1.00
R5379:Dnah17	UTSW	11	118,008,029 (GRCm39)	intron	probably benign
R5396:Dnah17	UTSW	11	118,018,108 (GRCm39)	missense	probably benign
R5418:Dnah17	UTSW	11	117,985,810 (GRCm39)	missense	probably benign	0.04
R5534:Dnah17	UTSW	11	117,943,596 (GRCm39)	missense	possibly damaging	0.83
R5539:Dnah17	UTSW	11	117,964,486 (GRCm39)	missense	probably benign	0.03
R5594:Dnah17	UTSW	11	117,934,055 (GRCm39)	splice site	probably null
R5634:Dnah17	UTSW	11	117,943,752 (GRCm39)	splice site	probably null
R5696:Dnah17	UTSW	11	117,991,882 (GRCm39)	missense	probably benign	0.44
R5802:Dnah17	UTSW	11	117,927,272 (GRCm39)	missense	possibly damaging	0.79
R5826:Dnah17	UTSW	11	117,925,193 (GRCm39)	missense	probably damaging	1.00
R5873:Dnah17	UTSW	11	117,947,723 (GRCm39)	missense	probably benign	0.01
R5898:Dnah17	UTSW	11	118,005,039 (GRCm39)	missense	probably benign	0.00
R5934:Dnah17	UTSW	11	117,931,928 (GRCm39)	missense	probably benign
R6030:Dnah17	UTSW	11	117,916,375 (GRCm39)	missense	probably benign	0.32
R6030:Dnah17	UTSW	11	117,916,375 (GRCm39)	missense	probably benign	0.32
R6038:Dnah17	UTSW	11	117,946,715 (GRCm39)	missense	probably benign	0.00
R6038:Dnah17	UTSW	11	117,946,715 (GRCm39)	missense	probably benign	0.00
R6113:Dnah17	UTSW	11	118,017,101 (GRCm39)	missense	probably damaging	1.00
R6117:Dnah17	UTSW	11	118,010,397 (GRCm39)	missense	probably benign	0.00
R6137:Dnah17	UTSW	11	117,916,480 (GRCm39)	missense	probably damaging	1.00
R6173:Dnah17	UTSW	11	117,930,772 (GRCm39)	missense	probably damaging	1.00
R6258:Dnah17	UTSW	11	118,017,149 (GRCm39)	nonsense	probably null
R6258:Dnah17	UTSW	11	118,017,148 (GRCm39)	missense	probably damaging	1.00
R6258:Dnah17	UTSW	11	118,017,150 (GRCm39)	missense	probably damaging	1.00
R6260:Dnah17	UTSW	11	118,017,150 (GRCm39)	missense	probably damaging	1.00
R6260:Dnah17	UTSW	11	118,017,148 (GRCm39)	missense	probably damaging	1.00
R6260:Dnah17	UTSW	11	118,017,149 (GRCm39)	nonsense	probably null
R6278:Dnah17	UTSW	11	118,017,116 (GRCm39)	missense	probably damaging	0.99
R6298:Dnah17	UTSW	11	117,998,987 (GRCm39)	missense	probably benign	0.00
R6300:Dnah17	UTSW	11	117,925,136 (GRCm39)	missense	probably damaging	1.00
R6302:Dnah17	UTSW	11	118,019,981 (GRCm39)	missense	probably benign	0.09
R6363:Dnah17	UTSW	11	118,001,331 (GRCm39)	missense	probably benign
R6381:Dnah17	UTSW	11	118,020,011 (GRCm39)	missense	probably benign	0.08
R6418:Dnah17	UTSW	11	118,020,023 (GRCm39)	missense	probably damaging	0.99
R6660:Dnah17	UTSW	11	117,991,014 (GRCm39)	missense	probably benign
R6803:Dnah17	UTSW	11	118,016,198 (GRCm39)	missense	probably benign	0.00
R6820:Dnah17	UTSW	11	117,959,826 (GRCm39)	missense	probably damaging	0.99
R6885:Dnah17	UTSW	11	117,981,598 (GRCm39)	missense	possibly damaging	0.47
R6921:Dnah17	UTSW	11	117,932,310 (GRCm39)	missense	probably damaging	0.98
R6932:Dnah17	UTSW	11	117,950,905 (GRCm39)	missense	possibly damaging	0.95
R6954:Dnah17	UTSW	11	117,957,258 (GRCm39)	missense	probably damaging	1.00
R7000:Dnah17	UTSW	11	117,916,528 (GRCm39)	critical splice acceptor site	probably null
R7007:Dnah17	UTSW	11	118,009,697 (GRCm39)	missense	possibly damaging	0.92
R7048:Dnah17	UTSW	11	117,936,944 (GRCm39)	missense	possibly damaging	0.80
R7056:Dnah17	UTSW	11	118,016,212 (GRCm39)	missense	probably benign
R7131:Dnah17	UTSW	11	117,970,484 (GRCm39)	missense	probably benign	0.14
R7143:Dnah17	UTSW	11	117,976,956 (GRCm39)	missense	probably damaging	1.00
R7146:Dnah17	UTSW	11	117,972,936 (GRCm39)	missense	probably damaging	0.98
R7147:Dnah17	UTSW	11	117,985,755 (GRCm39)	missense	probably benign	0.31
R7172:Dnah17	UTSW	11	117,931,957 (GRCm39)	nonsense	probably null
R7183:Dnah17	UTSW	11	118,020,014 (GRCm39)	missense	probably benign
R7297:Dnah17	UTSW	11	117,994,182 (GRCm39)	missense	probably damaging	0.98
R7297:Dnah17	UTSW	11	117,946,556 (GRCm39)	critical splice donor site	probably null
R7367:Dnah17	UTSW	11	118,006,022 (GRCm39)	missense	probably benign
R7398:Dnah17	UTSW	11	117,971,550 (GRCm39)	missense	probably damaging	0.96
R7426:Dnah17	UTSW	11	117,981,543 (GRCm39)	missense	probably null	0.79
R7524:Dnah17	UTSW	11	118,012,307 (GRCm39)	missense	probably benign	0.03
R7529:Dnah17	UTSW	11	117,940,692 (GRCm39)	critical splice donor site	probably null
R7615:Dnah17	UTSW	11	118,001,373 (GRCm39)	nonsense	probably null
R7681:Dnah17	UTSW	11	117,916,012 (GRCm39)	missense	probably damaging	1.00
R7702:Dnah17	UTSW	11	118,012,304 (GRCm39)	missense	possibly damaging	0.64
R7702:Dnah17	UTSW	11	117,916,466 (GRCm39)	missense	probably benign	0.00
R7713:Dnah17	UTSW	11	117,915,997 (GRCm39)	missense	probably benign	0.02
R7809:Dnah17	UTSW	11	117,995,462 (GRCm39)	missense	probably benign	0.09
R7842:Dnah17	UTSW	11	117,970,508 (GRCm39)	critical splice acceptor site	probably null
R7935:Dnah17	UTSW	11	118,018,048 (GRCm39)	missense	probably benign	0.20
R7951:Dnah17	UTSW	11	118,009,592 (GRCm39)	missense	possibly damaging	0.64
R8070:Dnah17	UTSW	11	117,915,497 (GRCm39)	missense	probably damaging	0.97
R8098:Dnah17	UTSW	11	117,941,193 (GRCm39)	missense	probably damaging	1.00
R8101:Dnah17	UTSW	11	118,016,744 (GRCm39)	missense	probably benign
R8177:Dnah17	UTSW	11	118,019,753 (GRCm39)	missense	possibly damaging	0.60
R8343:Dnah17	UTSW	11	118,005,021 (GRCm39)	missense	probably benign
R8350:Dnah17	UTSW	11	117,977,873 (GRCm39)	missense	probably damaging	0.98
R8393:Dnah17	UTSW	11	117,947,855 (GRCm39)	missense	probably damaging	1.00
R8401:Dnah17	UTSW	11	117,915,485 (GRCm39)	missense	probably damaging	0.96
R8418:Dnah17	UTSW	11	117,994,284 (GRCm39)	missense	probably benign	0.01
R8450:Dnah17	UTSW	11	117,977,873 (GRCm39)	missense	probably damaging	0.98
R8546:Dnah17	UTSW	11	118,015,101 (GRCm39)	missense	probably benign	0.00
R8697:Dnah17	UTSW	11	117,976,985 (GRCm39)	missense	possibly damaging	0.96
R8710:Dnah17	UTSW	11	117,932,973 (GRCm39)	missense	probably damaging	1.00
R8713:Dnah17	UTSW	11	117,979,028 (GRCm39)	missense	probably damaging	1.00
R8722:Dnah17	UTSW	11	117,961,283 (GRCm39)	nonsense	probably null
R8797:Dnah17	UTSW	11	117,992,201 (GRCm39)	missense	probably benign	0.00
R8953:Dnah17	UTSW	11	118,016,238 (GRCm39)	splice site	probably benign
R8965:Dnah17	UTSW	11	117,915,492 (GRCm39)	missense	probably damaging	1.00
R8976:Dnah17	UTSW	11	117,917,666 (GRCm39)	missense	probably damaging	1.00
R9090:Dnah17	UTSW	11	117,931,870 (GRCm39)	missense	probably damaging	1.00
R9128:Dnah17	UTSW	11	117,937,004 (GRCm39)	missense	possibly damaging	0.76
R9134:Dnah17	UTSW	11	117,978,972 (GRCm39)	missense	probably damaging	1.00
R9245:Dnah17	UTSW	11	118,016,503 (GRCm39)	missense	probably benign	0.02
R9251:Dnah17	UTSW	11	118,012,618 (GRCm39)	missense	probably benign	0.03
R9271:Dnah17	UTSW	11	117,931,870 (GRCm39)	missense	probably damaging	1.00
R9367:Dnah17	UTSW	11	118,012,212 (GRCm39)	missense	possibly damaging	0.93
R9367:Dnah17	UTSW	11	117,987,464 (GRCm39)	missense	possibly damaging	0.95
R9381:Dnah17	UTSW	11	117,914,219 (GRCm39)	missense	probably benign
R9405:Dnah17	UTSW	11	118,009,737 (GRCm39)	missense	probably benign
R9449:Dnah17	UTSW	11	117,987,452 (GRCm39)	missense	probably benign	0.07
R9517:Dnah17	UTSW	11	117,915,440 (GRCm39)	missense	possibly damaging	0.76
R9588:Dnah17	UTSW	11	118,012,783 (GRCm39)	missense	probably benign	0.00
R9629:Dnah17	UTSW	11	117,979,804 (GRCm39)	missense	probably damaging	1.00
R9654:Dnah17	UTSW	11	117,927,156 (GRCm39)	critical splice donor site	probably null
R9655:Dnah17	UTSW	11	117,971,649 (GRCm39)	missense	possibly damaging	0.94
R9662:Dnah17	UTSW	11	117,925,166 (GRCm39)	missense	probably damaging	0.97
R9686:Dnah17	UTSW	11	117,979,048 (GRCm39)	missense	possibly damaging	0.46
R9689:Dnah17	UTSW	11	117,963,731 (GRCm39)	missense	probably damaging	1.00
R9706:Dnah17	UTSW	11	118,017,026 (GRCm39)	missense	probably damaging	1.00
X0058:Dnah17	UTSW	11	117,973,751 (GRCm39)	missense	probably damaging	1.00
Z1176:Dnah17	UTSW	11	118,017,992 (GRCm39)	missense	probably benign	0.01
Z1177:Dnah17	UTSW	11	117,977,786 (GRCm39)	missense	probably damaging	1.00
Z1177:Dnah17	UTSW	11	117,969,389 (GRCm39)	missense	possibly damaging	0.91
Z1177:Dnah17	UTSW	11	118,017,968 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- ATGAATGGTCCTTCCACAGCCACG -3'
(R):5'- GTCACGGATTAGAGGTTCAGCCAAG -3'

Sequencing Primer
(F):5'- ATGGTCTCATTGCCAGCC -3'
(R):5'- cacacacacacacacacac -3'

Posted On

2013-06-11