Incidental Mutation 'R5927:Kif15'
ID 459959
Institutional Source Beutler Lab
Gene Symbol Kif15
Ensembl Gene ENSMUSG00000036768
Gene Name kinesin family member 15
Synonyms N-10 kinesin, 3930402I10Rik, 3110023M17Rik, HKLP2, Knsl7
MMRRC Submission 044122-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5927 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 122780146-122847798 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 122846326 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 76 (S76G)
Ref Sequence ENSEMBL: ENSMUSP00000149776 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040717] [ENSMUST00000084733] [ENSMUST00000213514] [ENSMUST00000216062] [ENSMUST00000216048] [ENSMUST00000214785]
AlphaFold Q6P9L6
Predicted Effect probably benign
Transcript: ENSMUST00000040717
AA Change: S1275G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000035490
Gene: ENSMUSG00000036768
AA Change: S1275G

DomainStartEndE-ValueType
KISc 24 371 2.86e-179 SMART
Pfam:Kinesin-relat_1 463 551 6.6e-26 PFAM
coiled coil region 579 643 N/A INTRINSIC
coiled coil region 706 1037 N/A INTRINSIC
coiled coil region 1065 1133 N/A INTRINSIC
Pfam:HMMR_C 1265 1387 3.5e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000084733
SMART Domains Protein: ENSMUSP00000081784
Gene: ENSMUSG00000066233

DomainStartEndE-ValueType
transmembrane domain 37 59 N/A INTRINSIC
transmembrane domain 66 88 N/A INTRINSIC
transmembrane domain 98 120 N/A INTRINSIC
transmembrane domain 127 144 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000213514
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213945
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214077
Predicted Effect unknown
Transcript: ENSMUST00000214311
AA Change: S144G
Predicted Effect probably benign
Transcript: ENSMUST00000216062
AA Change: S76G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000216048
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217036
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217077
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217612
Predicted Effect probably benign
Transcript: ENSMUST00000214785
Meta Mutation Damage Score 0.0617 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.0%
Validation Efficiency 100% (73/73)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadm T A 3: 153,644,745 (GRCm39) I60F probably damaging Het
Ankrd26 A G 6: 118,484,597 (GRCm39) probably null Het
Arhgdib A T 6: 136,901,136 (GRCm39) W198R probably damaging Het
Atad5 T A 11: 80,018,111 (GRCm39) I1354N probably damaging Het
Ccdc146 T A 5: 21,513,619 (GRCm39) K500* probably null Het
Cdk11b G A 4: 155,732,697 (GRCm39) probably benign Het
Cmip A T 8: 117,984,048 (GRCm39) T70S possibly damaging Het
Col22a1 G T 15: 71,878,815 (GRCm39) A114E probably damaging Het
Cpeb1 T C 7: 81,011,428 (GRCm39) D171G possibly damaging Het
Crebzf C T 7: 90,093,531 (GRCm39) probably benign Het
Cybb C G X: 9,316,989 (GRCm39) D246H probably benign Het
D630036H23Rik C A 12: 36,431,671 (GRCm39) probably benign Het
Dnah5 A T 15: 28,335,864 (GRCm39) T2277S probably benign Het
Dysf T A 6: 84,184,194 (GRCm39) F2083Y probably damaging Het
Elavl4 T A 4: 110,147,440 (GRCm39) probably benign Het
Elp3 A G 14: 65,819,626 (GRCm39) Y111H probably damaging Het
Eps8l2 A T 7: 140,936,259 (GRCm39) Q243L probably benign Het
Eri2 C A 7: 119,385,291 (GRCm39) L403F probably damaging Het
Fgfr4 T A 13: 55,314,700 (GRCm39) N614K probably damaging Het
Gm5108 T G 5: 68,134,214 (GRCm39) I74S unknown Het
Gpn1 T C 5: 31,658,235 (GRCm39) F130L probably damaging Het
Gpr176 T A 2: 118,203,521 (GRCm39) I50F probably benign Het
Gramd1a A G 7: 30,839,246 (GRCm39) S221P probably benign Het
Hivep3 A G 4: 119,954,305 (GRCm39) T874A possibly damaging Het
Igkv12-40 A G 6: 69,856,383 (GRCm39) noncoding transcript Het
Itgb2 C A 10: 77,381,868 (GRCm39) P57T probably damaging Het
Kcmf1 T A 6: 72,819,988 (GRCm39) D286V possibly damaging Het
Kcnt1 T A 2: 25,799,388 (GRCm39) probably benign Het
Kpna3 C T 14: 61,622,096 (GRCm39) V223I probably damaging Het
Krt80 A G 15: 101,262,089 (GRCm39) probably benign Het
Lama4 A G 10: 38,948,808 (GRCm39) Y857C probably damaging Het
Lcorl G T 5: 45,882,766 (GRCm39) probably benign Het
Map4k3 A G 17: 80,921,348 (GRCm39) V528A probably benign Het
Mmp8 T A 9: 7,563,203 (GRCm39) N255K possibly damaging Het
Npat A T 9: 53,473,521 (GRCm39) K438* probably null Het
Or4a73 T A 2: 89,421,444 (GRCm39) N5I possibly damaging Het
P4htm T C 9: 108,474,582 (GRCm39) Y61C probably damaging Het
Pgap6 T C 17: 26,340,972 (GRCm39) Y692H probably benign Het
Polr3h G T 15: 81,801,480 (GRCm39) probably null Het
Prlr C T 15: 10,322,532 (GRCm39) T176I probably benign Het
Psme4 T G 11: 30,754,294 (GRCm39) F184V possibly damaging Het
Ptgfrn A T 3: 100,967,968 (GRCm39) F542I possibly damaging Het
Rock1 T C 18: 10,116,792 (GRCm39) E448G probably damaging Het
Rpf1 A T 3: 146,225,218 (GRCm39) probably null Het
Sectm1b T C 11: 120,946,500 (GRCm39) I132V probably benign Het
Sestd1 T A 2: 77,017,503 (GRCm39) H688L probably benign Het
Sidt2 T C 9: 45,855,752 (GRCm39) Y530C probably damaging Het
Sin3a A T 9: 57,018,395 (GRCm39) K938M probably damaging Het
Sin3b C A 8: 73,476,506 (GRCm39) R647S probably benign Het
Slc16a14 T C 1: 84,889,988 (GRCm39) H439R possibly damaging Het
Stc1 T C 14: 69,269,822 (GRCm39) V134A probably benign Het
Stk11ip G A 1: 75,501,335 (GRCm39) V24I possibly damaging Het
Tbx6 G A 7: 126,384,025 (GRCm39) A359T possibly damaging Het
Thra G A 11: 98,654,514 (GRCm39) V295I possibly damaging Het
Tnr T C 1: 159,740,336 (GRCm39) M1170T probably damaging Het
Tpcn2 T A 7: 144,832,521 (GRCm39) I112F probably damaging Het
Trdv2-2 T C 14: 54,198,998 (GRCm39) L96P probably damaging Het
Trim24 T A 6: 37,935,504 (GRCm39) W832R probably damaging Het
Usp4 T G 9: 108,268,959 (GRCm39) S891A probably benign Het
Vmn1r88 A T 7: 12,912,440 (GRCm39) R265S probably benign Het
Vmn2r118 A G 17: 55,931,494 (GRCm39) L60S probably benign Het
Wdr74 T C 19: 8,717,197 (GRCm39) C220R possibly damaging Het
Xpo1 A T 11: 23,218,653 (GRCm39) probably benign Het
Xpo1 A T 11: 23,218,656 (GRCm39) probably benign Het
Zfp850 C A 7: 27,689,620 (GRCm39) G196V probably benign Het
Other mutations in Kif15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01459:Kif15 APN 9 122,804,820 (GRCm39) missense probably damaging 1.00
IGL01577:Kif15 APN 9 122,825,399 (GRCm39) missense probably benign 0.06
IGL01647:Kif15 APN 9 122,792,536 (GRCm39) intron probably benign
IGL01921:Kif15 APN 9 122,808,569 (GRCm39) missense probably damaging 1.00
IGL02040:Kif15 APN 9 122,846,450 (GRCm39) missense probably damaging 0.99
IGL02191:Kif15 APN 9 122,804,744 (GRCm39) missense probably damaging 1.00
IGL02218:Kif15 APN 9 122,824,892 (GRCm39) splice site probably benign
IGL02537:Kif15 APN 9 122,822,914 (GRCm39) missense probably benign 0.08
IGL02814:Kif15 APN 9 122,832,705 (GRCm39) missense possibly damaging 0.83
PIT4480001:Kif15 UTSW 9 122,840,608 (GRCm39) missense probably benign
R0034:Kif15 UTSW 9 122,828,350 (GRCm39) missense possibly damaging 0.47
R0458:Kif15 UTSW 9 122,838,424 (GRCm39) missense probably benign
R0526:Kif15 UTSW 9 122,826,862 (GRCm39) missense probably damaging 0.96
R0533:Kif15 UTSW 9 122,838,498 (GRCm39) unclassified probably benign
R0726:Kif15 UTSW 9 122,788,993 (GRCm39) missense probably benign 0.21
R1580:Kif15 UTSW 9 122,789,021 (GRCm39) missense probably benign 0.22
R1597:Kif15 UTSW 9 122,823,074 (GRCm39) missense probably benign 0.22
R2096:Kif15 UTSW 9 122,815,252 (GRCm39) missense probably damaging 1.00
R3125:Kif15 UTSW 9 122,817,026 (GRCm39) missense probably damaging 0.99
R3176:Kif15 UTSW 9 122,816,905 (GRCm39) splice site probably benign
R4088:Kif15 UTSW 9 122,815,254 (GRCm39) missense probably benign 0.29
R4308:Kif15 UTSW 9 122,843,047 (GRCm39) missense probably benign 0.00
R4597:Kif15 UTSW 9 122,822,914 (GRCm39) missense probably benign 0.08
R4705:Kif15 UTSW 9 122,789,058 (GRCm39) splice site probably null
R4832:Kif15 UTSW 9 122,831,191 (GRCm39) splice site probably null
R5100:Kif15 UTSW 9 122,821,059 (GRCm39) missense probably damaging 0.98
R5126:Kif15 UTSW 9 122,804,823 (GRCm39) missense probably damaging 1.00
R5180:Kif15 UTSW 9 122,828,275 (GRCm39) missense probably damaging 0.99
R5247:Kif15 UTSW 9 122,815,507 (GRCm39) missense possibly damaging 0.65
R5376:Kif15 UTSW 9 122,823,036 (GRCm39) missense probably benign 0.04
R5392:Kif15 UTSW 9 122,825,360 (GRCm39) missense probably damaging 0.99
R5422:Kif15 UTSW 9 122,813,954 (GRCm39) splice site probably null
R5562:Kif15 UTSW 9 122,807,081 (GRCm39) missense probably damaging 1.00
R5663:Kif15 UTSW 9 122,820,916 (GRCm39) splice site probably null
R5767:Kif15 UTSW 9 122,843,039 (GRCm39) missense possibly damaging 0.78
R6049:Kif15 UTSW 9 122,840,687 (GRCm39) missense probably damaging 0.98
R6435:Kif15 UTSW 9 122,815,556 (GRCm39) missense probably damaging 1.00
R7040:Kif15 UTSW 9 122,840,679 (GRCm39) missense possibly damaging 0.67
R7158:Kif15 UTSW 9 122,828,379 (GRCm39) missense probably benign
R7163:Kif15 UTSW 9 122,846,722 (GRCm39) missense probably damaging 1.00
R7197:Kif15 UTSW 9 122,838,991 (GRCm39) critical splice donor site probably null
R7318:Kif15 UTSW 9 122,817,014 (GRCm39) missense probably damaging 1.00
R7360:Kif15 UTSW 9 122,820,202 (GRCm39) missense probably benign
R8039:Kif15 UTSW 9 122,836,490 (GRCm39) missense possibly damaging 0.82
R8228:Kif15 UTSW 9 122,821,041 (GRCm39) missense possibly damaging 0.82
R8549:Kif15 UTSW 9 122,815,236 (GRCm39) missense probably benign
R9001:Kif15 UTSW 9 122,826,855 (GRCm39) missense probably benign 0.00
R9031:Kif15 UTSW 9 122,846,492 (GRCm39) intron probably benign
R9044:Kif15 UTSW 9 122,840,781 (GRCm39) missense probably benign 0.01
R9063:Kif15 UTSW 9 122,833,706 (GRCm39) missense probably damaging 1.00
R9306:Kif15 UTSW 9 122,807,056 (GRCm39) missense probably damaging 1.00
R9490:Kif15 UTSW 9 122,788,203 (GRCm39) missense probably benign 0.10
R9554:Kif15 UTSW 9 122,828,585 (GRCm39) missense probably damaging 1.00
R9682:Kif15 UTSW 9 122,815,712 (GRCm39) missense probably damaging 0.98
R9752:Kif15 UTSW 9 122,824,890 (GRCm39) critical splice donor site probably null
Z1177:Kif15 UTSW 9 122,780,116 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- TCACCTAGGTTCAGTCCAGTTC -3'
(R):5'- TCTCTGCACACTAGAGAAACTG -3'

Sequencing Primer
(F):5'- AGGTTCAGTCCAGTTCTAGCTTATGC -3'
(R):5'- GTATTTCTACATAGCATGGAAAACCC -3'
Posted On 2017-02-28