Incidental Mutation 'R5930:Megf8'
| ID |
460162 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Megf8
|
| Ensembl Gene |
ENSMUSG00000045039 |
| Gene Name |
multiple EGF-like-domains 8 |
| Synonyms |
m687Ddg, b2b1702Clo, Egfl4, b2b288Clo |
| MMRRC Submission |
044125-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.952)
|
| Stock # |
R5930 (G1)
|
| Quality Score |
213 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
25016589-25065342 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 25025866 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 83
(Y83*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000122192
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000128119]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000128119
AA Change: Y83*
|
| SMART Domains |
Protein: ENSMUSP00000122192
Gene: ENSMUSG00000045039
AA Change: Y83*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
CUB
|
33 |
140 |
1.24e-15 |
SMART |
|
EGF
|
141 |
170 |
4.26e0 |
SMART |
|
EGF
|
173 |
203 |
2.43e1 |
SMART |
|
Pfam:Kelch_4
|
227 |
277 |
1.3e-11 |
PFAM |
|
Pfam:Kelch_3
|
240 |
287 |
1.6e-7 |
PFAM |
|
low complexity region
|
320 |
341 |
N/A |
INTRINSIC |
|
low complexity region
|
517 |
531 |
N/A |
INTRINSIC |
|
low complexity region
|
728 |
738 |
N/A |
INTRINSIC |
|
PSI
|
847 |
899 |
1.37e0 |
SMART |
|
low complexity region
|
932 |
938 |
N/A |
INTRINSIC |
|
PSI
|
949 |
991 |
2.11e-2 |
SMART |
|
PSI
|
1005 |
1073 |
7.82e-1 |
SMART |
|
EGF_CA
|
1074 |
1115 |
2.62e-9 |
SMART |
|
EGF
|
1117 |
1160 |
5.4e-2 |
SMART |
|
EGF_like
|
1163 |
1208 |
4e-1 |
SMART |
|
EGF_Lam
|
1211 |
1259 |
1.03e-7 |
SMART |
|
Blast:CUB
|
1263 |
1401 |
1e-30 |
BLAST |
|
EGF_like
|
1406 |
1445 |
3.29e1 |
SMART |
|
Pfam:Kelch_4
|
1509 |
1564 |
6.5e-12 |
PFAM |
|
Pfam:Kelch_3
|
1520 |
1574 |
1.2e-10 |
PFAM |
|
PSI
|
1868 |
1923 |
2.75e-1 |
SMART |
|
PSI
|
2004 |
2062 |
1.6e0 |
SMART |
|
PSI
|
2064 |
2121 |
1.68e-5 |
SMART |
|
EGF
|
2125 |
2164 |
1.08e-1 |
SMART |
|
EGF
|
2166 |
2194 |
4.26e0 |
SMART |
|
EGF
|
2204 |
2244 |
2.2e1 |
SMART |
|
EGF_like
|
2248 |
2321 |
6.37e-1 |
SMART |
|
low complexity region
|
2493 |
2504 |
N/A |
INTRINSIC |
|
low complexity region
|
2530 |
2541 |
N/A |
INTRINSIC |
|
transmembrane domain
|
2592 |
2614 |
N/A |
INTRINSIC |
|
low complexity region
|
2649 |
2668 |
N/A |
INTRINSIC |
|
low complexity region
|
2674 |
2702 |
N/A |
INTRINSIC |
|
low complexity region
|
2759 |
2774 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.1%
- 20x: 94.5%
|
| Validation Efficiency |
94% (102/109) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for an ENU mutation exhibit varying degrees of heterotaxia and congenital heart defects. Mice homozygous for another ENU-induced mutation exhibit abnormal development and patterning of the peripheral nervous system. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrv1 |
C |
T |
13: 81,545,570 (GRCm39) |
V5572I |
probably benign |
Het |
| Agap1 |
C |
T |
1: 89,770,818 (GRCm39) |
T656I |
probably damaging |
Het |
| Als2cl |
C |
T |
9: 110,716,432 (GRCm39) |
R247W |
probably damaging |
Het |
| Ankfy1 |
A |
T |
11: 72,603,071 (GRCm39) |
R33S |
probably benign |
Het |
| Ano5 |
T |
C |
7: 51,235,079 (GRCm39) |
F671L |
probably damaging |
Het |
| Arhgap26 |
A |
G |
18: 39,283,145 (GRCm39) |
M361V |
probably damaging |
Het |
| Bckdk |
A |
G |
7: 127,505,145 (GRCm39) |
E175G |
probably damaging |
Het |
| Bptf |
G |
T |
11: 106,964,022 (GRCm39) |
T1724K |
probably damaging |
Het |
| Btn2a2 |
T |
A |
13: 23,670,398 (GRCm39) |
I112F |
probably damaging |
Het |
| Cln8 |
T |
A |
8: 14,946,621 (GRCm39) |
W212R |
probably damaging |
Het |
| Cnbd1 |
T |
C |
4: 18,886,119 (GRCm39) |
E300G |
probably benign |
Het |
| Cnksr3 |
T |
C |
10: 7,092,993 (GRCm39) |
I173V |
probably benign |
Het |
| Cntn2 |
T |
A |
1: 132,451,170 (GRCm39) |
D484V |
probably damaging |
Het |
| Cyp4a14 |
C |
A |
4: 115,348,607 (GRCm39) |
G319V |
probably damaging |
Het |
| Cyp4f37 |
G |
A |
17: 32,848,957 (GRCm39) |
R275Q |
possibly damaging |
Het |
| Def8 |
C |
T |
8: 124,186,809 (GRCm39) |
|
probably benign |
Het |
| Dnaaf4 |
T |
C |
9: 72,879,280 (GRCm39) |
V356A |
probably damaging |
Het |
| Dnah10 |
T |
C |
5: 124,868,855 (GRCm39) |
|
probably null |
Het |
| Dock6 |
A |
G |
9: 21,735,712 (GRCm39) |
V1012A |
probably benign |
Het |
| Dus3l |
T |
A |
17: 57,076,579 (GRCm39) |
N586K |
probably damaging |
Het |
| Dyrk2 |
T |
A |
10: 118,696,173 (GRCm39) |
I362F |
probably damaging |
Het |
| Eeig2 |
A |
T |
3: 108,887,468 (GRCm39) |
S265R |
probably benign |
Het |
| Erc2 |
T |
A |
14: 27,498,815 (GRCm39) |
D230E |
probably damaging |
Het |
| Fat1 |
A |
G |
8: 45,497,073 (GRCm39) |
H4186R |
probably benign |
Het |
| Fbxo44 |
A |
G |
4: 148,241,052 (GRCm39) |
F179S |
probably damaging |
Het |
| Fech |
A |
G |
18: 64,611,720 (GRCm39) |
|
probably null |
Het |
| Fer1l5 |
T |
A |
1: 36,424,254 (GRCm39) |
C289* |
probably null |
Het |
| Fhl5 |
T |
A |
4: 25,214,756 (GRCm39) |
D7V |
probably benign |
Het |
| Flvcr1 |
G |
T |
1: 190,741,748 (GRCm39) |
T514K |
probably damaging |
Het |
| Fmo1 |
A |
T |
1: 162,667,185 (GRCm39) |
|
probably null |
Het |
| Gabra6 |
G |
A |
11: 42,198,268 (GRCm39) |
T384M |
probably benign |
Het |
| Gli3 |
A |
G |
13: 15,723,210 (GRCm39) |
Y117C |
probably damaging |
Het |
| Gnao1 |
A |
G |
8: 94,622,873 (GRCm39) |
D59G |
probably benign |
Het |
| Gria2 |
T |
C |
3: 80,614,556 (GRCm39) |
I495V |
possibly damaging |
Het |
| Hnf1b |
C |
A |
11: 83,754,811 (GRCm39) |
H161Q |
probably benign |
Het |
| Itga8 |
T |
A |
2: 12,235,019 (GRCm39) |
D413V |
possibly damaging |
Het |
| Itpr3 |
A |
T |
17: 27,329,895 (GRCm39) |
Q1563L |
possibly damaging |
Het |
| Kctd16 |
A |
G |
18: 40,663,882 (GRCm39) |
N337S |
probably benign |
Het |
| Klra4 |
C |
T |
6: 130,030,016 (GRCm39) |
V190M |
possibly damaging |
Het |
| Krtap4-9 |
T |
A |
11: 99,676,462 (GRCm39) |
|
probably benign |
Het |
| L3mbtl1 |
GGCCG |
GG |
2: 162,809,256 (GRCm39) |
|
probably benign |
Het |
| Mchr1 |
T |
C |
15: 81,122,044 (GRCm39) |
F265L |
probably damaging |
Het |
| Mettl18 |
A |
G |
1: 163,824,746 (GRCm39) |
M356V |
probably null |
Het |
| Mrm1 |
G |
A |
11: 84,710,018 (GRCm39) |
R61W |
probably damaging |
Het |
| Muc4 |
A |
T |
16: 32,570,523 (GRCm39) |
T528S |
probably benign |
Het |
| Myef2 |
A |
T |
2: 124,937,651 (GRCm39) |
L530* |
probably null |
Het |
| Nhlrc4 |
T |
C |
17: 26,162,693 (GRCm39) |
E18G |
probably benign |
Het |
| Nisch |
C |
T |
14: 30,895,102 (GRCm39) |
V1065I |
probably benign |
Het |
| Nlgn2 |
C |
T |
11: 69,724,975 (GRCm39) |
R97H |
probably damaging |
Het |
| Nos2 |
T |
C |
11: 78,828,741 (GRCm39) |
L321S |
probably damaging |
Het |
| Oaz3 |
T |
C |
3: 94,343,717 (GRCm39) |
M49V |
possibly damaging |
Het |
| Olfm5 |
A |
G |
7: 103,803,362 (GRCm39) |
V367A |
probably damaging |
Het |
| Omd |
C |
T |
13: 49,743,112 (GRCm39) |
P54L |
possibly damaging |
Het |
| Or10ak12 |
C |
T |
4: 118,666,575 (GRCm39) |
R162H |
probably benign |
Het |
| Or11g26 |
C |
A |
14: 50,753,249 (GRCm39) |
A196D |
probably benign |
Het |
| Or2g7 |
C |
A |
17: 38,378,641 (GRCm39) |
A193D |
probably benign |
Het |
| Or51f23 |
A |
T |
7: 102,453,481 (GRCm39) |
R265S |
probably damaging |
Het |
| Or7d10 |
A |
G |
9: 19,832,206 (GRCm39) |
K234E |
probably damaging |
Het |
| Pard3b |
T |
A |
1: 61,807,289 (GRCm39) |
|
probably benign |
Het |
| Pcdhb18 |
A |
C |
18: 37,624,988 (GRCm39) |
I773L |
possibly damaging |
Het |
| Pde11a |
T |
C |
2: 75,970,175 (GRCm39) |
|
probably null |
Het |
| Pfkfb4 |
A |
C |
9: 108,859,462 (GRCm39) |
|
probably benign |
Het |
| Phb2 |
T |
G |
6: 124,692,612 (GRCm39) |
I260S |
probably damaging |
Het |
| Pkd1l1 |
G |
A |
11: 8,908,969 (GRCm39) |
T345I |
unknown |
Het |
| Pla2g6 |
T |
C |
15: 79,187,728 (GRCm39) |
|
probably benign |
Het |
| Pou4f2 |
G |
A |
8: 79,163,020 (GRCm39) |
S5F |
unknown |
Het |
| Ppp1r9a |
A |
T |
6: 5,157,002 (GRCm39) |
|
probably null |
Het |
| Pramel5 |
A |
G |
4: 143,999,553 (GRCm39) |
I178T |
probably benign |
Het |
| Prom2 |
C |
T |
2: 127,372,053 (GRCm39) |
W745* |
probably null |
Het |
| Pros1 |
T |
A |
16: 62,748,424 (GRCm39) |
N632K |
probably damaging |
Het |
| Rab4b |
A |
G |
7: 26,873,927 (GRCm39) |
I117T |
probably benign |
Het |
| Rbm25 |
T |
A |
12: 83,724,640 (GRCm39) |
H796Q |
possibly damaging |
Het |
| Rnf151 |
A |
T |
17: 24,937,004 (GRCm39) |
|
probably null |
Het |
| Rps6ka1 |
A |
T |
4: 133,598,882 (GRCm39) |
L97I |
probably damaging |
Het |
| Scart1 |
C |
T |
7: 139,810,359 (GRCm39) |
P984S |
probably benign |
Het |
| Semp2l2a |
T |
A |
8: 13,887,263 (GRCm39) |
D276V |
probably benign |
Het |
| Sergef |
T |
A |
7: 46,092,888 (GRCm39) |
T374S |
probably benign |
Het |
| Sh3rf3 |
G |
T |
10: 58,966,808 (GRCm39) |
G717C |
probably damaging |
Het |
| Slc29a4 |
C |
T |
5: 142,707,157 (GRCm39) |
T500I |
possibly damaging |
Het |
| Smc1b |
T |
A |
15: 84,970,322 (GRCm39) |
D977V |
probably damaging |
Het |
| Spata31d1d |
C |
T |
13: 59,874,829 (GRCm39) |
C902Y |
probably benign |
Het |
| St14 |
A |
T |
9: 31,015,056 (GRCm39) |
V314D |
probably damaging |
Het |
| Stat3 |
A |
T |
11: 100,784,496 (GRCm39) |
I602N |
possibly damaging |
Het |
| Stx4a |
T |
A |
7: 127,445,661 (GRCm39) |
I189N |
probably damaging |
Het |
| Tacc1 |
A |
G |
8: 25,672,215 (GRCm39) |
S338P |
probably benign |
Het |
| Tcirg1 |
T |
A |
19: 3,952,424 (GRCm39) |
T315S |
possibly damaging |
Het |
| Tenm4 |
A |
T |
7: 96,503,926 (GRCm39) |
N1295I |
probably damaging |
Het |
| Tm7sf3 |
T |
C |
6: 146,505,409 (GRCm39) |
K516E |
possibly damaging |
Het |
| Tmem198b |
T |
C |
10: 128,637,323 (GRCm39) |
E272G |
possibly damaging |
Het |
| Tnip3 |
A |
G |
6: 65,582,937 (GRCm39) |
Q237R |
probably damaging |
Het |
| Trim15 |
C |
T |
17: 37,173,252 (GRCm39) |
|
probably null |
Het |
| Trim30a |
T |
A |
7: 104,070,657 (GRCm39) |
N252I |
possibly damaging |
Het |
| Ttc39a |
A |
G |
4: 109,288,075 (GRCm39) |
E227G |
probably benign |
Het |
| Ttll13 |
A |
G |
7: 79,902,914 (GRCm39) |
E194G |
probably damaging |
Het |
| Upf1 |
G |
A |
8: 70,796,912 (GRCm39) |
T107I |
probably benign |
Het |
| Vac14 |
A |
G |
8: 111,436,981 (GRCm39) |
I565V |
probably damaging |
Het |
| Zcchc14 |
A |
T |
8: 122,338,097 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Megf8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00639:Megf8
|
APN |
7 |
25,043,109 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL00696:Megf8
|
APN |
7 |
25,041,817 (GRCm39) |
missense |
probably benign |
|
|
IGL01021:Megf8
|
APN |
7 |
25,037,799 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01290:Megf8
|
APN |
7 |
25,049,083 (GRCm39) |
nonsense |
probably null |
|
|
IGL01392:Megf8
|
APN |
7 |
25,063,174 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01410:Megf8
|
APN |
7 |
25,059,296 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01634:Megf8
|
APN |
7 |
25,058,206 (GRCm39) |
splice site |
probably benign |
|
|
IGL01648:Megf8
|
APN |
7 |
25,026,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01930:Megf8
|
APN |
7 |
25,034,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01954:Megf8
|
APN |
7 |
25,048,439 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02150:Megf8
|
APN |
7 |
25,045,842 (GRCm39) |
splice site |
probably null |
|
|
IGL02192:Megf8
|
APN |
7 |
25,053,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02250:Megf8
|
APN |
7 |
25,042,000 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02301:Megf8
|
APN |
7 |
25,037,325 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02317:Megf8
|
APN |
7 |
25,063,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02324:Megf8
|
APN |
7 |
25,039,873 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02503:Megf8
|
APN |
7 |
25,062,988 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL02583:Megf8
|
APN |
7 |
25,055,218 (GRCm39) |
missense |
probably benign |
|
|
IGL02636:Megf8
|
APN |
7 |
25,057,857 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02704:Megf8
|
APN |
7 |
25,059,207 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02898:Megf8
|
APN |
7 |
25,045,933 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL03082:Megf8
|
APN |
7 |
25,029,661 (GRCm39) |
missense |
probably benign |
|
|
IGL03182:Megf8
|
APN |
7 |
25,046,773 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
megatherium
|
UTSW |
7 |
25,041,850 (GRCm39) |
critical splice donor site |
probably null |
|
|
PIT4810001:Megf8
|
UTSW |
7 |
25,041,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0076:Megf8
|
UTSW |
7 |
25,053,383 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0217:Megf8
|
UTSW |
7 |
25,063,504 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0514:Megf8
|
UTSW |
7 |
25,063,728 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0561:Megf8
|
UTSW |
7 |
25,028,257 (GRCm39) |
missense |
probably benign |
0.21 |
|
R0563:Megf8
|
UTSW |
7 |
25,041,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0601:Megf8
|
UTSW |
7 |
25,027,965 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0879:Megf8
|
UTSW |
7 |
25,037,896 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R1323:Megf8
|
UTSW |
7 |
25,059,527 (GRCm39) |
splice site |
probably null |
|
|
R1323:Megf8
|
UTSW |
7 |
25,059,527 (GRCm39) |
splice site |
probably null |
|
|
R1430:Megf8
|
UTSW |
7 |
25,063,768 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1445:Megf8
|
UTSW |
7 |
25,042,081 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1533:Megf8
|
UTSW |
7 |
25,034,280 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1606:Megf8
|
UTSW |
7 |
25,058,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1635:Megf8
|
UTSW |
7 |
25,046,172 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1654:Megf8
|
UTSW |
7 |
25,037,911 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R1661:Megf8
|
UTSW |
7 |
25,063,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1880:Megf8
|
UTSW |
7 |
25,034,285 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1962:Megf8
|
UTSW |
7 |
25,062,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2077:Megf8
|
UTSW |
7 |
25,053,163 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2127:Megf8
|
UTSW |
7 |
25,064,007 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2129:Megf8
|
UTSW |
7 |
25,030,140 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2199:Megf8
|
UTSW |
7 |
25,039,039 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R2201:Megf8
|
UTSW |
7 |
25,040,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2205:Megf8
|
UTSW |
7 |
25,041,173 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2207:Megf8
|
UTSW |
7 |
25,049,222 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2361:Megf8
|
UTSW |
7 |
25,048,379 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2680:Megf8
|
UTSW |
7 |
25,016,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3084:Megf8
|
UTSW |
7 |
25,048,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3085:Megf8
|
UTSW |
7 |
25,048,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3086:Megf8
|
UTSW |
7 |
25,048,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3433:Megf8
|
UTSW |
7 |
25,059,549 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3939:Megf8
|
UTSW |
7 |
25,058,627 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4022:Megf8
|
UTSW |
7 |
25,037,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4214:Megf8
|
UTSW |
7 |
25,054,793 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4357:Megf8
|
UTSW |
7 |
25,055,174 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4521:Megf8
|
UTSW |
7 |
25,042,126 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4620:Megf8
|
UTSW |
7 |
25,054,523 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4700:Megf8
|
UTSW |
7 |
25,062,940 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4916:Megf8
|
UTSW |
7 |
25,039,089 (GRCm39) |
missense |
probably benign |
0.24 |
|
R4940:Megf8
|
UTSW |
7 |
25,060,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5048:Megf8
|
UTSW |
7 |
25,030,517 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5258:Megf8
|
UTSW |
7 |
25,047,751 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5271:Megf8
|
UTSW |
7 |
25,041,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5390:Megf8
|
UTSW |
7 |
25,039,714 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5391:Megf8
|
UTSW |
7 |
25,039,714 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5708:Megf8
|
UTSW |
7 |
25,034,022 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5752:Megf8
|
UTSW |
7 |
25,054,539 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6037:Megf8
|
UTSW |
7 |
25,063,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6037:Megf8
|
UTSW |
7 |
25,063,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6153:Megf8
|
UTSW |
7 |
25,046,796 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6210:Megf8
|
UTSW |
7 |
25,043,145 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6457:Megf8
|
UTSW |
7 |
25,049,120 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6659:Megf8
|
UTSW |
7 |
25,058,159 (GRCm39) |
missense |
probably benign |
0.38 |
|
R6867:Megf8
|
UTSW |
7 |
25,030,460 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6896:Megf8
|
UTSW |
7 |
25,029,357 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6899:Megf8
|
UTSW |
7 |
25,060,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6905:Megf8
|
UTSW |
7 |
25,037,357 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7099:Megf8
|
UTSW |
7 |
25,045,945 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7172:Megf8
|
UTSW |
7 |
25,043,092 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7378:Megf8
|
UTSW |
7 |
25,048,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7427:Megf8
|
UTSW |
7 |
25,037,796 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7492:Megf8
|
UTSW |
7 |
25,053,273 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7699:Megf8
|
UTSW |
7 |
25,029,353 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7700:Megf8
|
UTSW |
7 |
25,029,353 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7756:Megf8
|
UTSW |
7 |
25,041,850 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7758:Megf8
|
UTSW |
7 |
25,041,850 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7786:Megf8
|
UTSW |
7 |
25,017,120 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7797:Megf8
|
UTSW |
7 |
25,034,022 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7881:Megf8
|
UTSW |
7 |
25,040,060 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8165:Megf8
|
UTSW |
7 |
25,053,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8258:Megf8
|
UTSW |
7 |
25,057,848 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8259:Megf8
|
UTSW |
7 |
25,057,848 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8328:Megf8
|
UTSW |
7 |
25,046,917 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8362:Megf8
|
UTSW |
7 |
25,039,943 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8680:Megf8
|
UTSW |
7 |
25,059,166 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9080:Megf8
|
UTSW |
7 |
25,041,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9297:Megf8
|
UTSW |
7 |
25,030,511 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9314:Megf8
|
UTSW |
7 |
25,029,297 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9378:Megf8
|
UTSW |
7 |
25,039,840 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9530:Megf8
|
UTSW |
7 |
25,030,124 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9557:Megf8
|
UTSW |
7 |
25,058,511 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9592:Megf8
|
UTSW |
7 |
25,028,228 (GRCm39) |
missense |
probably benign |
0.29 |
|
R9612:Megf8
|
UTSW |
7 |
25,054,488 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9629:Megf8
|
UTSW |
7 |
25,043,194 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R9643:Megf8
|
UTSW |
7 |
25,046,907 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9666:Megf8
|
UTSW |
7 |
25,030,166 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R9745:Megf8
|
UTSW |
7 |
25,058,133 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
Z1088:Megf8
|
UTSW |
7 |
25,039,094 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
Z1177:Megf8
|
UTSW |
7 |
25,046,794 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Megf8
|
UTSW |
7 |
25,045,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTGGATGTTCAGCCCAATAGC -3'
(R):5'- TAGGCTTGTGCTCCTAGGAC -3'
Sequencing Primer
(F):5'- AGAGGCTACGAGTTGACTCC -3'
(R):5'- GTGCTCCTAGGACCCCCTC -3'
|
| Posted On |
2017-02-28 |
Incidental Mutation