|Institutional Source||Beutler Lab|
|Gene Name||CD163 antigen|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R5943 (G1)|
|Chromosomal Location||124304656-124330527 bp(+) (GRCm38)|
|Type of Mutation||makesense|
|DNA Base Change (assembly)||T to C at 124329602 bp|
|Amino Acid Change||Stop codon to Arginine at position 1160 (*1160R)|
|Ref Sequence||ENSEMBL: ENSMUSP00000108160 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000032234] [ENSMUST00000112541]|
|Predicted Effect||probably benign
|Predicted Effect||probably null
AA Change: *1160R
AA Change: *1160R
|Predicted Effect||noncoding transcript
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
PHENOTYPE: After hindlimb ischemia, mice homozygous for a knock-out allele exhibit increased muscle satellite cell proliferation, and enhanced skeletal muscle regeneration not limited to the site of injury. Knock-out mice also exhibit increased eosinophilic airway inflammation in house dust mite-challenged. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cd163||
(F):5'- TTGAAATGTGACGGGATCCTG -3'
(R):5'- AAGGCCTCATACAGGTGGTC -3'
(F):5'- CGGGATCCTGTCAGGCAGTTATAAC -3'
(R):5'- CAAGCAGATCTCTGTGAATTCTAGGC -3'