Incidental Mutation 'R5943:Wwc2'
ID 460423
Institutional Source Beutler Lab
Gene Symbol Wwc2
Ensembl Gene ENSMUSG00000031563
Gene Name WW, C2 and coiled-coil domain containing 2
Synonyms D8Ertd594e
MMRRC Submission 044135-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R5943 (G1)
Quality Score 134
Status Not validated
Chromosome 8
Chromosomal Location 48279117-48443579 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 48443137 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 32 (N32S)
Ref Sequence ENSEMBL: ENSMUSP00000056121 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057561]
AlphaFold Q6NXJ0
Predicted Effect possibly damaging
Transcript: ENSMUST00000057561
AA Change: N32S

PolyPhen 2 Score 0.904 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000056121
Gene: ENSMUSG00000031563
AA Change: N32S

DomainStartEndE-ValueType
WW 11 43 3.92e-11 SMART
WW 58 90 4.65e-4 SMART
low complexity region 143 156 N/A INTRINSIC
coiled coil region 162 194 N/A INTRINSIC
coiled coil region 223 254 N/A INTRINSIC
coiled coil region 302 333 N/A INTRINSIC
low complexity region 341 358 N/A INTRINSIC
coiled coil region 359 423 N/A INTRINSIC
low complexity region 540 567 N/A INTRINSIC
C2 713 818 5.29e0 SMART
coiled coil region 857 884 N/A INTRINSIC
coiled coil region 1067 1144 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212282
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 93.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WW-and-C2-domain-containing family of proteins. Members of this family have two N-terminal WW domains that mediate binding to target proteins harboring L/PPxY motifs, an internal C2 domain for membrane association, and C-terminal alpha protein kinase C binding sites and class III PDZ domain-interaction motifs. Proteins of this family are able to form homo- and heterodimers and to modulate hippo pathway signaling. [provided by RefSeq, Sep 2016]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars2 C A 17: 45,828,637 (GRCm39) Q671K probably benign Het
Acaa2 A G 18: 74,925,453 (GRCm39) H72R probably damaging Het
Acad8 A G 9: 26,910,740 (GRCm39) L18P probably benign Het
Acap3 T C 4: 155,983,879 (GRCm39) V115A possibly damaging Het
Adamts9 T C 6: 92,880,767 (GRCm39) T503A probably benign Het
Adcy1 T C 11: 7,111,337 (GRCm39) F876S probably damaging Het
Adgrv1 T C 13: 81,534,985 (GRCm39) E5760G probably damaging Het
Ankrd26 A T 6: 118,482,707 (GRCm39) I1631K probably damaging Het
Ccdc150 A G 1: 54,339,526 (GRCm39) T457A probably benign Het
Cd163 T C 6: 124,306,561 (GRCm39) *1160R probably null Het
Cdc6 T C 11: 98,811,589 (GRCm39) S517P probably damaging Het
Cenpf A T 1: 189,392,166 (GRCm39) D555E possibly damaging Het
Cfap251 A G 5: 123,424,420 (GRCm39) T205A probably benign Het
Clcn1 T A 6: 42,269,900 (GRCm39) I241N probably damaging Het
Clrn2 A T 5: 45,621,061 (GRCm39) I152F probably benign Het
Col4a4 A G 1: 82,502,737 (GRCm39) I349T unknown Het
Coq8b T A 7: 26,933,428 (GRCm39) F96L probably damaging Het
Cp A T 3: 20,018,470 (GRCm39) N58I probably benign Het
Dcst1 A T 3: 89,263,718 (GRCm39) probably null Het
Dhrs3 A T 4: 144,646,546 (GRCm39) M199L possibly damaging Het
Dido1 A T 2: 180,303,675 (GRCm39) S1410T probably benign Het
Dnase1l2 C T 17: 24,661,721 (GRCm39) A13T probably damaging Het
Duox1 G A 2: 122,163,916 (GRCm39) R861Q probably benign Het
Eya2 A G 2: 165,566,609 (GRCm39) H220R probably damaging Het
Fas T G 19: 34,297,987 (GRCm39) probably null Het
Fezf1 T A 6: 23,246,948 (GRCm39) K295* probably null Het
Gldn T G 9: 54,245,721 (GRCm39) I424R possibly damaging Het
Gnptab T C 10: 88,269,376 (GRCm39) V693A probably benign Het
Gsdma A T 11: 98,563,852 (GRCm39) T269S probably benign Het
Hectd4 A T 5: 121,460,357 (GRCm39) T2209S probably benign Het
Hoxd3 A G 2: 74,577,173 (GRCm39) N351S probably benign Het
Itpkc T A 7: 26,912,404 (GRCm39) N581I possibly damaging Het
Kank3 G T 17: 34,037,375 (GRCm39) E226D probably damaging Het
Krtap5-1 A G 7: 141,850,788 (GRCm39) S7P unknown Het
Lrriq3 A G 3: 154,869,587 (GRCm39) Y304C probably damaging Het
Man2a1 A G 17: 64,932,375 (GRCm39) K154R probably benign Het
Mdn1 T C 4: 32,678,330 (GRCm39) S653P probably damaging Het
Mri1 A T 8: 84,980,948 (GRCm39) L194* probably null Het
Mtus1 T C 8: 41,537,302 (GRCm39) E138G probably benign Het
Myo3b G A 2: 70,117,285 (GRCm39) R906Q probably benign Het
Nckipsd C T 9: 108,689,435 (GRCm39) P199S possibly damaging Het
Or52n5 T A 7: 104,587,850 (GRCm39) I39N possibly damaging Het
Or9i16 C T 19: 13,865,116 (GRCm39) V153I possibly damaging Het
Pacsin1 T C 17: 27,925,045 (GRCm39) L253P probably damaging Het
Pcca T A 14: 122,896,188 (GRCm39) I268N probably damaging Het
Pcdhga8 A G 18: 37,949,565 (GRCm39) D327G probably damaging Het
Pcnx4 A G 12: 72,626,232 (GRCm39) H1146R probably damaging Het
Pnma8b T C 7: 16,680,362 (GRCm39) S449P probably benign Het
Psmb9 T C 17: 34,403,265 (GRCm39) E61G probably damaging Het
Pxylp1 A G 9: 96,721,203 (GRCm39) Y101H probably damaging Het
Radil A G 5: 142,471,213 (GRCm39) I1044T probably damaging Het
Rnf43 G A 11: 87,622,561 (GRCm39) R554H probably damaging Het
Sp5 A T 2: 70,305,659 (GRCm39) Q17L probably null Het
Spmip1 T A 6: 29,471,908 (GRCm39) L128Q possibly damaging Het
Strn C A 17: 78,977,276 (GRCm39) V211F probably damaging Het
Sult3a1 A G 10: 33,742,637 (GRCm39) D88G probably damaging Het
Trim14 T C 4: 46,522,136 (GRCm39) I180M probably benign Het
Tsnax C A 8: 125,751,278 (GRCm39) S90* probably null Het
Ttn A G 2: 76,798,780 (GRCm39) M498T probably benign Het
Vmn1r198 T A 13: 22,539,367 (GRCm39) Y195* probably null Het
Vmn2r70 T C 7: 85,215,199 (GRCm39) T112A probably benign Het
Yme1l1 G T 2: 23,058,342 (GRCm39) R158L probably damaging Het
Zc2hc1c C A 12: 85,336,483 (GRCm39) H47N probably damaging Het
Zc3h10 C A 10: 128,381,396 (GRCm39) probably benign Het
Zfp825 T C 13: 74,629,007 (GRCm39) R170G probably benign Het
Other mutations in Wwc2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00969:Wwc2 APN 8 48,299,193 (GRCm39) missense unknown
IGL01397:Wwc2 APN 8 48,321,311 (GRCm39) missense unknown
IGL01522:Wwc2 APN 8 48,321,668 (GRCm39) missense unknown
IGL01530:Wwc2 APN 8 48,316,974 (GRCm39) missense unknown
IGL01867:Wwc2 APN 8 48,336,615 (GRCm39) missense probably benign 0.02
IGL01991:Wwc2 APN 8 48,322,901 (GRCm39) nonsense probably null
IGL02092:Wwc2 APN 8 48,317,570 (GRCm39) missense unknown
IGL02320:Wwc2 APN 8 48,316,882 (GRCm39) splice site probably null
IGL02503:Wwc2 APN 8 48,302,418 (GRCm39) missense unknown
H8562:Wwc2 UTSW 8 48,373,701 (GRCm39) missense possibly damaging 0.77
R0244:Wwc2 UTSW 8 48,353,756 (GRCm39) missense probably benign 0.16
R0331:Wwc2 UTSW 8 48,333,239 (GRCm39) missense probably benign 0.15
R0349:Wwc2 UTSW 8 48,321,701 (GRCm39) missense unknown
R0542:Wwc2 UTSW 8 48,321,414 (GRCm39) missense unknown
R0645:Wwc2 UTSW 8 48,353,674 (GRCm39) splice site probably benign
R1081:Wwc2 UTSW 8 48,281,799 (GRCm39) unclassified probably benign
R1167:Wwc2 UTSW 8 48,311,814 (GRCm39) nonsense probably null
R1646:Wwc2 UTSW 8 48,295,937 (GRCm39) missense unknown
R1860:Wwc2 UTSW 8 48,443,137 (GRCm39) missense possibly damaging 0.90
R2070:Wwc2 UTSW 8 48,321,356 (GRCm39) missense unknown
R2183:Wwc2 UTSW 8 48,295,961 (GRCm39) missense unknown
R3969:Wwc2 UTSW 8 48,309,358 (GRCm39) missense unknown
R4096:Wwc2 UTSW 8 48,295,937 (GRCm39) missense unknown
R4387:Wwc2 UTSW 8 48,284,681 (GRCm39) missense unknown
R4447:Wwc2 UTSW 8 48,321,702 (GRCm39) missense unknown
R4448:Wwc2 UTSW 8 48,321,702 (GRCm39) missense unknown
R4450:Wwc2 UTSW 8 48,321,702 (GRCm39) missense unknown
R4646:Wwc2 UTSW 8 48,373,636 (GRCm39) missense probably damaging 1.00
R4869:Wwc2 UTSW 8 48,373,713 (GRCm39) missense probably damaging 0.99
R5159:Wwc2 UTSW 8 48,353,796 (GRCm39) missense probably benign 0.03
R5317:Wwc2 UTSW 8 48,300,590 (GRCm39) missense unknown
R5391:Wwc2 UTSW 8 48,316,906 (GRCm39) missense unknown
R5728:Wwc2 UTSW 8 48,317,096 (GRCm39) missense unknown
R5871:Wwc2 UTSW 8 48,321,458 (GRCm39) missense unknown
R6137:Wwc2 UTSW 8 48,309,298 (GRCm39) missense unknown
R6169:Wwc2 UTSW 8 48,311,878 (GRCm39) missense unknown
R6363:Wwc2 UTSW 8 48,340,197 (GRCm39) splice site probably null
R6421:Wwc2 UTSW 8 48,353,781 (GRCm39) missense probably damaging 1.00
R6467:Wwc2 UTSW 8 48,304,943 (GRCm39) missense unknown
R6712:Wwc2 UTSW 8 48,353,838 (GRCm39) missense probably benign 0.42
R6765:Wwc2 UTSW 8 48,353,826 (GRCm39) missense possibly damaging 0.85
R6766:Wwc2 UTSW 8 48,353,826 (GRCm39) missense possibly damaging 0.85
R6767:Wwc2 UTSW 8 48,353,826 (GRCm39) missense possibly damaging 0.85
R6768:Wwc2 UTSW 8 48,353,826 (GRCm39) missense possibly damaging 0.85
R6782:Wwc2 UTSW 8 48,353,826 (GRCm39) missense possibly damaging 0.85
R6993:Wwc2 UTSW 8 48,300,500 (GRCm39) missense unknown
R7016:Wwc2 UTSW 8 48,300,583 (GRCm39) missense unknown
R7079:Wwc2 UTSW 8 48,300,580 (GRCm39) missense unknown
R7219:Wwc2 UTSW 8 48,311,919 (GRCm39) missense unknown
R7258:Wwc2 UTSW 8 48,296,034 (GRCm39) missense unknown
R7334:Wwc2 UTSW 8 48,322,829 (GRCm39) missense unknown
R7375:Wwc2 UTSW 8 48,316,955 (GRCm39) missense unknown
R7451:Wwc2 UTSW 8 48,317,610 (GRCm39) missense not run
R7505:Wwc2 UTSW 8 48,333,185 (GRCm39) missense probably damaging 0.96
R7825:Wwc2 UTSW 8 48,443,197 (GRCm39) missense probably damaging 1.00
R7854:Wwc2 UTSW 8 48,321,512 (GRCm39) missense unknown
R7904:Wwc2 UTSW 8 48,309,270 (GRCm39) missense unknown
R8811:Wwc2 UTSW 8 48,336,579 (GRCm39) missense possibly damaging 0.48
R8985:Wwc2 UTSW 8 48,331,919 (GRCm39) missense probably benign 0.09
R9004:Wwc2 UTSW 8 48,373,732 (GRCm39) missense probably damaging 0.99
R9133:Wwc2 UTSW 8 48,305,007 (GRCm39) missense unknown
R9339:Wwc2 UTSW 8 48,353,859 (GRCm39) missense probably damaging 1.00
R9598:Wwc2 UTSW 8 48,328,360 (GRCm39) missense probably damaging 0.98
R9633:Wwc2 UTSW 8 48,304,959 (GRCm39) frame shift probably null
R9634:Wwc2 UTSW 8 48,304,959 (GRCm39) frame shift probably null
R9691:Wwc2 UTSW 8 48,281,799 (GRCm39) unclassified probably benign
R9799:Wwc2 UTSW 8 48,321,595 (GRCm39) missense unknown
Z1176:Wwc2 UTSW 8 48,321,584 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- AGTGTCTACAAGTCCCCGAG -3'
(R):5'- CAGACATGGTGGACTGATCTC -3'

Sequencing Primer
(F):5'- AGATACAGCCGCGCCTAG -3'
(R):5'- TGGACTGATCTCCGGCAG -3'
Posted On 2017-02-28