Incidental Mutation 'R5943:Zc3h10'
ID 460433
Institutional Source Beutler Lab
Gene Symbol Zc3h10
Ensembl Gene ENSMUSG00000039810
Gene Name zinc finger CCCH type containing 10
Synonyms
MMRRC Submission 044135-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.893) question?
Stock # R5943 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 128379429-128383877 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) C to A at 128381396 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000134737 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040572] [ENSMUST00000133458] [ENSMUST00000152539] [ENSMUST00000176010] [ENSMUST00000177163] [ENSMUST00000176683] [ENSMUST00000176906]
AlphaFold Q8R205
Predicted Effect probably benign
Transcript: ENSMUST00000040572
SMART Domains Protein: ENSMUSP00000042727
Gene: ENSMUSG00000039810

DomainStartEndE-ValueType
ZnF_C3H1 36 62 3.44e-4 SMART
ZnF_C3H1 75 98 7.41e0 SMART
ZnF_C3H1 134 160 5.67e-5 SMART
low complexity region 167 186 N/A INTRINSIC
SCOP:d1fxkc_ 241 272 2e-3 SMART
low complexity region 334 357 N/A INTRINSIC
low complexity region 378 403 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000133458
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135226
Predicted Effect probably benign
Transcript: ENSMUST00000152539
Predicted Effect probably benign
Transcript: ENSMUST00000176010
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176184
Predicted Effect noncoding transcript
Transcript: ENSMUST00000188089
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177513
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176966
Predicted Effect probably benign
Transcript: ENSMUST00000177163
Predicted Effect probably benign
Transcript: ENSMUST00000176683
Predicted Effect probably benign
Transcript: ENSMUST00000176906
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219955
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 93.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars2 C A 17: 45,828,637 (GRCm39) Q671K probably benign Het
Acaa2 A G 18: 74,925,453 (GRCm39) H72R probably damaging Het
Acad8 A G 9: 26,910,740 (GRCm39) L18P probably benign Het
Acap3 T C 4: 155,983,879 (GRCm39) V115A possibly damaging Het
Adamts9 T C 6: 92,880,767 (GRCm39) T503A probably benign Het
Adcy1 T C 11: 7,111,337 (GRCm39) F876S probably damaging Het
Adgrv1 T C 13: 81,534,985 (GRCm39) E5760G probably damaging Het
Ankrd26 A T 6: 118,482,707 (GRCm39) I1631K probably damaging Het
Ccdc150 A G 1: 54,339,526 (GRCm39) T457A probably benign Het
Cd163 T C 6: 124,306,561 (GRCm39) *1160R probably null Het
Cdc6 T C 11: 98,811,589 (GRCm39) S517P probably damaging Het
Cenpf A T 1: 189,392,166 (GRCm39) D555E possibly damaging Het
Cfap251 A G 5: 123,424,420 (GRCm39) T205A probably benign Het
Clcn1 T A 6: 42,269,900 (GRCm39) I241N probably damaging Het
Clrn2 A T 5: 45,621,061 (GRCm39) I152F probably benign Het
Col4a4 A G 1: 82,502,737 (GRCm39) I349T unknown Het
Coq8b T A 7: 26,933,428 (GRCm39) F96L probably damaging Het
Cp A T 3: 20,018,470 (GRCm39) N58I probably benign Het
Dcst1 A T 3: 89,263,718 (GRCm39) probably null Het
Dhrs3 A T 4: 144,646,546 (GRCm39) M199L possibly damaging Het
Dido1 A T 2: 180,303,675 (GRCm39) S1410T probably benign Het
Dnase1l2 C T 17: 24,661,721 (GRCm39) A13T probably damaging Het
Duox1 G A 2: 122,163,916 (GRCm39) R861Q probably benign Het
Eya2 A G 2: 165,566,609 (GRCm39) H220R probably damaging Het
Fas T G 19: 34,297,987 (GRCm39) probably null Het
Fezf1 T A 6: 23,246,948 (GRCm39) K295* probably null Het
Gldn T G 9: 54,245,721 (GRCm39) I424R possibly damaging Het
Gnptab T C 10: 88,269,376 (GRCm39) V693A probably benign Het
Gsdma A T 11: 98,563,852 (GRCm39) T269S probably benign Het
Hectd4 A T 5: 121,460,357 (GRCm39) T2209S probably benign Het
Hoxd3 A G 2: 74,577,173 (GRCm39) N351S probably benign Het
Itpkc T A 7: 26,912,404 (GRCm39) N581I possibly damaging Het
Kank3 G T 17: 34,037,375 (GRCm39) E226D probably damaging Het
Krtap5-1 A G 7: 141,850,788 (GRCm39) S7P unknown Het
Lrriq3 A G 3: 154,869,587 (GRCm39) Y304C probably damaging Het
Man2a1 A G 17: 64,932,375 (GRCm39) K154R probably benign Het
Mdn1 T C 4: 32,678,330 (GRCm39) S653P probably damaging Het
Mri1 A T 8: 84,980,948 (GRCm39) L194* probably null Het
Mtus1 T C 8: 41,537,302 (GRCm39) E138G probably benign Het
Myo3b G A 2: 70,117,285 (GRCm39) R906Q probably benign Het
Nckipsd C T 9: 108,689,435 (GRCm39) P199S possibly damaging Het
Or52n5 T A 7: 104,587,850 (GRCm39) I39N possibly damaging Het
Or9i16 C T 19: 13,865,116 (GRCm39) V153I possibly damaging Het
Pacsin1 T C 17: 27,925,045 (GRCm39) L253P probably damaging Het
Pcca T A 14: 122,896,188 (GRCm39) I268N probably damaging Het
Pcdhga8 A G 18: 37,949,565 (GRCm39) D327G probably damaging Het
Pcnx4 A G 12: 72,626,232 (GRCm39) H1146R probably damaging Het
Pnma8b T C 7: 16,680,362 (GRCm39) S449P probably benign Het
Psmb9 T C 17: 34,403,265 (GRCm39) E61G probably damaging Het
Pxylp1 A G 9: 96,721,203 (GRCm39) Y101H probably damaging Het
Radil A G 5: 142,471,213 (GRCm39) I1044T probably damaging Het
Rnf43 G A 11: 87,622,561 (GRCm39) R554H probably damaging Het
Sp5 A T 2: 70,305,659 (GRCm39) Q17L probably null Het
Spmip1 T A 6: 29,471,908 (GRCm39) L128Q possibly damaging Het
Strn C A 17: 78,977,276 (GRCm39) V211F probably damaging Het
Sult3a1 A G 10: 33,742,637 (GRCm39) D88G probably damaging Het
Trim14 T C 4: 46,522,136 (GRCm39) I180M probably benign Het
Tsnax C A 8: 125,751,278 (GRCm39) S90* probably null Het
Ttn A G 2: 76,798,780 (GRCm39) M498T probably benign Het
Vmn1r198 T A 13: 22,539,367 (GRCm39) Y195* probably null Het
Vmn2r70 T C 7: 85,215,199 (GRCm39) T112A probably benign Het
Wwc2 T C 8: 48,443,137 (GRCm39) N32S possibly damaging Het
Yme1l1 G T 2: 23,058,342 (GRCm39) R158L probably damaging Het
Zc2hc1c C A 12: 85,336,483 (GRCm39) H47N probably damaging Het
Zfp825 T C 13: 74,629,007 (GRCm39) R170G probably benign Het
Other mutations in Zc3h10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01681:Zc3h10 APN 10 128,381,109 (GRCm39) nonsense probably null
IGL02616:Zc3h10 APN 10 128,380,751 (GRCm39) missense probably benign 0.15
R0316:Zc3h10 UTSW 10 128,380,624 (GRCm39) missense probably damaging 1.00
R1502:Zc3h10 UTSW 10 128,380,151 (GRCm39) missense probably damaging 0.97
R1705:Zc3h10 UTSW 10 128,380,672 (GRCm39) nonsense probably null
R5739:Zc3h10 UTSW 10 128,380,670 (GRCm39) missense probably benign
R6931:Zc3h10 UTSW 10 128,380,553 (GRCm39) missense probably damaging 1.00
R7939:Zc3h10 UTSW 10 128,380,376 (GRCm39) missense probably damaging 0.99
R8876:Zc3h10 UTSW 10 128,380,163 (GRCm39) missense probably damaging 0.96
Z1176:Zc3h10 UTSW 10 128,380,818 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCAGGAAGTCTCTACAGATGGC -3'
(R):5'- GTTAGCCAGGCAAGTGTGAATC -3'

Sequencing Primer
(F):5'- ATGGCATCTGAGGTGGCTCC -3'
(R):5'- ACCAGGTGCATAAGGGCCTG -3'
Posted On 2017-02-28