|Institutional Source||Beutler Lab|
|Gene Name||zinc finger protein 39|
|Is this an essential gene?||Possibly non essential (E-score: 0.390)|
|Stock #||R5906 (G1)|
|Chromosomal Location||58888153-58904225 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 58902891 bp|
|Amino Acid Change||Aspartic acid to Glycine at position 7 (D7G)|
|Ref Sequence||ENSEMBL: ENSMUSP00000099764 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000102703]|
|Predicted Effect||probably benign
AA Change: D7G
PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
AA Change: D7G
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.0448|
|Coding Region Coverage||
|Validation Efficiency||95% (81/85)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a Kruppel-associated box (KRAB) zinc-finger protein, which belongs to a large group of transcriptional regulators in mammals. These proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation and apoptosis, and in regulating viral replication and transcription. A pseudogene of this gene was identified on chromosome 1. [provided by RefSeq, May 2016]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Zfp39||
(F):5'- ACAAGCACAATGTTGTATCTCTCC -3'
(R):5'- GCACTGCATTTGCCAAGAGC -3'
(F):5'- ATCTAACTCAGGTCGTCAGGACTG -3'
(R):5'- GCACAAGATGACAGTGACTCCTTTG -3'