Incidental Mutation 'R5915:Zfp599'
ID 461265
Institutional Source Beutler Lab
Gene Symbol Zfp599
Ensembl Gene ENSMUSG00000062794
Gene Name zinc finger protein 599
Synonyms
MMRRC Submission 044112-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R5915 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 22158726-22171191 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 22161130 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 345 (C345Y)
Ref Sequence ENSEMBL: ENSMUSP00000083462 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086281]
AlphaFold E9PWP1
Predicted Effect probably damaging
Transcript: ENSMUST00000086281
AA Change: C345Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000083462
Gene: ENSMUSG00000062794
AA Change: C345Y

DomainStartEndE-ValueType
KRAB 4 64 5.35e-33 SMART
ZnF_C2H2 228 250 5.59e-4 SMART
ZnF_C2H2 256 278 2.43e-4 SMART
ZnF_C2H2 284 306 1.69e-3 SMART
ZnF_C2H2 312 334 8.94e-3 SMART
ZnF_C2H2 340 362 8.47e-4 SMART
ZnF_C2H2 368 390 5.06e-2 SMART
ZnF_C2H2 396 418 7.9e-4 SMART
ZnF_C2H2 424 446 7.67e-2 SMART
ZnF_C2H2 452 474 1.64e-1 SMART
ZnF_C2H2 480 503 7.37e-4 SMART
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.2%
Validation Efficiency 98% (60/61)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T A 6: 121,644,122 (GRCm39) V940E probably damaging Het
Adgrg7 A T 16: 56,550,748 (GRCm39) probably null Het
Alox12e T C 11: 70,209,050 (GRCm39) I399V possibly damaging Het
Apoa5 C A 9: 46,180,607 (GRCm39) Q42K probably damaging Het
Arfgap1 A G 2: 180,620,215 (GRCm39) Y243C possibly damaging Het
Arhgap12 A G 18: 6,037,016 (GRCm39) probably null Het
Arl16 G A 11: 120,357,431 (GRCm39) probably benign Het
Atp8b5 A G 4: 43,370,577 (GRCm39) D951G probably damaging Het
Babam2 T A 5: 31,942,955 (GRCm39) L80Q probably damaging Het
Celsr1 C T 15: 85,822,176 (GRCm39) V1714I probably benign Het
Celsr1 C T 15: 85,914,550 (GRCm39) R1141H probably damaging Het
Cep295 A G 9: 15,252,775 (GRCm39) L351P probably damaging Het
Dlc1 T A 8: 37,405,829 (GRCm39) probably benign Het
Dpy30 G T 17: 74,622,906 (GRCm39) D25E probably benign Het
Drosha T C 15: 12,935,152 (GRCm39) W998R probably damaging Het
Fibp A G 19: 5,513,644 (GRCm39) D220G possibly damaging Het
Grm3 C T 5: 9,561,927 (GRCm39) C641Y probably damaging Het
Gulo A T 14: 66,245,570 (GRCm39) V8D probably benign Het
Ifrd1 A T 12: 40,263,095 (GRCm39) C164S possibly damaging Het
Jam2 G A 16: 84,606,295 (GRCm39) S103N probably benign Het
Krtap17-1 T C 11: 99,884,444 (GRCm39) T108A unknown Het
Man2a2 A G 7: 80,010,669 (GRCm39) F774S probably benign Het
Map1b G A 13: 99,566,839 (GRCm39) R1961W unknown Het
Mib2 A G 4: 155,740,508 (GRCm39) probably benign Het
Mr1 A T 1: 155,012,534 (GRCm39) F127I probably damaging Het
Mrgprb2 A G 7: 48,202,554 (GRCm39) I57T probably benign Het
Ncan G T 8: 70,550,731 (GRCm39) Y1154* probably null Het
Nfx1 T A 4: 40,977,285 (GRCm39) S320T probably benign Het
Nlrp4f A G 13: 65,335,369 (GRCm39) L740P probably damaging Het
Nprl2 T C 9: 107,422,277 (GRCm39) probably benign Het
Opn1sw A G 6: 29,379,754 (GRCm39) probably null Het
Or5bw2 A T 7: 6,573,172 (GRCm39) I61F probably benign Het
Palld A G 8: 61,986,386 (GRCm39) probably null Het
Phf14 T A 6: 11,933,726 (GRCm39) M196K possibly damaging Het
Rnf145 T C 11: 44,433,549 (GRCm39) probably null Het
Sbf2 A T 7: 109,977,303 (GRCm39) C610* probably null Het
Sec24a C T 11: 51,646,964 (GRCm39) A13T probably benign Het
Smim8 TCTCCTC TCTC 4: 34,769,010 (GRCm39) probably benign Het
Sox8 A C 17: 25,786,443 (GRCm39) L420R probably damaging Het
Sry C G Y: 2,662,612 (GRCm39) Q349H unknown Het
Sspo A G 6: 48,441,530 (GRCm39) D1889G probably benign Het
Sspo A T 6: 48,468,418 (GRCm39) H4382L possibly damaging Het
Tmem65 T C 15: 58,662,037 (GRCm39) I141V probably damaging Het
Tpr A T 1: 150,301,400 (GRCm39) T1329S probably benign Het
Trim17 C T 11: 58,859,388 (GRCm39) R201W probably damaging Het
Trim3 A G 7: 105,267,182 (GRCm39) L399P possibly damaging Het
Trim7 A G 11: 48,736,477 (GRCm39) D277G possibly damaging Het
Vstm2b A G 7: 40,552,107 (GRCm39) N153S possibly damaging Het
Wnk2 G T 13: 49,231,561 (GRCm39) Q786K probably damaging Het
Wnk4 A G 11: 101,154,720 (GRCm39) *286W probably null Het
Xpot A T 10: 121,450,998 (GRCm39) L134Q probably damaging Het
Ylpm1 C T 12: 85,087,660 (GRCm39) P1148L probably damaging Het
Zc3h7a G A 16: 10,982,466 (GRCm39) Q20* probably null Het
Other mutations in Zfp599
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00580:Zfp599 APN 9 22,160,768 (GRCm39) missense possibly damaging 0.94
IGL00845:Zfp599 APN 9 22,162,814 (GRCm39) splice site probably benign
R0136:Zfp599 UTSW 9 22,161,038 (GRCm39) missense probably benign 0.13
R0239:Zfp599 UTSW 9 22,161,055 (GRCm39) missense probably damaging 1.00
R0239:Zfp599 UTSW 9 22,161,055 (GRCm39) missense probably damaging 1.00
R0421:Zfp599 UTSW 9 22,161,843 (GRCm39) splice site probably benign
R1699:Zfp599 UTSW 9 22,161,700 (GRCm39) missense probably benign 0.20
R1723:Zfp599 UTSW 9 22,169,361 (GRCm39) missense probably damaging 1.00
R1899:Zfp599 UTSW 9 22,162,845 (GRCm39) missense probably benign 0.00
R4231:Zfp599 UTSW 9 22,161,041 (GRCm39) nonsense probably null
R4233:Zfp599 UTSW 9 22,161,041 (GRCm39) nonsense probably null
R4236:Zfp599 UTSW 9 22,161,041 (GRCm39) nonsense probably null
R4931:Zfp599 UTSW 9 22,169,419 (GRCm39) missense probably damaging 0.98
R5117:Zfp599 UTSW 9 22,161,396 (GRCm39) nonsense probably null
R5615:Zfp599 UTSW 9 22,165,165 (GRCm39) missense probably benign
R5759:Zfp599 UTSW 9 22,160,957 (GRCm39) missense probably damaging 1.00
R6184:Zfp599 UTSW 9 22,160,947 (GRCm39) missense probably benign 0.18
R6188:Zfp599 UTSW 9 22,161,286 (GRCm39) missense probably damaging 1.00
R6657:Zfp599 UTSW 9 22,161,538 (GRCm39) missense probably damaging 1.00
R6736:Zfp599 UTSW 9 22,161,140 (GRCm39) missense probably damaging 1.00
R6752:Zfp599 UTSW 9 22,160,840 (GRCm39) missense probably damaging 1.00
R7071:Zfp599 UTSW 9 22,169,392 (GRCm39) missense probably benign 0.38
R7643:Zfp599 UTSW 9 22,161,188 (GRCm39) missense probably benign 0.19
R7714:Zfp599 UTSW 9 22,161,811 (GRCm39) missense probably benign 0.07
R7951:Zfp599 UTSW 9 22,160,764 (GRCm39) missense probably damaging 1.00
R7967:Zfp599 UTSW 9 22,160,830 (GRCm39) missense possibly damaging 0.66
R8014:Zfp599 UTSW 9 22,160,777 (GRCm39) missense probably benign 0.03
R8187:Zfp599 UTSW 9 22,161,111 (GRCm39) nonsense probably null
R9562:Zfp599 UTSW 9 22,160,999 (GRCm39) missense probably damaging 0.98
R9684:Zfp599 UTSW 9 22,160,824 (GRCm39) missense probably damaging 1.00
R9722:Zfp599 UTSW 9 22,160,741 (GRCm39) missense probably damaging 0.96
RF005:Zfp599 UTSW 9 22,165,180 (GRCm39) missense probably benign 0.03
RF024:Zfp599 UTSW 9 22,165,180 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- ACTTTGATGTCGAATGAGGTGTGAC -3'
(R):5'- TTCTGCTCTCAGGGAAAACTTACTC -3'

Sequencing Primer
(F):5'- CACAGTCTGTGCATGCATAAG -3'
(R):5'- GCAAGAAGCCTTATGCATGTACTG -3'
Posted On 2017-02-28