Incidental Mutation 'R5918:Ceacam3'
ID 461461
Institutional Source Beutler Lab
Gene Symbol Ceacam3
Ensembl Gene ENSMUSG00000053228
Gene Name CEA cell adhesion molecule 3
Synonyms EG384557, cea12, Psg24
MMRRC Submission 044115-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5918 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 16884207-16898178 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 16893670 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Tyrosine at position 394 (D394Y)
Ref Sequence ENSEMBL: ENSMUSP00000104131 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108491]
AlphaFold E9Q6J4
Predicted Effect probably damaging
Transcript: ENSMUST00000065540
AA Change: D394Y

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000069892
Gene: ENSMUSG00000053228
AA Change: D394Y

DomainStartEndE-ValueType
low complexity region 14 25 N/A INTRINSIC
IG 35 136 2.83e-3 SMART
IG 155 256 6.31e-1 SMART
IG 275 376 1.42e-3 SMART
IG 395 494 2.08e-1 SMART
IG 511 610 1.26e0 SMART
IGc2 628 692 7.64e-9 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000108491
AA Change: D394Y

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000104131
Gene: ENSMUSG00000053228
AA Change: D394Y

DomainStartEndE-ValueType
IG 40 141 2.83e-3 SMART
IG 160 261 6.31e-1 SMART
IG 280 379 8.01e-3 SMART
IG 398 497 2.08e-1 SMART
IG 514 613 1.26e0 SMART
IGc2 631 695 7.64e-9 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.8%
  • 20x: 93.6%
Validation Efficiency 93% (66/71)
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afap1 A T 5: 36,131,869 (GRCm39) I399F possibly damaging Het
Aknad1 C T 3: 108,659,703 (GRCm39) P239L probably benign Het
Ankrd9 A G 12: 110,943,200 (GRCm39) V245A probably benign Het
Anxa1 T C 19: 20,355,857 (GRCm39) probably benign Het
Arhgef2 A G 3: 88,543,387 (GRCm39) K454R probably damaging Het
AU040320 A G 4: 126,708,064 (GRCm39) T227A probably benign Het
Bbs2 C T 8: 94,824,931 (GRCm39) R17H probably damaging Het
Bcl2l12 A G 7: 44,640,888 (GRCm39) probably benign Het
C1qtnf9 G T 14: 61,009,737 (GRCm39) probably benign Het
Ccdc38 C G 10: 93,406,748 (GRCm39) Y219* probably null Het
Crip1 A C 12: 113,117,287 (GRCm39) probably null Het
Dnah7b T C 1: 46,260,803 (GRCm39) V1987A probably benign Het
Dnah9 C A 11: 65,725,025 (GRCm39) C4376F probably damaging Het
Galnt9 T C 5: 110,763,332 (GRCm39) F446L probably damaging Het
Garin1a A G 6: 29,285,942 (GRCm39) R76G probably null Het
Gm14322 A G 2: 177,411,499 (GRCm39) D103G probably benign Het
Gpa33 T C 1: 165,958,107 (GRCm39) probably null Het
Lactb2 T A 1: 13,720,954 (GRCm39) I93F probably benign Het
Lifr A T 15: 7,188,897 (GRCm39) T93S probably benign Het
Lmbr1l A T 15: 98,810,308 (GRCm39) I101N probably damaging Het
Lrrc8c G A 5: 105,756,117 (GRCm39) V631M possibly damaging Het
Mctp2 A C 7: 71,878,288 (GRCm39) D263E probably damaging Het
Nbeal1 T A 1: 60,307,051 (GRCm39) I1627N possibly damaging Het
Neb T C 2: 52,087,906 (GRCm39) Y5188C probably damaging Het
Nf1 T C 11: 79,460,048 (GRCm39) probably benign Het
Nr6a1 T C 2: 38,629,103 (GRCm39) D250G probably damaging Het
Ola1 T C 2: 72,987,128 (GRCm39) E168G probably benign Het
Or1a1 T C 11: 74,086,944 (GRCm39) V205A probably damaging Het
Or2d2b T A 7: 106,705,828 (GRCm39) Q80L probably damaging Het
Or4k2 A G 14: 50,424,425 (GRCm39) I83T probably benign Het
Or7g22 T C 9: 19,048,684 (GRCm39) Y132H probably damaging Het
Or9i1b T A 19: 13,897,139 (GRCm39) F252I probably damaging Het
Pik3r6 C T 11: 68,416,497 (GRCm39) Q29* probably null Het
Ppargc1a C T 5: 51,620,579 (GRCm39) probably benign Het
Ppl C T 16: 4,922,765 (GRCm39) R242H probably benign Het
Ppp1r37 G T 7: 19,266,036 (GRCm39) Q577K probably benign Het
Prcd A G 11: 116,548,366 (GRCm39) E25G probably damaging Het
Prpsap2 C T 11: 61,627,870 (GRCm39) R202H probably damaging Het
Ptgs1 A C 2: 36,141,089 (GRCm39) E512A probably damaging Het
Radil T G 5: 142,473,357 (GRCm39) I535L probably benign Het
Rbl2 G T 8: 91,816,758 (GRCm39) V373F probably benign Het
Ryr1 T C 7: 28,708,577 (GRCm39) Y4802C probably benign Het
Sdc2 A G 15: 33,028,313 (GRCm39) T144A probably benign Het
Senp6 T C 9: 80,021,398 (GRCm39) probably null Het
Sipa1l3 T C 7: 29,096,631 (GRCm39) D531G probably damaging Het
Slc22a27 C A 19: 7,887,411 (GRCm39) C189F possibly damaging Het
Srcin1 T C 11: 97,424,323 (GRCm39) probably null Het
Svep1 C T 4: 58,069,345 (GRCm39) E2814K possibly damaging Het
Tjp3 T G 10: 81,113,746 (GRCm39) H504P probably benign Het
Tmprss4 T A 9: 45,086,414 (GRCm39) K378* probably null Het
Tns4 C T 11: 98,964,497 (GRCm39) probably null Het
Ttn T C 2: 76,580,298 (GRCm39) T15205A possibly damaging Het
Ush2a G T 1: 188,089,011 (GRCm39) G322V probably benign Het
Vac14 A T 8: 111,363,104 (GRCm39) probably null Het
Vmn1r175 T G 7: 23,508,372 (GRCm39) D85A probably damaging Het
Vmn2r93 T C 17: 18,546,030 (GRCm39) L634P probably damaging Het
Zeb2 A T 2: 45,001,271 (GRCm39) probably benign Het
Zfp616 T A 11: 73,974,086 (GRCm39) H118Q possibly damaging Het
Zfp945 T A 17: 23,069,955 (GRCm39) H648L probably damaging Het
Zscan29 G T 2: 120,994,518 (GRCm39) T489N probably damaging Het
Other mutations in Ceacam3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01161:Ceacam3 APN 7 16,885,782 (GRCm39) missense probably benign 0.03
IGL01510:Ceacam3 APN 7 16,893,767 (GRCm39) missense probably benign 0.00
IGL01830:Ceacam3 APN 7 16,888,925 (GRCm39) missense possibly damaging 0.79
IGL02155:Ceacam3 APN 7 16,896,906 (GRCm39) missense possibly damaging 0.58
IGL02281:Ceacam3 APN 7 16,895,656 (GRCm39) missense probably benign 0.43
IGL02301:Ceacam3 APN 7 16,897,026 (GRCm39) missense probably damaging 1.00
IGL02320:Ceacam3 APN 7 16,895,865 (GRCm39) missense probably benign 0.43
IGL02514:Ceacam3 APN 7 16,896,906 (GRCm39) missense possibly damaging 0.58
IGL02929:Ceacam3 APN 7 16,892,115 (GRCm39) missense probably damaging 1.00
IGL03143:Ceacam3 APN 7 16,892,045 (GRCm39) nonsense probably null
IGL03269:Ceacam3 APN 7 16,895,767 (GRCm39) missense probably damaging 0.99
R0408:Ceacam3 UTSW 7 16,885,808 (GRCm39) critical splice donor site probably benign
R0591:Ceacam3 UTSW 7 16,885,808 (GRCm39) critical splice donor site probably null
R1274:Ceacam3 UTSW 7 16,897,064 (GRCm39) missense probably damaging 0.98
R1376:Ceacam3 UTSW 7 16,897,088 (GRCm39) missense probably damaging 1.00
R1376:Ceacam3 UTSW 7 16,897,088 (GRCm39) missense probably damaging 1.00
R1490:Ceacam3 UTSW 7 16,897,071 (GRCm39) missense probably damaging 1.00
R1635:Ceacam3 UTSW 7 16,893,902 (GRCm39) missense probably damaging 1.00
R1769:Ceacam3 UTSW 7 16,892,301 (GRCm39) missense probably damaging 1.00
R2345:Ceacam3 UTSW 7 16,888,925 (GRCm39) missense possibly damaging 0.79
R2367:Ceacam3 UTSW 7 16,885,813 (GRCm39) splice site probably null
R2403:Ceacam3 UTSW 7 16,895,779 (GRCm39) missense probably damaging 1.00
R4030:Ceacam3 UTSW 7 16,892,267 (GRCm39) missense probably benign 0.43
R4240:Ceacam3 UTSW 7 16,893,949 (GRCm39) missense possibly damaging 0.95
R5305:Ceacam3 UTSW 7 16,885,501 (GRCm39) missense probably damaging 1.00
R5314:Ceacam3 UTSW 7 16,892,296 (GRCm39) missense possibly damaging 0.94
R5433:Ceacam3 UTSW 7 16,893,808 (GRCm39) missense possibly damaging 0.48
R5538:Ceacam3 UTSW 7 16,892,346 (GRCm39) missense probably damaging 1.00
R5638:Ceacam3 UTSW 7 16,893,860 (GRCm39) missense probably damaging 0.98
R5787:Ceacam3 UTSW 7 16,888,971 (GRCm39) missense possibly damaging 0.80
R5891:Ceacam3 UTSW 7 16,885,718 (GRCm39) missense probably damaging 1.00
R6074:Ceacam3 UTSW 7 16,885,484 (GRCm39) missense probably benign 0.05
R6386:Ceacam3 UTSW 7 16,892,144 (GRCm39) missense probably benign 0.22
R6439:Ceacam3 UTSW 7 16,892,253 (GRCm39) missense possibly damaging 0.59
R6455:Ceacam3 UTSW 7 16,895,863 (GRCm39) missense possibly damaging 0.81
R7150:Ceacam3 UTSW 7 16,885,487 (GRCm39) missense
R7196:Ceacam3 UTSW 7 16,888,881 (GRCm39) missense
R7201:Ceacam3 UTSW 7 16,892,163 (GRCm39) nonsense probably null
R7731:Ceacam3 UTSW 7 16,892,275 (GRCm39) missense
R7833:Ceacam3 UTSW 7 16,893,778 (GRCm39) missense
R8202:Ceacam3 UTSW 7 16,896,953 (GRCm39) missense
R8237:Ceacam3 UTSW 7 16,897,082 (GRCm39) missense
R8420:Ceacam3 UTSW 7 16,895,608 (GRCm39) missense
R8696:Ceacam3 UTSW 7 16,893,937 (GRCm39) missense
R9381:Ceacam3 UTSW 7 16,893,715 (GRCm39) missense
R9616:Ceacam3 UTSW 7 16,892,078 (GRCm39) missense
R9633:Ceacam3 UTSW 7 16,895,688 (GRCm39) missense
R9686:Ceacam3 UTSW 7 16,892,123 (GRCm39) missense
R9727:Ceacam3 UTSW 7 16,892,262 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- TGCTGACTTCCACCAGGTTG -3'
(R):5'- GCAGCAGGGATCCATTGGTATAC -3'

Sequencing Primer
(F):5'- CTTCCACCAGGTTGGGTAGAAATG -3'
(R):5'- GCAGGGATCCATTGGTATACACTATC -3'
Posted On 2017-02-28