Incidental Mutation 'R5924:Or2y3'
ID 461756
Institutional Source Beutler Lab
Gene Symbol Or2y3
Ensembl Gene ENSMUSG00000043312
Gene Name olfactory receptor family 2 subfamily Y member 3
Synonyms GA_x6K02T2PSCP-2531299-2530355, MOR256-4, Olfr131
MMRRC Submission 044119-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R5924 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 38392923-38393867 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 38393254 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 205 (V205A)
Ref Sequence ENSEMBL: ENSMUSP00000150562 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059560] [ENSMUST00000172933] [ENSMUST00000215940] [ENSMUST00000216523]
AlphaFold Q8VGC8
Predicted Effect probably benign
Transcript: ENSMUST00000059560
AA Change: V205A

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000061861
Gene: ENSMUSG00000043312
AA Change: V205A

DomainStartEndE-ValueType
Pfam:7tm_1 43 294 4e-35 PFAM
Pfam:7tm_4 141 287 2.7e-40 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000172933
AA Change: V205A

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000134532
Gene: ENSMUSG00000043312
AA Change: V205A

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 9.5e-57 PFAM
Pfam:7tm_1 43 294 1.2e-29 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173218
Predicted Effect probably benign
Transcript: ENSMUST00000215940
AA Change: V205A

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
Predicted Effect probably benign
Transcript: ENSMUST00000216523
AA Change: V205A

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd3 T C 18: 10,706,085 (GRCm39) Y76C probably damaging Het
Agbl1 C T 7: 76,058,982 (GRCm39) T204I probably benign Het
Apc2 A T 10: 80,147,984 (GRCm39) I984F probably damaging Het
Art3 A T 5: 92,560,091 (GRCm39) probably benign Het
B4galnt4 A G 7: 140,650,742 (GRCm39) M839V probably damaging Het
Bnip2 A G 9: 69,904,444 (GRCm39) D67G probably benign Het
Cdhr2 A C 13: 54,874,496 (GRCm39) D856A probably benign Het
Cep78 A T 19: 15,938,430 (GRCm39) L506Q probably damaging Het
Col6a1 A G 10: 76,554,205 (GRCm39) probably null Het
Cyp3a44 A T 5: 145,731,137 (GRCm39) F221Y possibly damaging Het
Dcakd C A 11: 102,890,646 (GRCm39) R47L probably benign Het
Ddr2 A G 1: 169,822,197 (GRCm39) V417A probably benign Het
Dnah5 A T 15: 28,307,473 (GRCm39) T1734S probably benign Het
Eefsec A T 6: 88,332,529 (GRCm39) M227K probably damaging Het
Eif4g3 T G 4: 137,929,237 (GRCm39) N1628K probably damaging Het
Epha5 A T 5: 84,381,533 (GRCm39) Y439* probably null Het
Esrp1 G T 4: 11,361,174 (GRCm39) T324K probably damaging Het
Flnb T A 14: 7,890,765 (GRCm38) M549K probably benign Het
Fndc1 T A 17: 7,992,442 (GRCm39) Q418L unknown Het
Ggnbp2 A G 11: 84,749,363 (GRCm39) S144P possibly damaging Het
Gk5 T C 9: 96,032,563 (GRCm39) probably null Het
Gpr137 A G 19: 6,916,729 (GRCm39) L228P probably damaging Het
Gpt2 C A 8: 86,219,633 (GRCm39) S26R probably damaging Het
Hras C T 7: 140,772,374 (GRCm39) E91K possibly damaging Het
Ighv1-36 G A 12: 114,843,777 (GRCm39) P28S possibly damaging Het
Kalrn G A 16: 34,064,203 (GRCm39) T807M probably damaging Het
Lifr A G 15: 7,202,453 (GRCm39) T365A probably benign Het
Lpin1 A T 12: 16,594,658 (GRCm39) S795T possibly damaging Het
Magi2 A C 5: 20,816,067 (GRCm39) M1128L probably benign Het
Magi3 A T 3: 103,961,854 (GRCm39) probably null Het
Mier1 T A 4: 103,016,899 (GRCm39) L380* probably null Het
Mtmr14 A G 6: 113,230,750 (GRCm39) Y118C probably damaging Het
Myof A T 19: 37,971,421 (GRCm39) M277K probably damaging Het
Nlrp6 T C 7: 140,503,403 (GRCm39) V473A probably damaging Het
Nsfl1c T A 2: 151,347,320 (GRCm39) N164K probably benign Het
Olfm3 A T 3: 114,916,187 (GRCm39) Q353L probably benign Het
Opn5 A T 17: 42,922,199 (GRCm39) M1K probably null Het
Or4k15 A G 14: 50,364,139 (GRCm39) Y35C probably damaging Het
Or5d41 T C 2: 88,054,891 (GRCm39) I162V probably benign Het
Pax8 A G 2: 24,311,634 (GRCm39) S434P probably damaging Het
Pigo G A 4: 43,023,389 (GRCm39) Q256* probably null Het
Pik3ap1 A C 19: 41,284,895 (GRCm39) F597V probably damaging Het
Pkd2 A G 5: 104,646,424 (GRCm39) K744E probably damaging Het
Prom1 T C 5: 44,162,305 (GRCm39) T729A probably benign Het
Rasal1 T C 5: 120,813,582 (GRCm39) L652P probably damaging Het
Sebox T C 11: 78,395,017 (GRCm39) probably null Het
Setd2 A T 9: 110,403,112 (GRCm39) I1918F probably benign Het
Slc24a2 A T 4: 86,929,825 (GRCm39) probably null Het
Slc28a1 G T 7: 80,765,360 (GRCm39) G25V probably benign Het
Slc51a A G 16: 32,295,990 (GRCm39) F259L possibly damaging Het
Slco2a1 T A 9: 102,923,898 (GRCm39) C37* probably null Het
Speer4f2 A G 5: 17,581,622 (GRCm39) D188G probably damaging Het
Stim2 A G 5: 54,259,985 (GRCm39) K156E probably benign Het
Strn4 T C 7: 16,572,246 (GRCm39) I653T probably damaging Het
Tacr3 G T 3: 134,638,060 (GRCm39) D406Y possibly damaging Het
Utp20 G A 10: 88,651,784 (GRCm39) R400C probably benign Het
V1rd19 C T 7: 23,703,374 (GRCm39) S280L probably benign Het
Vmn2r4 C T 3: 64,296,685 (GRCm39) C700Y probably damaging Het
Zup1 A T 10: 33,803,543 (GRCm39) C514S probably damaging Het
Other mutations in Or2y3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01063:Or2y3 APN 17 38,393,544 (GRCm39) missense possibly damaging 0.48
IGL01287:Or2y3 APN 17 38,392,998 (GRCm39) missense probably damaging 1.00
IGL01637:Or2y3 APN 17 38,392,994 (GRCm39) missense possibly damaging 0.90
IGL02833:Or2y3 APN 17 38,393,243 (GRCm39) missense possibly damaging 0.84
IGL02927:Or2y3 APN 17 38,393,114 (GRCm39) missense probably benign 0.00
R0662:Or2y3 UTSW 17 38,393,824 (GRCm39) missense probably benign 0.09
R0755:Or2y3 UTSW 17 38,393,085 (GRCm39) nonsense probably null
R1526:Or2y3 UTSW 17 38,393,486 (GRCm39) missense probably damaging 0.99
R2155:Or2y3 UTSW 17 38,393,071 (GRCm39) missense probably damaging 1.00
R3123:Or2y3 UTSW 17 38,392,903 (GRCm39) splice site probably null
R3125:Or2y3 UTSW 17 38,392,903 (GRCm39) splice site probably null
R4135:Or2y3 UTSW 17 38,393,248 (GRCm39) missense possibly damaging 0.52
R4244:Or2y3 UTSW 17 38,393,321 (GRCm39) missense probably benign 0.12
R5104:Or2y3 UTSW 17 38,393,174 (GRCm39) missense possibly damaging 0.47
R5182:Or2y3 UTSW 17 38,393,005 (GRCm39) missense probably benign 0.03
R5293:Or2y3 UTSW 17 38,393,131 (GRCm39) missense probably damaging 1.00
R5738:Or2y3 UTSW 17 38,393,347 (GRCm39) missense probably damaging 1.00
R6218:Or2y3 UTSW 17 38,393,620 (GRCm39) missense probably damaging 0.98
R6362:Or2y3 UTSW 17 38,393,620 (GRCm39) missense probably damaging 0.99
R6961:Or2y3 UTSW 17 38,393,096 (GRCm39) missense probably damaging 0.99
R7838:Or2y3 UTSW 17 38,393,293 (GRCm39) missense probably benign 0.00
R8088:Or2y3 UTSW 17 38,393,452 (GRCm39) missense possibly damaging 0.78
R8730:Or2y3 UTSW 17 38,392,925 (GRCm39) makesense probably null
R9303:Or2y3 UTSW 17 38,393,629 (GRCm39) missense probably damaging 1.00
R9305:Or2y3 UTSW 17 38,393,629 (GRCm39) missense probably damaging 1.00
R9378:Or2y3 UTSW 17 38,393,056 (GRCm39) missense possibly damaging 0.92
R9776:Or2y3 UTSW 17 38,393,470 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GTGCCAAAAGCTTGCCCTTC -3'
(R):5'- GCAGCAGTAGCCTGGATAACTG -3'

Sequencing Primer
(F):5'- GTGCCATGTATGCATATCCACTGATG -3'
(R):5'- GCCTGGATAACTGGTTTCAGCAATTC -3'
Posted On 2017-02-28