Incidental Mutation 'R0566:Zfp112'
ID 46182
Institutional Source Beutler Lab
Gene Symbol Zfp112
Ensembl Gene ENSMUSG00000052675
Gene Name zinc finger protein 112
Synonyms
MMRRC Submission 038757-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.144) question?
Stock # R0566 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 23811739-23827377 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 23825102 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 357 (S357P)
Ref Sequence ENSEMBL: ENSMUSP00000150734 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000005413] [ENSMUST00000120006] [ENSMUST00000215113]
AlphaFold Q0VAW7
Predicted Effect probably benign
Transcript: ENSMUST00000005413
AA Change: S361P

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000005413
Gene: ENSMUSG00000052675
AA Change: S361P

DomainStartEndE-ValueType
KRAB 8 68 7.93e-27 SMART
low complexity region 385 397 N/A INTRINSIC
ZnF_C2H2 523 545 4.11e-2 SMART
ZnF_C2H2 551 573 3.44e-4 SMART
ZnF_C2H2 579 601 1.6e-4 SMART
ZnF_C2H2 607 629 1.5e-4 SMART
ZnF_C2H2 635 657 3.89e-3 SMART
ZnF_C2H2 663 685 1.58e-3 SMART
ZnF_C2H2 691 713 6.42e-4 SMART
ZnF_C2H2 719 741 5.99e-4 SMART
ZnF_C2H2 747 769 7.78e-3 SMART
ZnF_C2H2 775 797 3.95e-4 SMART
ZnF_C2H2 803 825 2.01e-5 SMART
ZnF_C2H2 831 853 1.36e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000120006
AA Change: S355P

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000113031
Gene: ENSMUSG00000052675
AA Change: S355P

DomainStartEndE-ValueType
KRAB 2 62 7.93e-27 SMART
low complexity region 379 391 N/A INTRINSIC
ZnF_C2H2 517 539 4.11e-2 SMART
ZnF_C2H2 545 567 3.44e-4 SMART
ZnF_C2H2 573 595 1.6e-4 SMART
ZnF_C2H2 601 623 1.5e-4 SMART
ZnF_C2H2 629 651 3.89e-3 SMART
ZnF_C2H2 657 679 1.58e-3 SMART
ZnF_C2H2 685 707 6.42e-4 SMART
ZnF_C2H2 713 735 5.99e-4 SMART
ZnF_C2H2 741 763 7.78e-3 SMART
ZnF_C2H2 769 791 3.95e-4 SMART
ZnF_C2H2 797 819 2.01e-5 SMART
ZnF_C2H2 825 847 1.36e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000215113
AA Change: S357P

PolyPhen 2 Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
Meta Mutation Damage Score 0.0623 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.9%
Validation Efficiency 96% (24/25)
Allele List at MGI

All alleles(1) : Gene trapped(1)

Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsf3 T C 8: 123,508,266 (GRCm39) L254P possibly damaging Het
Adamts6 C A 13: 104,581,435 (GRCm39) A850E probably benign Het
Ccdc112 A C 18: 46,423,877 (GRCm39) V287G probably damaging Het
Ctbp2 A G 7: 132,592,876 (GRCm39) V811A probably damaging Het
Dchs1 A G 7: 105,408,402 (GRCm39) V1810A probably benign Het
Dhx15 T G 5: 52,328,767 (GRCm39) K287T probably damaging Het
Extl1 TGCGTTGCACCGATACCGGG TG 4: 134,084,988 (GRCm39) probably benign Het
Fryl T C 5: 73,221,840 (GRCm39) probably benign Het
Gnpda2 A G 5: 69,742,304 (GRCm39) probably benign Het
Mto1 T C 9: 78,355,583 (GRCm39) F2S possibly damaging Het
Nlrp1a A G 11: 71,013,768 (GRCm39) L494P probably benign Het
Or2r2 T A 6: 42,464,025 (GRCm39) Y34F probably damaging Het
Paqr8 C A 1: 21,005,687 (GRCm39) H280Q possibly damaging Het
Perm1 A T 4: 156,302,316 (GRCm39) M287L probably benign Het
Piwil2 A G 14: 70,647,843 (GRCm39) V323A probably damaging Het
Pon3 A G 6: 5,232,408 (GRCm39) V131A possibly damaging Het
Prima1 C A 12: 103,163,573 (GRCm39) A133S probably benign Het
Prl7c1 A G 13: 27,962,961 (GRCm39) L14P probably damaging Het
Prr23a2 T A 9: 98,739,041 (GRCm39) L133H possibly damaging Het
Samd3 T C 10: 26,120,396 (GRCm39) V157A possibly damaging Het
Slc35e1 T C 8: 73,246,415 (GRCm39) probably benign Het
Tep1 A T 14: 51,082,871 (GRCm39) probably null Het
Tmem208 T C 8: 106,061,475 (GRCm39) V167A probably benign Het
Tnrc6a A T 7: 122,770,136 (GRCm39) N642I probably benign Het
Vps26a A G 10: 62,316,325 (GRCm39) probably benign Het
Other mutations in Zfp112
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Zfp112 APN 7 23,821,668 (GRCm39) missense probably damaging 1.00
IGL00575:Zfp112 APN 7 23,825,757 (GRCm39) missense probably damaging 1.00
IGL00944:Zfp112 APN 7 23,825,021 (GRCm39) missense probably benign 0.02
IGL01662:Zfp112 APN 7 23,825,379 (GRCm39) missense probably benign 0.44
IGL03383:Zfp112 APN 7 23,825,103 (GRCm39) missense probably damaging 1.00
2107:Zfp112 UTSW 7 23,826,266 (GRCm39) missense probably damaging 1.00
FR4737:Zfp112 UTSW 7 23,824,832 (GRCm39) small insertion probably benign
R0581:Zfp112 UTSW 7 23,825,288 (GRCm39) missense probably damaging 0.97
R0613:Zfp112 UTSW 7 23,826,453 (GRCm39) missense probably benign 0.33
R1521:Zfp112 UTSW 7 23,825,210 (GRCm39) missense probably damaging 0.97
R1614:Zfp112 UTSW 7 23,826,024 (GRCm39) missense probably damaging 1.00
R1827:Zfp112 UTSW 7 23,824,385 (GRCm39) missense probably damaging 1.00
R1906:Zfp112 UTSW 7 23,821,720 (GRCm39) missense probably benign 0.34
R1920:Zfp112 UTSW 7 23,824,662 (GRCm39) missense probably benign 0.01
R2008:Zfp112 UTSW 7 23,826,176 (GRCm39) missense probably damaging 1.00
R2012:Zfp112 UTSW 7 23,824,725 (GRCm39) missense possibly damaging 0.69
R2192:Zfp112 UTSW 7 23,824,863 (GRCm39) missense probably damaging 0.98
R2985:Zfp112 UTSW 7 23,821,720 (GRCm39) missense probably benign 0.34
R4191:Zfp112 UTSW 7 23,825,568 (GRCm39) missense probably benign 0.19
R4373:Zfp112 UTSW 7 23,824,473 (GRCm39) missense probably damaging 0.99
R4374:Zfp112 UTSW 7 23,825,798 (GRCm39) missense probably damaging 1.00
R4674:Zfp112 UTSW 7 23,826,399 (GRCm39) missense probably damaging 1.00
R4676:Zfp112 UTSW 7 23,825,685 (GRCm39) missense probably damaging 0.97
R5023:Zfp112 UTSW 7 23,825,909 (GRCm39) missense probably damaging 0.99
R5198:Zfp112 UTSW 7 23,824,281 (GRCm39) missense possibly damaging 0.49
R6559:Zfp112 UTSW 7 23,825,888 (GRCm39) nonsense probably null
R6835:Zfp112 UTSW 7 23,825,231 (GRCm39) missense probably damaging 1.00
R6946:Zfp112 UTSW 7 23,824,766 (GRCm39) missense probably damaging 0.98
R7263:Zfp112 UTSW 7 23,824,952 (GRCm39) missense probably benign 0.04
R7512:Zfp112 UTSW 7 23,824,604 (GRCm39) missense possibly damaging 0.73
R7533:Zfp112 UTSW 7 23,824,752 (GRCm39) missense possibly damaging 0.58
R7535:Zfp112 UTSW 7 23,826,135 (GRCm39) missense probably damaging 1.00
R8179:Zfp112 UTSW 7 23,825,063 (GRCm39) missense probably benign 0.10
R8516:Zfp112 UTSW 7 23,823,389 (GRCm39) missense probably benign
R8525:Zfp112 UTSW 7 23,825,322 (GRCm39) missense probably benign 0.38
R8701:Zfp112 UTSW 7 23,825,165 (GRCm39) missense probably damaging 1.00
R8756:Zfp112 UTSW 7 23,824,997 (GRCm39) missense probably benign 0.03
R8853:Zfp112 UTSW 7 23,823,390 (GRCm39) synonymous silent
R8994:Zfp112 UTSW 7 23,825,490 (GRCm39) missense probably benign 0.06
R9295:Zfp112 UTSW 7 23,824,805 (GRCm39) missense probably benign
R9530:Zfp112 UTSW 7 23,824,665 (GRCm39) missense probably benign 0.01
R9537:Zfp112 UTSW 7 23,826,512 (GRCm39) missense probably damaging 1.00
R9559:Zfp112 UTSW 7 23,826,108 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTACACGGAGTCTGTCTGGAGAG -3'
(R):5'- GGCACAAAGTTTGACTGAAGCCTG -3'

Sequencing Primer
(F):5'- TGGTGATAGGTCAGCCCTC -3'
(R):5'- ATCAGGGTTACAGAGAGTCTCCTC -3'
Posted On 2013-06-11