Incidental Mutation 'R5933:Rasgrp2'
| ID |
462057 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rasgrp2
|
| Ensembl Gene |
ENSMUSG00000032946 |
| Gene Name |
RAS, guanyl releasing protein 2 |
| Synonyms |
Caldaggef1, CalDAG-GEFI |
| MMRRC Submission |
044127-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5933 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
19 |
| Chromosomal Location |
6449370-6465246 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 6452543 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Valine
at position 39
(F39V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000121635
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000035269]
[ENSMUST00000035716]
[ENSMUST00000113467]
[ENSMUST00000113468]
[ENSMUST00000113469]
[ENSMUST00000113471]
[ENSMUST00000113472]
[ENSMUST00000113475]
[ENSMUST00000113476]
[ENSMUST00000138555]
[ENSMUST00000139522]
[ENSMUST00000146601]
[ENSMUST00000113483]
[ENSMUST00000127021]
[ENSMUST00000146831]
[ENSMUST00000150713]
[ENSMUST00000167240]
|
| AlphaFold |
Q9QUG9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000035269
|
| SMART Domains |
Protein: ENSMUSP00000047564
Gene: ENSMUSG00000032648
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Phosphorylase
|
113 |
829 |
N/A |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000035716
AA Change: F39V
PolyPhen 2
Score 0.585 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000041135
Gene: ENSMUSG00000032946
AA Change: F39V
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
3 |
126 |
3.56e-29 |
SMART |
|
RasGEF
|
150 |
388 |
1.08e-100 |
SMART |
|
EFh
|
430 |
458 |
8.25e-3 |
SMART |
|
EFh
|
459 |
487 |
1.42e1 |
SMART |
|
C1
|
499 |
548 |
3.22e-14 |
SMART |
|
low complexity region
|
575 |
595 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113467
|
| SMART Domains |
Protein: ENSMUSP00000109095
Gene: ENSMUSG00000032946
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:RasGEFN
|
3 |
24 |
9e-8 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113468
AA Change: F39V
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000109096
Gene: ENSMUSG00000032946
AA Change: F39V
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
3 |
97 |
1.93e-7 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113469
|
| SMART Domains |
Protein: ENSMUSP00000109097
Gene: ENSMUSG00000032946
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:RasGEFN
|
3 |
24 |
1e-7 |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000113471
AA Change: F39V
PolyPhen 2
Score 0.585 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000109099
Gene: ENSMUSG00000032946
AA Change: F39V
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
3 |
126 |
7.2e-31 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000113472
AA Change: F39V
PolyPhen 2
Score 0.585 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000109100
Gene: ENSMUSG00000032946
AA Change: F39V
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
3 |
126 |
7.2e-31 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000113475
AA Change: F39V
PolyPhen 2
Score 0.585 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000109103
Gene: ENSMUSG00000032946
AA Change: F39V
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
3 |
126 |
7.2e-31 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000113476
AA Change: F39V
PolyPhen 2
Score 0.585 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000109104
Gene: ENSMUSG00000032946
AA Change: F39V
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
3 |
126 |
3.56e-29 |
SMART |
|
RasGEF
|
150 |
388 |
1.08e-100 |
SMART |
|
EFh
|
430 |
458 |
8.25e-3 |
SMART |
|
EFh
|
459 |
487 |
1.42e1 |
SMART |
|
C1
|
499 |
548 |
3.22e-14 |
SMART |
|
low complexity region
|
575 |
595 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000138555
AA Change: F39V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000121635
Gene: ENSMUSG00000032946
AA Change: F39V
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
3 |
126 |
3.56e-29 |
SMART |
|
Pfam:RasGEF
|
151 |
231 |
1.6e-15 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000139522
AA Change: F39V
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000123036
Gene: ENSMUSG00000032946
AA Change: F39V
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
3 |
125 |
6.02e-27 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000146601
AA Change: F39V
PolyPhen 2
Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000117681
Gene: ENSMUSG00000032946
AA Change: F39V
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:RasGEFN
|
3 |
58 |
1e-35 |
BLAST |
|
SCOP:d1bkds_
|
9 |
58 |
1e-8 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000123661
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000135532
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000122930
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000130480
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139775
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000145611
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000133968
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113483
|
| SMART Domains |
Protein: ENSMUSP00000109111
Gene: ENSMUSG00000032648
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Phosphorylase
|
62 |
742 |
N/A |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000127021
|
| SMART Domains |
Protein: ENSMUSP00000119740
Gene: ENSMUSG00000032946
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:RasGEFN
|
3 |
24 |
1e-7 |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000146831
AA Change: F39V
PolyPhen 2
Score 0.585 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000120630
Gene: ENSMUSG00000032946
AA Change: F39V
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
3 |
126 |
3.56e-29 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000150713
AA Change: F39V
PolyPhen 2
Score 0.585 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000120949
Gene: ENSMUSG00000032946
AA Change: F39V
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
3 |
95 |
6.73e-7 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000167240
AA Change: F39V
PolyPhen 2
Score 0.585 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000129873
Gene: ENSMUSG00000032946
AA Change: F39V
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
3 |
126 |
3.56e-29 |
SMART |
|
RasGEF
|
150 |
388 |
1.08e-100 |
SMART |
|
EFh
|
430 |
458 |
8.25e-3 |
SMART |
|
EFh
|
459 |
487 |
1.42e1 |
SMART |
|
C1
|
499 |
548 |
3.22e-14 |
SMART |
|
low complexity region
|
575 |
595 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000152022
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148906
|
| Meta Mutation Damage Score |
0.1863 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.2%
- 20x: 95.1%
|
| Validation Efficiency |
94% (99/105) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
PHENOTYPE: Mice homozygous for a knock-out allele do not undergo spontaneous hemorrhaging but exhibit impaired platelet aggregation, resistance to collagen-induced thrombosis, and increased bleeding times after tail transection. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
C |
T |
3: 137,776,109 (GRCm39) |
P1766L |
probably damaging |
Het |
| Abca13 |
A |
G |
11: 9,199,658 (GRCm39) |
Q119R |
possibly damaging |
Het |
| Acot11 |
C |
T |
4: 106,617,327 (GRCm39) |
G240R |
probably damaging |
Het |
| Aipl1 |
A |
C |
11: 71,921,108 (GRCm39) |
C237G |
probably benign |
Het |
| Ankdd1a |
C |
T |
9: 65,416,978 (GRCm39) |
A154T |
probably benign |
Het |
| Arglu1 |
T |
C |
8: 8,740,047 (GRCm39) |
S91G |
probably benign |
Het |
| Arhgef33 |
C |
A |
17: 80,644,709 (GRCm39) |
H13N |
probably benign |
Het |
| Atp1a4 |
A |
G |
1: 172,059,841 (GRCm39) |
I796T |
possibly damaging |
Het |
| Birc6 |
C |
G |
17: 74,906,232 (GRCm39) |
S1374R |
probably damaging |
Het |
| Birc6 |
T |
A |
17: 74,906,233 (GRCm39) |
S72T |
probably damaging |
Het |
| Bmpr1b |
T |
C |
3: 141,577,128 (GRCm39) |
*59W |
probably null |
Het |
| Btbd16 |
A |
T |
7: 130,386,011 (GRCm39) |
Q63L |
probably damaging |
Het |
| Cacna1c |
C |
T |
6: 118,589,541 (GRCm39) |
R1592H |
probably damaging |
Het |
| Caps2 |
G |
A |
10: 112,051,351 (GRCm39) |
E541K |
probably benign |
Het |
| Card9 |
T |
C |
2: 26,242,509 (GRCm39) |
E500G |
probably damaging |
Het |
| Carnmt1 |
T |
C |
19: 18,681,469 (GRCm39) |
V396A |
probably benign |
Het |
| Ccnl1 |
T |
A |
3: 65,855,763 (GRCm39) |
K320M |
probably damaging |
Het |
| Cdh20 |
A |
C |
1: 104,912,396 (GRCm39) |
D550A |
probably damaging |
Het |
| Cdhr1 |
T |
A |
14: 36,811,419 (GRCm39) |
T231S |
probably benign |
Het |
| Cenpe |
T |
C |
3: 134,967,389 (GRCm39) |
V2177A |
probably benign |
Het |
| Cfap69 |
A |
G |
5: 5,690,183 (GRCm39) |
C161R |
probably damaging |
Het |
| Ctsd |
C |
T |
7: 141,930,316 (GRCm39) |
V403I |
probably benign |
Het |
| Cyth1 |
C |
T |
11: 118,076,585 (GRCm39) |
|
probably null |
Het |
| Dazl |
A |
T |
17: 50,594,781 (GRCm39) |
|
probably null |
Het |
| Disp3 |
A |
T |
4: 148,325,770 (GRCm39) |
C1329* |
probably null |
Het |
| Dld |
C |
T |
12: 31,383,982 (GRCm39) |
V374I |
probably benign |
Het |
| Dnah7c |
T |
C |
1: 46,558,375 (GRCm39) |
Y494H |
probably damaging |
Het |
| Dnttip2 |
T |
A |
3: 122,069,217 (GRCm39) |
M144K |
probably benign |
Het |
| Drc1 |
A |
T |
5: 30,502,873 (GRCm39) |
D132V |
probably damaging |
Het |
| Enpp6 |
A |
G |
8: 47,519,039 (GRCm39) |
D269G |
probably benign |
Het |
| Ephx4 |
T |
A |
5: 107,551,631 (GRCm39) |
|
probably null |
Het |
| Evl |
T |
C |
12: 108,649,516 (GRCm39) |
S345P |
possibly damaging |
Het |
| Fam193a |
A |
T |
5: 34,623,024 (GRCm39) |
D1204V |
probably damaging |
Het |
| Fat2 |
A |
T |
11: 55,174,877 (GRCm39) |
D1945E |
probably damaging |
Het |
| Fat4 |
T |
C |
3: 39,005,524 (GRCm39) |
|
probably null |
Het |
| Fbln7 |
A |
T |
2: 128,719,418 (GRCm39) |
M72L |
probably benign |
Het |
| Flnc |
T |
C |
6: 29,441,105 (GRCm39) |
V353A |
probably damaging |
Het |
| Fry |
T |
C |
5: 150,314,265 (GRCm39) |
|
probably benign |
Het |
| Galnt14 |
A |
T |
17: 73,833,300 (GRCm39) |
C225S |
probably benign |
Het |
| Gapvd1 |
T |
C |
2: 34,574,303 (GRCm39) |
S1265G |
probably benign |
Het |
| Gm13030 |
A |
G |
4: 138,598,515 (GRCm39) |
F136S |
unknown |
Het |
| Gucy1a1 |
T |
C |
3: 82,002,114 (GRCm39) |
H655R |
probably damaging |
Het |
| Hk1 |
A |
G |
10: 62,105,773 (GRCm39) |
L890P |
probably damaging |
Het |
| Igfn1 |
T |
A |
1: 135,898,341 (GRCm39) |
R742* |
probably null |
Het |
| Igkv12-49 |
T |
C |
6: 69,693,553 (GRCm39) |
|
noncoding transcript |
Het |
| Igkv2-109 |
T |
A |
6: 68,279,965 (GRCm39) |
L62Q |
possibly damaging |
Het |
| Itgb3 |
A |
G |
11: 104,528,805 (GRCm39) |
T311A |
possibly damaging |
Het |
| Kl |
A |
G |
5: 150,912,948 (GRCm39) |
E899G |
probably damaging |
Het |
| Kyat3 |
A |
T |
3: 142,429,021 (GRCm39) |
D151V |
probably damaging |
Het |
| Morc2b |
A |
T |
17: 33,357,583 (GRCm39) |
M63K |
possibly damaging |
Het |
| Mtbp |
T |
A |
15: 55,434,723 (GRCm39) |
F298L |
possibly damaging |
Het |
| Mtmr3 |
C |
T |
11: 4,448,951 (GRCm39) |
V272I |
probably benign |
Het |
| Muc4 |
A |
G |
16: 32,574,480 (GRCm39) |
T977A |
probably benign |
Het |
| Nebl |
G |
A |
2: 17,408,998 (GRCm39) |
H367Y |
probably benign |
Het |
| Nop58 |
T |
A |
1: 59,743,824 (GRCm39) |
Y274* |
probably null |
Het |
| Nuak1 |
T |
A |
10: 84,210,666 (GRCm39) |
Q474L |
probably damaging |
Het |
| Obscn |
A |
G |
11: 58,889,331 (GRCm39) |
S7523P |
unknown |
Het |
| Oosp3 |
T |
A |
19: 11,682,753 (GRCm39) |
D140E |
probably benign |
Het |
| Or52z15 |
T |
A |
7: 103,332,680 (GRCm39) |
C242S |
probably damaging |
Het |
| Padi2 |
G |
A |
4: 140,644,952 (GRCm39) |
R62H |
probably benign |
Het |
| Patl1 |
A |
G |
19: 11,917,136 (GRCm39) |
N661S |
probably benign |
Het |
| Pcyox1l |
G |
T |
18: 61,831,544 (GRCm39) |
N238K |
probably benign |
Het |
| Pmch |
A |
G |
10: 87,927,011 (GRCm39) |
T5A |
probably benign |
Het |
| Polr3h |
A |
G |
15: 81,800,835 (GRCm39) |
L169P |
probably damaging |
Het |
| Ptpn4 |
A |
G |
1: 119,615,453 (GRCm39) |
V567A |
probably damaging |
Het |
| Setd1b |
G |
A |
5: 123,296,815 (GRCm39) |
|
probably benign |
Het |
| Sh3glb2 |
A |
T |
2: 30,240,401 (GRCm39) |
|
probably null |
Het |
| Slc46a3 |
A |
T |
5: 147,830,700 (GRCm39) |
N44K |
probably benign |
Het |
| Slc9b1 |
T |
A |
3: 135,099,756 (GRCm39) |
N425K |
probably benign |
Het |
| Slfn14 |
A |
T |
11: 83,170,288 (GRCm39) |
V452E |
probably damaging |
Het |
| Slfn8 |
A |
T |
11: 82,894,161 (GRCm39) |
M826K |
probably benign |
Het |
| Slit3 |
G |
A |
11: 35,520,578 (GRCm39) |
V572M |
probably benign |
Het |
| Smr3a |
C |
A |
5: 88,155,873 (GRCm39) |
|
probably null |
Het |
| Snap29 |
T |
C |
16: 17,224,194 (GRCm39) |
S70P |
probably damaging |
Het |
| Svopl |
T |
A |
6: 37,993,949 (GRCm39) |
|
probably benign |
Het |
| Tbc1d17 |
A |
T |
7: 44,494,761 (GRCm39) |
F186I |
probably damaging |
Het |
| Tgm6 |
T |
C |
2: 129,983,176 (GRCm39) |
V255A |
probably damaging |
Het |
| Tjp1 |
G |
T |
7: 64,952,600 (GRCm39) |
T1498K |
probably benign |
Het |
| Tkfc |
C |
A |
19: 10,574,711 (GRCm39) |
E176D |
probably benign |
Het |
| Tmem102 |
C |
T |
11: 69,694,506 (GRCm39) |
V489I |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,551,781 (GRCm39) |
V22930A |
probably damaging |
Het |
| Tyms |
A |
T |
5: 30,278,357 (GRCm39) |
|
probably null |
Het |
| Uaca |
T |
A |
9: 60,748,238 (GRCm39) |
D67E |
probably damaging |
Het |
| Unc119b |
G |
A |
5: 115,265,508 (GRCm39) |
|
probably benign |
Het |
| Usp29 |
A |
T |
7: 6,964,744 (GRCm39) |
T196S |
probably benign |
Het |
| Usp37 |
A |
G |
1: 74,525,141 (GRCm39) |
S228P |
probably damaging |
Het |
| Usp42 |
C |
A |
5: 143,701,270 (GRCm39) |
A918S |
probably benign |
Het |
| Vmn2r72 |
T |
A |
7: 85,387,058 (GRCm39) |
L835F |
probably benign |
Het |
| Vps13a |
T |
C |
19: 16,637,894 (GRCm39) |
T2396A |
probably benign |
Het |
| Whrn |
A |
T |
4: 63,412,945 (GRCm39) |
S176T |
probably damaging |
Het |
| Zbtb42 |
T |
C |
12: 112,647,055 (GRCm39) |
F410S |
probably damaging |
Het |
| Zfp616 |
T |
C |
11: 73,973,952 (GRCm39) |
S74P |
probably damaging |
Het |
| Zswim6 |
A |
G |
13: 107,880,642 (GRCm39) |
|
noncoding transcript |
Het |
|
| Other mutations in Rasgrp2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01013:Rasgrp2
|
APN |
19 |
6,454,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03053:Rasgrp2
|
APN |
19 |
6,457,362 (GRCm39) |
splice site |
probably benign |
|
|
afar
|
UTSW |
19 |
6,453,595 (GRCm39) |
critical splice donor site |
probably null |
|
|
thither
|
UTSW |
19 |
6,454,757 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1593:Rasgrp2
|
UTSW |
19 |
6,453,490 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1604:Rasgrp2
|
UTSW |
19 |
6,457,087 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R2016:Rasgrp2
|
UTSW |
19 |
6,463,195 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2017:Rasgrp2
|
UTSW |
19 |
6,463,195 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2119:Rasgrp2
|
UTSW |
19 |
6,454,425 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2120:Rasgrp2
|
UTSW |
19 |
6,454,425 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2122:Rasgrp2
|
UTSW |
19 |
6,454,425 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2124:Rasgrp2
|
UTSW |
19 |
6,454,425 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3879:Rasgrp2
|
UTSW |
19 |
6,463,920 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4049:Rasgrp2
|
UTSW |
19 |
6,454,757 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4655:Rasgrp2
|
UTSW |
19 |
6,454,876 (GRCm39) |
intron |
probably benign |
|
|
R5250:Rasgrp2
|
UTSW |
19 |
6,454,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5320:Rasgrp2
|
UTSW |
19 |
6,458,864 (GRCm39) |
splice site |
probably null |
|
|
R5620:Rasgrp2
|
UTSW |
19 |
6,455,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6155:Rasgrp2
|
UTSW |
19 |
6,452,531 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6157:Rasgrp2
|
UTSW |
19 |
6,452,531 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6867:Rasgrp2
|
UTSW |
19 |
6,463,213 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7237:Rasgrp2
|
UTSW |
19 |
6,454,838 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7575:Rasgrp2
|
UTSW |
19 |
6,454,397 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7659:Rasgrp2
|
UTSW |
19 |
6,451,857 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7744:Rasgrp2
|
UTSW |
19 |
6,455,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7960:Rasgrp2
|
UTSW |
19 |
6,464,839 (GRCm39) |
missense |
probably benign |
|
|
R7975:Rasgrp2
|
UTSW |
19 |
6,458,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8415:Rasgrp2
|
UTSW |
19 |
6,454,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8470:Rasgrp2
|
UTSW |
19 |
6,453,595 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8745:Rasgrp2
|
UTSW |
19 |
6,463,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8853:Rasgrp2
|
UTSW |
19 |
6,464,855 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8897:Rasgrp2
|
UTSW |
19 |
6,453,100 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9108:Rasgrp2
|
UTSW |
19 |
6,458,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9127:Rasgrp2
|
UTSW |
19 |
6,454,438 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9725:Rasgrp2
|
UTSW |
19 |
6,463,907 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9725:Rasgrp2
|
UTSW |
19 |
6,454,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTTGGATCCTGTGGTACCCC -3'
(R):5'- GGTCCTAGAAGACTGATCAGTGTC -3'
Sequencing Primer
(F):5'- GGATCCTGTGGTACCCCTCATC -3'
(R):5'- GAAGACTGATCAGTGTCTGAATTG -3'
|
| Posted On |
2017-02-28 |
Incidental Mutation