Incidental Mutation 'R5938:Iigp1c'
ID 462403
Institutional Source Beutler Lab
Gene Symbol Iigp1c
Ensembl Gene ENSMUSG00000073555
Gene Name interferon inducible GTPase 1C
Synonyms Gm4951
MMRRC Submission 044131-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5938 (G1)
Quality Score 225
Status Validated
Chromosome 18
Chromosomal Location 60345152-60380892 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 60378724 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 86 (N86K)
Ref Sequence ENSEMBL: ENSMUSP00000031549 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031549]
AlphaFold Q3UED7
Predicted Effect probably damaging
Transcript: ENSMUST00000031549
AA Change: N86K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000031549
Gene: ENSMUSG00000073555
AA Change: N86K

DomainStartEndE-ValueType
Pfam:IIGP 34 402 4.8e-157 PFAM
Pfam:MMR_HSR1 70 198 2.8e-8 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.3%
Validation Efficiency 94% (63/67)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatf A C 11: 84,333,400 (GRCm39) D503E possibly damaging Het
Bsn C T 9: 107,990,208 (GRCm39) R1848Q possibly damaging Het
Cacna1d C T 14: 29,825,692 (GRCm39) V1001I probably damaging Het
Calhm3 T C 19: 47,140,516 (GRCm39) I192M probably damaging Het
Cep44 A G 8: 57,000,457 (GRCm39) S19P possibly damaging Het
Cxcl15 T A 5: 90,949,225 (GRCm39) I130K unknown Het
Cxcl3 C T 5: 90,934,175 (GRCm39) probably benign Het
Emc1 T G 4: 139,084,931 (GRCm39) H167Q probably benign Het
Epb41l3 T G 17: 69,566,066 (GRCm39) Y416D probably damaging Het
Erbb2 G A 11: 98,326,397 (GRCm39) R1007H probably damaging Het
Esr1 A G 10: 4,916,245 (GRCm39) probably benign Het
Fat4 G A 3: 39,005,388 (GRCm39) R1929Q probably damaging Het
Fsip2 T A 2: 82,807,835 (GRCm39) C1385S probably benign Het
Gbf1 T C 19: 46,256,891 (GRCm39) I777T probably damaging Het
Gm16092 T G 1: 85,440,689 (GRCm39) noncoding transcript Het
Greb1 T A 12: 16,767,259 (GRCm39) K314N probably damaging Het
Ipcef1 A G 10: 6,858,029 (GRCm39) probably benign Het
Iqank1 G A 15: 75,917,281 (GRCm39) E305K possibly damaging Het
Mgat4a C A 1: 37,491,344 (GRCm39) L292F probably damaging Het
Mill1 A G 7: 17,996,613 (GRCm39) N143S probably benign Het
Mindy1 A G 3: 95,201,067 (GRCm39) T324A probably benign Het
Mpdz T A 4: 81,202,851 (GRCm39) H1882L probably damaging Het
Ncapg2 T A 12: 116,393,277 (GRCm39) W494R probably damaging Het
Oas1c A T 5: 120,943,598 (GRCm39) H180Q probably benign Het
Or2q1 T A 6: 42,794,701 (GRCm39) C99S probably damaging Het
Or4c108 T C 2: 88,803,357 (GRCm39) M293V probably benign Het
Or4k49 A G 2: 111,494,708 (GRCm39) M46V probably benign Het
Or5ak20 A T 2: 85,183,620 (GRCm39) S217T probably damaging Het
Or6c88 A G 10: 129,407,396 (GRCm39) R291G probably damaging Het
Pelp1 A G 11: 70,285,693 (GRCm39) V725A probably damaging Het
Plxna4 T C 6: 32,211,541 (GRCm39) E666G probably benign Het
Pprc1 ATCCTCCTCCTCCTCCTCCTC ATCCTCCTCCTCCTCCTC 19: 46,059,755 (GRCm39) probably benign Het
Prdm16 T C 4: 154,432,411 (GRCm39) D285G probably damaging Het
Rasa2 A G 9: 96,493,442 (GRCm39) S81P possibly damaging Het
Rhd T A 4: 134,623,287 (GRCm39) F418Y probably benign Het
Rnf207 T C 4: 152,402,385 (GRCm39) probably benign Het
Rsf1 C T 7: 97,334,766 (GRCm39) R1300C probably damaging Het
Ryr1 A C 7: 28,746,290 (GRCm39) L3830R probably damaging Het
Sgsh A G 11: 119,237,625 (GRCm39) Y330H probably benign Het
Sh3bp5 T C 14: 31,109,791 (GRCm39) E130G possibly damaging Het
Slc29a3 A G 10: 60,588,563 (GRCm39) probably benign Het
Slco1a5 A G 6: 142,194,443 (GRCm39) L400P probably damaging Het
Snd1 A G 6: 28,874,858 (GRCm39) probably null Het
Sox15 C T 11: 69,546,556 (GRCm39) R120C probably damaging Het
Srsf11 C T 3: 157,728,981 (GRCm39) probably benign Het
Tas2r110 A T 6: 132,845,016 (GRCm39) I16L probably benign Het
Tmx3 T A 18: 90,546,058 (GRCm39) V213D possibly damaging Het
Uba2 A T 7: 33,864,915 (GRCm39) probably null Het
Wfikkn1 T A 17: 26,097,886 (GRCm39) D112V probably damaging Het
Zfhx4 A G 3: 5,467,198 (GRCm39) N2452S probably damaging Het
Other mutations in Iigp1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00717:Iigp1c APN 18 60,379,365 (GRCm39) missense probably damaging 1.00
IGL00807:Iigp1c APN 18 60,378,483 (GRCm39) missense probably damaging 1.00
IGL00956:Iigp1c APN 18 60,379,262 (GRCm39) missense probably damaging 1.00
IGL01017:Iigp1c APN 18 60,378,508 (GRCm39) missense possibly damaging 0.87
IGL01929:Iigp1c APN 18 60,379,554 (GRCm39) missense probably benign 0.02
IGL02267:Iigp1c APN 18 60,379,470 (GRCm39) missense probably damaging 0.97
IGL02276:Iigp1c APN 18 60,379,151 (GRCm39) missense probably damaging 0.99
IGL02499:Iigp1c APN 18 60,378,710 (GRCm39) missense probably damaging 1.00
IGL02538:Iigp1c APN 18 60,378,944 (GRCm39) nonsense probably null
IGL03139:Iigp1c APN 18 60,379,221 (GRCm39) missense probably benign 0.01
IGL03209:Iigp1c APN 18 60,379,143 (GRCm39) missense probably damaging 1.00
IGL03270:Iigp1c APN 18 60,378,548 (GRCm39) missense probably benign 0.01
IGL03325:Iigp1c APN 18 60,378,883 (GRCm39) nonsense probably null
Carboniferous UTSW 18 60,378,840 (GRCm39) missense probably damaging 1.00
Oily UTSW 18 60,378,724 (GRCm39) missense probably damaging 1.00
R0554:Iigp1c UTSW 18 60,378,489 (GRCm39) missense probably benign 0.15
R2046:Iigp1c UTSW 18 60,378,571 (GRCm39) missense probably benign 0.00
R2296:Iigp1c UTSW 18 60,378,542 (GRCm39) missense probably benign 0.00
R4583:Iigp1c UTSW 18 60,379,152 (GRCm39) missense possibly damaging 0.93
R5500:Iigp1c UTSW 18 60,379,092 (GRCm39) missense probably damaging 0.99
R5532:Iigp1c UTSW 18 60,379,142 (GRCm39) missense probably benign 0.23
R6446:Iigp1c UTSW 18 60,378,840 (GRCm39) missense probably damaging 1.00
R7191:Iigp1c UTSW 18 60,379,329 (GRCm39) missense probably benign 0.01
R7238:Iigp1c UTSW 18 60,379,355 (GRCm39) missense possibly damaging 0.64
R7443:Iigp1c UTSW 18 60,379,122 (GRCm39) missense probably benign 0.11
R9261:Iigp1c UTSW 18 60,353,820 (GRCm39) intron probably benign
R9650:Iigp1c UTSW 18 60,379,470 (GRCm39) missense probably damaging 0.97
Z1177:Iigp1c UTSW 18 60,379,368 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- ACCAAGATTTGTCCTCCAGC -3'
(R):5'- GCGTGTGGCCGAAATAATAATG -3'

Sequencing Primer
(F):5'- AAGATTTGTCCTCCAGCTTTATTG -3'
(R):5'- TGGCCGAAATAATAATGAAGAAGTC -3'
Posted On 2017-02-28