Incidental Mutation 'R5919:Or9i16'
ID 462593
Institutional Source Beutler Lab
Gene Symbol Or9i16
Ensembl Gene ENSMUSG00000059105
Gene Name olfactory receptor family 9 subfamily I member 16
Synonyms GA_x6K02T2RE5P-4223635-4222688, Olfr1504, MOR212-2
MMRRC Submission 044116-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R5919 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 13864625-13865572 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 13865209 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 122 (Y122H)
Ref Sequence ENSEMBL: ENSMUSP00000146610 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078282] [ENSMUST00000209192]
AlphaFold Q8VFQ4
Predicted Effect probably damaging
Transcript: ENSMUST00000078282
AA Change: Y122H

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000077400
Gene: ENSMUSG00000059105
AA Change: Y122H

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 4.3e-46 PFAM
Pfam:7tm_1 40 313 1.5e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000209192
AA Change: Y122H

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.5%
Validation Efficiency 100% (68/68)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700025G04Rik T C 1: 151,791,249 (GRCm39) D104G probably damaging Het
6030458C11Rik A T 15: 12,823,754 (GRCm39) H40Q probably damaging Het
Abcc3 A G 11: 94,248,132 (GRCm39) V1156A possibly damaging Het
Adgrl1 G T 8: 84,659,239 (GRCm39) D648Y probably damaging Het
Adgrl3 C A 5: 81,794,417 (GRCm39) D547E probably benign Het
Aebp1 A T 11: 5,821,421 (GRCm39) M607L probably benign Het
Angptl1 T C 1: 156,686,116 (GRCm39) Y401H probably damaging Het
Arl4d A G 11: 101,557,962 (GRCm39) T163A probably benign Het
Bltp2 A T 11: 78,180,176 (GRCm39) N2152I probably damaging Het
Camk2b A G 11: 5,929,718 (GRCm39) S331P probably damaging Het
Ccdc15 C T 9: 37,231,692 (GRCm39) probably null Het
Ccdc168 T C 1: 44,096,146 (GRCm39) N1651D probably benign Het
Ccdc38 A T 10: 93,414,700 (GRCm39) I370F possibly damaging Het
Clstn1 A T 4: 149,719,703 (GRCm39) H416L probably damaging Het
Col12a1 C T 9: 79,509,580 (GRCm39) R3030H probably damaging Het
Cop1 T A 1: 159,147,294 (GRCm39) V540E probably damaging Het
Crebbp C T 16: 3,925,991 (GRCm39) R710H probably damaging Het
Dsel T C 1: 111,787,983 (GRCm39) I851V probably benign Het
Esrp1 A G 4: 11,344,146 (GRCm39) V642A probably damaging Het
Fanci T C 7: 79,094,486 (GRCm39) L1139P probably damaging Het
Fat1 T C 8: 45,479,910 (GRCm39) probably null Het
Fsip2 A G 2: 82,822,953 (GRCm39) N6229D possibly damaging Het
Garin5b T C 7: 4,773,385 (GRCm39) E144G possibly damaging Het
Gas2l3 G A 10: 89,252,917 (GRCm39) R243W probably damaging Het
Hectd1 G A 12: 51,815,855 (GRCm39) R1406W probably damaging Het
Hecw2 T C 1: 53,976,249 (GRCm39) H180R probably damaging Het
Ift172 T A 5: 31,418,006 (GRCm39) Q1261L possibly damaging Het
Il17rd T C 14: 26,818,001 (GRCm39) V230A probably damaging Het
Kif17 A T 4: 137,997,202 (GRCm39) I42F probably damaging Het
Kif24 T C 4: 41,394,477 (GRCm39) K799E possibly damaging Het
Lrp4 A T 2: 91,303,552 (GRCm39) I84F probably damaging Het
Mplkipl1 T C 19: 61,163,907 (GRCm39) Y176C probably damaging Het
Mroh7 T C 4: 106,551,509 (GRCm39) probably null Het
Ms4a14 C A 19: 11,291,661 (GRCm39) V13F possibly damaging Het
Muc2 T A 7: 141,281,171 (GRCm39) V445D probably damaging Het
Muc6 A T 7: 141,227,837 (GRCm39) M1317K possibly damaging Het
Myof T A 19: 38,012,818 (GRCm39) D39V possibly damaging Het
Ndufaf1 A C 2: 119,490,709 (GRCm39) V117G possibly damaging Het
Ndufs1 C G 1: 63,182,991 (GRCm39) *728S probably null Het
Nup188 A T 2: 30,229,906 (GRCm39) N1375Y probably damaging Het
Oasl1 T A 5: 115,066,329 (GRCm39) I149N probably damaging Het
Pelo C A 13: 115,225,845 (GRCm39) C204F possibly damaging Het
Phf11d A C 14: 59,593,712 (GRCm39) probably benign Het
Rars2 T C 4: 34,657,232 (GRCm39) L526P probably damaging Het
Rrp1 A G 10: 78,241,422 (GRCm39) L177P probably damaging Het
S100a9 A G 3: 90,602,495 (GRCm39) L33P probably damaging Het
Slc4a7 A G 14: 14,791,092 (GRCm38) D1045G probably benign Het
Slc9a3 C T 13: 74,306,859 (GRCm39) T328I probably damaging Het
Spata6 A G 4: 111,636,405 (GRCm39) D232G probably damaging Het
Taar6 A T 10: 23,861,168 (GRCm39) I126N probably damaging Het
Tmeff2 C A 1: 51,171,311 (GRCm39) C182* probably null Het
Tmem178 T A 17: 81,297,187 (GRCm39) C190S probably damaging Het
Trerf1 T G 17: 47,634,208 (GRCm39) noncoding transcript Het
Trgv6 A G 13: 19,374,782 (GRCm39) Y16C probably benign Het
Ubn2 A G 6: 38,468,423 (GRCm39) I1046V possibly damaging Het
Vmn1r221 A T 13: 23,401,466 (GRCm39) noncoding transcript Het
Vmn2r2 T C 3: 64,044,723 (GRCm39) N141S probably benign Het
Zfp64 T A 2: 168,768,419 (GRCm39) N398Y probably benign Het
Zfp787 T G 7: 6,135,834 (GRCm39) Q139P probably damaging Het
Other mutations in Or9i16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00332:Or9i16 APN 19 13,864,945 (GRCm39) missense probably benign
IGL00885:Or9i16 APN 19 13,865,532 (GRCm39) missense probably benign 0.17
IGL01084:Or9i16 APN 19 13,864,866 (GRCm39) missense probably damaging 1.00
IGL01522:Or9i16 APN 19 13,864,722 (GRCm39) nonsense probably null
IGL01727:Or9i16 APN 19 13,865,242 (GRCm39) missense probably damaging 0.98
IGL02440:Or9i16 APN 19 13,865,223 (GRCm39) missense probably damaging 1.00
IGL03342:Or9i16 APN 19 13,864,801 (GRCm39) missense probably damaging 1.00
R0531:Or9i16 UTSW 19 13,865,116 (GRCm39) missense possibly damaging 0.62
R0577:Or9i16 UTSW 19 13,865,167 (GRCm39) missense probably damaging 1.00
R1028:Or9i16 UTSW 19 13,865,159 (GRCm39) missense probably damaging 0.97
R1674:Or9i16 UTSW 19 13,864,954 (GRCm39) missense probably benign 0.01
R3906:Or9i16 UTSW 19 13,865,070 (GRCm39) missense probably damaging 1.00
R4598:Or9i16 UTSW 19 13,865,381 (GRCm39) missense probably damaging 1.00
R4658:Or9i16 UTSW 19 13,864,912 (GRCm39) missense probably benign 0.19
R4676:Or9i16 UTSW 19 13,864,765 (GRCm39) missense probably damaging 1.00
R5943:Or9i16 UTSW 19 13,865,116 (GRCm39) missense possibly damaging 0.62
R8112:Or9i16 UTSW 19 13,864,753 (GRCm39) missense probably damaging 1.00
R9616:Or9i16 UTSW 19 13,864,861 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TACAGGCAAGCTTCATCAGGG -3'
(R):5'- TAATTCAGAGTGACCCTCGGC -3'

Sequencing Primer
(F):5'- CAAGCTTCATCAGGGGTGGG -3'
(R):5'- GAGTGACCCTCGGCTCCAAAC -3'
Posted On 2017-02-28