Incidental Mutation 'R0569:Or5j3'
ID 46285
Institutional Source Beutler Lab
Gene Symbol Or5j3
Ensembl Gene ENSMUSG00000047149
Gene Name olfactory receptor family 5 subfamily J member 3
Synonyms GA_x6K02T2Q125-47777498-47778436, Olfr1052, MOR172-1
MMRRC Submission 038760-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.138) question?
Stock # R0569 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 86128162-86129100 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 86128941 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 260 (I260M)
Ref Sequence ENSEMBL: ENSMUSP00000149344 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054746] [ENSMUST00000215090] [ENSMUST00000217166]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000054746
AA Change: I260M

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000058454
Gene: ENSMUSG00000047149
AA Change: I260M

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.3e-51 PFAM
Pfam:7tm_1 41 290 6.9e-16 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215090
AA Change: I260M

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000217166
AA Change: I260M

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Meta Mutation Damage Score 0.1720 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 93.8%
Validation Efficiency 97% (56/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833420G17Rik A G 13: 119,621,016 (GRCm39) I572M possibly damaging Het
4930447A16Rik T C 15: 37,425,863 (GRCm39) M1T probably null Het
4930590J08Rik C A 6: 91,919,559 (GRCm39) C739* probably null Het
Adcy1 T A 11: 7,096,514 (GRCm39) V634E probably benign Het
Ankfy1 T A 11: 72,644,434 (GRCm39) H710Q possibly damaging Het
Ankrd60 C T 2: 173,412,859 (GRCm39) V90M probably damaging Het
Asgr2 A T 11: 69,988,703 (GRCm39) Q132L probably benign Het
Cchcr1 T A 17: 35,839,865 (GRCm39) probably null Het
Ces1h T C 8: 94,078,774 (GRCm39) K523E unknown Het
Clec3a G T 8: 115,152,476 (GRCm39) G161C probably damaging Het
Cracr2b G A 7: 141,044,848 (GRCm39) probably benign Het
Cyp2b10 A T 7: 25,597,160 (GRCm39) L17F probably damaging Het
Dhx29 T A 13: 113,084,748 (GRCm39) N655K probably benign Het
Dst C A 1: 34,332,508 (GRCm39) L4748I probably damaging Het
Eif2b5 G C 16: 20,321,303 (GRCm39) L285F probably benign Het
Enox1 T A 14: 77,875,117 (GRCm39) D441E probably damaging Het
Fam110a T C 2: 151,812,404 (GRCm39) E122G probably damaging Het
Fam161b T A 12: 84,395,413 (GRCm39) E510V probably damaging Het
Gabrd T C 4: 155,469,880 (GRCm39) Y443C probably damaging Het
Gcn1 T G 5: 115,733,118 (GRCm39) S1052A probably benign Het
Gnptab A G 10: 88,264,419 (GRCm39) E279G possibly damaging Het
Hoxa6 T A 6: 52,185,163 (GRCm39) probably null Het
Ibtk T A 9: 85,590,234 (GRCm39) probably benign Het
Il6ra A T 3: 89,785,149 (GRCm39) probably null Het
Iqgap3 C T 3: 87,998,032 (GRCm39) probably benign Het
Kcnk2 A C 1: 189,071,998 (GRCm39) L110R probably damaging Het
Knl1 T A 2: 118,927,916 (GRCm39) V1919D possibly damaging Het
Lrp1b A T 2: 40,779,251 (GRCm39) L2597Q probably benign Het
Magi3 A G 3: 103,923,358 (GRCm39) S1120P probably benign Het
Map3k8 T C 18: 4,349,162 (GRCm39) D52G probably benign Het
Mcat C T 15: 83,433,449 (GRCm39) R198H probably benign Het
Mnd1 A G 3: 84,012,286 (GRCm39) V141A probably benign Het
Morc1 T C 16: 48,407,485 (GRCm39) L667P probably benign Het
Mrps6 A G 16: 91,908,808 (GRCm39) K125E possibly damaging Het
Mst1 T C 9: 107,959,500 (GRCm39) F262S probably damaging Het
Or7e178 T A 9: 20,225,875 (GRCm39) I114F probably damaging Het
Pbsn C G X: 76,897,046 (GRCm39) G15A possibly damaging Het
Pcnx1 T C 12: 82,038,804 (GRCm39) I2023T probably benign Het
Pds5a T G 5: 65,813,744 (GRCm39) N247T probably damaging Het
Peak1 T C 9: 56,167,373 (GRCm39) Y185C probably damaging Het
Phkb T A 8: 86,744,031 (GRCm39) I560N probably damaging Het
Plekhn1 T C 4: 156,309,658 (GRCm39) I160V probably damaging Het
Rabgap1 T G 2: 37,379,729 (GRCm39) probably benign Het
Rdh10 T G 1: 16,199,517 (GRCm39) V241G probably damaging Het
Selenow A T 7: 15,654,042 (GRCm39) C37S probably benign Het
Sema6a A T 18: 47,403,872 (GRCm39) probably null Het
Slc12a3 T C 8: 95,057,153 (GRCm39) probably null Het
Slc22a21 T G 11: 53,842,636 (GRCm39) M498L probably benign Het
Spink5 A T 18: 44,122,486 (GRCm39) N317I probably damaging Het
Srek1 A G 13: 103,885,370 (GRCm39) probably benign Het
Syt11 A G 3: 88,655,230 (GRCm39) V357A probably benign Het
Tcof1 T A 18: 60,962,107 (GRCm39) K707N possibly damaging Het
Tfip11 C T 5: 112,475,960 (GRCm39) R42C probably damaging Het
Trim39 T C 17: 36,574,623 (GRCm39) K260E probably benign Het
Ttn T C 2: 76,553,663 (GRCm39) T22658A possibly damaging Het
Unc45b C T 11: 82,827,638 (GRCm39) probably benign Het
Vmn1r236 A G 17: 21,507,172 (GRCm39) I97V probably benign Het
Vps13c T C 9: 67,881,001 (GRCm39) V657A probably damaging Het
Zkscan2 A G 7: 123,097,898 (GRCm39) V166A probably benign Het
Other mutations in Or5j3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02632:Or5j3 APN 2 86,128,904 (GRCm39) missense probably damaging 0.99
IGL02988:Or5j3 UTSW 2 86,128,823 (GRCm39) missense probably damaging 0.99
R0382:Or5j3 UTSW 2 86,128,937 (GRCm39) missense probably damaging 1.00
R1476:Or5j3 UTSW 2 86,128,823 (GRCm39) missense probably damaging 0.99
R1510:Or5j3 UTSW 2 86,128,715 (GRCm39) missense probably damaging 1.00
R1667:Or5j3 UTSW 2 86,129,080 (GRCm39) missense probably null 0.02
R2912:Or5j3 UTSW 2 86,128,733 (GRCm39) missense probably damaging 0.96
R2913:Or5j3 UTSW 2 86,128,733 (GRCm39) missense probably damaging 0.96
R3937:Or5j3 UTSW 2 86,128,360 (GRCm39) missense probably damaging 1.00
R4299:Or5j3 UTSW 2 86,128,585 (GRCm39) missense possibly damaging 0.46
R4774:Or5j3 UTSW 2 86,129,042 (GRCm39) missense possibly damaging 0.91
R5027:Or5j3 UTSW 2 86,128,540 (GRCm39) missense possibly damaging 0.84
R5080:Or5j3 UTSW 2 86,128,258 (GRCm39) missense probably benign 0.22
R5254:Or5j3 UTSW 2 86,128,265 (GRCm39) missense probably damaging 1.00
R5389:Or5j3 UTSW 2 86,128,561 (GRCm39) missense possibly damaging 0.90
R6110:Or5j3 UTSW 2 86,129,019 (GRCm39) missense probably damaging 0.99
R6492:Or5j3 UTSW 2 86,128,990 (GRCm39) missense probably benign 0.05
R6810:Or5j3 UTSW 2 86,128,267 (GRCm39) missense probably benign 0.01
R7095:Or5j3 UTSW 2 86,129,021 (GRCm39) missense probably benign 0.08
R7104:Or5j3 UTSW 2 86,128,564 (GRCm39) missense probably benign
R7320:Or5j3 UTSW 2 86,128,338 (GRCm39) frame shift probably null
R7328:Or5j3 UTSW 2 86,128,338 (GRCm39) frame shift probably null
R7363:Or5j3 UTSW 2 86,128,338 (GRCm39) frame shift probably null
R8048:Or5j3 UTSW 2 86,128,672 (GRCm39) missense probably benign 0.04
R8202:Or5j3 UTSW 2 86,128,968 (GRCm39) missense probably benign 0.06
R8968:Or5j3 UTSW 2 86,128,526 (GRCm39) missense probably benign 0.00
R9160:Or5j3 UTSW 2 86,128,330 (GRCm39) missense probably benign 0.40
R9321:Or5j3 UTSW 2 86,128,297 (GRCm39) missense probably benign 0.01
R9694:Or5j3 UTSW 2 86,128,718 (GRCm39) missense probably benign 0.03
Z1176:Or5j3 UTSW 2 86,128,570 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCTGTGACATACCATCGCTGCTGATAC -3'
(R):5'- GAGAAGGACTTCATCTCTATGGCTCTCT -3'

Sequencing Primer
(F):5'- ACCTCCATGAATGAATTTCTGC -3'
(R):5'- ATCTCTATGGCTCTCTTTGCAGC -3'
Posted On 2013-06-11