|Institutional Source||Beutler Lab|
|Gene Name||selenoprotein W|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R0569 (G1)|
|Chromosomal Location||15917208-15922402 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to T at 15920117 bp|
|Amino Acid Change||Cysteine to Serine at position 37 (C37S)|
|Ref Sequence||ENSEMBL: ENSMUSP00000038943 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000044355]|
|Predicted Effect||probably benign
AA Change: C37S
PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
AA Change: C37S
|Meta Mutation Damage Score||0.016|
|Coding Region Coverage||
|Validation Efficiency||97% (56/58)|
|MGI Phenotype||FUNCTION: This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein has been shown to function as a glutathione-dependent antioxidant in vivo. It is highly expressed in proliferating myoblasts and suggested to be involved in muscle growth and differentiation by protecting the developing myoblasts from oxidative stress. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Selenow||
(F):5'- GCTTTGATGGCGGTCACCAGTTTC -3'
(R):5'- CTAGAACATGAGTTCCCCGGATGC -3'
(F):5'- GAACTTGCTCTCTGTATCCACATAG -3'
(R):5'- TCTTAGAATGGGCATAGGATCATGAC -3'