|Institutional Source||Beutler Lab|
|Gene Name||dopamine receptor D5|
|Synonyms||D5R, Gpcr1, Drd1b, Drd-5, DRD1b|
|Is this an essential gene?||Probably non essential (E-score: 0.112)|
|Stock #||R0571 (G1)|
|Chromosomal Location||38319367-38322518 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to A at 38319927 bp|
|Amino Acid Change||Valine to Methionine at position 88 (V88M)|
|Ref Sequence||ENSEMBL: ENSMUSP00000039691 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000041646]|
|Predicted Effect||probably damaging
AA Change: V88M
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: V88M
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.26|
|Coding Region Coverage||
|Validation Efficiency||100% (71/71)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice develop hypertension and exhibit elevated blood pressure caused by increased sympathetic tone. Mice homozygous for another knock-out allele exhibit increased methamphetamine-induced ambulatory activity. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Drd5||
(F):5'- CTCTGCGTTTCTACGACTCAGAACC -3'
(R):5'- AGGGTCTGGAAATAGCCCAGTACC -3'
(F):5'- AAGTTGGGATCGCACGC -3'
(R):5'- CGGTCCACGCTGATGATAC -3'