Incidental Mutation 'R0471:Cdk11b'
ID 46746
Institutional Source Beutler Lab
Gene Symbol Cdk11b
Ensembl Gene ENSMUSG00000029062
Gene Name cyclin dependent kinase 11B
Synonyms Cdc2l2, PITSLRE proteins, Cdc2l1, CDK11-p110, CDK11-p46, CDK11-p58
MMRRC Submission 038671-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0471 (G1)
Quality Score 222
Status Validated
Chromosome 4
Chromosomal Location 155709311-155734395 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to G at 155731999 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000111488 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030937] [ENSMUST00000067081] [ENSMUST00000105598] [ENSMUST00000105600] [ENSMUST00000115821]
AlphaFold P24788
Predicted Effect probably benign
Transcript: ENSMUST00000030937
SMART Domains Protein: ENSMUSP00000030937
Gene: ENSMUSG00000029061

DomainStartEndE-ValueType
low complexity region 19 41 N/A INTRINSIC
ZnMc 85 256 8.39e-48 SMART
ShKT 255 291 4.06e-10 SMART
IG 307 390 4.53e-2 SMART
Predicted Effect unknown
Transcript: ENSMUST00000067081
AA Change: T470A
SMART Domains Protein: ENSMUSP00000070527
Gene: ENSMUSG00000029062
AA Change: T470A

DomainStartEndE-ValueType
low complexity region 19 48 N/A INTRINSIC
low complexity region 93 112 N/A INTRINSIC
coiled coil region 123 214 N/A INTRINSIC
low complexity region 252 259 N/A INTRINSIC
low complexity region 261 272 N/A INTRINSIC
coiled coil region 290 337 N/A INTRINSIC
low complexity region 369 383 N/A INTRINSIC
S_TKc 427 712 5.05e-93 SMART
Predicted Effect unknown
Transcript: ENSMUST00000105598
AA Change: T436A
SMART Domains Protein: ENSMUSP00000101223
Gene: ENSMUSG00000029062
AA Change: T436A

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
low complexity region 59 78 N/A INTRINSIC
coiled coil region 89 180 N/A INTRINSIC
low complexity region 218 225 N/A INTRINSIC
low complexity region 227 238 N/A INTRINSIC
coiled coil region 256 303 N/A INTRINSIC
low complexity region 335 349 N/A INTRINSIC
S_TKc 393 678 5.05e-93 SMART
Predicted Effect unknown
Transcript: ENSMUST00000105600
AA Change: T470A
SMART Domains Protein: ENSMUSP00000101225
Gene: ENSMUSG00000029062
AA Change: T470A

DomainStartEndE-ValueType
low complexity region 19 48 N/A INTRINSIC
low complexity region 93 112 N/A INTRINSIC
coiled coil region 123 214 N/A INTRINSIC
low complexity region 252 259 N/A INTRINSIC
low complexity region 261 272 N/A INTRINSIC
coiled coil region 290 337 N/A INTRINSIC
low complexity region 369 383 N/A INTRINSIC
S_TKc 427 712 5.05e-93 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115821
SMART Domains Protein: ENSMUSP00000111488
Gene: ENSMUSG00000073682

DomainStartEndE-ValueType
SCOP:d1l9ha_ 17 52 2e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130944
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155100
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143196
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139242
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156906
Meta Mutation Damage Score 0.1395 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency 100% (67/67)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
PHENOTYPE: Homozygous null embryos display embryonic lethality from cell cycle arrest. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp6 T C 3: 97,075,891 (GRCm39) probably null Het
Adam33 C A 2: 130,896,399 (GRCm39) G437C probably damaging Het
Aldh1a1 T A 19: 20,579,377 (GRCm39) M1K probably null Het
Amotl2 C A 9: 102,597,718 (GRCm39) P126Q probably damaging Het
Ap1g1 T A 8: 110,580,275 (GRCm39) M576K possibly damaging Het
Apob C A 12: 8,040,406 (GRCm39) A581E probably damaging Het
Asb7 A T 7: 66,328,907 (GRCm39) D44E probably damaging Het
Bcl2 G A 1: 106,640,292 (GRCm39) R107C probably damaging Het
C9orf72 G A 4: 35,193,257 (GRCm39) T232I probably benign Het
Ccdc65 A T 15: 98,615,348 (GRCm39) H118L probably benign Het
Cdc25b A G 2: 131,039,204 (GRCm39) E523G probably damaging Het
Cilk1 G T 9: 78,062,799 (GRCm39) probably null Het
Clec1b A G 6: 129,378,570 (GRCm39) probably benign Het
Cntrl A G 2: 35,017,392 (GRCm39) T400A probably benign Het
Cpne4 T G 9: 104,899,481 (GRCm39) probably null Het
Cyp2j6 T A 4: 96,419,985 (GRCm39) R249* probably null Het
Dock2 T C 11: 34,579,380 (GRCm39) I678V probably benign Het
Dqx1 C T 6: 83,036,407 (GRCm39) probably benign Het
Dsp A T 13: 38,377,326 (GRCm39) K1704* probably null Het
Eif2b2 T C 12: 85,266,957 (GRCm39) F121S probably benign Het
Ephx4 T C 5: 107,561,379 (GRCm39) V69A possibly damaging Het
Epn2 T C 11: 61,426,134 (GRCm39) Q281R probably damaging Het
Fgf3 A C 7: 144,396,547 (GRCm39) D187A probably damaging Het
Galnt18 C A 7: 111,378,506 (GRCm39) probably benign Het
Gm4871 C T 5: 144,968,402 (GRCm39) probably benign Het
Inpp4b T C 8: 82,768,528 (GRCm39) I679T possibly damaging Het
Itpkb A G 1: 180,245,820 (GRCm39) E779G probably damaging Het
Itsn1 G A 16: 91,696,477 (GRCm39) V27M probably damaging Het
Lrp2 C A 2: 69,355,578 (GRCm39) R422L probably damaging Het
Mmp25 G A 17: 23,858,858 (GRCm39) A231V possibly damaging Het
Mprip T C 11: 59,650,561 (GRCm39) S1422P probably damaging Het
Mro A T 18: 74,009,860 (GRCm39) Q176L probably benign Het
Mrpl12 A G 11: 120,379,229 (GRCm39) E192G probably damaging Het
Myo5b A T 18: 74,862,025 (GRCm39) probably benign Het
Ncam2 G T 16: 80,997,772 (GRCm39) probably benign Het
Nip7 T C 8: 107,783,949 (GRCm39) L63P probably damaging Het
Nsd3 T C 8: 26,138,450 (GRCm39) probably benign Het
Nup98 A T 7: 101,788,004 (GRCm39) V1022D probably benign Het
Or2y1e T A 11: 49,218,744 (GRCm39) C169S probably damaging Het
Or5d43 A G 2: 88,104,559 (GRCm39) V278A possibly damaging Het
Or5h22 A G 16: 58,894,633 (GRCm39) I270T probably benign Het
Or7g28 A T 9: 19,272,177 (GRCm39) L158* probably null Het
P4ha2 T C 11: 54,008,434 (GRCm39) Y214H possibly damaging Het
Pacrg A T 17: 10,795,407 (GRCm39) F184L possibly damaging Het
Parpbp T A 10: 87,929,569 (GRCm39) R426S probably damaging Het
Pcdhb5 T A 18: 37,454,359 (GRCm39) Y246* probably null Het
Pik3cg T A 12: 32,244,770 (GRCm39) T895S probably damaging Het
Prkch T C 12: 73,738,426 (GRCm39) Y178H probably benign Het
Rusc2 G T 4: 43,425,486 (GRCm39) R1197L probably damaging Het
Svep1 T C 4: 58,054,700 (GRCm39) E3296G possibly damaging Het
Svs3a A G 2: 164,131,801 (GRCm39) K123R probably benign Het
Sycp2l A G 13: 41,304,006 (GRCm39) probably null Het
Syne3 T C 12: 104,909,685 (GRCm39) H717R probably benign Het
Tiprl A G 1: 165,050,092 (GRCm39) probably null Het
Trim24 T G 6: 37,892,130 (GRCm39) V151G possibly damaging Het
Trim33 T C 3: 103,234,217 (GRCm39) V56A possibly damaging Het
Trim67 C A 8: 125,521,397 (GRCm39) T253K probably benign Het
Trip12 T C 1: 84,703,928 (GRCm39) E698G probably damaging Het
Tspan14 T C 14: 40,637,353 (GRCm39) D145G probably damaging Het
Ushbp1 G A 8: 71,847,021 (GRCm39) Q204* probably null Het
Vmn1r71 G C 7: 10,482,019 (GRCm39) S223C possibly damaging Het
Vmn2r75 G T 7: 85,814,721 (GRCm39) N257K probably benign Het
Washc4 T C 10: 83,394,598 (GRCm39) probably benign Het
Zc3h7b G A 15: 81,666,169 (GRCm39) D560N probably damaging Het
Zscan21 T C 5: 138,123,402 (GRCm39) V27A probably benign Het
Zzef1 A C 11: 72,813,937 (GRCm39) E2842A probably damaging Het
Other mutations in Cdk11b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01764:Cdk11b APN 4 155,713,260 (GRCm39) missense possibly damaging 0.54
R0071:Cdk11b UTSW 4 155,733,880 (GRCm39) unclassified probably benign
R0071:Cdk11b UTSW 4 155,733,880 (GRCm39) unclassified probably benign
R0145:Cdk11b UTSW 4 155,726,076 (GRCm39) intron probably benign
R0372:Cdk11b UTSW 4 155,725,957 (GRCm39) intron probably benign
R0426:Cdk11b UTSW 4 155,726,969 (GRCm39) intron probably benign
R0627:Cdk11b UTSW 4 155,725,229 (GRCm39) intron probably benign
R1475:Cdk11b UTSW 4 155,718,674 (GRCm39) missense probably damaging 1.00
R1611:Cdk11b UTSW 4 155,726,032 (GRCm39) intron probably benign
R1719:Cdk11b UTSW 4 155,732,854 (GRCm39) unclassified probably benign
R1750:Cdk11b UTSW 4 155,713,137 (GRCm39) splice site probably null
R2061:Cdk11b UTSW 4 155,726,061 (GRCm39) intron probably benign
R2274:Cdk11b UTSW 4 155,732,051 (GRCm39) unclassified probably benign
R2922:Cdk11b UTSW 4 155,725,201 (GRCm39) intron probably benign
R3719:Cdk11b UTSW 4 155,711,343 (GRCm39) missense probably damaging 1.00
R3917:Cdk11b UTSW 4 155,711,258 (GRCm39) missense probably damaging 1.00
R4077:Cdk11b UTSW 4 155,724,204 (GRCm39) intron probably benign
R4078:Cdk11b UTSW 4 155,724,204 (GRCm39) intron probably benign
R5033:Cdk11b UTSW 4 155,733,282 (GRCm39) unclassified probably benign
R5212:Cdk11b UTSW 4 155,723,072 (GRCm39) splice site probably null
R5556:Cdk11b UTSW 4 155,718,604 (GRCm39) nonsense probably null
R5622:Cdk11b UTSW 4 155,714,674 (GRCm39) missense probably damaging 1.00
R5927:Cdk11b UTSW 4 155,732,697 (GRCm39) unclassified probably benign
R5975:Cdk11b UTSW 4 155,732,697 (GRCm39) unclassified probably benign
R6276:Cdk11b UTSW 4 155,718,647 (GRCm39) missense probably benign 0.11
R6278:Cdk11b UTSW 4 155,734,060 (GRCm39) unclassified probably benign
R6905:Cdk11b UTSW 4 155,726,065 (GRCm39) intron probably benign
R6998:Cdk11b UTSW 4 155,732,800 (GRCm39) nonsense probably null
R7021:Cdk11b UTSW 4 155,726,024 (GRCm39) intron probably benign
R7062:Cdk11b UTSW 4 155,711,268 (GRCm39) missense probably damaging 1.00
R7100:Cdk11b UTSW 4 155,710,050 (GRCm39) missense probably damaging 1.00
R7338:Cdk11b UTSW 4 155,732,008 (GRCm39) missense unknown
R7811:Cdk11b UTSW 4 155,724,359 (GRCm39) missense unknown
R8213:Cdk11b UTSW 4 155,724,338 (GRCm39) missense unknown
R8257:Cdk11b UTSW 4 155,732,398 (GRCm39) missense unknown
R8696:Cdk11b UTSW 4 155,732,779 (GRCm39) missense unknown
R9419:Cdk11b UTSW 4 155,724,302 (GRCm39) missense unknown
R9546:Cdk11b UTSW 4 155,733,589 (GRCm39) missense unknown
R9628:Cdk11b UTSW 4 155,734,154 (GRCm39) missense unknown
R9792:Cdk11b UTSW 4 155,732,378 (GRCm39) missense unknown
R9793:Cdk11b UTSW 4 155,732,378 (GRCm39) missense unknown
Z1088:Cdk11b UTSW 4 155,726,021 (GRCm39) intron probably benign
Predicted Primers
Posted On 2013-06-11