Incidental Mutation 'R5171:Cdc25a'
ID 470004
Institutional Source Beutler Lab
Gene Symbol Cdc25a
Ensembl Gene ENSMUSG00000032477
Gene Name cell division cycle 25A
Synonyms D9Ertd393e
MMRRC Submission 042751-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5171 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 109704647-109722963 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 109706229 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 57 (S57R)
Ref Sequence ENSEMBL: ENSMUSP00000142819 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094324] [ENSMUST00000198308] [ENSMUST00000198848]
AlphaFold P48964
Predicted Effect probably benign
Transcript: ENSMUST00000094324
AA Change: S57R

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000091882
Gene: ENSMUSG00000032477
AA Change: S57R

DomainStartEndE-ValueType
Pfam:M-inducer_phosp 85 318 3.6e-69 PFAM
RHOD 356 469 2.6e-25 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000198308
SMART Domains Protein: ENSMUSP00000142958
Gene: ENSMUSG00000032477

DomainStartEndE-ValueType
Pfam:M-inducer_phosp 24 258 1.2e-88 PFAM
RHOD 295 408 5.97e-25 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000198848
AA Change: S57R

PolyPhen 2 Score 0.247 (Sensitivity: 0.91; Specificity: 0.88)
Meta Mutation Damage Score 0.0864 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a spontaneous mutation exhibit elevated levels of early erythroid progenitor cell cycling but erythropoiesis is normally unaffected. Homozygous deletion of this gene is lethal and male heterozygotes display decreased vertebral trabecular bone. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AA986860 C A 1: 130,670,584 (GRCm39) Q269K probably benign Het
Acad9 T A 3: 36,128,547 (GRCm39) I136N possibly damaging Het
Adtrp A G 13: 41,931,039 (GRCm39) S183P probably damaging Het
Atp11b C T 3: 35,887,086 (GRCm39) T690I probably damaging Het
Bcl2l12 G A 7: 44,640,818 (GRCm39) probably benign Het
Btnl7-ps T A 17: 34,752,503 (GRCm39) noncoding transcript Het
Ccl12 T C 11: 81,993,460 (GRCm39) C33R probably damaging Het
Coro2a T A 4: 46,542,372 (GRCm39) probably benign Het
Cpne6 T C 14: 55,749,605 (GRCm39) V55A possibly damaging Het
Ddn A G 15: 98,704,207 (GRCm39) S362P possibly damaging Het
Dmpk C G 7: 18,821,944 (GRCm39) L301V probably benign Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Donson A G 16: 91,478,181 (GRCm39) V258A possibly damaging Het
Gm3336 G A 8: 71,174,524 (GRCm39) V163I probably benign Het
Gper1 C T 5: 139,412,413 (GRCm39) R253C probably damaging Het
Gpsm1 T A 2: 26,217,476 (GRCm39) probably benign Het
Hip1 A G 5: 135,469,156 (GRCm39) S251P probably damaging Het
Ifi214 A G 1: 173,354,200 (GRCm39) S157P possibly damaging Het
Igkv4-80 A C 6: 68,993,649 (GRCm39) S81A probably benign Het
Kntc1 T C 5: 123,937,907 (GRCm39) V1535A probably benign Het
Mbd3l1 A G 9: 18,396,430 (GRCm39) N185S probably benign Het
Mnx1 T C 5: 29,679,851 (GRCm39) Q252R unknown Het
Mroh3 A T 1: 136,119,394 (GRCm39) L463Q possibly damaging Het
Myom1 T C 17: 71,406,967 (GRCm39) V1030A possibly damaging Het
Or3a1d T C 11: 74,237,640 (GRCm39) T257A probably benign Het
Or5ak20 T C 2: 85,184,114 (GRCm39) D52G probably benign Het
Or5w1 T G 2: 87,486,888 (GRCm39) I126L possibly damaging Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Ranbp17 A G 11: 33,167,419 (GRCm39) Y1015H probably benign Het
Rasal1 C T 5: 120,801,829 (GRCm39) T256I probably benign Het
Rexo5 T A 7: 119,423,002 (GRCm39) I278N probably damaging Het
Rims2 T A 15: 39,300,499 (GRCm39) S77T probably damaging Het
Sdk2 C T 11: 113,741,808 (GRCm39) A804T probably benign Het
Slc24a2 T A 4: 86,914,871 (GRCm39) I589F probably benign Het
Slc25a38 T A 9: 119,951,181 (GRCm39) I217K probably benign Het
Slc5a7 T C 17: 54,583,704 (GRCm39) T529A probably benign Het
Spata22 T A 11: 73,227,034 (GRCm39) S83T probably damaging Het
Spata31e4 A T 13: 50,854,414 (GRCm39) T91S possibly damaging Het
Stac2 A T 11: 97,934,324 (GRCm39) C127S possibly damaging Het
Tep1 T C 14: 51,062,259 (GRCm39) H2531R probably benign Het
Tmem151a G T 19: 5,132,061 (GRCm39) R382S probably damaging Het
Trim60 T C 8: 65,453,176 (GRCm39) T358A probably benign Het
Unc13c T A 9: 73,665,236 (GRCm39) M1048L probably benign Het
Usp29 T C 7: 6,965,074 (GRCm39) S306P probably damaging Het
Zfp26 T C 9: 20,356,203 (GRCm39) K35R probably benign Het
Zfp462 T A 4: 55,016,986 (GRCm39) probably null Het
Other mutations in Cdc25a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01658:Cdc25a APN 9 109,705,194 (GRCm39) splice site probably null
IGL01761:Cdc25a APN 9 109,720,933 (GRCm39) intron probably benign
IGL02808:Cdc25a APN 9 109,712,667 (GRCm39) splice site probably null
IGL03241:Cdc25a APN 9 109,713,267 (GRCm39) splice site probably null
P4748:Cdc25a UTSW 9 109,713,176 (GRCm39) splice site probably benign
R1472:Cdc25a UTSW 9 109,705,157 (GRCm39) missense probably benign 0.00
R1571:Cdc25a UTSW 9 109,710,614 (GRCm39) missense possibly damaging 0.56
R1598:Cdc25a UTSW 9 109,708,961 (GRCm39) frame shift probably null
R4135:Cdc25a UTSW 9 109,710,585 (GRCm39) missense possibly damaging 0.62
R4301:Cdc25a UTSW 9 109,718,810 (GRCm39) missense probably benign 0.23
R4386:Cdc25a UTSW 9 109,718,801 (GRCm39) missense probably damaging 1.00
R5074:Cdc25a UTSW 9 109,713,208 (GRCm39) missense possibly damaging 0.46
R5896:Cdc25a UTSW 9 109,713,433 (GRCm39) missense probably benign 0.00
R5928:Cdc25a UTSW 9 109,718,861 (GRCm39) missense probably damaging 1.00
R6223:Cdc25a UTSW 9 109,718,842 (GRCm39) missense possibly damaging 0.85
R6240:Cdc25a UTSW 9 109,713,226 (GRCm39) missense probably damaging 1.00
R6440:Cdc25a UTSW 9 109,710,566 (GRCm39) missense probably benign
R6854:Cdc25a UTSW 9 109,708,995 (GRCm39) missense probably damaging 1.00
R7219:Cdc25a UTSW 9 109,718,154 (GRCm39) missense probably damaging 0.99
R7980:Cdc25a UTSW 9 109,708,949 (GRCm39) missense probably damaging 1.00
R8506:Cdc25a UTSW 9 109,720,820 (GRCm39) missense probably damaging 0.99
R8790:Cdc25a UTSW 9 109,716,416 (GRCm39) critical splice donor site probably null
R8807:Cdc25a UTSW 9 109,708,303 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CTTTGTTTAAATGCCAACTGGGG -3'
(R):5'- CGAATGGCTGACTCCAGATG -3'

Sequencing Primer
(F):5'- AAATGCCAACTGGGGTATTCTG -3'
(R):5'- GATCTACATGGTGAGACCCTGTC -3'
Posted On 2017-03-06